Interleukin-10 inhibits interferon-gamma-induced intercellular adhesion molecule-1 gene transcription in human monocytes.

abstract：:Mpl ligand (thrombopoietin [TPO]) is the physiological regulator of platelet production. In mice, mRNA encoding the Mpl ligand (Mpl-L) is predominantly found by Northern blot analysis in the liver and kidney. To investigate the mode of regulation of the Mpl-L gene, we have developed several experimental models of seve...

journal_title：Blood

authors： Cohen-Solal K,Villeval JL,Titeux M,Lok S,Vainchenker W,Wendling F

更新日期：1996-10-01 00:00:00

abstract：:Fanconi anemia (FA) is a hereditary disorder caused by mutations in any 1 of 22 FA genes. The disease is characterized by hypersensitivity to interstrand crosslink (ICL) inducers such as mitomycin C (MMC). In addition to promoting ICL repair, FA proteins such as RAD51, BRCA2, or FANCD2 protect stalled replication fork...

journal_title：Blood

authors： Okamoto Y,Abe M,Mu A,Tempaku Y,Rogers CB,Mochizuki AL,Katsuki Y,Kanemaki MT,Takaori-Kondo A,Sobeck AT,Bielinsky AK,Takata M

更新日期：2020-07-31 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is expressed in almost all types of malignancies, making this protein a useful tool for the development of broadly applicable vaccination therapies. We used a recently identified HLA-A2 binding peptide and dendritic cells (DCs) from healthy donors to ind...

journal_title：Blood

authors： Schmidt SM,Schag K,Müller MR,Weck MM,Appel S,Kanz L,Grünebach F,Brossart P

更新日期：2003-07-15 00:00:00

abstract：:In previous studies we have found that monocytes produce soluble factors that stimulate human umbilical vein endothelial cells to produce granulocyte-macrophage colony-stimulating activity (CSA), burst-promoting activity (BPA), and megakaryocyte colony-stimulating activity (Meg-CSA) as well as factors that stimulate T...

journal_title：Blood

authors： Broudy VC,Zuckerman KS,Jetmalani S,Fitchen JH,Bagby GC Jr

更新日期：1986-08-01 00:00:00

abstract：:Redox biology is fundamental to both normal cellular homeostasis and pathological states associated with excessive oxidative stress. Reactive oxygen species function not only as signaling molecules but also as redox regulators of protein function. In the vascular system, redox reactions help regulate key physiologic r...

journal_title：Blood

authors： Gu SX,Stevens JW,Lentz SR

更新日期：2015-06-18 00:00:00

abstract：:The Duffy blood group system is of clinical and biological significance. Antibodies to Duffy antigens are responsible for some cases of transfusion incompatibility and newborn hemolytic disease. The Duffy protein is a receptor for the Plasmodium vivax erythrocyte-binding protein and is also a receptor for various chem...

journal_title：Blood

authors： Parasol N,Reid M,Rios M,Castilho L,Harari I,Kosower NS

更新日期：1998-10-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self-renews, proliferates, and differentiates to give rise to a myeloproliferative disease. Although tyrosine kinase inhibitors (TKIs) that target...

journal_title：Blood

authors： Holyoake TL,Vetrie D

更新日期：2017-03-23 00:00:00

abstract：:Platelet activation is normally induced by primary agonists such as adenosine diphosphate (ADP), thrombin, and collagen, whereas other agonists, such as epinephrine, can play important accessory roles. It is now reported that the macrophage-derived chemokine (MDC), thymus activation-regulated chemokine (TARC), and str...

journal_title：Blood

authors： Gear AR,Suttitanamongkol S,Viisoreanu D,Polanowska-Grabowska RK,Raha S,Camerini D

更新日期：2001-02-15 00:00:00

abstract：:We previously reported that RO(+) expression correlated with increased mutation, activation, and selection among human germinal center (GC) B cells. Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, into different fractions based on RB expression. Although each subset contained RB(+) cel...

journal_title：Blood

authors： Jackson SM,Harp N,Patel D,Wulf J,Spaeth ED,Dike UK,James JA,Capra JD

更新日期：2009-04-23 00:00:00

abstract：:This phase 2 study evaluated whether substituting bortezomib for vincristine in frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy could improve efficacy in non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB DLBCL), centrally confirmed by immunohist...

journal_title：Blood

authors： Offner F,Samoilova O,Osmanov E,Eom HS,Topp MS,Raposo J,Pavlov V,Ricci D,Chaturvedi S,Zhu E,van de Velde H,Enny C,Rizo A,Ferhanoglu B

更新日期：2015-10-15 00:00:00

abstract：:Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predom...

journal_title：Blood

authors： Markovic OS,Shulman NR

更新日期：1977-11-01 00:00:00

abstract：:The purpose of this study was to define, in a phase I study in leukemia, the maximally tolerated dose (MTD), major toxicities, and possible antitumor activity of Topotecan, a new topoisomerase I (topo I) inhibitor. Topotecan was delivered by a 5-day continuous infusion every 3 to 4 weeks to patients with refractory or...

journal_title：Blood

authors： Kantarjian HM,Beran M,Ellis A,Zwelling L,O'Brien S,Cazenave L,Koller C,Rios MB,Plunkett W,Keating MJ

更新日期：1993-03-01 00:00:00

abstract：:Essential thrombocythemia (ET) is characterized by abnormal megakaryopoiesis and enhanced thrombotic risk. Once-daily low-dose aspirin is the recommended antithrombotic regimen, but accelerated platelet generation may reduce the duration of platelet cyclooxygenase-1 (COX-1) inhibition. We performed a multicenter doubl...

journal_title：Blood

authors： Rocca B,Tosetto A,Betti S,Soldati D,Petrucci G,Rossi E,Timillero A,Cavalca V,Porro B,Iurlo A,Cattaneo D,Bucelli C,Dragani A,Di Ianni M,Ranalli P,Palandri F,Vianelli N,Beggiato E,Lanzarone G,Ruggeri M,Carli G,Ell

更新日期：2020-07-09 00:00:00

abstract：:The frequent occurrence of TF gene involvement in translocations associated with leukemia is remarkable, although not yet explained. The wide variety of TFs involved in these translocations and the different stages of cellular maturation argue against a unifying mechanism. Recombinases, active during B-cell and T-cell...

journal_title：Blood

authors： Nichols J,Nimer SD

更新日期：1992-12-15 00:00:00

abstract：:High-dose chemoradiotherapy (HDT) with autologous stem cell transplantation (ASCT) is the treatment of choice for patients with relapsed aggressive non-Hodgkin lymphoma (NHL). However, its role in the treatment of patients with primary refractory disease is not well defined. The outcomes of 85 patients with primary re...

journal_title：Blood

authors： Kewalramani T,Zelenetz AD,Hedrick EE,Donnelly GB,Hunte S,Priovolos AC,Qin J,Lyons NC,Yahalom J,Nimer SD,Moskowitz CH

更新日期：2000-10-01 00:00:00

abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain var...

journal_title：Blood

authors： Bahler DW,Miklos JA,Swerdlow SH

更新日期：1997-05-01 00:00:00

abstract：:A deficiency of adenosine deaminase, an enzyme important in purine nucleoside catabolism, is associated with a severe combined immunodeficiency disease in children. Inhibition of this enzyme in vitro and in vivo results in an impairment in lymphoblast proliferation. We have investigated the pharmacologic inhibition of...

journal_title：Blood

authors： Grever MR,Siaw MF,Jacob WF,Neidhart JA,Miser JS,Coleman MS,Hutton JJ,Balcerzak SP

更新日期：1981-03-01 00:00:00

abstract：:A simple and reliable cytogenetic test for Fanconi's anemia (FA) that is based on the hypersensitivity of FA cells to mitomycin C (MC) is described. Equal volumes of whole blood from a patient in whom the diagnosis of FA is suspected and from a normal person of the opposite sex are co-cultured in phytohemagglutinin-co...

journal_title：Blood

authors： German J,Schonberg S,Caskie S,Warburton D,Falk C,Ray JH

更新日期：1987-06-01 00:00:00

abstract：:The translocation between chromosomes 8 and 21, t(8;21) (q22;q22), is the most frequent abnormality in acute myeloid leukemia (AML) with French-American-British type M2 (FAB-M2) morphology. The breakpoints in this translocation have been characterized at the molecular level, and the genes involved are AML1 on chromoso...

journal_title：Blood

authors： Nucifora G,Larson RA,Rowley JD

更新日期：1993-08-01 00:00:00

abstract：:Fibrin deposition and platelet thrombus dimensions on subendothelium were studied in four groups of patients with coagulation factor deficiencies. Five patients with factor VIII deficiency (APTT 120 +/- 8 sec) and three patients with factor IX deficiency (APTT 125 +/- 11 sec) were severe bleeders, whereas four patient...

journal_title：Blood

authors： Weiss HJ,Turitto VT,Vicic WJ,Baumgartner HR

更新日期：1984-05-01 00:00:00

abstract：:Varying, limiting numbers of unseparated or purified cells (Ly-5.1), either from 14.5-day-old fetal liver (FL) or from adult bone marrow (BM) were coinjected with 10(5) unseparated BM cells (Ly-5.2) into lethally irradiated adult C57B1/6 recipients (Ly-5.2). The kinetics of donor cell repopulation of the lymphoid and ...

journal_title：Blood

authors： Rebel VI,Miller CL,Eaves CJ,Lansdorp PM

更新日期：1996-04-15 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of g...

journal_title：Blood

authors： Elliott NE,Cleveland SM,Grann V,Janik J,Waldmann TA,Davé UP

更新日期：2011-10-06 00:00:00

abstract：:Agammaglobulinemia is the most profound primary antibody deficiency that can occur due to an early termination of B-cell development. We here investigated 3 novel patients, including the first known adult, from unrelated families with agammaglobulinemia, recurrent infections, and hypertrophic cardiomyopathy (HCM). Two...

journal_title：Blood

authors： Saettini F,Poli C,Vengoechea J,Bonanomi S,Orellana JC,Fazio G,Rodriguez FH,Noguera LP,Booth CA,Jarur-Chamy V,Shams M,Iascone M,Vukic M,Gasperini S,Quadri M,Barroeta Seijas AB,Rivers E,Mauri M,Badolato R,Cazzaniga G

更新日期：2020-09-09 00:00:00

abstract：:Plasma fibronectin (pFN) cross-linked to fibrin during the injury response provides a provisional matrix required for cells to begin tissue repair. Using a synthetic matrix of pFN and fibrin as a substrate for cell adhesion and spreading, we have determined that pFN covalently cross-linked to fibrin into a complex mul...

journal_title：Blood

authors： Corbett SA,Wilson CL,Schwarzbauer JE

更新日期：1996-07-01 00:00:00

abstract：:Human erythrocyte p55 is a peripheral membrane protein that contains three distinct domains in its primary structure: an N-terminal domain, an SH3 motif, and a C-terminal guanylate kinase domain. We used naturally mutated red blood cells (RBCs) with primary genetic defects resulting in the absence of protein 4.1 (4.1[...

journal_title：Blood

authors： Alloisio N,Dalla Venezia N,Rana A,Andrabi K,Texier P,Gilsanz F,Cartron JP,Delaunay J,Chishti AH

更新日期：1993-08-15 00:00:00

abstract：:Pure red cell aplasia (PRCA) is a rare complication in patients with chronic lymphocytic leukemia (CLL). It is characterized by reticulocytopenia and by an absence of red cell precursors in the bone marrow. Unlike autoimmune hemolytic anemia, which is characterized by an increased number of reticulocytes, positive Coo...

journal_title：Blood

authors： Ghazal H

更新日期：2002-02-01 00:00:00

abstract：:Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and t...

journal_title：Blood

authors： Chim CS,Ma SY,Au WY,Choy C,Lie AK,Liang R,Yau CC,Kwong YL

更新日期：2004-01-01 00:00:00

abstract：:Thalidomide (Thal) can overcome drug resistance in multiple myeloma (MM) but is associated with somnolence, constipation, and neuropathy. In previous in vitro studies, we have shown that the potent immunomodulatory derivative of thalidomide (IMiD) CC-5013 induces apoptosis or growth arrest even in resistant MM cell li...

journal_title：Blood

authors： Richardson PG,Schlossman RL,Weller E,Hideshima T,Mitsiades C,Davies F,LeBlanc R,Catley LP,Doss D,Kelly K,McKenney M,Mechlowicz J,Freeman A,Deocampo R,Rich R,Ryoo JJ,Chauhan D,Balinski K,Zeldis J,Anderson KC

更新日期：2002-11-01 00:00:00

abstract：:Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...

journal_title：Blood

authors： Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

更新日期：2004-11-01 00:00:00

abstract：:The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients aged 18 to 86 years treated on 2 phase 3 trials of the German AML...

journal_title：Blood

authors： Metzeler KH,Herold T,Rothenberg-Thurley M,Amler S,Sauerland MC,Görlich D,Schneider S,Konstandin NP,Dufour A,Bräundl K,Ksienzyk B,Zellmeier E,Hartmann L,Greif PA,Fiegl M,Subklewe M,Bohlander SK,Krug U,Faldum A,Berdel

更新日期：2016-08-04 00:00:00