当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation.

Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation.

Abstract：

:The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic mice, we show that, in adult hematopoiesis, constitutive expression of TAL-1 protein causes disorders in the hematopoietic lineages that normally switch off tal-1 gene expression during their differentiation process. Myelopoiesis was characterized by a moderate increase of myeloid precursors and by Sca-1 antigen persistence. Although no lymphoid leukemia was observed, T lymphopoiesis and B lymphopoiesis were severely impaired. Transgenic mice showed reduced thymic cellularity together with a decrease in double-positive cells and a concurrent increase in the single-positive population. B cells exhibited a differentiation defect characterized by a reduction of the B-cell compartment most likely because of a differentiation block upstream of the intermediate pro-B progenitor. B cells escaping this defect developed normally, but transgenic splenocytes presented a defect in immunoglobulin class switch recombination. Altogether, these results enlighten the fine-tuning of TAL-1 expression during adult hematopoiesis and indicate why TAL-1 expression has to be switched off in the lymphoid lineages.

journal_name

Blood

journal_title

Blood

authors

Goardon N,Schuh A,Hajar I,Ma X,Jouault H,Dzierzak E,Roméo PH,Maouche-Chrétien L

doi

10.1182/blood.v100.2.491

subject

Has Abstract

pub_date

2002-07-15 00:00:00

pages

491-500

issue

2

eissn

0006-4971

issn

1528-0020

journal_volume

100

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Bleeding time and bleeding: an analysis of the relationship of the bleeding time test with parameters of surgical bleeding.

    abstract：:The bleeding time is currently the only clinically available comprehensive test to explore primary hemostasis. It is currently performed mostly as a screening procedure before surgery, to detect otherwise unknown defects in platelet-vessel wall interactions, but its use in this specific setting has been seriously ques...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：

    authors： De Caterina R,Lanza M,Manca G,Strata GB,Maffei S,Salvatore L

    更新日期：1994-11-15 00:00:00

  • STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation.

    abstract：:Fcgamma receptors (FcgammaRs) on mononuclear phagocytes trigger autoantibody and immune complex-induced diseases through coupling the self-reactive immunoglobulin G (IgG) response to innate effector pathways, such as phagocytosis, and the recruitment of inflammatory cells. FcRgamma-based activation is critical in the ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-05-158477

    authors： Braun A,Gessner JE,Varga-Szabo D,Syed SN,Konrad S,Stegner D,Vögtle T,Schmidt RE,Nieswandt B

    更新日期：2009-01-29 00:00:00

  • Aurora-A kinase: a novel target of cellular immunotherapy for leukemia.

    abstract：:Aurora-A kinase (Aur-A) is a member of the serine/threonine kinase family that regulates the cell division process, and has recently been implicated in tumorigenesis. In this study, we identified an antigenic 9-amino-acid epitope (Aur-A(207-215): YLILEYAPL) derived from Aur-A capable of generating leukemia-reactive cy...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-06-164889

    authors： Ochi T,Fujiwara H,Suemori K,Azuma T,Yakushijin Y,Hato T,Kuzushima K,Yasukawa M

    更新日期：2009-01-01 00:00:00

  • Applications of high-throughput DNA sequencing to benign hematology.

    abstract：:The development of novel technologies for high-throughput DNA sequencing is having a major impact on our ability to measure and define normal and pathologic variation in humans. This review discusses advances in DNA sequencing that have been applied to benign hematologic disorders, including those affecting the red bl...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2013-07-460337

    authors： Sankaran VG,Gallagher PG

    更新日期：2013-11-21 00:00:00

  • Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia.

    abstract：:Epo-induced endocytosis of EpoR plays important roles in the down-regulation of EpoR signaling and is the primary means that regulates circulating Epo concentrations. Here we show that cell-surface EpoR is internalized via clathrin-mediated endocytosis. Both JAK2 kinase activity and EpoR cytoplasmic tyrosines are impo...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-09-179572

    authors： Sulahian R,Cleaver O,Huang LJ

    更新日期：2009-05-21 00:00:00

  • Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56bright and CD56dim NK cells.

    abstract：:Soluble HLA-G (sHLA-G) inhibits natural killer (NK) cell functions. Here, we investigated sHLA-G-mediated modulation of (1) chemokine receptor and NK receptor expression and function and (2) cytokine and chemokine secretion in CD56bright and CD56dim NK cells. sHLA-G-treated or untreated peripheral blood (PB) and tonsi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-05-352393

    authors： Morandi F,Ferretti E,Castriconi R,Dondero A,Petretto A,Bottino C,Pistoia V

    更新日期：2011-11-24 00:00:00

  • Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo.

    abstract：:Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts that proliferate and differentiate to generate red cells. Although this process has been extensively studied in mice, its characterization in humans is limited. By examining the dynamic changes of expression of membrane protei...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-01-476390

    authors： Hu J,Liu J,Xue F,Halverson G,Reid M,Guo A,Chen L,Raza A,Galili N,Jaffray J,Lane J,Chasis JA,Taylor N,Mohandas N,An X

    更新日期：2013-04-18 00:00:00

  • Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils.

    abstract：:Neutrophil gelatinase-associated lipocalin (NGAL) is a novel 25-kD protein of human neutrophils, that is in part covalently complexed with neutrophil gelatinase. However, both NGAL and gelatinase exist mainly in forms not associated with each other. An explanation for this phenomenon might be that the unassociated pro...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kjeldsen L,Bainton DF,Sengeløv H,Borregaard N

    更新日期：1994-02-01 00:00:00

  • von Willebrand factor proteolytic processing and multimerization precede the formation of Weibel-Palade bodies.

    abstract：:We investigated the intracellular site of pro-von Willebrand factor (pro-vWF) cleavage and multimerization, as well as the fate of the propolypeptide (von Willebrand antigen II) after cleavage. Analysis of subcellular fractions of endothelial cells metabolically labeled with sulfate showed that both cleavage and coval...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Vischer UM,Wagner DD

    更新日期：1994-06-15 00:00:00

  • Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status.

    abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-11-4394

    authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

    更新日期：2005-06-15 00:00:00

  • Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133.

    abstract：:AC133 is a member of a novel family of cell surface proteins with 5 transmembrane domains. The function of AC133 is unknown. Although AC133 mRNA is detected in different tissues, its expression in the hematopoietic system is restricted to CD34+ stem cells. AC133 is also expressed on stem cells of other tissues, includ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-06-1881

    authors： Shmelkov SV,Jun L,St Clair R,McGarrigle D,Derderian CA,Usenko JK,Costa C,Zhang F,Guo X,Rafii S

    更新日期：2004-03-15 00:00:00

  • Comparison of the ankyrin (AC)n microsatellites in genomic DNA and mRNA reveals absence of one ankyrin mRNA allele in 20% of patients with hereditary spherocytosis.

    abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Jarolim P,Rubin HL,Brabec V,Palek J

    更新日期：1995-06-01 00:00:00

  • Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.

    abstract：:We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E). With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules. We have generated transgenic ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-01-0012

    authors： Kim MR,Manoukian R,Yeh R,Silbiger SM,Danilenko DM,Scully S,Sun J,DeRose ML,Stolina M,Chang D,Van GY,Clarkin K,Nguyen HQ,Yu YB,Jing S,Senaldi G,Elliott G,Medlock ES

    更新日期：2002-10-01 00:00:00

  • Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.

    abstract：:Both mast cells and IL-17 can contribute to host defense and pathology in part by orchestrating neutrophil recruitment, but the possible role of mast cells in IL-17-induced inflammation remains to be defined. We found that mast cells and IL-17, but neither IFN-gamma nor FcRgamma signaling, contributed significantly to...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-09-046128

    authors： Nakae S,Suto H,Berry GJ,Galli SJ

    更新日期：2007-05-01 00:00:00

  • Following aggressive B-cell lymphoma.

    abstract：:In this issue of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput sequencing as a tool for disease monitoring and surveillance in aggressive B-cell lymphoma. ...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2015-04-641738

    authors： Sweetenham JW

    更新日期：2015-06-11 00:00:00

  • Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations.

    abstract：:T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MT...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Madani A,Choukroun V,Soulier J,Cacheux V,Claisse JF,Valensi F,Daliphard S,Cazin B,Levy V,Leblond V,Daniel MT,Sigaux F,Stern MH

    更新日期：1996-03-01 00:00:00

  • Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia.

    abstract：:Sixteen patients treated by allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr/abl-specific RNA transcripts at various time points after BMT. In reconstitution experiments, one CML cell per million normal mononuclear cells c...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Roth MS,Antin JH,Bingham EL,Ginsburg D

    更新日期：1989-08-01 00:00:00

  • Malaria selectively targets pregnancy receptors.

    abstract：:In this issue of Blood, Rieger et al show that malaria parasite infiltration in the human placenta requires a specific geometry and affinity of host receptors to facilitate strong adhesion. ...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2014-11-610634

    authors： Chishti AH

    更新日期：2015-01-08 00:00:00

  • Evidence for a role of glycoprotein IIb-IIIa, distinct from its ability to support aggregation, in platelet activation by ionophores in the presence of extracellular divalent cations.

    abstract：:Ionophore A23187-induced 14C-serotonin secretion and thromboxane B2(TxB2) formation were found to be absent in citrated platelet-rich plasma (PRP) from thrombasthenic subjects and in normal PRP treated with glycoprotein (GP) IIb-IIIa complex-specific monoclonal antibodies. Both responses were restored to normal levels...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lages B,Weiss HJ

    更新日期：1994-05-01 00:00:00

  • Mast cells play a protumorigenic role in primary cutaneous lymphoma.

    abstract：:Primary cutaneous lymphomas (PCLs) are clonal T- or B-cell neoplasms, which originate in the skin. In recent years, mast cells were described as regulators of the tumor microenvironment in different human malignancies. Here, we investigated the role of mast cells in the tumor microenvironment of PCL. We found signific...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-03-415638

    authors： Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

    更新日期：2012-09-06 00:00:00

  • A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study.

    abstract：:Interest in high-dose cytarabine (HDAC) for both induction and postremission therapy for acute myeloid leukemia (AML) prompted the Southwest Oncology Group (SWOG) to initiate a randomized trial comparing HDAC with standard-dose cytarabine (SDAC) for remission induction of previously untreated AML and to compare high-d...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Weick JK,Kopecky KJ,Appelbaum FR,Head DR,Kingsbury LL,Balcerzak SP,Bickers JN,Hynes HE,Welborn JL,Simon SR,Grever M

    更新日期：1996-10-15 00:00:00

  • Ferritin iron absorption in man.

    abstract：:The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Layrisse M,Martínez-Torres C,Renzy M,Leets I

    更新日期：1975-05-01 00:00:00

  • The effect of alpha-thalassemia on the expression of the beta-thalassemia/HPFH heterozygote in a black family.

    abstract：:A 2-yr-old black girl presented with a thalassemic clinical picture and was found to have nearly 100% fetal hemoglobin in her red cells. Pedigree analysis indicated that she was a heterozygote for the hereditary persistence of fetal hemoglobin gene and for a beta O-thalassemia gene. A brother, who also had nearly 100%...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Beutler E,Turner E,Kuhl W

    更新日期：1981-06-01 00:00:00

  • Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein.

    abstract：:Custom-made monoclonal anti-idiotype antibodies (anti-Id MoAbs) have been tested as a treatment modality in 34 non-Hodgkin's lymphoma (NHL) patients. Partial or complete tumor remissions have been induced with this treatment in 68% of these patients. One mechanism by which anti-idiotype antibodies may have induced the...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Vuist WM,Levy R,Maloney DG

    更新日期：1994-02-15 00:00:00

  • Lymphocyte dysfunction in chronic graft-versus-host disease.

    abstract：:Three recipients of HLA-identical bone marrow transplants developed chronic graft-versus-host disease (cGVHD) and hypergammaglobulinemia. All three had evidence of abnormal B-lymphocyte function, including a polyclonal increase in immunoglobulins (Ig), antinuclear antibodies, rheumatoid factor, lymphocytotoxins, and i...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Saxon A,McIntyre RE,Stevens RH,Gale RP

    更新日期：1981-10-01 00:00:00

  • Naive recirculating B cells mature simultaneously in the spleen and bone marrow.

    abstract：:We have recently demonstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in addition to the well-established follicular niche in conventional secondary lymphoid organs. The spleen has long been considered to be the site at which newly formed B lymphocytes mature into IgD(h...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-05-021089

    authors： Cariappa A,Chase C,Liu H,Russell P,Pillai S

    更新日期：2007-03-15 00:00:00

  • Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

    abstract：:A polymorphic variant of the phosphatase PTPN22 has been associated with increased risk for multiple autoimmune diseases. The risk allele is thought to function by diminishing antigen-receptor signals responsible for negative selection of autoreactive lymphocytes. We now show that PTPN22 is markedly overexpressed in c...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-01-403162

    authors： Negro R,Gobessi S,Longo PG,He Y,Zhang ZY,Laurenti L,Efremov DG

    更新日期：2012-06-28 00:00:00

  • Cyclophosphamide metabolism is affected by azole antifungals.

    abstract：:We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, ...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1182/blood-2003-07-2512

    authors： Marr KA,Leisenring W,Crippa F,Slattery JT,Corey L,Boeckh M,McDonald GB

    更新日期：2004-02-15 00:00:00

  • The embryonic origins of erythropoiesis in mammals.

    abstract：:Erythroid (red blood) cells are the first cell type to be specified in the postimplantation mammalian embryo and serve highly specialized, essential functions throughout gestation and postnatal life. The existence of 2 developmentally and morphologically distinct erythroid lineages, primitive (embryonic) and definitiv...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2012-01-153486

    authors： Baron MH,Isern J,Fraser ST

    更新日期：2012-05-24 00:00:00

  • Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

    abstract：:Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restrict...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-10-247130

    authors： Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

    更新日期：2010-07-15 00:00:00