Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis.

abstract：:Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. In an unselected series of 1897 AML cases, 54 patients with an 11q23/MLL rearrangement were identified, resulting in an incidence of 2.8%. The incidence...

journal_title：Blood

authors： Schoch C,Schnittger S,Klaus M,Kern W,Hiddemann W,Haferlach T

更新日期：2003-10-01 00:00:00

abstract：:Activated platelets release their granule content in a concentrated fashion at sites of injury. We examined whether ectopically expressed factor VIII in developing megakaryocytes would be stored in alpha-granules and whether its release from circulating platelets would effectively ameliorate bleeding in a factor VIIIn...

journal_title：Blood

authors： Yarovoi HV,Kufrin D,Eslin DE,Thornton MA,Haberichter SL,Shi Q,Zhu H,Camire R,Fakharzadeh SS,Kowalska MA,Wilcox DA,Sachais BS,Montgomery RR,Poncz M

更新日期：2003-12-01 00:00:00

abstract：:Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to independently predict for clinical outcome in patients receiving combination chemoimmunotherapy in the frontline setting. However, the long-term prognostic value of MRD s...

journal_title：Blood

authors： Kwok M,Rawstron AC,Varghese A,Evans PA,O'Connor SJ,Doughty C,Newton DJ,Moreton P,Hillmen P

更新日期：2016-12-15 00:00:00

abstract：:The effects of alpha 2-antiplasmin and fibrin on the activation of plasminogen by recombinant staphylokinase (STAR) were studied in an effort to elucidate further the molecular basis of the fibrin-specificity of this fibrinolytic agent. In purified systems consisting of 1.5 mumol/L intact or low-M(r) plasminogen and 3...

journal_title：Blood

authors： Silence K,Collen D,Lijnen HR

更新日期：1993-08-15 00:00:00

abstract：:We have established four hybridoma cells that produce monoclonal antibodies (MoAbs) R2, R4, R6, and R12 directed toward recombinant human erythropoietin (rHuEPO). MoAbs R2, R4, and R6 bound to EPO with high affinities (kd = approximately 2, 4, and 1 nmol/L, respectively) but MoAb R12 had a low affinity (240 nmol/L). T...

journal_title：Blood

authors： Goto M,Murakami A,Akai K,Kawanishi G,Ueda M,Chiba H,Sasaki R

更新日期：1989-09-01 00:00:00

abstract：:Protein S is a vitamin K-dependent nonenzymatic anticoagulant protein that acts as a cofactor to activated protein C. Recently it was shown that protein S inhibits the prothrombinase reaction independent of activated protein C. In this study, we show that protein S can also inhibit the intrinsic factor X activation vi...

journal_title：Blood

authors： Koppelman SJ,Hackeng TM,Sixma JJ,Bouma BN

更新日期：1995-08-01 00:00:00

abstract：:Biosynthesis of leukotrienes (LTs) occurs in human myeloid cells and B lymphocytes. However, the function of leukotrienes in B lymphocytes is unclear. Here, we report that B-cell chronic lymphocytic leukemia (B-CLL) cells produce leukotriene B(4), and that specific leukotriene biosynthesis inhibitors counteracted CD40...

journal_title：Blood

authors： Runarsson G,Liu A,Mahshid Y,Feltenmark S,Pettersson A,Klein E,Björkholm M,Claesson HE

更新日期：2005-02-01 00:00:00

abstract：:In systemic light-chain amyloidosis, λ light chains produced by clonal plasma cells cause organ damage and early death. In pursuit of novel therapy, we developed 1 pool of short interfering RNA (siRNA) targeting the constant region of λ light chains that substantially and promptly reduces λ-light-chain production and ...

journal_title：Blood

authors： Zhou P,Ma X,Iyer L,Chaulagain C,Comenzo RL

更新日期：2014-05-29 00:00:00

abstract：:Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of developing lymphoid and myeloid cells. Deregulation of Notch signaling determines several human diso...

journal_title：Blood

authors： Nwabo Kamdje AH,Krampera M

更新日期：2011-12-15 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:Myeloperoxidase (MPO) is a heme containing enzyme involved in the oxygen-dependent microbicidal activity of human polymorphonuclear leukocytes (PMN). Complete hereditary and acquired MPO deficiencies are defined as lack of peroxidase activity in PMN. Using this criterion, we studied a patient with complete hereditary ...

journal_title：Blood

authors： Tobler A,Selsted ME,Miller CW,Johnson KR,Novotny MJ,Rovera G,Koeffler HP

更新日期：1989-05-15 00:00:00

abstract：:In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the...

journal_title：Blood

authors： Flowers ME,Parker PM,Johnston LJ,Matos AV,Storer B,Bensinger WI,Storb R,Appelbaum FR,Forman SJ,Blume KG,Martin PJ

更新日期：2002-07-15 00:00:00

abstract：:Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined mechanisms. Our studies indicate that T(H) cells frequently interact with monocytes in inflamed skin and elicit the differentiation of specialized DC subsets c...

journal_title：Blood

authors： Alonso MN,Wong MT,Zhang AL,Winer D,Suhoski MM,Tolentino LL,Gaitan J,Davidson MG,Kung TH,Galel DM,Nadeau KC,Kim J,Utz PJ,Söderström K,Engleman EG

更新日期：2011-09-22 00:00:00

abstract：:The present studies were undertaken to determine whether factor VIII/von Willebrand factor (vWF) present in the vessel wall (in addition to that in plasma) may mediate the attachment of platelets to subendothelium. Subendothelium from everted rabbit aorta was exposed to human citrated blood flowing through an annular ...

journal_title：Blood

authors： Turitto VT,Weiss HJ,Zimmerman TS,Sussman II

更新日期：1985-04-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules from secretory lysosomes. Loss of munc13-4 function inhibits this process and causes familial hemophagocytic lymphohistiocytosis type 3 (FHL3). munc13-4 binds rab27a, but the necessity of the complex remains enigmatic, be...

journal_title：Blood

authors： Elstak ED,Neeft M,Nehme NT,Voortman J,Cheung M,Goodarzifard M,Gerritsen HC,van Bergen En Henegouwen PM,Callebaut I,de Saint Basile G,van der Sluijs P

更新日期：2011-08-11 00:00:00

abstract：:To investigate the role of peritoneal mesothelial cells in regulating hematopoiesis, as well as inflammation, healing, and tissue regeneration processes, long-term cultures of peritoneal mesothelial cells from human endocavitarian fluids were established. The purity of the cell population was assessed by morphologic a...

journal_title：Blood

authors： Lanfrancone L,Boraschi D,Ghiara P,Falini B,Grignani F,Peri G,Mantovani A,Pelicci PG

更新日期：1992-12-01 00:00:00

abstract：:In this issue of Blood, Goussetis et al identify autophagy as a new pathway for the degradation of the oncoprotein BCR-ABL. They show that the therapeutic drug arsenic trioxide (AS(2)O(3)) targets BCR-ABL for autophagic degradation via a p62/SQSTM1-dependent mechanism that is critical for the antileukemic effect of th...

journal_title：Blood

authors： Auberger P

更新日期：2012-10-25 00:00:00

abstract：:The purpose of this study was to define, in a phase I study in leukemia, the maximally tolerated dose (MTD), major toxicities, and possible antitumor activity of Topotecan, a new topoisomerase I (topo I) inhibitor. Topotecan was delivered by a 5-day continuous infusion every 3 to 4 weeks to patients with refractory or...

journal_title：Blood

authors： Kantarjian HM,Beran M,Ellis A,Zwelling L,O'Brien S,Cazenave L,Koller C,Rios MB,Plunkett W,Keating MJ

更新日期：1993-03-01 00:00:00

abstract：:We determined the role of the heterophilic interaction of alphavbeta3 integrin on endothelial cells with CD31 on leukocytes in mediating leukocyte-endothelial cell interactions. Preincubation of interleukin-4 (IL-4)-stimulated human umbilical vein endothelial cells (HUVECs) with anti-CD31 monoclonal antibodies (MoAbs)...

journal_title：Blood

authors： Chiba R,Nakagawa N,Kurasawa K,Tanaka Y,Saito Y,Iwamoto I

更新日期：1999-08-15 00:00:00

abstract：:Loxosceles is the most venomous spider in Brazil, and envenomation causes dermonecrosis and complement (C)-dependent intravascular hemolysis. The authors studied the mechanism of induction of C-induced hemolysis. Purified Loxosceles toxins rendered human erythrocytes susceptible to lysis by human C but did not have an...

journal_title：Blood

authors： Tambourgi DV,Morgan BP,de Andrade RM,Magnoli FC,van Den Berg CW

更新日期：2000-01-15 00:00:00

abstract：:Notch is a major factor mediating interaction between hematopoietic progenitor cells (HPCs) and bone marrow stroma (BMS). However its contribution to dendritic cell (DC) differentiation is controversial. We found that main Notch ligands Delta-1 and Jagged-1 had the opposite effect on DC differentiation. Delta-1 promot...

journal_title：Blood

authors： Cheng P,Nefedova Y,Corzo CA,Gabrilovich DI

更新日期：2007-01-15 00:00:00

abstract：:We studied T-cell reconstitution in 31 primary T-cell-immunodeficient patients who had undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 patients, there was no evidence of myeloid chimerism because little or no myeloablation had been performed. Given this context, we sought facto...

journal_title：Blood

authors： Cavazzana-Calvo M,Carlier F,Le Deist F,Morillon E,Taupin P,Gautier D,Radford-Weiss I,Caillat-Zucman S,Neven B,Blanche S,Cheynier R,Fischer A,Hacein-Bey-Abina S

更新日期：2007-05-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) has previously been shown to stimulate granulocyte, macrophage, and megakaryocyte lineages to act as an erythroid burst-promoting activity and to stimulate limited replication of spleen colony-forming cells. Here we demonstrate that murine GM-CSF alone or in co...

journal_title：Blood

authors： McNiece IK,Robinson BE,Quesenberry PJ

更新日期：1988-07-01 00:00:00

abstract：:The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...

journal_title：Blood

authors： Luyendyk JP,Schoenecker JG,Flick MJ

更新日期：2019-02-07 00:00:00

abstract：:Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we designed a multicenter, randomized trial aiming to determine whether quinine would improve the survival of adult patients (15-60 years old) with de novo acute myelogenous leukemia (AML). These pa...

journal_title：Blood

authors： Solary E,Drenou B,Campos L,de Crémoux P,Mugneret F,Moreau P,Lioure B,Falkenrodt A,Witz B,Bernard M,Hunault-Berger M,Delain M,Fernandes J,Mounier C,Guilhot F,Garnache F,Berthou C,Kara-Slimane F,Harousseau JL,Groupe O

更新日期：2003-08-15 00:00:00

abstract：:Between 1990 and 1996, we conducted a randomized trial in adults with newly diagnosed acute myeloid leukemia (AML) in order to compare relapse-free interval (RFI) after double induction (arm B), timed-sequential induction (arm C), or control "3 + 7" induction (arm A). Patients achieving complete remission (CR) after i...

journal_title：Blood

authors： Castaigne S,Chevret S,Archimbaud E,Fenaux P,Bordessoule D,Tilly H,de Revel T,Simon M,Dupriez B,Renoux M,Janvier M,Micléa JM,Thomas X,Bastard C,Preudhomme C,Bauters F,Degos L,Dombret H

更新日期：2004-10-15 00:00:00

abstract：:Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the rele...

journal_title：Blood

authors： White JG

更新日期：1987-03-01 00:00:00

abstract：:The presence of a serum factor in chronic renal failure (CRF) which inhibits erythropoietin-stimulated erythropoiesis was studied, using a technique in which dog marrow cells were stimulated to produce heme in the presence of human serum. In the total series comparing 27 normal sera with 52 CRF sera, less heme was syn...

journal_title：Blood

authors： Wallner SF,Kurnick JE,Ward HP,Vautrin R,Alfrey AC

更新日期：1976-04-01 00:00:00

abstract：:Using a cohort of C57BL/6 (B6) x (NZB x B6)F1 backcross male mice bearing the Yaa (Y-linked autoimmune acceleration) mutation, we mapped and characterized the NZB-derived susceptibility loci predisposing to the development of autoimmune hemolytic anemia (AHA). Our analysis identified 2 major loci on NZB chromosome 7 a...

journal_title：Blood

authors： Kikuchi S,Amano H,Amano E,Fossati-Jimack L,Santiago-Raber ML,Moll T,Ida A,Kotzin BL,Izui S

更新日期：2005-08-15 00:00:00

abstract：:Multinucleated giant cells (MGC) are a common feature of granulomas that develop during various inflammatory reactions. MGC originate from fusion of monocytes or macrophages, but the exact mechanism of their generation is still unclear. In the present study, we investigated the influence of monocyte to macrophage matu...

journal_title：Blood

authors： Möst J,Spötl L,Mayr G,Gasser A,Sarti A,Dierich MP

更新日期：1997-01-15 00:00:00