Abstract:
:Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic infections and asthma. However, is this consensus correct? This review argues that the wealth of available studies investigating the role(s) of eosinophils in both health and disease demonstrates that the activities of these granulocytes are far more expansive and complex than previously appreciated. In turn, this greater understanding has led to the realization that eosinophils have significant contributory roles in a wide range of diseases. Furthermore, published studies even implicate eosinophil-mediated activities in otherwise healthy persons. We suggest that the collective reports in the literature showing a role for eosinophils in an ever-increasing number of novel settings highlight the true complexity and importance of this granulocyte. Indeed, discussions of eosinophils are no longer simple and more often than not now begin with the question/statement "Did you know …?"
journal_name
Bloodjournal_title
Bloodauthors
Jacobsen EA,Helmers RA,Lee JJ,Lee NAdoi
10.1182/blood-2012-06-330845subject
Has Abstractpub_date
2012-11-08 00:00:00pages
3882-90issue
19eissn
0006-4971issn
1528-0020pii
blood-2012-06-330845journal_volume
120pub_type
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