Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis.

abstract：:We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant che...

journal_title：Blood

authors： Linker CA,Levitt LJ,O'Donnell M,Forman SJ,Ries CA

更新日期：1991-12-01 00:00:00

abstract：:Fluid shear stress in arteries and arterioles partially obstructed by atherosclerosis or spasm may exceed the normal time-average level of 20 dyne/cm2. In vitro, at fluid shear stresses of 30 to 60 dyne/cm2 applied for 30 seconds, platelet aggregation occurs. At these shear stresses, either large or unusually large vo...

journal_title：Blood

authors： Moake JL,Turner NA,Stathopoulos NA,Nolasco L,Hellums JD

更新日期：1988-05-01 00:00:00

abstract：:Following allogeneic hematopoietic stem cell transplantation (alloHSCT), children are at risk of life-threatening pneumococcal infections. Whereas vaccination with polysaccharide vaccines fails to elicit protective immunity in most alloHSC transplant recipients, pneumococcal conjugate vaccines may effectively prevent ...

journal_title：Blood

authors： Meisel R,Kuypers L,Dirksen U,Schubert R,Gruhn B,Strauss G,Beutel K,Groll AH,Duffner U,Blütters-Sawatzki R,Holter W,Feuchtinger T,Grüttner HP,Schroten H,Zielen S,Ohmann C,Laws HJ,Dilloo D,Impfung von Kindern nach allog

更新日期：2007-03-15 00:00:00

abstract：:Unseparated or Ficoll-Hypaque (Pharmacia, Piscataway, NJ)--fractionated human cord blood cells were transplanted into sublethally irradiated severe combined immunodeficient (SCID) mice. High levels of multilineage engraftment, including myeloid and lymphoid lineages, were obtained with 80% of the donor samples as asse...

journal_title：Blood

authors： Vormoor J,Lapidot T,Pflumio F,Risdon G,Patterson B,Broxmeyer HE,Dick JE

更新日期：1994-05-01 00:00:00

abstract：:The interleukin-4 receptor (IL-4R) is expressed as a 140-Kd membrane glycoprotein that binds IL-4 with high affinity. Recently, cDNA clones for the murine IL-4R have been isolated. One clone encodes an integral membrane protein, while another encodes a protein in which translation is terminated before the transmembran...

journal_title：Blood

authors： Jacobs CA,Lynch DH,Roux ER,Miller R,Davis B,Widmer MB,Wignall J,VandenBos T,Park LS,Beckmann MP

更新日期：1991-06-01 00:00:00

abstract：:Twenty-one human immunodeficiency virus (HIV)-positive patients, including 11 acquired immunodeficiency syndrome (AIDS)-free patients with immune thrombocytopenic purpura (ITP), were studied to determine whether the megakaryocytic/platelet lineage was infected by HIV. Because purification of platelets did not reach a ...

journal_title：Blood

authors： Louache F,Bettaieb A,Henri A,Oksenhendler E,Farcet JP,Bierling P,Seligmann M,Vainchenker W

更新日期：1991-10-01 00:00:00

abstract：:The CD28 family of receptors (CD28, cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding...

journal_title：Blood

authors： Riley JL,June CH

更新日期：2005-01-01 00:00:00

abstract：:We analyzed factors having an impact on response to treatment and survival in 78 consecutive patients with chronic myeloid leukemia (CML) in blastic transformation (BT) referred to the Hammersmith Hospital from January 1995 to December 2000. BT was defined as the presence of at least 30% blasts in blood or marrow or e...

journal_title：Blood

authors： Wadhwa J,Szydlo RM,Apperley JF,Chase A,Bua M,Marin D,Olavarria E,Kanfer E,Goldman JM

更新日期：2002-04-01 00:00:00

abstract：:Coated vesicles bearing the transferrin-transferrin receptor complex were isolated from rabbit reticulocytes by freeze-thaw cell lysis, followed by differential centrifugation with pelleting of vesicles at 100,000 g. Electronmicroscopy demonstrated the vesicles to have the characteristic morphology of coated vesicles,...

journal_title：Blood

authors： Choe HR,Moseley ST,Glass J,Nunez MT

更新日期：1987-10-01 00:00:00

abstract：:A cytologic and cytogenetic study of 10 cases of acute myeloblastic leukemia with maturation and t(8;21) translocation is reported. Despite a certain polymorphic appearance, the characteristic cytologic picture, consisting essentially of large myeloblasts with an abundant cytoplasma containing a large Auer rod, allowe...

journal_title：Blood

authors： Berger R,Bernheim A,Daniel MT,Valensi F,Sigaux F,Flandrin G

更新日期：1982-01-01 00:00:00

abstract：:Nitric oxide is a short-lived reactive mediator that inhibits bone marrow (BM) cell proliferation induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). The present studies show that nitric oxide also inhibits macrophage colony-stimulating factor (M-CSF)-induced growth of mouse BM cells, an effect that ...

journal_title：Blood

authors： Punjabi CJ,Laskin JD,Hwang SM,MacEachern L,Laskin DL

更新日期：1994-06-01 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we designed a multicenter, randomized trial aiming to determine whether quinine would improve the survival of adult patients (15-60 years old) with de novo acute myelogenous leukemia (AML). These pa...

journal_title：Blood

authors： Solary E,Drenou B,Campos L,de Crémoux P,Mugneret F,Moreau P,Lioure B,Falkenrodt A,Witz B,Bernard M,Hunault-Berger M,Delain M,Fernandes J,Mounier C,Guilhot F,Garnache F,Berthou C,Kara-Slimane F,Harousseau JL,Groupe O

更新日期：2003-08-15 00:00:00

abstract：:To study the role of the stress-induced "readthrough" acetylcholinesterase splice variant, AChE-R, in thrombopoiesis, we used transgenic mice overexpressing human AChE-R (TgR). Increased AChE hydrolytic activity in the peripheral blood of TgR mice was associated with increased thrombopoietin levels and platelet counts...

journal_title：Blood

authors： Pick M,Perry C,Lapidot T,Guimaraes-Sternberg C,Naparstek E,Deutsch V,Soreq H

更新日期：2006-04-15 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed 3 separate iPSC clones from f...

journal_title：Blood

authors： Mills JA,Wang K,Paluru P,Ying L,Lu L,Galvão AM,Xu D,Yao Y,Sullivan SK,Sullivan LM,Mac H,Omari A,Jean JC,Shen S,Gower A,Spira A,Mostoslavsky G,Kotton DN,French DL,Weiss MJ,Gadue P

更新日期：2013-09-19 00:00:00

abstract：:In this issue of Blood, Rieger et al show that malaria parasite infiltration in the human placenta requires a specific geometry and affinity of host receptors to facilitate strong adhesion. ...

journal_title：Blood

authors： Chishti AH

更新日期：2015-01-08 00:00:00

abstract：:We have analyzed the reactivation of fetal hemoglobin (HbF) synthesis under rigorous in vitro conditions, ie, in mature erythroblasts generated by erythroid burst-forming units (BFU-E) stringently purified from normal adult peripheral blood and grown in fetal calf serum(FCS)-free semisolid or liquid phase culture. In ...

journal_title：Blood

authors： Peschle C,Gabbianelli M,Testa U,Pelosi E,Barberi T,Fossati C,Valtieri M,Leone L

更新日期：1993-01-15 00:00:00

abstract：:We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

journal_title：Blood

authors： Nakano T,Waki N,Asai H,Kitamura Y

更新日期：1989-04-01 00:00:00

abstract：:CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using...

journal_title：Blood

authors： Tomkowicz B,Lee C,Ravyn V,Cheung R,Ptasznik A,Collman RG

更新日期：2006-08-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is driven by niche-derived and cell-autonomous stimuli. Although many cell-autonomous disease drivers are known, niche-dependent signaling in the context of the genetic disease heterogeneity has been difficult to investigate. Here, we analyzed the role of Bruton tyrosine kinase (BTK) in AM...

journal_title：Blood

authors： Oellerich T,Mohr S,Corso J,Beck J,Döbele C,Braun H,Cremer A,Münch S,Wicht J,Oellerich MF,Bug G,Bohnenberger H,Perske C,Schütz E,Urlaub H,Serve H

更新日期：2015-03-19 00:00:00

abstract：:Lymphoproliferative disorders involving Epstein-Barr virus (EBV) infected natural killer (NK) cells are reported with increasing frequency, but the nature and role of EBV infection in these cells remains undefined. In this study, we have investigated virus-cell interactions in the EBV-positive YTN10 cell line, an NK-l...

journal_title：Blood

authors： Kanegane H,Wang F,Tosato G

更新日期：1996-12-15 00:00:00

abstract：:Aberrant activation of the Wnt pathway plays a pathogenetic role in various tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). LEF1, a key mediator of Wnt signaling, has been linked to leukemic transformation, and recurrent mutations of LEF1 have been identified in pediatric T-A...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Kaiser M,Schlee C,Stroux A,Burmeister T,Mochmann LH,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2011-12-08 00:00:00

abstract：:The presence and physiologic role of cyclic GMP-dependent protein kinase (G-kinase) in human neutrophils was investigated by Western blot analysis and immunocytochemistry. Small quantities of G-kinase were found in the cytoskeletal-enriched fraction of neutrophil lysates as detected by Western blots using a polyclonal...

journal_title：Blood

authors： Pryzwansky KB,Wyatt TA,Nichols H,Lincoln TM

更新日期：1990-08-01 00:00:00

abstract：:In France, more than 80% of children with Burkitt's lymphoma or Burkitt's leukemia (ALL3) are now cured with the LMB (B-cell non-Hodgkin's lymphoma and B-ALL) protocols of the Société Française d'Oncologie Pédiatrique, but so far, poor results have been obtained in the few adult studies available. We have analyzed the...

journal_title：Blood

authors： Soussain C,Patte C,Ostronoff M,Delmer A,Rigal-Huguet F,Cambier N,Leprisé PY,François S,Cony-Makhoul P,Harousseau JL

更新日期：1995-02-01 00:00:00

abstract：:After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) is responsible for cytoadherence of infected cells to host endothelial receptors. Thi...

journal_title：Blood

authors： Knuepfer E,Rug M,Klonis N,Tilley L,Cowman AF

更新日期：2005-05-15 00:00:00

abstract：:T gamma lymphocytes are those lymphocytes that express receptors for both the Fc portion of IgG and sheep erythrocytes. A very high proportion of normal T gamma lymphocytes are large granular lymphocytes (LGL), the cell responsible for most, if not all, natural killer (NK) and antibody-dependent cell-mediated cytotoxi...

journal_title：Blood

authors： Reynolds CW,Foon KA

更新日期：1984-12-01 00:00:00

abstract：:We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by (99m)Tc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (PIT) and quantitative Howell-Jolly bodies (HJB) enumerated by flow c...

journal_title：Blood

authors： Rogers ZR,Wang WC,Luo Z,Iyer RV,Shalaby-Rana E,Dertinger SD,Shulkin BL,Miller JH,Files B,Lane PA,Thompson BW,Miller ST,Ware RE,BABY HUG.

更新日期：2011-03-03 00:00:00

abstract：:A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)-mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor-kappaB (NF-kappaB). In this study, we evaluated the molecular basis of ...

journal_title：Blood

authors： Daniel S,Arvelo MB,Patel VI,Longo CR,Shrikhande G,Shukri T,Mahiou J,Sun DW,Mottley C,Grey ST,Ferran C

更新日期：2004-10-15 00:00:00

abstract：:Dense, dehydrated red blood cells (DRBCs) are a characteristic feature of sickle-cell disease (SCD). DRBCs play a role in the pathophysiology of SCD acute and chronic organ damage because of heightened tendency to undergo polymerization and sickling because of their higher hemoglobin S concentration. Relations between...

journal_title：Blood

authors： Bartolucci P,Brugnara C,Teixeira-Pinto A,Pissard S,Moradkhani K,Jouault H,Galacteros F

更新日期：2012-10-11 00:00:00

abstract：:In adult bone marrow, mature erythroblasts are produced within structures called erythroblastic islands and then cross the endothelial barrier to reach circulation. Erythroblastic islands are composed of a central macrophage surrounded by maturing erythroblasts. In this study, it is shown that erythroid cells, but not...

journal_title：Blood

authors： Tordjman R,Delaire S,Plouët J,Ting S,Gaulard P,Fichelson S,Roméo PH,Lemarchandel V

更新日期：2001-04-01 00:00:00