Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis.

abstract：:Setdb1, also known as Eset, is a methyltransferase that catalyzes trimethylation of H3K9 (H3K9me3) and plays an essential role in the silencing of endogenous retroviral elements (ERVs) in the developing embryo and embryonic stem cells (ESCs). Its role in somatic stem cells, however, remains unclear because of the earl...

journal_title：Blood

authors： Koide S,Oshima M,Takubo K,Yamazaki S,Nitta E,Saraya A,Aoyama K,Kato Y,Miyagi S,Nakajima-Takagi Y,Chiba T,Matsui H,Arai F,Suzuki Y,Kimura H,Nakauchi H,Suda T,Shinkai Y,Iwama A

更新日期：2016-08-04 00:00:00

abstract：:Although chemotherapy can induce complete responses in patients with chronic lymphocytic leukemia (CLL), it is not considered curative. Treated patients generally develop recurrent disease requiring additional therapy, which can cause worsening immune dysfunction, myelosuppression, and selection for chemotherapy-resis...

journal_title：Blood

authors： Kater AP,van Oers MH,Kipps TJ

更新日期：2007-10-15 00:00:00

abstract：:Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (T(CD8)). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitor...

journal_title：Blood

authors： Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH

更新日期：2012-12-06 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of platelet shedding. Despite this, loss of Bcl-x(L) does not prevent the growth and maturation of megakaryocytes, suggesting redundancy with other prosurvival proteins....

journal_title：Blood

authors： Debrincat MA,Josefsson EC,James C,Henley KJ,Ellis S,Lebois M,Betterman KL,Lane RM,Rogers KL,White MJ,Roberts AW,Harvey NL,Metcalf D,Kile BT

更新日期：2012-06-14 00:00:00

abstract：:Iron is a transition metal whose physicochemical properties make it the focus of vital biologic processes in virtually all living organisms. Among numerous roles, iron is essential for oxygen transport, cellular respiration, and DNA synthesis. Paradoxically, the same characteristics that biochemistry exploits make iro...

journal_title：Blood

authors： Sheftel AD,Zhang AS,Brown C,Shirihai OS,Ponka P

更新日期：2007-07-01 00:00:00

abstract：:Peripheral lymphocytes from normal individuals and from patients with chronic lymphocytic leukemia (CLL) were cultured in vitro for 1-7 days. The growth response to phytohemagglutinin (PHA) was quantitated by the incorporation of tritiated uridine into RNA nucleotide during a 2-hr pulse with the radioisotope. While th...

journal_title：Blood

authors： Schultz EF,Davis S,Rubin AD

更新日期：1976-08-01 00:00:00

abstract：:Integrin-β7 (ITGB7) mRNA is detected in multiple myeloma (MM) cells and its presence is correlated with MAF gene activation. Although the involvement of several integrin family members in MM-stoma cell interaction is well documented, the specific biologic functions regulated by integrin-β7 in MM are largely unknown. C...

journal_title：Blood

authors： Neri P,Ren L,Azab AK,Brentnall M,Gratton K,Klimowicz AC,Lin C,Duggan P,Tassone P,Mansoor A,Stewart DA,Boise LH,Ghobrial IM,Bahlis NJ

更新日期：2011-06-09 00:00:00

abstract：:Follicular lymphoma (FL) grades 1 and 2 are regarded as a distinct disease entity, whereas data suggest that FL grade 3 might be an inhomogeneous tumor category. To define the biologic spectrum of FL, 89 follicular lymphomas were studied for their cytologic composition, antigen expression, mitotic and proliferation in...

journal_title：Blood

authors： Ott G,Katzenberger T,Lohr A,Kindelberger S,Rüdiger T,Wilhelm M,Kalla J,Rosenwald A,Müller JG,Ott MM,Müller-Hermelink HK

更新日期：2002-05-15 00:00:00

abstract：:The purpose of this study was to estimate the incidence and to establish which factors were associated with an increased risk of hemorrhagic complications in an historic cohort of 117 consecutive and unselected patients with chronic idiopathic thrombocytopenic purpura (ITP). Sixty-eight patients (58%) underwent medica...

journal_title：Blood

authors： Cortelazzo S,Finazzi G,Buelli M,Molteni A,Viero P,Barbui T

更新日期：1991-01-01 00:00:00

abstract：:The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately r...

journal_title：Blood

authors： Guo Y,Chan R,Ramsey H,Li W,Xie X,Shelley WC,Martinez-Barbera JP,Bort B,Zaret K,Yoder M,Hromas R

更新日期：2003-10-01 00:00:00

abstract：:Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Platelet packaging and release concludes at the tips of each proplatelet. Essential in this process is the distribution of organelles and platelet-specific granules i...

journal_title：Blood

authors： Richardson JL,Shivdasani RA,Boers C,Hartwig JH,Italiano JE Jr

更新日期：2005-12-15 00:00:00

abstract：:To understand the etiology of bone modulation and hypercalcemia observed in granulocytosis of a tumor-bearing animal model and to gain insight into the implication of sustained hematopoietic stimulation on the bone tissue, in vivo responses of normal mouse hematopoietic and bone tissues to long-term injections of reco...

journal_title：Blood

authors： Lee MY,Fukunaga R,Lee TJ,Lottsfeldt JL,Nagata S

更新日期：1991-05-15 00:00:00

abstract：:Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. We now tested whether endogenous platelet PF4 content affects APC generation. Mice completely deficient in PF4 (mPF4(-/-)) had impaired AP...

journal_title：Blood

authors： Kowalska MA,Mahmud SA,Lambert MP,Poncz M,Slungaard A

更新日期：2007-09-15 00:00:00

abstract：:Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic ...

journal_title：Blood

authors： Jacobsen EA,Helmers RA,Lee JJ,Lee NA

更新日期：2012-11-08 00:00:00

abstract：:Surface marker and gene rearrangement data have supported various hypotheses about the origin of the malignant cell in Hodgkin's disease. Cytogenetic data about this disorder, however, are very scanty. To determine if any chromosomal abnormalities that could add further information to this controversial point are pres...

journal_title：Blood

authors： Cabanillas F,Pathak S,Trujillo J,Grant G,Cork A,Hagemeister FB,Velasquez WS,McLaughlin P,Redman J,Katz R

更新日期：1988-06-01 00:00:00

abstract：:To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particula...

journal_title：Blood

authors： Nishiwaki S,Inamoto Y,Sakamaki H,Kurokawa M,Iida H,Ogawa H,Fukuda T,Ozawa Y,Kobayashi N,Kasai M,Mori T,Iwato K,Yoshida T,Onizuka M,Kawa K,Morishima Y,Suzuki R,Atsuta Y,Miyamura K

更新日期：2010-11-18 00:00:00

abstract：:Mutations of the type III receptor tyrosine kinase FLT3 occur in approximately 30% of acute myeloid leukemia patients and lead to constitutive activation. This has made FLT3-activating mutations an attractive drug target because they are probable driver mutations of this disease. As more potent FLT3 inhibitors are dev...

journal_title：Blood

authors： Galanis A,Ma H,Rajkhowa T,Ramachandran A,Small D,Cortes J,Levis M

更新日期：2014-01-02 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:Atypical hemolytic-uremic syndrome (aHUS) is associated with genetic complement abnormalities/anti-complement factor H antibodies, which paved the way to treatment with eculizumab. We studied 44 aHUS patients and their relatives to (1) test new assays of complement activation, (2) verify whether such abnormality occur...

journal_title：Blood

authors： Noris M,Galbusera M,Gastoldi S,Macor P,Banterla F,Bresin E,Tripodo C,Bettoni S,Donadelli R,Valoti E,Tedesco F,Amore A,Coppo R,Ruggenenti P,Gotti E,Remuzzi G

更新日期：2014-09-11 00:00:00

abstract：:Whereas the chimeric type I anti-CD20 Ab rituximab has improved outcomes for patients with B-cell malignancies significantly, many patients with non-Hodgkin lymphoma (NHL) remain incurable. Obinutuzumab (GA101) is a glycoengineered, humanized anti-CD20 type II Ab that has demonstrated superior activity against type I ...

journal_title：Blood

authors： Salles G,Morschhauser F,Lamy T,Milpied N,Thieblemont C,Tilly H,Bieska G,Asikanius E,Carlile D,Birkett J,Pisa P,Cartron G

更新日期：2012-05-31 00:00:00

abstract：:In this issue of Blood, in a first-rate example of collaboration between academia (University of California) and industry (Sangamo), Hoban et al show in situ gene correction of sickle cell anemia (SCA), a prototypical hemoglobinopathy. ...

journal_title：Blood

authors： Tolar J

更新日期：2015-04-23 00:00:00

abstract：:Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may...

journal_title：Blood

authors： Tyner JW,Erickson H,Deininger MW,Willis SG,Eide CA,Levine RL,Heinrich MC,Gattermann N,Gilliland DG,Druker BJ,Loriaux MM

更新日期：2009-02-19 00:00:00

abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...

journal_title：Blood

authors： Monroy RL,Skelly RR,MacVittie TJ,Davis TA,Sauber JJ,Clark SC,Donahue RE

更新日期：1987-11-01 00:00:00

abstract：:Gene expression patterns of CD34(+)CD38(-) cells derived from human embryonic stem cells (ESCs) were compared with those of cells isolated from adult human bone marrow (BM) using microarrays; 1692 and 1494 genes were expressed at levels at least 3-fold above background in cells from BM and ESCs, respectively. Of these...

journal_title：Blood

authors： Lu SJ,Li F,Vida L,Honig GR

更新日期：2004-06-01 00:00:00

abstract：:The urokinase receptor (uPAR) plays an important role in regulation of fibronolysis, cell migration, and adhesion. In this study, we examined whether uPAR plays a role in modulating efferocytosis of neutrophils. Macrophages from uPAR(-/-) mice demonstrated enhanced ability to engulf viable wild-type (WT) neutrophils i...

journal_title：Blood

authors： Park YJ,Liu G,Tsuruta Y,Lorne E,Abraham E

更新日期：2009-07-23 00:00:00

abstract：:Truncation of asparaginase treatment due to asparaginase related toxicities or silent inactivation (SI) is common and may increase relapse risk in acute lymphoblastic leukemia (ALL). We investigated relapse risk following suboptimal asparaginase exposure among 1401 children aged 1-17 years, diagnosed with ALL between ...

journal_title：Blood

authors： Gottschalk Højfeldt S,Grell K,Abrahamsson J,Lund B,Vettenranta K,Jonsson OG,Frandsen TL,Wolthers BO,Marquart HVH,Vaitkeviciene G,Lepik K,Heyman M,Schmiegelow K,Albertsen BK

更新日期：2020-11-04 00:00:00

abstract：:Thrombopoietin (TPO, c-mpl ligand) has emerged as a major hematopoietic cytokine stimulating megakaryocyte proliferation, endomitosis, and platelet production. This study shows that a single administration of an adenovirus (Ad) vector encoding TPO (AdCMV.TPO) abrogates thrombocytopenia induced in mice by carboplatin a...

journal_title：Blood

authors： Ohwada A,Rafii S,Moore MA,Crystal RG

更新日期：1996-08-01 00:00:00

abstract：:The effectiveness of arabinosylcytosine (ara-C) for the treatment of acute myelogenous leukemia (AML) depends on the formation of its active metabolite, the triphosphate of ara-C (ara-CTP). Using biochemical modulation strategies to increase the accumulation of ara-CTP in leukemia blasts, a clinical protocol was desig...

journal_title：Blood

authors： Gandhi V,Estey E,Keating MJ,Chucrallah A,Plunkett W

更新日期：1996-01-01 00:00:00

abstract：:Delivery of biologically active peptides into human polymorphonuclear neutrophils (PMNs) has implications for studying cellular functions and may be therapeutically relevant. The transcription factor nuclear factor-kappaB (NF-kappaB) regulates the expression of multiple genes controlling inflammation, proliferation, a...

journal_title：Blood

authors： Choi M,Rolle S,Wellner M,Cardoso MC,Scheidereit C,Luft FC,Kettritz R

更新日期：2003-09-15 00:00:00