Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet.

abstract：:One of the functions of HLA class I alleles is interaction with natural killer (NK) cells. Receptors termed killer immunoglobulin-like receptors (KIRs) on NK cells recognize groups of HLA class I alleles, and interaction between receptor and class I allele inhibits reactivity of the NK cell. Failure to recognize the a...

journal_title：Blood

authors： Davies SM,Ruggieri L,DeFor T,Wagner JE,Weisdorf DJ,Miller JS,Velardi A,Blazar BR

更新日期：2002-11-15 00:00:00

abstract：:Prothrombin activation can proceed through the intermediates meizothrombin or prethrombin-2. To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)-activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and α-thrombin antithr...

journal_title：Blood

authors： Whelihan MF,Zachary V,Orfeo T,Mann KG

更新日期：2012-11-01 00:00:00

abstract：:Fc receptors play an important role in leukocyte activation and the modulation of ligand binding ("activation") is a critical point of regulation. Previous studies demonstrated that the Fc receptor for IgA (FcalphaRI/CD89) is regulated by cytokine stimulation, switching it to a high-binding state. To investigate the m...

journal_title：Blood

authors： Bracke M,Lammers JW,Coffer PJ,Koenderman L

更新日期：2001-06-01 00:00:00

abstract：:The formation and functioning of the factor X activating complex on the surface of cultured human venous endothelial cells (HVEC) were investigated. To the HVEC monolayer human factors IXa, VIII, X, CaCl2, and S-2222 were added, and a gradually increasing activation of factor X was observed. The maximum activity of 88...

journal_title：Blood

authors： Váradi K,Elödi S

更新日期：1987-02-01 00:00:00

abstract：:Donor lymphocyte infusions (DLIs) induce potent graft versus tumor (GVT) effects for relapsed chronic myelogenous leukemia (CML) after allogeneic stem cell transplantation (SCT) but are disappointing for other diseases. Disease resistance can occur if donor T cells are not appropriately activated in vivo. Ex vivo T-ce...

journal_title：Blood

authors： Porter DL,Levine BL,Bunin N,Stadtmauer EA,Luger SM,Goldstein S,Loren A,Phillips J,Nasta S,Perl A,Schuster S,Tsai D,Sohal A,Veloso E,Emerson S,June CH

更新日期：2006-02-15 00:00:00

abstract：:Through the procedure of gene amplification combined with hybridization to synthetic 19 base pair (bp) oligonucleotide probes, it has been possible to identify nine different mutations in the DNA of 47 subjects from Turkey and Northern Cyprus with a beta-thalassemia homozygosity. The IVS-I nucleotide (nt) 110 G----A a...

journal_title：Blood

authors： Diaz-Chico JC,Yang KG,Stoming TA,Efremov DG,Kutlar A,Kutlar F,Aksoy M,Altay C,Gurgey A,Kilinc Y

更新日期：1988-01-01 00:00:00

abstract：:Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of gran...

journal_title：Blood

authors： Wong WY,Powars DR,Operskalski EA,Hassett J,Parker JW,Sarnaik S,Pegelow CH,Hilgartner MW,Johnson CS,Zhou Y

更新日期：1995-04-15 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV), a DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia. MCPyV sequences have also been detected in various normal tissues in tumor-affected patients. Immunologic studies have detected MCPyV antibodies in as many as 80% of healthy...

journal_title：Blood

authors： Pancaldi C,Corazzari V,Maniero S,Mazzoni E,Comar M,Martini F,Tognon M

更新日期：2011-06-30 00:00:00

abstract：:We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, ...

journal_title：Blood

authors： Yokota T,Oritani K,Takahashi I,Ishikawa J,Matsuyama A,Ouchi N,Kihara S,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:Fibrin is a hallmark of immune-mediated tissue lesions. The presence of fibrin in such lesions implies both the formation of fibrin via coagulation and the accompanying restriction of fibrinolysis, allowing fibrin to persist. Previous work has shown that human monocytes exposed to an inflammatory stimulus such as lipo...

journal_title：Blood

authors： Schwartz BS,Bradshaw JD

更新日期：1989-10-01 00:00:00

abstract：:The treatment of multiple myeloma is considered a continuously evolving paradigm as a result of the growing availability of new and highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Clinical trials advocate long-term rather than sh...

journal_title：Blood

authors： Delforge M,Ludwig H

更新日期：2017-04-27 00:00:00

abstract：:Cytokine expression was analyzed in CD14++ regular monocytes and in the novel subset of CD14+/CD16+ small monocytes. Biologic activity for tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 in the supernatant of elutriator-enriched, cell sorter-purified small monocytes was about 10-fold lower compared with re...

journal_title：Blood

authors： Ziegler-Heitbrock HW,Ströbel M,Kieper D,Fingerle G,Schlunck T,Petersmann I,Ellwart J,Blumenstein M,Haas JG

更新日期：1992-01-15 00:00:00

abstract：:Although chemotherapy can induce complete responses in patients with chronic lymphocytic leukemia (CLL), it is not considered curative. Treated patients generally develop recurrent disease requiring additional therapy, which can cause worsening immune dysfunction, myelosuppression, and selection for chemotherapy-resis...

journal_title：Blood

authors： Kater AP,van Oers MH,Kipps TJ

更新日期：2007-10-15 00:00:00

abstract：:We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

journal_title：Blood

authors： Nakano T,Waki N,Asai H,Kitamura Y

更新日期：1989-04-01 00:00:00

abstract：:CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

journal_title：Blood

authors： Wei S,Kryczek I,Zou W

更新日期：2006-07-15 00:00:00

abstract：:Cytotoxic T lymphocytes kill target cells via the polarized secretion of cytotoxic granules at the immune synapse. The lytic granules are initially recruited around the polarized microtubule-organizing center. In a dynein-dependent transport process, the granules move along microtubules toward the microtubule-organizi...

journal_title：Blood

authors： Kurowska M,Goudin N,Nehme NT,Court M,Garin J,Fischer A,de Saint Basile G,Ménasché G

更新日期：2012-04-26 00:00:00

abstract：:Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARalpha fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but recurrent, APL has been described that does not respond to ATRA treatment and is associated with a variant chromosomal translocati...

journal_title：Blood

authors： Guidez F,Ivins S,Zhu J,Söderström M,Waxman S,Zelent A

更新日期：1998-04-15 00:00:00

abstract：:Dendritic cells are the most potent antigen-presenting cells of the immune system. Although dendritic cells are likely to secrete selective cytokines that facilitate antigen presentation, the difficulty in isolating pure dendritic cells in sufficient numbers has made assessment of this function imprecise. In this stud...

journal_title：Blood

authors： Zhou LJ,Tedder TF

更新日期：1995-11-01 00:00:00

abstract：:Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor active clinically in cutaneous T-cell lymphoma and preclinically in leukemia. A phase 1 study was conducted to evaluate the safety and activity of oral vorinostat 100 to 300 mg twice or thrice daily for 14 days followed by 1-week res...

journal_title：Blood

authors： Garcia-Manero G,Yang H,Bueso-Ramos C,Ferrajoli A,Cortes J,Wierda WG,Faderl S,Koller C,Morris G,Rosner G,Loboda A,Fantin VR,Randolph SS,Hardwick JS,Reilly JF,Chen C,Ricker JL,Secrist JP,Richon VM,Frankel SR,Kantarj

更新日期：2008-02-01 00:00:00

abstract：:The role of interleukin-12 (IL-12) in Th1 cell differentiation is well established. The heterodimer p70, composed of a p40 and a p35 chain, is the biologically active form. IL-12 production by human monocytes is enhanced by interferon-gamma (IFN-gamma) and inhibited by IL-10 and prostaglandin E2 (PGE2). Peripheral blo...

journal_title：Blood

authors： Meyaard L,Hovenkamp E,Pakker N,van der Pouw Kraan TC,Miedema F

更新日期：1997-01-15 00:00:00

abstract：:Coagulation factors VII (FVII), IX (FIX), X (FX), and protein C share the same domain organization but display very different plasma half-lives. It is plausible that the half-life is influenced by the activation peptide, differing in length and glycosylation and missing in FVII. To test this hypothesis, the influence ...

journal_title：Blood

authors： Johansson L,Karpf DM,Hansen L,Pelzer H,Persson E

更新日期：2011-03-24 00:00:00

abstract：:A mechanism to control development of mast cells was investigated in mice. Although mast cells in the skin of normal C57BL/6 mice were still of host type 290 days after irradiation and injection of bone marrow cells from beige (Chediak-Higashi syndrome, C57BL/6 bgJ/bgJ) mice, donor-type mast cells with giant granules ...

journal_title：Blood

authors： Hatanaka K,Kitamura Y,Nishimune Y

更新日期：1979-01-01 00:00:00

abstract：:In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable an...

journal_title：Blood

authors： Carobbio A,Thiele J,Passamonti F,Rumi E,Ruggeri M,Rodeghiero F,Randi ML,Bertozzi I,Vannucchi AM,Antonioli E,Gisslinger H,Buxhofer-Ausch V,Finazzi G,Gangat N,Tefferi A,Barbui T

更新日期：2011-06-02 00:00:00

abstract：:Human umbilical vein endothelial cells were analyzed for the presence of prothrombin, factor VII, protein C, and protein S in culture supernatants and cell extracts using specific radioimmunoassays. Only protein S was detected. Conditioned medium from 24-hour cultures and cell lysates contained 21.7 ng/mL and 88.8 ng/...

journal_title：Blood

authors： Fair DS,Marlar RA,Levin EG

更新日期：1986-04-01 00:00:00

abstract：:During the course of differentiation of early human myeloid cells toward monocytes and granulocytes, cell surface expression of the cell adhesion molecule, CD11b/CD18 (Mo1) increases dramatically and expression of myeloperoxidase (MPO), a bacteriocidal enzyme, decreases markedly. Using the inducible promyelocytic cell...

journal_title：Blood

authors： Rosmarin AG,Weil SC,Rosner GL,Griffin JD,Arnaout MA,Tenen DG

更新日期：1989-01-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is f...

journal_title：Blood

authors： Morales-Ortíz J,Deal V,Reyes F,Maldonado-Martínez G,Ledesma N,Staback F,Croft C,Pacheco A,Ortiz-Zuazaga H,Yost CC,Rowley JW,Madera B,John AS,Chen J,Lopez J,Rondina MT,Hunter R,Gibson A,Washington AV

更新日期：2018-12-06 00:00:00

abstract：:Red blood cell (RBC) and platelet transfusion requirements in patients given nonmyeloablative versus conventional peripheral blood stem cell (PBSC) transplants from HLA-matched siblings were compared. Between December 1997 and March 2000, 40 patients, aged 21 to 67 years (median 51), with hematologic malignancies unde...

journal_title：Blood

authors： Weissinger F,Sandmaier BM,Maloney DG,Bensinger WI,Gooley T,Storb R

更新日期：2001-12-15 00:00:00

abstract：:Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We ra...

journal_title：Blood

authors： Machlus KR,Cardenas JC,Church FC,Wolberg AS

更新日期：2011-05-05 00:00:00

abstract：:Although the chromosomal localization (9q34) of the gene encoding the human form of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13) and its exclusive expression in the liver have been established, the cells that produce this enzyme are yet to be determined. We investigated the ...

journal_title：Blood

authors： Uemura M,Tatsumi K,Matsumoto M,Fujimoto M,Matsuyama T,Ishikawa M,Iwamoto TA,Mori T,Wanaka A,Fukui H,Fujimura Y

更新日期：2005-08-01 00:00:00