Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).

abstract：:Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia (ATL), a fatal T-cell leukemia resistant to chemotherapy, after more than 50 years of clinical latency from transmission through breast-feeding. Polyclonal expansion of virus-infected T cells predisposes them to transformation. Constitutive activ...

journal_title：Blood

authors： Watanabe M,Ohsugi T,Shoda M,Ishida T,Aizawa S,Maruyama-Nagai M,Utsunomiya A,Koga S,Yamada Y,Kamihira S,Okayama A,Kikuchi H,Uozumi K,Yamaguchi K,Higashihara M,Umezawa K,Watanabe T,Horie R

更新日期：2005-10-01 00:00:00

abstract：:Although phospholipid scramblase 1 (PLSCR1) was originally identified based on its capacity to promote transbilayer movement of membrane phospholipids, subsequent studies also provided evidence for its role in cell proliferation, maturation, and apoptosis. In this report, we investigate the potential role of PLSCR1 in...

journal_title：Blood

authors： Zhao KW,Li X,Zhao Q,Huang Y,Li D,Peng ZG,Shen WZ,Zhao J,Zhou Q,Chen Z,Sims PJ,Wiedmer T,Chen GQ

更新日期：2004-12-01 00:00:00

abstract：:Hematopoietic bone marrow stem cells generate differentiated blood cells and, when transplanted, may contribute to other organs, such as the brain, heart, and liver. An understanding of in vivo clonal behavior of stem cells will have important implications for cellular and gene therapy. For the first time, we have dir...

journal_title：Blood

authors： Schmidt M,Zickler P,Hoffmann G,Haas S,Wissler M,Muessig A,Tisdale JF,Kuramoto K,Andrews RG,Wu T,Kiem HP,Dunbar CE,von Kalle C

更新日期：2002-10-15 00:00:00

abstract：:Both total metabolic tumor volume (TMTV), computed on baseline positron emission tomography (PET), and end of induction (EOI) PET are imaging biomarkers showing promise for early risk stratification in patients with high-tumor-burden follicular lymphoma. A model was built incorporating these 2 factors in 159 patients ...

journal_title：Blood

authors： Cottereau AS,Versari A,Luminari S,Dupuis J,Chartier L,Casasnovas RO,Berriolo-Riedinger A,Menga M,Haioun C,Tilly H,Tarantino V,Federico M,Salles G,Trotman J,Meignan M

更新日期：2018-05-31 00:00:00

abstract：:While the interferon (IFN)-inducible double-stranded RNA (dsRNA)-dependent protein kinase PKR is reported to initiate apoptosis in some instances, the mechanism by which diverse stress stimuli activate PKR remains unknown. Now we report that RAX, the only known cellular activator for PKR, initiates PKR activation in r...

journal_title：Blood

authors： Bennett RL,Blalock WL,Abtahi DM,Pan Y,Moyer SA,May WS

更新日期：2006-08-01 00:00:00

abstract：:Recently, Dawson et al identified a previously unrecognized nuclear role of JAK2 in the phosphorylation of histone H3 in hematopoietic cell lines. We searched nuclear JAK2 in total bone marrow (BM) cells and in 4 sorted BM cell populations (CD34(+), CD15(+), CD41(+), and CD71(+)) of 10 myeloproliferative neoplasia (MP...

journal_title：Blood

authors： Rinaldi CR,Rinaldi P,Alagia A,Gemei M,Esposito N,Formiggini F,Martinelli V,Senyuk V,Nucifora G,Pane F

更新日期：2010-12-23 00:00:00

abstract：:Peripheral blood (PB) CD34+ cells from four commonly used mobilization protocols were studied to compare their phenotype and proliferative capacity with steady-state PB or bone marrow (BM) CD34+ cells. Mobilized PB CD34+ cells were collected during hematopoietic recovery after myelosuppressive chemotherapy with or wit...

journal_title：Blood

authors： To LB,Haylock DN,Dowse T,Simmons PJ,Trimboli S,Ashman LK,Juttner CA

更新日期：1994-11-01 00:00:00

abstract：:The anti-CD33 antibody calicheamicinconjugate gemtuzumab ozogamicin (GO) was used to treat 16 patients with acute promyelocytic leukemia (APL) who had relapsed at the molecular level. Of these patients, 8 were experiencing a first, 5 a second, 2 a third, and 1 a fourth relapse. GO was administered at 6 mg/m2 for 2 dos...

journal_title：Blood

authors： Lo-Coco F,Cimino G,Breccia M,Noguera NI,Diverio D,Finolezzi E,Pogliani EM,Di Bona E,Micalizzi C,Kropp M,Venditti A,Tafuri A,Mandelli F

更新日期：2004-10-01 00:00:00

abstract：:Antigens implicated in the graft-versus-leukemia (GVL) effect in chronic myeloid leukemia (CML) include WT1, PR1, and BCR-ABL. To detect very low frequencies of these antigen-specific CD8+ T cells, we used quantitative polymerase chain reaction (qPCR) to measure interferon-gamma (IFN-gamma) mRNA production by peptide-...

journal_title：Blood

authors： Rezvani K,Grube M,Brenchley JM,Sconocchia G,Fujiwara H,Price DA,Gostick E,Yamada K,Melenhorst J,Childs R,Hensel N,Douek DC,Barrett AJ

更新日期：2003-10-15 00:00:00

abstract：:Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligo...

journal_title：Blood

authors： Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H

更新日期：2003-09-01 00:00:00

abstract：:In this issue of Blood, Vérollet et al show that expression of the HIV-1–derived protein Nef alters the migratory mode adopted by macrophages, enhancing macrophage tissue infiltration and explaining the observed accumulation of tissue-resident macrophages in some HIV-infected patients. ...

journal_title：Blood

authors： Morley SC

更新日期：2015-03-05 00:00:00

abstract：:Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pathway. Previously we have shown that a single in vivo treatment of se...

journal_title：Blood

authors： Ezekowitz RA,Sieff CA,Dinauer MC,Nathan DG,Orkin SH,Newburger PE

更新日期：1990-12-15 00:00:00

abstract：:Endothelial sialomucin CD34 functions as an L-selectin ligand mediating lymphocyte extravasation only when properly glycosylated to express a sulfated carbohydrate epitope, 6-sulfo sialyl Lewis x (6-sulfo SLe(x)). It is thought that multivalent 6-sulfo SLe(x) expression promotes high-affinity binding to L-selectin by ...

journal_title：Blood

authors： Hernandez Mir G,Helin J,Skarp KP,Cummings RD,Mäkitie A,Renkonen R,Leppänen A

更新日期：2009-07-16 00:00:00

abstract：:We evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTL...

journal_title：Blood

authors： Cunha R,Zago MA,Querol S,Volt F,Ruggeri A,Sanz G,Pouthier F,Kogler G,Vicario JL,Bergamaschi P,Saccardi R,Lamas CH,Díaz-de-Heredia C,Michel G,Bittencourt H,Tavella M,Panepucci RA,Fernandes F,Pavan J,Gluckman E,Roch

更新日期：2017-01-26 00:00:00

abstract：:The contention that erythropoietin (Epo) affects platelet production was investigated in the rat with recombinant human Epo (rHuEpo). In normal rats, Epo caused a dose-dependent increase in both reticulocyte and platelet numbers, the reticulocyte response preceding that of platelets. Withdrawal of Epo resulted in reti...

journal_title：Blood

authors： Berridge MV,Fraser JK,Carter JM,Lin FK

更新日期：1988-09-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune prothrombotic disorder in association with autoantibodies to phospholipid (PL)-binding plasma proteins, such as beta(2)-glycoprotein I (beta(2)GPI). We have recently found that CD4(+) T cells autoreactive to beta(2)GPI in patients with APS preferentially recognize a cry...

journal_title：Blood

authors： Kuwana M,Matsuura E,Kobayashi K,Okazaki Y,Kaburaki J,Ikeda Y,Kawakami Y

更新日期：2005-02-15 00:00:00

abstract：:Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRgamma-chain complex is a central collagen receptor and inhibitors of GPVI produce a major defect in arterial thrombogenesis. In this study we have examined art...

journal_title：Blood

authors： Mangin P,Yap CL,Nonne C,Sturgeon SA,Goncalves I,Yuan Y,Schoenwaelder SM,Wright CE,Lanza F,Jackson SP

更新日期：2006-06-01 00:00:00

abstract：:Oxidative stress has been implicated in the triggering of apoptosis in neutrophils. Because red blood cells (RBCs) are well known to scavenge oxidants including H2O2, we tested the hypothesis that RBCs inhibit apoptosis of neutrophils by reducing intracellular oxidative stress. Apoptosis of neutrophils was evaluated b...

journal_title：Blood

authors： Aoshiba K,Nakajima Y,Yasui S,Tamaoki J,Nagai A

更新日期：1999-06-01 00:00:00

abstract：:The effects of recombinant human erythropoietin (rEp) on murine hematopoietic progenitors were studied using a serum-free culture. A high concentration of rEp stimulated the formation of mixed erythroid-megakaryocyte colonies (EM colonies) and blast cell colonies, as well as erythroid colonies, erythroid bursts, and m...

journal_title：Blood

authors： Nishi N,Nakahata T,Koike K,Takagi M,Naganuma K,Akabane T

更新日期：1990-10-01 00:00:00

abstract：:A patient with recurrent pulmonary abscess, weight loss, and alcoholism was found to have extremely high serum vitamin B12 and unsaturated vitamin B12-binding capacity (UBBC) levels. While transcobalamin (TC) II was also increased, most of his UBBC was due to an abnormal binding protein which carried greater than 80% ...

journal_title：Blood

authors： Carmel R,Tatsis B,Baril L

更新日期：1977-06-01 00:00:00

abstract：:Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is a distinct peripheral T-cell lymphoma, which closely resembles angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and/or IBL, but is characterized by focal or sheet-like proliferation of immunoblasts and pale cells of T-cell nature. In this report,...

journal_title：Blood

authors： Tobinai K,Minato K,Ohtsu T,Mukai K,Kagami Y,Miwa M,Watanabe S,Shimoyama M

更新日期：1988-09-01 00:00:00

abstract：:Genome and transcriptome sequencing have revealed a rich assortment of noncoding RNAs in eukaryote cells, including long noncoding RNAs (lncRNAs), which regulate gene expression independent of protein coding potential. LncRNAs modulate protein coding gene expression in many cell types by regulating multiple processes,...

journal_title：Blood

authors： Paralkar VR,Weiss MJ

更新日期：2013-06-13 00:00:00

abstract：:The tyrosine kinase inhibitors sorafenib and sunitinib are approved for the treatment of patients with malignant diseases. To analyze the possible use of these compounds in combination with immunotherapeutic approaches, we analyzed the effects of both inhibitors on the immunostimulatory capacity of human dendritic cel...

journal_title：Blood

authors： Hipp MM,Hilf N,Walter S,Werth D,Brauer KM,Radsak MP,Weinschenk T,Singh-Jasuja H,Brossart P

更新日期：2008-06-15 00:00:00

abstract：:The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic mice, we show that...

journal_title：Blood

authors： Goardon N,Schuh A,Hajar I,Ma X,Jouault H,Dzierzak E,Roméo PH,Maouche-Chrétien L

更新日期：2002-07-15 00:00:00

abstract：:Analysis of a growing number of chromosomal translocations in human tumors have shown that they frequently result in gene fusions encoding chimeric proteins. We have characterized the recurrent t(12;21)(p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1,...

journal_title：Blood

authors： Romana SP,Mauchauffé M,Le Coniat M,Chumakov I,Le Paslier D,Berger R,Bernard OA

更新日期：1995-06-15 00:00:00

abstract：:Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of...

journal_title：Blood

authors： Peffault de Latour R,Soulier J

更新日期：2016-06-16 00:00:00

abstract：:Recombinant rat stem cell factor (rrSCF) administered to rats as a single intravenous injection causes a dose-dependent neutrophilia and lymphocytosis as well as the appearance of immature myeloid cells and occasional blast cells in the circulation. Neutrophilia begins at 2 hours, peaks at 4 to 6 hours, and subsides b...

journal_title：Blood

authors： Ulich TR,del Castillo J,Yi ES,Yin S,McNiece I,Yung YP,Zsebo KM

更新日期：1991-08-01 00:00:00

abstract：:The biochemical basis for complement acting directly on antigen-presenting cells to enhance their function in T-cell stimulation has been unclear. Here we present evidence that engagement of C3a receptor (C3aR) on the surface of dendritic cells (DCs) leads to alterations in the level of intracellular cyclic adenosine ...

journal_title：Blood

authors： Li K,Anderson KJ,Peng Q,Noble A,Lu B,Kelly AP,Wang N,Sacks SH,Zhou W

更新日期：2008-12-15 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a hematopoietic cytokine that stimulates stromal and stem cell growth. It binds to a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan on human bone marrow (BM) stromal cells. The bFGF-proteoglycan complex is biologically active and is released by additio...

journal_title：Blood

authors： Brunner G,Metz CN,Nguyen H,Gabrilove J,Patel SR,Davitz MA,Rifkin DB,Wilson EL

更新日期：1994-04-15 00:00:00

abstract：:Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide-specific IgG responses totally independent of T-cell help. Ind...

journal_title：Blood

authors： Pihlgren M,Silva AB,Madani R,Giriens V,Waeckerle-Men Y,Fettelschoss A,Hickman DT,López-Deber MP,Ndao DM,Vukicevic M,Buccarello AL,Gafner V,Chuard N,Reis P,Piorkowska K,Pfeifer A,Kündig TM,Muhs A,Johansen P

更新日期：2013-01-03 00:00:00