Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.

abstract：:Patients who are chronically infected with hepatitis C virus (HCV) often develop mixed cryoglobulinemia (MC), a B-cell proliferative disorder with polyclonal activation and autoantibody production. We investigated if MC is associated with a deficit of CD4(+)CD25(+) immunoregulatory T (Treg) cells, which have been show...

journal_title：Blood

authors： Boyer O,Saadoun D,Abriol J,Dodille M,Piette JC,Cacoub P,Klatzmann D

更新日期：2004-05-01 00:00:00

abstract：:The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based evaluation of survival, the available data fully justify critical reassessment of CML management. The panel therefore reviewed treatment of CML sinc...

journal_title：Blood

authors： Baccarani M,Saglio G,Goldman J,Hochhaus A,Simonsson B,Appelbaum F,Apperley J,Cervantes F,Cortes J,Deininger M,Gratwohl A,Guilhot F,Horowitz M,Hughes T,Kantarjian H,Larson R,Niederwieser D,Silver R,Hehlmann R,Europea

更新日期：2006-09-15 00:00:00

abstract：:Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alphavbeta3 integrin. To determine the contribution of LW activation...

journal_title：Blood

authors： Zennadi R,Moeller BJ,Whalen EJ,Batchvarova M,Xu K,Shan S,Delahunty M,Dewhirst MW,Telen MJ

更新日期：2007-10-01 00:00:00

abstract：:The value of a postremission treatment in acute myelogenous leukemia (AML), with alternating combinations of non-cross-resistant drugs, has been prospectively assessed. Of 515 evaluable patients, 347 (67.4%) entered into complete remission (CR), following induction treatment with daunorubicin (DNR), vincristine (VCR),...

journal_title：Blood

authors： Zittoun R,Jehn U,Fière D,Haanen C,Löwenberg B,Willemze R,Abels J,Bury J,Peetermans M,Hayat M

更新日期：1989-03-01 00:00:00

abstract：:Using 2-dimensional gel electrophoresis (2D-gel) analysis, we show here that cell-cycle entry is associated with a significant increase in p27(kip1) phosphorylation in human primary B cells. A similar pattern of increase in p27(kip1) phosphorylation was also seen in 2 fast-growing tumor cell lines, Burkitt lymphoma ce...

journal_title：Blood

authors： Zhang W,Bergamaschi D,Jin B,Lu X

更新日期：2005-05-01 00:00:00

abstract：:Human polymorphonuclear leukocytes adhesion to endothelial cells during the early stage of inflammation leads to cell surface externalization of Annexin A1 (AnxA1), an effector of endogenous anti-inflammation. The antiadhesive properties of AnxA1 become operative to finely tune polymorphonuclear leukocytes transmigrat...

journal_title：Blood

authors： Pederzoli-Ribeil M,Maione F,Cooper D,Al-Kashi A,Dalli J,Perretti M,D'Acquisto F

更新日期：2010-11-18 00:00:00

abstract：:The alternatively spliced and highly conserved EIIIA domain of fibronectin (FN) is included in most FN of the extracellular matrix in embryos. In adults, both extracellular matrix and plasma FN essentially lack EIIIA. In diverse inflammatory situations however, EIIIA is specifically included by regulated RNA splicing....

journal_title：Blood

authors： Tan MH,Sun Z,Opitz SL,Schmidt TE,Peters JH,George EL

更新日期：2004-07-01 00:00:00

abstract：:We sequentially studied bone marrow (BM) samples of 25 patients in complete remission of an acute lymphoblastic leukemia (ALL) using a simplified polymerase chain reaction (PCR) strategy (direct use of the PCR product as a clonogenic probe recognizing rearranged Ig heavy chain sequences) as a first approach. BM aspira...

journal_title：Blood

authors： Nizet Y,Van Daele S,Lewalle P,Vaerman JL,Philippe M,Vermylen C,Cornu G,Ferrant A,Michaux JL,Martiat P

更新日期：1993-09-01 00:00:00

abstract：:This study demonstrates that when platelets are stimulated by thrombin in the presence of low concentrations of purified human fibrinogen (10 to 20 micrograms/mL, final concentration) binding of released platelet von Willebrand factor (plt-vWF) to the platelet membrane is enhanced. This effect appears to be mediated b...

journal_title：Blood

authors： Parker RI,Gralnick HR

更新日期：1987-11-01 00:00:00

abstract：:Bone disease is one of the most debilitating manifestations of multiple myeloma. A complex interdependence exists between myeloma bone disease and tumor growth, creating a vicious circle of extensive bone destruction and myeloma progression. Proteasome inhibitors have recently been shown to promote bone formation in v...

journal_title：Blood

authors： Terpos E,Sezer O,Croucher P,Dimopoulos MA

更新日期：2007-08-15 00:00:00

abstract：:Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self-renews, proliferates, and differentiates to give rise to a myeloproliferative disease. Although tyrosine kinase inhibitors (TKIs) that target...

journal_title：Blood

authors： Holyoake TL,Vetrie D

更新日期：2017-03-23 00:00:00

abstract：:A hairy cell leukemia population was used as a clonal model for studying the direct immunomodulatory effects of recombinant interferon-alpha A (rIFN-alpha A) and rIFN-gamma on human B-cell proliferation. The leukemic cell population KON was notably quiescent when incubated in medium alone but was induced to significan...

journal_title：Blood

authors： Mongini P,Seremetis S,Blessinger C,Rudich S,Winchester R,Brunda M

更新日期：1988-11-01 00:00:00

abstract：:The duration of immunodeficiency following marrow transplantation is not known. Questionnaires were used to study the infection rates in 72 patients surviving 20 to 30 years after marrow grafting. Furthermore, in 33 of the 72 patients and in 16 donors (siblings who originally donated the marrow) leukocyte subsets were...

journal_title：Blood

authors： Storek J,Joseph A,Espino G,Dawson MA,Douek DC,Sullivan KM,Flowers ME,Martin P,Mathioudakis G,Nash RA,Storb R,Appelbaum FR,Maloney DG

更新日期：2001-12-15 00:00:00

abstract：:In this issue of Blood, Pozzi et al demonstrate that removing an anionic cage promotes exposure of R169 thereby generating a protein C (PC) that is far more readily activated. ...

journal_title：Blood

authors： Maurer MC

更新日期：2012-07-19 00:00:00

abstract：:In contrast to other diverse therapies for the X-linked bleeding disorder hemophilia that are currently in clinical development, gene therapy holds the promise of a lasting cure with a single drug administration. Near-to-complete correction of hemophilia A (factor VIII deficiency) and hemophilia B (factor IX deficienc...

journal_title：Blood

authors： Perrin GQ,Herzog RW,Markusic DM

更新日期：2019-01-31 00:00:00

abstract：:Immune-mediated platelet destruction is most frequently caused by allo- or autoantibodies via Fcγ receptor-dependent phagocytosis. Disease severity can be predicted neither by antibody isotype nor by titer, indicating that other factors play a role. Here we show that the acute phase protein C-reactive protein (CRP), a...

journal_title：Blood

authors： Kapur R,Heitink-Pollé KM,Porcelijn L,Bentlage AE,Bruin MC,Visser R,Roos D,Schasfoort RB,de Haas M,van der Schoot CE,Vidarsson G

更新日期：2015-03-12 00:00:00

abstract：:The combination of cyclophosphamide, vincristine, and prednisone (CVP) is one of several standard treatment options for advanced follicular lymphoma. This, like similar chemotherapeutic regimens, induces response rates of 60% to 80%, with a median response duration of under 2 years. Rituximab, a chimeric monoclonal an...

journal_title：Blood

authors： Marcus R,Imrie K,Belch A,Cunningham D,Flores E,Catalano J,Solal-Celigny P,Offner F,Walewski J,Raposo J,Jack A,Smith P

更新日期：2005-02-15 00:00:00

abstract：:Hemophilic bleeding into joints causes synovial and microvascular proliferation and inflammation (hemophilic synovitis) that contribute to end-stage joint degeneration (hemophilic arthropathy), the major morbidity of hemophilia. New therapies are needed for joint deterioration that progresses despite standard intraven...

journal_title：Blood

authors： Sun J,Hakobyan N,Valentino LA,Feldman BL,Samulski RJ,Monahan PE

更新日期：2008-12-01 00:00:00

abstract：:ShcA is an important mediator of Ras/MAPK activation in PTK-regulated pathways triggered by surface receptors. This function is subserved by the constitutively expressed p52-kDa isoform. Besides activating Ras, p52Shc couples the TCR to Rho GTPases, and thereby participates in actin cytoskeleton remodeling in T cells....

journal_title：Blood

authors： Patrussi L,Ulivieri C,Lucherini OM,Paccani SR,Gamberucci A,Lanfrancone L,Pelicci PG,Baldari CT

更新日期：2007-09-15 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases incorporating phenotypic, functional, transcriptomic, and genomic studie...

journal_title：Blood

authors： Kwok M,Oldreive C,Rawstron AC,Goel A,Papatzikas G,Jones RE,Drennan S,Agathanggelou A,Sharma-Oates A,Evans P,Smith E,Dalal S,Mao J,Hollows R,Gordon N,Hamada M,Davies NJ,Parry H,Beggs AD,Munir T,Moreton P,Paneesha

更新日期：2020-02-06 00:00:00

abstract：:Platelets originate from megakaryocytes (MKs) by cytoplasmic elongation into proplatelets. Direct platelet release is not seen in bone marrow hematopoietic islands. It was suggested that proplatelet fragmentation into platelets can occur intravascularly, yet evidence of its dependence on hydrodynamic forces is missing...

journal_title：Blood

authors： Dunois-Lardé C,Capron C,Fichelson S,Bauer T,Cramer-Bordé E,Baruch D

更新日期：2009-08-27 00:00:00

abstract：:Allelic loss at nonrandom chromosomal sites is thought to mark the position of tumor suppressor genes involved in the pathogenesis and progression of human malignancies. Solid tumors in particular have been found to harbor multiple genetic changes resulting in loss of function mutations. Tumor suppressor genes have al...

journal_title：Blood

authors： Bullrich F,Veronese ML,Kitada S,Jurlander J,Caligiuri MA,Reed JC,Croce CM

更新日期：1996-10-15 00:00:00

abstract：:The nuclear factor-kappa B (NF-kappaB) gene transactivator serves in the formation of immune, inflammatory, and stress responses. In quiescent cells, NF-kappaB principally resides within the cytoplasm in association with inhibitory kappa (IkappaB) proteins. The status of IkappaB and NF-kappaB proteins was evaluated fo...

journal_title：Blood

authors： Granville DJ,Carthy CM,Jiang H,Levy JG,McManus BM,Matroule JY,Piette J,Hunt DW

更新日期：2000-01-01 00:00:00

abstract：:The induction of tumor cell differentiation represents an attractive strategy for the treatment of a wide range of malignancies. Differentiation of HL-60 promyelocytic leukemia cells towards neutrophils or monocytes has been shown to induce apoptotic cell death, which is inhibited by bcl-2 over-expression. However, th...

journal_title：Blood

authors： Benito A,Silva M,Grillot D,Nuñez G,Fernández-Luna JL

更新日期：1996-05-01 00:00:00

abstract：:Hypersensitivity to cross-linking agents and predisposition to malignancy are characteristic of the genetically heterogeneous inherited bone marrow failure syndrome, Fanconi anemia (FA). The protein encoded by the recently cloned FA complementation group A gene, FAA, has been expected to localize in the nucleus as bas...

journal_title：Blood

authors： Kruyt FA,Waisfisz Q,Dijkmans LM,Hermsen MA,Youssoufian H,Arwert F,Joenje H

更新日期：1997-11-01 00:00:00

abstract：:We hypothesized that a granulocyte macrophage colony-stimulating factor (GMCSF) and interleukin 15 (IL-15) fusokine (GIFT15) would possess greater immune-stimulatory properties than their combined use. Unexpectedly, tumor cells engineered to secrete GIFT15 protein led to suppression of natural killer (NK) and NKT-cell...

journal_title：Blood

authors： Rafei M,Wu JH,Annabi B,Lejeune L,François M,Galipeau J

更新日期：2007-03-01 00:00:00

abstract：:Studies on purified blood dendritic cells (DCs) are hampered by poor viability in tissue culture. We, therefore, attempted to study some of the interactions/relationships between DCs and other blood cells by culturing unseparated peripheral blood mononuclear cell (PBMC) preparations in vitro. Flow cytometric technique...

journal_title：Blood

authors： Ho CS,Munster D,Pyke CM,Hart DN,López JA

更新日期：2002-04-15 00:00:00

abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

journal_title：Blood

authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

更新日期：1998-01-15 00:00:00

abstract：:Until recently, IgE-activated mast cells have been regarded merely as effector cells of adaptive immune responses, involved in allergic reactions and mucosal immunity to parasites. Herein, we report that murine dermal mast cells, activated by local administration of a cream containing the synthetic TLR7 ligand imiquim...

journal_title：Blood

authors： Heib V,Becker M,Warger T,Rechtsteiner G,Tertilt C,Klein M,Bopp T,Taube C,Schild H,Schmitt E,Stassen M

更新日期：2007-08-01 00:00:00