Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations.

abstract：:Four patients with lymphoproliferative disease of granular lymphocytes (LDGL) coexpressing CD3 and the natural killer (NK)-related "p58" receptor for HLA-C alleles were studied. These CD3+p58+ LDGLs have been detected among a series of 44 CD3+ LDGLs analyzed. Two patients with LDGL (GI and BA) expressed only the p58 m...

journal_title：Blood

authors： Cambiaggi A,Orengo AM,Meazza R,Sforzini S,Tazzari PL,Lauria F,Raspadori D,Zambello R,Semenzato G,Moretta L,Ferrini S

更新日期：1996-03-15 00:00:00

abstract：:Isokinetic-gradient sedimentation employing a shallow linear gradient of Ficoll in tissue culture medium was used to isolate erythroid progenitor cells (CFU-e) from mouse bone marrow. Following gradient sedimentation, 34% of the total nucleated cells and 48% of the CFU-e applied to the gradient were recovered, and thr...

journal_title：Blood

authors： Misiti J,Spivak JL

更新日期：1979-07-01 00:00:00

abstract：:The class IA subgroup of phosphoinositide 3-kinase (PI3K) is activated downstream of antigen receptors, costimulatory molecules, and cytokine receptors on lymphocytes. Targeted deletion of individual genes for class IA regulatory subunits severely impairs the development and function of B cells but not T cells. Here w...

journal_title：Blood

authors： Deane JA,Kharas MG,Oak JS,Stiles LN,Luo J,Moore TI,Ji H,Rommel C,Cantley LC,Lane TE,Fruman DA

更新日期：2007-04-01 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving the erythroid phen...

journal_title：Blood

authors： Fagnan A,Bagger FO,Piqué-Borràs MR,Ignacimouttou C,Caulier A,Lopez CK,Robert E,Uzan B,Gelsi-Boyer V,Aid Z,Thirant C,Moll U,Tauchmann S,Kurtovic-Kozaric A,Maciejewski J,Dierks C,Spinelli O,Salmoiraghi S,Pabst T,Shimo

更新日期：2020-08-06 00:00:00

abstract：:Bone marrow (BM) cells from a child with an immature (CD3-) acute T lymphoblastic leukemia (T-ALL) bearing no chromosomal abnormalities failed to grow in long-term culture in the presence or absence of recombinant human (rh) growth factors but could be engrafted in severe combined immunodeficient (SCID) mice and induc...

journal_title：Blood

authors： Cesano A,O'Connor R,Nowell PC,Lange B,Clark SC,Santoli D

更新日期：1993-05-15 00:00:00

abstract：:Lipids extracted with chloroform-methanol from red blood cell membranes of 7 PNH and 13 control subjects were used for the preparation of liposomes, which were then examined with the reactive lysis test. PNH liposomes lysed to a higher extent than control liposomes as indicated by the higher dilution of the limiting c...

journal_title：Blood

authors： Tedesco F,Kahane I,Zanella A,Giovanetti AM,Sirchia G

更新日期：1981-05-01 00:00:00

abstract：:Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of...

journal_title：Blood

authors： Gaines AR

更新日期：2000-04-15 00:00:00

abstract：:Hydroxyurea, interferon, and HLA-identical sibling bone marrow transplantation are common therapies for chronic myelogenous leukemia (CML) in chronic phase. Which is best is controversial. The purpose of this study was to compare survival of patients with CML receiving HLA-identical sibling transplants versus hydroxyu...

journal_title：Blood

authors： Gale RP,Hehlmann R,Zhang MJ,Hasford J,Goldman JM,Heimpel H,Hochhaus A,Klein JP,Kolb HJ,McGlave PB,Passweg JR,Rowlings PA,Sobocinski KA,Horowitz MM

更新日期：1998-03-01 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells frequently resist apoptosis induction by chemotherapeutic agents; however, the mechanism of unresponsiveness has not been elucidated. Here, we show that cytochrome c fails to stimulate apop...

journal_title：Blood

authors： Sun Y,Orrenius S,Pervaiz S,Fadeel B

更新日期：2005-05-15 00:00:00

abstract：:Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood ce...

journal_title：Blood

authors： Lan Q,Lim U,Liu CS,Weinstein SJ,Chanock S,Bonner MR,Virtamo J,Albanes D,Rothman N

更新日期：2008-11-15 00:00:00

abstract：:Antibody-mediated pure red cell aplasia is a rare but serious event resulting from the induction of neutralizing erythropoietin (Epo)-specific antibodies provoked by treatment with recombinant Epo. Because of the crucial role of CD4 T cells in humoral response, we have quantified the number of Epo-specific CD4 T cells...

journal_title：Blood

authors： Delluc S,Ravot G,Maillere B

更新日期：2010-11-25 00:00:00

abstract：:Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, perip...

journal_title：Blood

authors： Moir S,Buckner CM,Ho J,Wang W,Chen J,Waldner AJ,Posada JG,Kardava L,O'Shea MA,Kottilil S,Chun TW,Proschan MA,Fauci AS

更新日期：2010-12-16 00:00:00

abstract：:Outgrowth, long-term self-renewal, and terminal maturation of human erythroid progenitors derived from umbilical cord blood in serum-free medium can be modulated by steroid hormones. Homogeneous erythroid cultures, as characterized by flow cytometry and dependence on a specific mixture of physiologic proliferation fac...

journal_title：Blood

authors： Leberbauer C,Boulmé F,Unfried G,Huber J,Beug H,Müllner EW

更新日期：2005-01-01 00:00:00

abstract：:Recently, the term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. By definition, patients with MGRS have B-cell clones that do not meet the definition of multiple myeloma or lymphoma. ...

journal_title：Blood

authors： Fermand JP,Bridoux F,Kyle RA,Kastritis E,Weiss BM,Cook MA,Drayson MT,Dispenzieri A,Leung N,International Kidney and Monoclonal Gammopathy Research Group.

更新日期：2013-11-21 00:00:00

abstract：:We have shown previously that the cause of anemia in healthy elderly subjects can usually not be identified. In this study, hematopoiesis was examined in 18 healthy elderly subjects with unexplained anemia and in 15 young and 15 healthy elderly individuals without anemia. No reduction in circulating testosterone was n...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Milton KY,Thompson CO

更新日期：1984-03-01 00:00:00

abstract：:Immunoglobulin E (IgE) bound to multivalent antigen (Ag) elicits mast cell degranulation but not survival; on the contrary, IgE in the absence of Ag (IgE(-Ag)) induces survival only but not degranulation. Although these distinct responses are mediated through the same receptor, FcepsilonRI, the molecular mechanism gen...

journal_title：Blood

authors： Yamasaki S,Ishikawa E,Kohno M,Saito T

更新日期：2004-04-15 00:00:00

abstract：:Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most ...

journal_title：Blood

authors： Lowenthal RM,Buskard NA,Goldman JM,Spiers AS,Bergier N,Graubner M,Galton DA

更新日期：1975-12-01 00:00:00

abstract：:Renal disease has not been considered a major late complication of bone marrow transplantation. Of 31 evaluable pediatric patients undergoing allogeneic or autologous bone marrow transplantation for neuroblastoma or acute lymphoblastic leukemia, 14 developed a hemolytic anemia, microscopic hematuria, and renal insuffi...

journal_title：Blood

authors： Guinan EC,Tarbell NJ,Niemeyer CM,Sallan SE,Weinstein HJ

更新日期：1988-08-01 00:00:00

abstract：:Down-regulation of immune responses by regulatory T (Treg) cells is an important mechanism involved in the induction of tolerance to allo-antigens (Ags). Recently, a novel subset of Ag-specific T-cell receptor (TCR)alpha beta+ CD4(-)CD8- (double-negative [DN]) Treg cells has been found to be able to prevent the reject...

journal_title：Blood

authors： Fischer K,Voelkl S,Heymann J,Przybylski GK,Mondal K,Laumer M,Kunz-Schughart L,Schmidt CA,Andreesen R,Mackensen A

更新日期：2005-04-01 00:00:00

abstract：:The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) an...

journal_title：Blood

authors： Tassara M,Döhner K,Brossart P,Held G,Götze K,Horst HA,Ringhoffer M,Köhne CH,Kremers S,Raghavachar A,Wulf G,Kirchen H,Nachbaur D,Derigs HG,Wattad M,Koller E,Brugger W,Matzdorff A,Greil R,Heil G,Paschka P,Gaidzik

更新日期：2014-06-26 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasomes, induces apoptosis in multiple myeloma (MM) cells; however, prolonged drug exposure may result in cumulative toxicity and the development of chemoresistance. Here we show that combining PK-11195 (PK), an antagonist to mitochondrial peripheral benzodiazepine rec...

journal_title：Blood

authors： Chauhan D,Li G,Podar K,Hideshima T,Mitsiades C,Schlossman R,Munshi N,Richardson P,Cotter FE,Anderson KC

更新日期：2004-10-15 00:00:00

abstract：:Immunological control may contribute to achievement of deep molecular response in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy and may promote treatment-free remission (TFR). We investigated effector and suppressor immune responses in CML patients at diagnosis (n = 21), on TKI (im...

journal_title：Blood

authors： Hughes A,Clarson J,Tang C,Vidovic L,White DL,Hughes TP,Yong AS

更新日期：2017-03-02 00:00:00

abstract：:Myeloid leukemias in AKXD23 mice contain proviral insertions at Evi1, resulting in transcriptional activation. Although Evi1 is clearly involved in leukemia, gene transfer studies in mice with Evi1 fail to cause leukemia, arguing that cooperating events are necessary. We reanalyzed AKXD-23 tumors for cooperating provi...

journal_title：Blood

authors： Boyd KE,Xiao YY,Fan K,Poholek A,Copeland NG,Jenkins NA,Perkins AS

更新日期：2006-01-15 00:00:00

abstract：:Purified human high-mol-wt kininogen (HMWK), the cofactor of the contact phase of blood coagulation, migrated as a single band (approximately 110,000 mol wt) in a continuous buffer sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), but appeared as two separated bands (approximately 120,000 and 105,0...

journal_title：Blood

authors： Berrettini M,Lämmle B,White T,Heeb MJ,Schwarz HP,Zuraw B,Curd J,Griffin JH

更新日期：1986-08-01 00:00:00

abstract：:Umbilical cord blood (UCB) is used for HSCT. It is known that UCB can comprise Ag-specific T cells. Here we question whether solely transmaternal cell flow may immunize UCB. Twenty-three female UCB samples were collected from healthy mothers and analyzed for minor histocompatibility Ag HY-specific responses. Forty-two...

journal_title：Blood

authors： Dierselhuis MP,Blokland EC,Pool J,Schrama E,Scherjon SA,Goulmy E

更新日期：2012-07-19 00:00:00

abstract：:Liver X receptors (LXRs) are transcription factors involved in the regulation of cholesterol homeostasis. LXR ligands have athero-protective properties independent of their effects on cholesterol metabolism. Platelets are involved in the initiation of atherosclerosis and despite being anucleate express nuclear recepto...

journal_title：Blood

authors： Spyridon M,Moraes LA,Jones CI,Sage T,Sasikumar P,Bucci G,Gibbins JM

更新日期：2011-05-26 00:00:00

abstract：:The mouse Pim-1 gene encodes two cytoplasmic serine-threonine-specific protein kinases. The gene has been found to be activated (overexpressed) by retroviral insertion in hematopoietic tumors in mice. Transgenic mice that overexpress Pim-1 (E mu-Pim-1) have a low incidence of spontaneous T-cell lymphomas and an increa...

journal_title：Blood

authors： Domen J,van der Lugt NM,Laird PW,Saris CJ,Clarke AR,Hooper ML,Berns A

更新日期：1993-09-01 00:00:00

abstract：:We prospectively evaluated 169 patients with a number of screening studies performed between 71 to 121 days after allogeneic marrow transplantation to detect the development of chronic graft-versus-host disease (GVHD). Group 1 patients (n = 78) were asymptomatic and had normal physical examinations at the time of scre...

journal_title：Blood

authors： Loughran TP Jr,Sullivan K,Morton T,Beckham C,Schubert M,Witherspoon R,Sale G,Sanders J,Fisher L,Shulman H

更新日期：1990-07-01 00:00:00

abstract：:Recently various genetic defects in immunity mediated by interferon gamma (IFN-gamma) have been described, including mutations in the IFN-gamma receptor 1 (IFN-gammaR1) and receptor 2 (IFN-gammaR2), signal transducer and activator of transcription 1 (STAT 1), and interleukin 12 receptor beta 1 (IL-12Rbeta1), and IL-12...

journal_title：Blood

authors： Höflich C,Sabat R,Rosseau S,Temmesfeld B,Slevogt H,Döcke WD,Grütz G,Meisel C,Halle E,Göbel UB,Volk HD,Suttorp N

更新日期：2004-01-15 00:00:00