Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: an international study of 891 patients.

abstract：:Human embryonic stem cells are a promising tool to study events associated with the earliest ontogenetic stages of hematopoiesis. We describe the generation of erythroid cells from hES (H1) by subsequent processing of cells present at early and late stages of embryoid body (EB) differentiation. Kinetics of hematopoiet...

journal_title：Blood

authors： Chang KH,Nelson AM,Cao H,Wang L,Nakamoto B,Ware CB,Papayannopoulou T

更新日期：2006-09-01 00:00:00

abstract：:We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD). PTLD developed in 78 recipients, with 64 cases occurring less than 1 year after transplantation. The cum...

journal_title：Blood

authors： Curtis RE,Travis LB,Rowlings PA,Socié G,Kingma DW,Banks PM,Jaffe ES,Sale GE,Horowitz MM,Witherspoon RP,Shriner DA,Weisdorf DJ,Kolb HJ,Sullivan KM,Sobocinski KA,Gale RP,Hoover RN,Fraumeni JF Jr,Deeg HJ

更新日期：1999-10-01 00:00:00

abstract：:Hereditary glutathione reductase (GR) deficiency was found in only 2 cases when testing more than 15 000 blood samples. We have investigated the blood cells of 2 patients (1a and 1b) in a previously described family suffering from favism and cataract and of a novel patient (2) presenting with severe neonatal jaundice....

journal_title：Blood

authors： Kamerbeek NM,van Zwieten R,de Boer M,Morren G,Vuil H,Bannink N,Lincke C,Dolman KM,Becker K,Schirmer RH,Gromer S,Roos D

更新日期：2007-04-15 00:00:00

abstract：:Hepatitis B virus (HBV)-infected individuals are occasionally used as donors for bone marrow transplantation (BMT). We studied the rate of HBV infection and the clinical expression of the associated liver disease in patients receiving marrow from HBsAg+ donors. We performed a retrospective survey in 14 BMT units in It...

journal_title：Blood

authors： Locasciulli A,Alberti A,Bandini G,Polchi P,Arcese W,Alessandrino P,Bosi A,Testa M,Bacigalupo A

更新日期：1995-10-15 00:00:00

abstract：:Hematopoietic stem cells differentiate in the thymus to T cells along precisely defined intermediates. This process is thymic epithelium dependent and involves cytokines and cell-cell interactions between thymic stroma and T-cell precursors. Here we report that highly purified human CD34++ fetal liver stem cells diffe...

journal_title：Blood

authors： Plum J,De Smedt M,Defresne MP,Leclercq G,Vandekerckhove B

更新日期：1994-09-01 00:00:00

abstract：:We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, ...

journal_title：Blood

authors： Marr KA,Leisenring W,Crippa F,Slattery JT,Corey L,Boeckh M,McDonald GB

更新日期：2004-02-15 00:00:00

abstract：:The role of hematopoietic growth factors in lineage commitment and differentiation is unclear. We present evidence that heterologous expression of an erythroid specific receptor allows granulocytic differentiation of a myeloid cell line. We have previously characterized a truncation mutant of the erythropoietin recept...

journal_title：Blood

authors： Harris KW,Hu XJ,Schultz S,Arcasoy MO,Forget BG,Clare N

更新日期：1998-08-15 00:00:00

abstract：:The successful induction of a T-cell-mediated tumor-protective immunity against poorly immunogenic malignancies remains a major challenge for cancer immunotherapy. We achieved this by immunization with a tyrosine hydroxylase (mTH)-based DNA vaccine, enhanced with the posttranscriptional regulatory acting RNA element (...

journal_title：Blood

authors： Pertl U,Wodrich H,Ruehlmann JM,Gillies SD,Lode HN,Reisfeld RA

更新日期：2003-01-15 00:00:00

abstract：:Previous studies on patients with storage pool deficiency (SPD) who are specifically deficient in platelet dense granules (delta-SPD) have suggested a role for dense granule substances, in all likelihood adenosine diphosphate (ADP), in mediating thrombus formation on subendothelium at high shear rates. The role of den...

journal_title：Blood

authors： Weiss HJ,Lages B,Hoffmann T,Turitto VT

更新日期：1996-05-15 00:00:00

abstract：:Antigens implicated in the graft-versus-leukemia (GVL) effect in chronic myeloid leukemia (CML) include WT1, PR1, and BCR-ABL. To detect very low frequencies of these antigen-specific CD8+ T cells, we used quantitative polymerase chain reaction (qPCR) to measure interferon-gamma (IFN-gamma) mRNA production by peptide-...

journal_title：Blood

authors： Rezvani K,Grube M,Brenchley JM,Sconocchia G,Fujiwara H,Price DA,Gostick E,Yamada K,Melenhorst J,Childs R,Hensel N,Douek DC,Barrett AJ

更新日期：2003-10-15 00:00:00

abstract：:E-cadherin gene is often termed a "metastasis suppressor" gene because the E-cadherin protein can suppress tumor cell invasion and metastasis. Inactivation of the E-cadherin gene occurs in undifferentiated solid tumors by both genetic and epigenetic mechanisms; however, the role of E-cadherin in hematologic malignanci...

journal_title：Blood

authors： Melki JR,Vincent PC,Brown RD,Clark SJ

更新日期：2000-05-15 00:00:00

abstract：:The mechanical properties of sickle erythrocyte membranes were evaluated in the ektacytometer. When ghosts from the total red blood cell population were examined, the rigidity of the resealed ghosts and their rate of fragmentation by shear stress (t1/2) were normal. However, fractionation on Stractan density gradients...

journal_title：Blood

authors： Messmann R,Gannon S,Sarnaik S,Johnson RM

更新日期：1990-04-15 00:00:00

abstract：:Multiple myeloma (MM) is one of the most common hematologic malignancies. Despite extensive therapeutical approaches, cures remain rare exceptions. An important issue for future immunologic treatments is the characterization of appropriate tumor-associated antigens. Recently, a highly glycosylated mucin MUC1 was detec...

journal_title：Blood

authors： Choi C,Witzens M,Bucur M,Feuerer M,Sommerfeldt N,Trojan A,Ho A,Schirrmacher V,Goldschmidt H,Beckhove P

更新日期：2005-03-01 00:00:00

abstract：:Fibrin forms the cohesive network of hemostatic plugs and thrombi, and it also provides the temporary matrix for initial support of healing and revascularization. Because cell proliferation is needed for revascularization after vessel injury, we have characterized structural requirements of fibrin needed to support ce...

journal_title：Blood

authors： Sporn LA,Bunce LA,Francis CW

更新日期：1995-09-01 00:00:00

abstract：:Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of Plasmodium falciparum The parasite unfolded protein response (UPR) has also been implicated as a proteostatic mechanism that may diminish artemisinin...

journal_title：Blood

authors： Bhattacharjee S,Coppens I,Mbengue A,Suresh N,Ghorbal M,Slouka Z,Safeukui I,Tang HY,Speicher DW,Stahelin RV,Mohandas N,Haldar K

更新日期：2018-03-15 00:00:00

abstract：:The recruitment of phagocytic leukocytes to sites of vessel wall injury plays an important role in thrombus dissolution by proteases elaborated on their adhesion. However, leukocyte adhesion to the fibrin clot can be detrimental at the early stages of wound healing when hemostatic plug integrity is critical for preven...

journal_title：Blood

authors： Lishko VK,Burke T,Ugarova T

更新日期：2007-02-15 00:00:00

abstract：:The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched contr...

journal_title：Blood

authors： Lindqvist EK,Goldin LR,Landgren O,Blimark C,Mellqvist UH,Turesson I,Wahlin A,Björkholm M,Kristinsson SY

更新日期：2011-12-08 00:00:00

abstract：:An association between platelets, angiogenesis, and cancer has long been recognized, but the mechanisms linking them remains unclear. Platelets regulate new blood vessel growth through numerous stimulators and inhibitors of angiogenesis by several pathways, including differential exocytosis of angiogenesis regulators....

journal_title：Blood

authors： Battinelli EM,Markens BA,Italiano JE Jr

更新日期：2011-08-04 00:00:00

abstract：:In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning or immunosuppression. The primary limitation to the clinical application of IUHSCTx has been minimal donor cell engraftment, well below therapeutic levels...

journal_title：Blood

authors： Hayashi S,Peranteau WH,Shaaban AF,Flake AW

更新日期：2002-08-01 00:00:00

abstract：:This article reports a Glanzmann thrombasthenia (GT) patient, N.M., with a point mutation in the third cysteine-rich repeat of beta3-integrin or platelet glycoprotein (GP) IIIa, leading to the expression of a constitutively activated fibrinogen receptor. The diagnosis of GT was based on a severely reduced platelet-agg...

journal_title：Blood

authors： Ruiz C,Liu CY,Sun QH,Sigaud-Fiks M,Fressinaud E,Muller JY,Nurden P,Nurden AT,Newman PJ,Valentin N

更新日期：2001-10-15 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) enhances thymopoiesis but given the broad distribution of IGF-1 receptors (IGF-1Rs), its mechanism of action has remained unclear. To identify points of thymic regulation by IGF-1, we examined its effects on T-cell precursors, thymocytes, and thymic epithelial cells (TECs) in norma...

journal_title：Blood

authors： Chu YW,Schmitz S,Choudhury B,Telford W,Kapoor V,Garfield S,Howe D,Gress RE

更新日期：2008-10-01 00:00:00

abstract：:Wilms' tumor 1 (WT1) is constantly expressed in leukemic cells of acute leukemia and myelodysplastic syndrome (MDS). A T-cell receptor (TCR) that specifically reacts with WT1 peptide in the context of HLA-A*24:02 has been identified. We conducted a first-in-human trial of TCR-gene transduced T-cell (TCR-T-cell) transf...

journal_title：Blood

authors： Tawara I,Kageyama S,Miyahara Y,Fujiwara H,Nishida T,Akatsuka Y,Ikeda H,Tanimoto K,Terakura S,Murata M,Inaguma Y,Masuya M,Inoue N,Kidokoro T,Okamoto S,Tomura D,Chono H,Nukaya I,Mineno J,Naoe T,Emi N,Yasukawa M,

更新日期：2017-11-02 00:00:00

abstract：:Stem cell proliferation induced by potent cytokines usually leads to a loss of primitive potential through differentiation. In this study, the ability of cytokines and murine MS5 stromal cells to independently regulate the proliferation and long-term culture-initiating cell (LTC-IC) activity of primitive CD34(+)CD38(l...

journal_title：Blood

authors： Bennaceur-Griscelli A,Pondarré C,Schiavon V,Vainchenker W,Coulombel L

更新日期：2001-01-15 00:00:00

abstract：:Thrombopoietin (Tpo), the ligand for c-mpl, has been shown to be the principal regulator of megakaryocytopoiesis and platelet production. The ability of Tpo to potently stimulate the growth of committed megakaryocyte (Mk) progenitor cells has been studied in detail. Murine fetal liver cells, highly enriched in primiti...

journal_title：Blood

authors： Ramsfjell V,Borge OJ,Veiby OP,Cardier J,Murphy MJ Jr,Lyman SD,Lok S,Jacobsen SE

更新日期：1996-12-15 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:The efficacy of the addition of intensive therapy with daunorubicin (45 mg/m2 IV on days 1, 2, 3) to an otherwise identical induction program consisting of vincristine, prednisone, and L-asparaginase was assessed in 177 previously untreated adults (greater than or equal to 20 years of age) with acute lymphocytic leuke...

journal_title：Blood

authors： Gottlieb AJ,Weinberg V,Ellison RR,Henderson ES,Terebelo H,Rafla S,Cuttner J,Silver RT,Carey RW,Levy RN

更新日期：1984-07-01 00:00:00

abstract：:Both extrinsic and intrinsic mechanisms tightly govern hematopoietic stem cell (HSC) decisions of self-renewal and differentiation. However, transcription factors that can selectively regulate HSC self-renewal division after stress remain to be identified. Slug is an evolutionarily conserved zinc-finger transcription ...

journal_title：Blood

authors： Sun Y,Shao L,Bai H,Wang ZZ,Wu WS

更新日期：2010-03-04 00:00:00

abstract：:The frequent occurrence of TF gene involvement in translocations associated with leukemia is remarkable, although not yet explained. The wide variety of TFs involved in these translocations and the different stages of cellular maturation argue against a unifying mechanism. Recombinases, active during B-cell and T-cell...

journal_title：Blood

authors： Nichols J,Nimer SD

更新日期：1992-12-15 00:00:00

abstract：:Fibronectin (FN) plays a role in several adhesion mediated functions including the interaction of platelets with subendothelium. We investigated the role of plasma FN in platelet adhesion and platelet thrombus formation under flow conditions. We used two different perfusion models: the annular chamber with alpha-chymo...

journal_title：Blood

authors： Bastida E,Escolar G,Ordinas A,Sixma JJ

更新日期：1987-11-01 00:00:00

abstract：:JMH is a high-frequency human erythrocyte blood group antigen. Previous work has shown that JMH is absent from complement-sensitive erythrocytes of patients with paroxysmal nocturnal hemoglobinuria (PNH); such cells have a broad defect in expression of phosphatidylinositol (PI)-linked proteins. Using both human JMH an...

journal_title：Blood

authors： Bobolis KA,Moulds JJ,Telen MJ

更新日期：1992-03-15 00:00:00