Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation.

abstract：:In The Netherlands from July 1988 to October 1991, children (0 to 16 years of age) with de novo acute lymphoblastic leukemia (ALL) were treated according to protocol ALL-7 of the Dutch Childhood Leukemia Study Group (DCLSG). In this protocol, chemotherapy and treatment stratification were identical to the ALL-BFM-86 p...

journal_title：Blood

authors： Kamps WA,Bökkerink JP,Hählen K,Hermans J,Riehm H,Gadner H,Schrappe M,Slater R,van den Berg-de Ruiter E,Smets LA,de Vaan GA,Weening RS,van Weerden JF,van Wering ER,den der Does-van den Berg A

更新日期：1999-08-15 00:00:00

abstract：:Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. In a murine retrovir...

journal_title：Blood

authors： Million RP,Aster J,Gilliland DG,Van Etten RA

更新日期：2002-06-15 00:00:00

abstract：:We have developed a novel cotransplantation system in which gene-transduced human CD34+ progenitor cells are transplanted into immunodeficient (bnx) mice together with primary human bone marrow (BM) stromal cells engineered to produce human interleukin-3 (IL-3). The IL-3-secreting stroma produced sustained circulating...

journal_title：Blood

authors： Nolta JA,Hanley MB,Kohn DB

更新日期：1994-05-15 00:00:00

abstract：:Although the proto-oncogene rhombotin-2 (RBTN-2) is widely expressed in most tissues, it is not expressed in T cells. We investigated the potential for overexpression of RBTN-2 to cause tumors in T cells and other tissues by constructing transgenic mice that expressed RBTN-2 under control of the metallothionein-1 prom...

journal_title：Blood

authors： Neale GA,Rehg JE,Goorha RM

更新日期：1995-10-15 00:00:00

abstract：:We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, ...

journal_title：Blood

authors： Yokota T,Oritani K,Takahashi I,Ishikawa J,Matsuyama A,Ouchi N,Kihara S,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

journal_title：Blood

authors： Jarolim P,Rubin HL,Brabec V,Palek J

更新日期：1995-06-01 00:00:00

abstract：:Primitive chronic myeloid leukemia cells display a unique autocrine interleukin 3 (IL-3)/granulocyte-colony-stimluating factor (G-CSF) mechanism that may explain their abnormal proliferation and differentiation control. Here we show that BCR-ABL transduction of primitive Sca-1(+) lin(-) mouse bone marrow (BM) cells ca...

journal_title：Blood

authors： Jiang X,Ng E,Yip C,Eisterer W,Chalandon Y,Stuible M,Eaves A,Eaves CJ

更新日期：2002-11-15 00:00:00

abstract：:Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

journal_title：Blood

authors： Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

更新日期：2019-11-28 00:00:00

abstract：:We have cloned, expressed, and partially purified a naturally occurring, truncated, soluble form of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit to investigate its biochemical and biologic properties. The soluble receptor species lacks the transmembrane and cytoplasmic dom...

journal_title：Blood

authors： Brown CB,Beaudry P,Laing TD,Shoemaker S,Kaushansky K

更新日期：1995-03-15 00:00:00

abstract：:The JAK2 V617F mutation is present in the majority of patients with a myeloproliferative neoplasm (MPN) and is sufficient to recapitulate an MPN in murine models. However, the consequences of JAK2 mutations for myeloid differentiation are poorly understood. After systematic analyses of a large cohort of JAK2-mutated M...

journal_title：Blood

authors： Anand S,Stedham F,Beer P,Gudgin E,Ortmann CA,Bench A,Erber W,Green AR,Huntly BJ

更新日期：2011-07-07 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:The CD11a/CD18 (leukocyte function-associated antigen 1 [LFA-1]) integrin mediates critical leukocyte adhesive interactions during immune and inflammatory responses. The CD11a promoter directs CD11a/CD18 integrin expression, and its activity in lymphoid cells depends on a functional RUNX1/AML-1-binding site (AML-110) ...

journal_title：Blood

authors： Puig-Kröger A,Sanchez-Elsner T,Ruiz N,Andreu EJ,Prosper F,Jensen UB,Gil J,Erickson P,Drabkin H,Groner Y,Corbi AL

更新日期：2003-11-01 00:00:00

abstract：:Plasmin cleaves fibrin at or near sites involved in platelet recognition and may modulate platelet adhesion and spreading. Using an in vitro system, we have characterized the effects of limited plasmic degradation of polymerized fibrin on platelet adhesion and spreading. As shown by scanning electron microscopy, expos...

journal_title：Blood

authors： Hamaguchi M,Bunce LA,Sporn LA,Francis CW

更新日期：1994-08-15 00:00:00

abstract：:Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mu...

journal_title：Blood

authors： Zhang X,Shang X,Guo F,Murphy K,Kirby M,Kelly P,Reeves L,Smith FO,Williams DA,Zheng Y,Pang Q

更新日期：2008-09-01 00:00:00

abstract：:The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP response element (CRE...

journal_title：Blood

authors： Sangerman J,Lee MS,Yao X,Oteng E,Hsiao CH,Li W,Zein S,Ofori-Acquah SF,Pace BS

更新日期：2006-11-15 00:00:00

abstract：:In this issue of Blood, the findings of Chakraborty et al and Emile et al support a model in which the mitogen-activated protein kinase (MAPK) and PI3K/AKT pathways are critical in the pathogenesis of 2 of the most common histiocytoses—Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD)—whereas their...

journal_title：Blood

authors： Prince HM

更新日期：2014-11-06 00:00:00

abstract：:The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gen...

journal_title：Blood

authors： Anderson KP,Crable SC,Lingrel JB

更新日期：2000-03-01 00:00:00

abstract：:The International Prognostic Scoring System (IPSS) has been widely used to predict the prognosis of patients with myelodysplastic syndrome (MDS). However, IPSS does not always provide a sufficiently precise evaluation of patients to allow the appropriate choice of clinical interventions. Here, we analyzed the expressi...

journal_title：Blood

authors： Mihara K,Chowdhury M,Nakaju N,Hidani S,Ihara A,Hyodo H,Yasunaga S,Takihara Y,Kimura A

更新日期：2006-01-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease defined by transcriptional classifications, specific signaling and survival pathways, and multiple low-frequency genetic alterations. Preclinical model systems that capture the genetic and functional heterogeneity of DLBCL are urgently needed. Here, we g...

journal_title：Blood

authors： Chapuy B,Cheng H,Watahiki A,Ducar MD,Tan Y,Chen L,Roemer MG,Ouyang J,Christie AL,Zhang L,Gusenleitner D,Abo RP,Farinha P,von Bonin F,Thorner AR,Sun HH,Gascoyne RD,Pinkus GS,van Hummelen P,Wulf GG,Aster JC,Weinst

更新日期：2016-05-05 00:00:00

abstract：:The human pluripotent UT-7 cell line is growth factor-dependent for proliferation and differentiation. We have previously shown that (1) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Epo) induce a myeloid and erythroid pattern of differentiation, respectively; (2) GM-CSF acts predominan...

journal_title：Blood

authors： Hermine O,Dubart A,Porteux F,Mayeux P,Titeux M,Dumenil D,Vainchenker W

更新日期：1996-03-01 00:00:00

abstract：:Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells....

journal_title：Blood

authors： Keren Z,Naor S,Nussbaum S,Golan K,Itkin T,Sasaki Y,Schmidt-Supprian M,Lapidot T,Melamed D

更新日期：2011-03-17 00:00:00

abstract：:Severe congenital neutropenia (CN) (Kostmann syndrome) is a hematologic disorder characterized by a maturation arrest of myelopoiesis at the promyelocyte/myelocyte stage of development. This arrest results in severe neutropenia leading to absolute neutrophil counts (ANC) below 0.2 x 10(9)/L associated with severe bact...

journal_title：Blood

authors： Zeidler C,Welte K,Barak Y,Barriga F,Bolyard AA,Boxer L,Cornu G,Cowan MJ,Dale DC,Flood T,Freedman M,Gadner H,Mandel H,O'Reilly RJ,Ramenghi U,Reiter A,Skinner R,Vermylen C,Levine JE

更新日期：2000-02-15 00:00:00

abstract：:Translation of small interfering RNA (siRNA)-based approaches into practical therapeutics is limited because of lack of an effective and cell-specific delivery system. Herein, we present a new method of selectively delivering siRNA to dendritic cells (DCs) in vivo using CD40 siRNA-containing immunoliposomes (siILs) th...

journal_title：Blood

authors： Zheng X,Vladau C,Zhang X,Suzuki M,Ichim TE,Zhang ZX,Li M,Carrier E,Garcia B,Jevnikar AM,Min WP

更新日期：2009-03-19 00:00:00

abstract：:Multicentric Castleman disease (MCD) is a lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by...

journal_title：Blood

authors： Casper C,Nichols WG,Huang ML,Corey L,Wald A

更新日期：2004-03-01 00:00:00

abstract：:To know the role and initiation mechanism of the interaction of glycoprotein (GP) Ib with surface-immobilized von Willebrand factor (vWF), we examined the effect of shear stress levels on platelet binding to vWF-coated plates using a cone-and-plate type viscometer capable of loading various levels of shear stress. The...

journal_title：Blood

authors： Tsuji S,Sugimoto M,Kuwahara M,Nishio K,Takahashi Y,Fujimura Y,Ikeda Y,Yoshioka A

更新日期：1996-11-15 00:00:00

abstract：:The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG) joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis of clinical, biologic, and early response data predictive of event-free survival (EFS) in acute lymphoblastic leukemia (ALL) to develop a new classification ...

journal_title：Blood

authors： Schultz KR,Pullen DJ,Sather HN,Shuster JJ,Devidas M,Borowitz MJ,Carroll AJ,Heerema NA,Rubnitz JE,Loh ML,Raetz EA,Winick NJ,Hunger SP,Carroll WL,Gaynon PS,Camitta BM

更新日期：2007-02-01 00:00:00

abstract：:In essential thrombocythemia (ET), the JAK2-V617F mutation is usually restricted to a subpopulation of neutrophils and platelets, and production of JAK2 wild-type (WT) platelets is not suppressed. Nonmutated precursor cells may, therefore, be susceptible to the acquisition of further JAK2 mutations. We used a common s...

journal_title：Blood

authors： Lambert JR,Everington T,Linch DC,Gale RE

更新日期：2009-10-01 00:00:00

abstract：:Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (T(CD8)). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitor...

journal_title：Blood

authors： Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH

更新日期：2012-12-06 00:00:00

abstract：:During the early period following bone marrow transplantation before the immune system has reached full functional maturity, unprimed, nonspecific lytic systems may play a critical role as antiviral or antitumor effectors. The reconstitution of cells with this potential is of particular importance in recipients of bon...

journal_title：Blood

authors： Keever CA,Welte K,Small T,Levick J,Sullivan M,Hauch M,Evans RL,O'Reilly RJ

更新日期：1987-12-01 00:00:00

abstract：:BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and to increase their self-renewal capacity during recovery from cytotoxic damage. Its use may constitute a novel approach for protect...

journal_title：Blood

authors： Clemons MJ,Marshall E,Dürig J,Watanabe K,Howell A,Miles D,Earl H,Kiernan J,Griffiths A,Towlson K,DeTakats P,Testa NG,Dougal M,Hunter MG,Wood LM,Czaplewski LG,Millar A,Dexter TM,Lord BI

更新日期：1998-09-01 00:00:00