Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC domains promotes integrin-dependent cell adhesion and signaling.

abstract：:p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation resulting in deregulated cyclin D1. We previously showed ...

journal_title：Blood

authors： Quintanilla-Martinez L,Davies-Hill T,Fend F,Calzada-Wack J,Sorbara L,Campo E,Jaffe ES,Raffeld M

更新日期：2003-04-15 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional profiling has been used to highlight similarities between DLBCL tumor cells and normal B-cell subtypes and associate genes and pathways with ...

journal_title：Blood

authors： Monti S,Savage KJ,Kutok JL,Feuerhake F,Kurtin P,Mihm M,Wu B,Pasqualucci L,Neuberg D,Aguiar RC,Dal Cin P,Ladd C,Pinkus GS,Salles G,Harris NL,Dalla-Favera R,Habermann TM,Aster JC,Golub TR,Shipp MA

更新日期：2005-03-01 00:00:00

abstract：:In this study, we examined in detail the interaction of platelet factor-4 (PF-4) with fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) and the effect of PF-4-derived synthetic peptides. We show that a peptide between amino acids 47 and 70 that contains the heparin-binding lysine-rich si...

journal_title：Blood

authors： Jouan V,Canron X,Alemany M,Caen JP,Quentin G,Plouet J,Bikfalvi A

更新日期：1999-08-01 00:00:00

abstract：:A recent clinical trial of gene therapy for X-linked severe combined immunodeficiency (XSCID) has shown that retroviral-mediated gene correction of bone marrow stem cells can lead to the development of normal immune function. These exciting results have been preceded by successful immune reconstitution in several XSCI...

journal_title：Blood

authors： Otsu M,Sugamura K,Candotti F

更新日期：2001-03-15 00:00:00

abstract：:The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has been reported that human myeloma cell lines (HMCLs) are highly sensitive to Gln depletion. In this study, we found that both HMCLs and primary bone marrow (BM) C...

journal_title：Blood

authors： Bolzoni M,Chiu M,Accardi F,Vescovini R,Airoldi I,Storti P,Todoerti K,Agnelli L,Missale G,Andreoli R,Bianchi MG,Allegri M,Barilli A,Nicolini F,Cavalli A,Costa F,Marchica V,Toscani D,Mancini C,Martella E,Dall'Asta V

更新日期：2016-08-04 00:00:00

abstract：:Cervical internal carotid artery (cICA) occlusion is a recognized cause of acute ischemic stroke (AIS) in sickle cell disease (SCD), but the associated clinical and radiologic features are not well described. We reviewed data on cervical magnetic resonance angiography (cMRA) performed prospectively in 67 patients (55 ...

journal_title：Blood

authors： Telfer PT,Evanson J,Butler P,Hemmaway C,Abdulla C,Gadong N,Whitmarsh S,Kaya B,Kirkham FJ

更新日期：2011-12-01 00:00:00

abstract：:Neutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into account. In the INSIGHT study,...

journal_title：Blood

authors： Eckhardt CL,van Velzen AS,Peters M,Astermark J,Brons PP,Castaman G,Cnossen MH,Dors N,Escuriola-Ettingshausen C,Hamulyak K,Hart DP,Hay CR,Haya S,van Heerde WL,Hermans C,Holmström M,Jimenez-Yuste V,Keenan RD,Klamroth R

更新日期：2013-09-12 00:00:00

abstract：:In this issue of Blood, Navarrete et al report that upfront immunization of follicular B-cell lymphoma patients with bacterially produced Fab fragments induces immune responses; however, the influence on patient outcome is not yet known. ...

journal_title：Blood

authors： Bogen B

更新日期：2011-02-03 00:00:00

abstract：:The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary from E7.5 and weakly...

journal_title：Blood

authors： Li W,Zheng X,Gu JM,Ferrell GL,Brady M,Esmon NL,Esmon CT

更新日期：2005-10-15 00:00:00

abstract：:Neutrophils were examined for their ability to recognize and ingest beads coated with amino-derivatives of glucose, mannose, and galactose. Radioactive or fluorescent beads coated with any of the three sugars were ingested to an extent three times that observed with albumin-coated beads. Enhancement of ingestion of su...

journal_title：Blood

authors： Doolittle RL,Packman CH,Lichtman MA

更新日期：1983-09-01 00:00:00

abstract：:The ontogeny of a 57-Kd cationic antimicrobial protein (CAP57) that has substantial similarities to bactericidal permeability increasing protein (BPI) has been determined immunocytochemically. CAP57 was detected in the granules of mature peripheral blood neutrophils. However, it was absent from other cells of the peri...

journal_title：Blood

authors： Pereira HA,Spitznagel JK,Winton EF,Shafer WM,Martin LE,Guzman GS,Pohl J,Scott RW,Marra MN,Kinkade JM Jr

更新日期：1990-08-15 00:00:00

abstract：:The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic mice, we show that...

journal_title：Blood

authors： Goardon N,Schuh A,Hajar I,Ma X,Jouault H,Dzierzak E,Roméo PH,Maouche-Chrétien L

更新日期：2002-07-15 00:00:00

abstract：:Recent phenotypic analysis of plasma cells showed that normal plasma cells do express the B-cell lineage-specific molecule CD19, but their malignant counterpart (myeloma cells) are CD19-. To clarify the meaning of loss of CD19 antigen on myeloma cells, we first compared the expression of CD19 and Pax-5 genes among B c...

journal_title：Blood

authors： Mahmoud MS,Huang N,Nobuyoshi M,Lisukov IA,Tanaka H,Kawano MM

更新日期：1996-05-15 00:00:00

abstract：:Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of 1298 allogeneic hematopoietic cell transplantation (HCT) donors and recipients. Of 40 previously reported candidate SNPs, 6 were successfully genotyp...

journal_title：Blood

authors： Chien JW,Zhang XC,Fan W,Wang H,Zhao LP,Martin PJ,Storer BE,Boeckh M,Warren EH,Hansen JA

更新日期：2012-05-31 00:00:00

abstract：:We have investigated whether recombinant erythropoietin (r-Epo) elicits a change in intracellular free calcium (IFC) in purified Epo-responsive cells in spleens of mice treated with phenylhydrazine. Colony-forming units (CFU-E) were prepared by negative selection through immunologic panning. Anti-Forssman, Mac-1, Ia, ...

journal_title：Blood

authors： Imagawa S,Smith BR,Palmer-Crocker R,Bunn HF

更新日期：1989-05-01 00:00:00

abstract：:Because of the expression of inhibitory receptors (KIR) for major histocompatibility complex (MHC) class I allotypes, a person's natural killer (NK) cells will not recognize and will, therefore, kill cells from individuals lacking his/her KIR epitopes. This study investigated the role of NK cell alloreactivity in huma...

journal_title：Blood

authors： Ruggeri L,Capanni M,Casucci M,Volpi I,Tosti A,Perruccio K,Urbani E,Negrin RS,Martelli MF,Velardi A

更新日期：1999-07-01 00:00:00

abstract：:The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in this respo...

journal_title：Blood

authors： Datta R,Banach D,Kojima H,Talanian RV,Alnemri ES,Wong WW,Kufe DW

更新日期：1996-09-15 00:00:00

abstract：:Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125I-fibrin-labeled thrombi in rabbit jugular...

journal_title：Blood

authors： Agnelli G,Buchanan MR,Fernandez F,Van Ryn J,Hirsh J

更新日期：1985-08-01 00:00:00

abstract：:The mechanical properties of sickle erythrocyte membranes were evaluated in the ektacytometer. When ghosts from the total red blood cell population were examined, the rigidity of the resealed ghosts and their rate of fragmentation by shear stress (t1/2) were normal. However, fractionation on Stractan density gradients...

journal_title：Blood

authors： Messmann R,Gannon S,Sarnaik S,Johnson RM

更新日期：1990-04-15 00:00:00

abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

journal_title：Blood

authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

更新日期：1998-01-15 00:00:00

abstract：:The heterodimeric transcription factor RUNX1/PEBP2-beta (also known as AML1/CBF-beta) is essential for definitive hematopoiesis. Here, we show that interaction with PEBP2-beta leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation. This is mediated by homeodomain interacting kinase 2 (HIPK2)...

journal_title：Blood

authors： Wee HJ,Voon DC,Bae SC,Ito Y

更新日期：2008-11-01 00:00:00

abstract：:The human erythrocyte blood group system Cromer consists of high-incidence and low-incidence antigens that reside on decay-accelerating factor (DAF; CD55), a glycosyl-phosphatidylinositol-anchored membrane protein that regulates complement activation on cell surfaces. In the Cromer phenotypes Dr(a-) and Inab there is ...

journal_title：Blood

authors： Lublin DM,Mallinson G,Poole J,Reid ME,Thompson ES,Ferdman BR,Telen MJ,Anstee DJ,Tanner MJ

更新日期：1994-08-15 00:00:00

abstract：:Interleukin-10 (IL-10) is a potent monocyte regulatory cytokine that inhibits gene expression of proinflammatory mediators. In this study, we investigated the mechanism by which IL-10 downregulates expression of intercellular adhesion molecule-1 (ICAM-1) on the cell surface of normal human monocytes activated with int...

journal_title：Blood

authors： Song S,Ling-Hu H,Roebuck KA,Rabbi MF,Donnelly RP,Finnegan A

更新日期：1997-06-15 00:00:00

abstract：:The multimeric size and the function of circulating von Willebrand factor are modulated via its proteolytic cleavage by the plasma metalloproteinase, ADAMTS13. It is unclear how ADAMTS13 activity is regulated within the vascular system. In the absence of a regulatory mechanism, ADAMTS13 activity might compromise plate...

journal_title：Blood

authors： Crawley JT,Lam JK,Rance JB,Mollica LR,O'Donnell JS,Lane DA

更新日期：2005-02-01 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative variants of VWF are now well cha...

journal_title：Blood

authors： Lillicrap D

更新日期：2013-11-28 00:00:00

abstract：:Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predom...

journal_title：Blood

authors： Markovic OS,Shulman NR

更新日期：1977-11-01 00:00:00

abstract：:We report the transient response of a patient with the ETV6-ABL fusion gene to imatinib mesylate (STI571). A 38-year-old man was referred with an erroneous diagnosis of Philadelphia-positive chronic myeloid leukemia in blastic transformation for treatment with the ABL tyrosine kinase inhibitor, STI571. Further investi...

journal_title：Blood

authors： O'Brien SG,Vieira SA,Connors S,Bown N,Chang J,Capdeville R,Melo JV

更新日期：2002-05-01 00:00:00

abstract：:Rabbit kidney tissue either from normal rabbits or from rabbits "programmed" by phlebotomy or varying periods of hypoxia was cultured and shown to release into the culture medium an erythropoietically active substance. The cultures established from rabbits programmed by 6-12 hr of hypoxia yielded the highest levels of...

journal_title：Blood

authors： Ogle JW,Lange RD,Dunn CD

更新日期：1978-07-01 00:00:00

abstract：:Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of gran...

journal_title：Blood

authors： Wong WY,Powars DR,Operskalski EA,Hassett J,Parker JW,Sarnaik S,Pegelow CH,Hilgartner MW,Johnson CS,Zhou Y

更新日期：1995-04-15 00:00:00