An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation.

abstract：:The calcium ionophore A23187 promotes histamine synthesis in murine bone marrow cells by increasing the expression of mRNA encoding histidine decarboxylase (HDC), the histamine-forming enzyme. The cells responsible for this biological activity copurify with hematopoietic progenitors in terms of density, light scatter ...

journal_title：Blood

authors： Dy M,Arnould A,Lemoine FM,Machavoine F,Ziltener H,Schneider E

更新日期：1996-04-15 00:00:00

abstract：:T-cell development requires a series of discrete selection and activation signals delivered to maturing progenitors in the thymic cortex and medulla. We have previously shown the constitutive activity of the integrin, alpha4beta1 (VLA4), on a unique subpopulation of immature cortical thymocytes and proposed a role for...

journal_title：Blood

authors： Salomon DR,Crisa L,Mojcik CF,Ishii JK,Klier G,Shevach EM

更新日期：1997-04-01 00:00:00

abstract：:The loss of body cell mass (bcm) in senescence and wasting is poorly understood. We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was sugge...

journal_title：Blood

authors： Hack V,Breitkreutz R,Kinscherf R,Röhrer H,Bärtsch P,Taut F,Benner A,Dröge W

更新日期：1998-07-01 00:00:00

abstract：:Using a polyclonal antiserum against canine CD34, we previously found that CD34 is expressed on canine bone marrow progenitor cells in a manner analogous to that found in humans. To further characterize CD34+ cells and to facilitate preclinical canine stem cell transplant studies, monoclonal antibodies (MoAbs) were ra...

journal_title：Blood

authors： McSweeney PA,Rouleau KA,Wallace PM,Bruno B,Andrews RG,Krizanac-Bengez L,Sandmaier BM,Storb R,Wayner E,Nash RA

更新日期：1998-03-15 00:00:00

abstract：:Allogeneic stem cell transplantation (SCT) is curative for hemophagocytic lymphohistiocytosis (HLH). However, patients frequently have significant morbidity before transplantation and there is high transplant-related mortality (TRM). Because first-degree HLH is caused by immune dysregulation, a reduced-intensity condi...

journal_title：Blood

authors： Cooper N,Rao K,Gilmour K,Hadad L,Adams S,Cale C,Davies G,Webb D,Veys P,Amrolia P

更新日期：2006-02-01 00:00:00

abstract：:Alterations in the vascular system and the onset of angioproliferative lesions such as Kaposi's sarcoma (KS) are common traits of human immunodeficiency virus-1 (HIV-1)-infected patients. To investigate possible factors involved in acquired immunodeficiency syndrome (AIDS)-associated vasculopathy and vascular malfunct...

journal_title：Blood

authors： Ascherl G,Hohenadl C,Schatz O,Shumay E,Bogner J,Eckhart L,Tschachler E,Monini P,Ensoli B,Stürzl M

更新日期：1999-06-15 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...

journal_title：Blood

authors：

更新日期：1998-04-15 00:00:00

abstract：:Severe congenital neutropenia (CN) is a rare bone marrow failure syndrome with a high incidence of acute leukemia. In previous studies, we could show that point mutations in the gene for the granulocyte colony-stimulating factor (G-CSF) receptor CSF3R are a highly predictive marker for leukemic development in CN patie...

journal_title：Blood

authors： Germeshausen M,Welte K,Ballmaier M

更新日期：2009-01-15 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF-alpha in cytoplasmic granules. In monocytes, TGF-alpha did not colocalize with component...

journal_title：Blood

authors： Calafat J,Janssen H,Ståhle-Bäckdahl M,Zuurbier AE,Knol EF,Egesten A

更新日期：1997-08-01 00:00:00

abstract：:Previous in vitro findings suggest a critical role for the polymorphonuclear leukocyte (PMN) membrane glycoprotein complex CD18 in PMN adherence and chemotaxis. We examined the effect of the murine monoclonal antibody (MoAb) 60.3, recognizing CD18, on induced PMN accumulation in vivo. Rabbits were pretreated with MoAb...

journal_title：Blood

authors： Arfors KE,Lundberg C,Lindbom L,Lundberg K,Beatty PG,Harlan JM

更新日期：1987-01-01 00:00:00

abstract：:Angiogenesis, the formation of new capillaries from preexisting blood vessels, is a multistep, highly orchestrated process involving vessel sprouting, endothelial cell migration, proliferation, tube differentiation, and survival. Eicosanoids, arachidonic acid (AA)-derived metabolites, have potent biologic activities o...

journal_title：Blood

authors： Nie D,Tang K,Diglio C,Honn KV

更新日期：2000-04-01 00:00:00

abstract：:FLT3 is constitutively activated by internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop mutations in acute myeloid leukemia (AML). We tested the sensitivity of 8 activation loop mutations to the small molecule FLT3 inhibitor, MLN518. Each FLT3 activation loop mutant, including D835Y, ...

journal_title：Blood

authors： Clark JJ,Cools J,Curley DP,Yu JC,Lokker NA,Giese NA,Gilliland DG

更新日期：2004-11-01 00:00:00

abstract：:Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitous...

journal_title：Blood

authors： Gilchrist M,McCauley SD,Befus AD

更新日期：2004-07-15 00:00:00

abstract：:Recent studies in humans have highlighted the importance of a distinct cellular entity, the plasmacytoid dendritic cell (PDC). To identify genes for which expression is restricted to human PDCs, a cDNA subtraction technique was applied using cDNA from activated monocyte-derived DCs (MDDCs) as competitor. In the 650 se...

journal_title：Blood

authors： Rissoan MC,Duhen T,Bridon JM,Bendriss-Vermare N,Péronne C,de Saint Vis B,Brière F,Bates EE

更新日期：2002-11-01 00:00:00

abstract：:An immunosuppressant Rapamycin (Rap) has been reported to cause G1 arrest by inhibiting p70 S6 kinase and G1 cyclin/cdks kinase activities when added to quiescent cells with mitogens. However, antiproliferative effects of Rap on exponentially growing cells have been poorly investigated. We examined the intracellular e...

journal_title：Blood

authors： Kawamata S,Sakaida H,Hori T,Maeda M,Uchiyama T

更新日期：1998-01-15 00:00:00

abstract：:The costimulatory effects of CD27 on T lymphocyte effector function and memory formation has been confined to evaluations in mouse models, in vitro human cell culture systems, and clinical observations. Here, we tested whether CD27 costimulation actively enhances human T-cell function, expansion, and survival in vitro...

journal_title：Blood

authors： Song DG,Ye Q,Poussin M,Harms GM,Figini M,Powell DJ Jr

更新日期：2012-01-19 00:00:00

abstract：:Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. However, only a limited number of target genes have been identified. We have studied 10 MCL cell lines and 28 primary tumors with a combination of a high-density single...

journal_title：Blood

authors： Beà S,Salaverria I,Armengol L,Pinyol M,Fernández V,Hartmann EM,Jares P,Amador V,Hernández L,Navarro A,Ott G,Rosenwald A,Estivill X,Campo E

更新日期：2009-03-26 00:00:00

abstract：:Interleukin-3 (IL-3) is exclusively expressed by activated T and natural killer cells, a function that is tightly controlled both in a lineage-specific and in a stimulation-dependent manner. We have investigated the protein binding characteristics and functional importance of the ACT-1-activating region of the IL-3 pr...

journal_title：Blood

authors： Davies K,TePas EC,Nathan DG,Mathey-Prevot B

更新日期：1993-02-15 00:00:00

abstract：:Identification of receptor activator of nuclear factor-kappaB (RANK) and RANK-ligand (RANKL) has provided new insights into the osteoclast differentiation pathway. Osteoclast precursor cells were isolated using monoclonal antibodies against c-Fms and RANK, and the effect of adherence on the in vitro differentiation an...

journal_title：Blood

authors： Miyamoto T,Arai F,Ohneda O,Takagi K,Anderson DM,Suda T

更新日期：2000-12-15 00:00:00

abstract：:Recently, we described a new genetic disorder (the "hereditary hyperferritinemia-cataract syndrome") clinically characterized by the combination of elevated serum ferritin and congenital bilateral nuclear cataract, both cotransmitted as an autosomal dominant trait. In affected subjects, hyperferritinemia (ranging from...

journal_title：Blood

authors： Girelli D,Corrocher R,Bisceglia L,Olivieri O,De Franceschi L,Zelante L,Gasparini P

更新日期：1995-12-01 00:00:00

abstract：:Congenital erythropoietic porphyria (CEP) is an autosomal recessive disorder of heme synthesis characterized by reduced activity of uroporphyrinogen III synthase and the accumulation of nonphysiologic isomer I porphyrin metabolites, resulting in ineffective erythropoiesis and devastating skin photosensitivity. Managem...

journal_title：Blood

authors： Egan DN,Yang Z,Phillips J,Abkowitz JL

更新日期：2015-07-09 00:00:00

abstract：:Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietin-dependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affy...

journal_title：Blood

authors： Merryweather-Clarke AT,Atzberger A,Soneji S,Gray N,Clark K,Waugh C,McGowan SJ,Taylor S,Nandi AK,Wood WG,Roberts DJ,Higgs DR,Buckle VJ,Robson KJ

更新日期：2011-03-31 00:00:00

abstract：UNLABELLED:Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-n...

journal_title：Blood

authors： Miller PH,Cheung AM,Beer PA,Knapp DJ,Dhillon K,Rabu G,Rostamirad S,Humphries RK,Eaves CJ

更新日期：2013-01-31 00:00:00

abstract：:The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We recently identified NUP214-ABL1 as a variant ABL1 fusion gene in 6% of T-ALL patients. Here we describe the identification of another ...

journal_title：Blood

authors： De Keersmaecker K,Graux C,Odero MD,Mentens N,Somers R,Maertens J,Wlodarska I,Vandenberghe P,Hagemeijer A,Marynen P,Cools J

更新日期：2005-06-15 00:00:00

abstract：:CD34 is expressed on human hematopoietic stem and progenitor cells, and its clinical usefulness for the purification of stem cells has been well established. However, a similar pattern of expression for murine CD34 (mCD34) has not yet been determined. Two polyclonal anti-mCD34 antibodies that specifically recognize bo...

journal_title：Blood

authors： Krause DS,Ito T,Fackler MJ,Smith OM,Collector MI,Sharkis SJ,May WS

更新日期：1994-08-01 00:00:00

abstract：:Natural killer (NK) activity against K-562 tumor cells was evaluated in peripheral blood leukocytes (PBL) obtained from untreated patients affected by hairy cell leukemia (HCL). NK activity present in PBL from 10 HCL patients was at least six-fold lower (p less than 0.01) than that present in PBL from 15 healthy donor...

journal_title：Blood

authors： Ruco LP,Procopio A,Maccallini V,Calogero A,Uccini S,Annino L,Mandelli F,Baroni CD

更新日期：1983-06-01 00:00:00

abstract：:The importance of the second messengers calcium (Ca(2+)) and diacylglycerol (DAG) in platelet signal transduction was established more than 30 years ago. Whereas protein kinase C (PKC) family members were discovered as the targets of DAG, little is known about the molecular identity of the main Ca(2+) sensor(s). We he...

journal_title：Blood

authors： Stefanini L,Roden RC,Bergmeier W

更新日期：2009-09-17 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:The human burst-forming unit-megakaryocyte (BFU-MK) is a primitive megakaryocytic progenitor cell. A marrow cell population enriched for BFU-MK (CD34+ DR-) was obtained by monoclonal antibody labeling and fluorescence-activated cell sorting. CD34+DR- cells were assayed in a serum-depleted, fibrin clot culture system. ...

journal_title：Blood

authors： Briddell RA,Hoffman R

更新日期：1990-08-01 00:00:00

abstract：:Human hematopoietic stem cells are pluripotent, ie, capable of producing both lymphoid and myeloid progeny, and are therefore used for transplantation and gene therapy. An in vitro culture system was developed to study the multi-lineage developmental potential of a candidate human hematopoietic stem cell population, C...

journal_title：Blood

authors： Hao QL,Smogorzewska EM,Barsky LW,Crooks GM

更新日期：1998-06-01 00:00:00