Fibronectin is required for platelet adhesion and for thrombus formation on subendothelium and collagen surfaces.

abstract：:Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant so...

journal_title：Blood

authors： Hao Z,Guo C,Jiang X,Krueger S,Pietri T,Dufour S,Cone RE,O'Rourke J

更新日期：2006-07-01 00:00:00

abstract：:The plasminogen activator inhibitor PAI-1 is markedly elevated in vivo and in vitro upon exposure to the inflammatory mediators tumor necrosis factor alpha (TNF alpha), interleukin-1 (IL-1), and bacterial lipopolysaccharide. Here we report that the isoflavone compound genistein prevents the increase in synthesis of PA...

journal_title：Blood

authors： van Hinsbergh VW,Vermeer M,Koolwijk P,Grimbergen J,Kooistra T

更新日期：1994-11-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry. It was recently demonstrated that HIV-1 glycoprotein 120 (gp120) elevated calcium and activated several ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo...

journal_title：Blood

authors： Del Corno M,Liu QH,Schols D,de Clercq E,Gessani S,Freedman BD,Collman RG

更新日期：2001-11-15 00:00:00

abstract：:The binding of neutrophil beta2 integrin to intercellular adhesion molecule-1 (ICAM-1) expressed on the inflamed endothelium is critical for neutrophil arrest at sites of tissue inflammation. To quantify the strength and kinetics of this interaction, we measured the adhesion between chemotactically stimulated neutroph...

journal_title：Blood

authors： Neelamegham S,Taylor AD,Burns AR,Smith CW,Simon SI

更新日期：1998-09-01 00:00:00

abstract：:The membrane-anchored CX3C chemokine fractalkine (FKN) is expressed on activated endothelium and is associated with the development of atherosclerosis. The potential of FKN in mediating platelet adhesion beyond platelet activation remains unexplored to date. A flow-based adhesion assay was used to study the adhesion o...

journal_title：Blood

authors： Meyer dos Santos S,Klinkhardt U,Scholich K,Nelson K,Monsefi N,Deckmyn H,Kuczka K,Zorn A,Harder S

更新日期：2011-05-05 00:00:00

abstract：:ShcA is an important mediator of Ras/MAPK activation in PTK-regulated pathways triggered by surface receptors. This function is subserved by the constitutively expressed p52-kDa isoform. Besides activating Ras, p52Shc couples the TCR to Rho GTPases, and thereby participates in actin cytoskeleton remodeling in T cells....

journal_title：Blood

authors： Patrussi L,Ulivieri C,Lucherini OM,Paccani SR,Gamberucci A,Lanfrancone L,Pelicci PG,Baldari CT

更新日期：2007-09-15 00:00:00

abstract：:There are many reports in the literature of blood test abnormalities occurring in patients with venous or arterial thrombosis. Most of these have not used acceptable criteria for establishing an association between thrombosis and blood tests and, therefore, their interpretation is questionable. Recently, sensitive and...

journal_title：Blood

authors： Hirsh J

更新日期：1981-01-01 00:00:00

abstract：:Crystallographic and electron microscopy studies revealed genuflexed (bent) integrins in both unliganded (inactive) and physiologic ligandbound (active) states, suggesting that local conformational changes are sufficient for activation. Herein we have explored the role of local changes in the contact region between th...

journal_title：Blood

authors： Gupta V,Gylling A,Alonso JL,Sugimori T,Ianakiev P,Xiong JP,Arnaout MA

更新日期：2007-04-15 00:00:00

abstract：:Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Both KG1a and KG1 cells express the CD34 antigen...

journal_title：Blood

authors： Morimoto K,Robin E,Le Bousse-Kerdiles MC,Li Y,Clay D,Jasmin C,Smadja-Joffe F

更新日期：1994-02-01 00:00:00

abstract：:As a mediator of neurogenic inflammation and pain, we hypothesized that levels of the neuropeptide Substance P (SP) would be elevated in patients with sickle cell disease (SCD) with vaso-occlusive pain crisis. SP is a known stimulator of tumor necrosis factor-alpha (TNF-alpha) release and a promoter of interleukin-8 (...

journal_title：Blood

authors： Michaels LA,Ohene-Frempong K,Zhao H,Douglas SD

更新日期：1998-11-01 00:00:00

abstract：:High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders. To determine the safety and efficacy of high-dose cyclophosphamide among patients with severe refractory autoimmune hemolytic anemia, we treated 9 patients with cyclophosphamide (50...

journal_title：Blood

authors： Moyo VM,Smith D,Brodsky I,Crilley P,Jones RJ,Brodsky RA

更新日期：2002-07-15 00:00:00

abstract：:We report five patients who had greater than 30% peripheral blasts and less than 30% marrow blasts. By the current standards these cases would be classified as myelodysplastic syndrome. Four of five patients progressed to acute leukemia within approximately 1 1/2 months of developing greater than 30% peripheral blasts...

journal_title：Blood

authors： Cason JD,Trujillo JM,Estey EH,Huh YO,Freireich EJ,Stass SA

更新日期：1989-10-01 00:00:00

abstract：:The molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome is the presence of a mutation in the iron-responsive element (IRE) of the L ferritin gene, located on chromosome 19q13.3-13.4. Two mutations have been reported so far, altering adjacent nucleotides in the IRE loop, in a regio...

journal_title：Blood

authors： Martin ME,Fargion S,Brissot P,Pellat B,Beaumont C

更新日期：1998-01-01 00:00:00

abstract：:To address the mechanism by which the human globin genes are activated during erythropoiesis, we have used a tiled microarray to analyze the pattern of transcription factor binding and associated histone modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroid cells. This ...

journal_title：Blood

authors： De Gobbi M,Anguita E,Hughes J,Sloane-Stanley JA,Sharpe JA,Koch CM,Dunham I,Gibbons RJ,Wood WG,Higgs DR

更新日期：2007-12-15 00:00:00

abstract：:Human T-cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL) transforms human T cells both in vivo and in vitro. However, the long latency period between infection and development of ATL, as well as the small fraction of the infected population that actually develops this disease, su...

journal_title：Blood

authors： Mori N,Kashanchi F,Prager D

更新日期：1997-12-15 00:00:00

abstract：:Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More...

journal_title：Blood

authors： Rossi L,Salvestrini V,Ferrari D,Di Virgilio F,Lemoli RM

更新日期：2012-09-20 00:00:00

abstract：:Cytarabine (Ara-C) is currently used in the treatment of adult acute myeloid leukemia (AML). To predict the results of induction chemotherapy, it could be useful to detect leukemic cells that are resistant to Ara-C in patients with AML. Using a bromodeoxyuridine/DNA (BrdUrd/DNA) staining method in flow cytometry (FCM)...

journal_title：Blood

authors： Lacombe F,Belloc F,Dumain P,Puntous M,Makhoul PC,Saux MC,Bernard P,Boisseau MR,Reiffers J

更新日期：1994-08-01 00:00:00

abstract：:Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-...

journal_title：Blood

authors： Maletto BA,Ropolo AS,Alignani DO,Liscovsky MV,Ranocchia RP,Moron VG,Pistoresi-Palencia MC

更新日期：2006-11-01 00:00:00

abstract：:A male neonate with Down's syndrome and congenital myeloproliferative disorder was studied. His blood picture showed the unique coexistence of leukocytosis with matured cells and a large number of blast cells. The in vitro proliferation and differentiation of blast cells into various lineages in the presence of phytoh...

journal_title：Blood

authors： Suda J,Eguchi M,Akiyama Y,Iwama Y,Furukawa T,Sato Y,Miura Y,Suda T,Saito M

更新日期：1987-02-01 00:00:00

abstract：:Reconstitution of cellular immunity by 3 months after hematopoietic stem cell transplantation (HSCT) is a critical determinant of the long-term success of the transplantation. We analyzed the factors affecting recovery of cytomegalovirus (CMV)-specific CD4+ and CD8+ function at 3 months after HSCT by univariate and mu...

journal_title：Blood

authors： Hakki M,Riddell SR,Storek J,Carter RA,Stevens-Ayers T,Sudour P,White K,Corey L,Boeckh M

更新日期：2003-10-15 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced both cytotoxic (apoptosis) and cytostatic (cell cycle perturbation) effects on the human myeloid K562 cell line. TRAIL stimulated caspase 3 and nitric oxide synthase (NOS) activities, and both pathways cooperate in mediating inhibition of K5...

journal_title：Blood

authors： Secchiero P,Gonelli A,Celeghini C,Mirandola P,Guidotti L,Visani G,Capitani S,Zauli G

更新日期：2001-10-01 00:00:00

abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

journal_title：Blood

authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

更新日期：2013-03-21 00:00:00

abstract：:We report the results of unrelated cord blood transplantation (CBT) for 18 adult patients with de novo acute myeloid leukemia (AML). The median age was 43 years, the median weight was 55.2 kg, and the median number of cryopreserved nucleated cells was 2.51 x 107/kg. Seventeen patients had myeloid reconstitution and th...

journal_title：Blood

authors： Ooi J,Iseki T,Takahashi S,Tomonari A,Takasugi K,Shimohakamada Y,Yamada T,Ishii K,Ohno N,Nagamura F,Uchimaru K,Tojo A,Asano S

更新日期：2004-01-15 00:00:00

abstract：:Induction of transplantation tolerance by means of bone marrow (BM) transplantation could become a reality if it was possible to achieve engraftment of hematopoietic stem cells under nonlethal preparatory cytoreduction of the recipient. To that end, BM facilitating cells, veto cells, or other tolerance-inducing cells,...

journal_title：Blood

authors： Bachar-Lustig E,Li HW,Gur H,Krauthgamer R,Marcus H,Reisner Y

更新日期：1999-11-01 00:00:00

abstract：:Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium by cytokines. We examined the contribution of these adhesive proteins to human peripheral blood monocyte adherence to endothelium using transfected Chinese hamster ovary (CHO) ...

journal_title：Blood

authors： Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J

更新日期：1991-05-15 00:00:00

abstract：:We investigated the effects of interleukin-4 (IL-4) on the survival of leukemic and normal B-cell progenitors cultured on bone marrow stroma. IL-4 (at 100 U/mL) was cytotoxic in 16 of 21 cases of B-lineage acute lymphoblastic leukemia, causing reductions in CD19+ cell numbers that ranged from 50% to greater than 99% (...

journal_title：Blood

authors： Manabe A,Coustan-Smith E,Kumagai M,Behm FG,Raimondi SC,Pui CH,Campana D

更新日期：1994-04-01 00:00:00

abstract：:Interactions of endothelial cells with fibrin(ogen) are implicated in inflammation, angiogenesis, and wound healing. Cross-linking of the fibrinogen alphaC domains with factor XIIIa generates ordered alphaC oligomers mimicking polymeric arrangement of the alphaC domains in fibrin. These oligomers and those prepared wi...

journal_title：Blood

authors： Belkin AM,Tsurupa G,Zemskov E,Veklich Y,Weisel JW,Medved L

更新日期：2005-05-01 00:00:00

abstract：:Forty patients with refractory Hodgkin's disease (24 patients) or non-Hodgkin's lymphoma (16 patients) who were considered for high-dose therapy but not for autologous bone marrow transplantation (ABMT) due to BM metastases, previous pelvic irradiation, a history of marrow involvement by tumor or hypocellular marrow i...

journal_title：Blood

authors： Kessinger A,Armitage JO,Smith DM,Landmark JD,Bierman PJ,Weisenburger DD

更新日期：1989-09-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that monitor the antigenic environment and activate naive T cells. The role of DCs is not only to sense danger but also to tolerize the immune system to antigens encountered in the absence of maturation/inflammatory stimuli. Indeed, if a naive T cell encou...

journal_title：Blood

authors： Levings MK,Gregori S,Tresoldi E,Cazzaniga S,Bonini C,Roncarolo MG

更新日期：2005-02-01 00:00:00