The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18.

abstract：:Optimal dose and timing of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy for aggressive non-Hodgkin lymphoma (NHL) is still an unresolved issue. We assessed whether dose intensifications with cyclophosphamide and doxorubicin might improve outcome in younger patients with intermediate-r...

journal_title：Blood

authors： Verdonck LF,Notenboom A,de Jong DD,MacKenzie MA,Verhoef GE,Kramer MH,Ossenkoppele GJ,Doorduijn JK,Sonneveld P,van Imhoff GW

更新日期：2007-04-01 00:00:00

abstract：:Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton. Using Lyn's Unique, SH3, and SH2 domains as bait in a yeast 2-hybrid screen, we isolated a novel gene product with features o...

journal_title：Blood

authors： Dombrosky-Ferlan P,Grishin A,Botelho RJ,Sampson M,Wang L,Rudert WA,Grinstein S,Corey SJ

更新日期：2003-04-01 00:00:00

abstract：:In this issue of Blood, Bartel and colleagues report the independent predictive value of the PET/CT and of the FDG suppression before transplantation in newly diagnosed myeloma patients who were treated using the TT3 regimen. ...

journal_title：Blood

authors： Dimopoulos MA,Moulopoulos LA,Terpos E

更新日期：2009-09-03 00:00:00

abstract：:Two patients developed thrombocytopenia associated with an in vitro platelet to leukocyte adherence phenomenon (PLAP). In one patient, whole serum, intact plasma, and the IgG fraction of the serum could induce the PLAP of normal platelets in normal whole blood or buffy coat preparations. Passage of serum over a Sephar...

journal_title：Blood

authors： Greipp PR,Gralnick HR

更新日期：1976-03-01 00:00:00

abstract：UNLABELLED:Polymorphonuclear neutrophil granulocytes (neutrophils) are tightly controlled by an incompletely understood homeostatic feedback loop adjusting the marrow's supply to peripheral needs. Although it has long been known that marrow cellularity is inversely correlated with G-CSF levels, the mechanism linking pe...

journal_title：Blood

authors： Bugl S,Wirths S,Radsak MP,Schild H,Stein P,André MC,Müller MR,Malenke E,Wiesner T,Märklin M,Frick JS,Handgretinger R,Rammensee HG,Kanz L,Kopp HG

更新日期：2013-01-31 00:00:00

abstract：:The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by graft-versus-host disease (GVHD). Thus, impr...

journal_title：Blood

authors： Kawase T,Matsuo K,Kashiwase K,Inoko H,Saji H,Ogawa S,Kato S,Sasazuki T,Kodera Y,Morishima Y,Japan Marrow Donor Program.

更新日期：2009-03-19 00:00:00

abstract：:Diverse human cancers with poor prognosis, including many lymphoid and myeloid malignancies, exhibit high levels of Mcl-1. To explore the impact of Mcl-1 overexpression on the hematopoietic compartment, we have generated vavP-Mcl-1 transgenic mice. Their lymphoid and myeloid cells displayed increased resistance to a v...

journal_title：Blood

authors： Campbell KJ,Bath ML,Turner ML,Vandenberg CJ,Bouillet P,Metcalf D,Scott CL,Cory S

更新日期：2010-10-28 00:00:00

abstract：:The mechanism of platelet release has been studied in mouse bone marrow, using scanning and transmission electron microscopy. Cytoplasmic processes extended into sinusoids by megakaryocytes were found to undergo attenuation, and at the distal end develop constrictions between segments of platelet size. Rupture at site...

journal_title：Blood

authors： Radley JM,Scurfield G

更新日期：1980-12-01 00:00:00

abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

journal_title：Blood

authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

更新日期：2006-05-01 00:00:00

abstract：:Neuropilin-1 (Npn-1) is a receptor shared by class 3 semaphorins and heparin-binding forms of vascular endothelial growth factor (VEGF), protein families that regulate endothelial and neuronal-cell function. Ligand interaction with Npn-1 dictates the choice of signal transducer; plexins transduce semaphorin signals, a...

journal_title：Blood

authors： Narazaki M,Tosato G

更新日期：2006-05-15 00:00:00

abstract：:Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging diagnosis after hematopoietic stem cell transplantation. Although endothelial injury represents the final common pathway of disease, the exact pathophysiology of TA-TMA remains unclear. Potential causes include infections, chemotherapy, ra...

journal_title：Blood

authors： Laskin BL,Goebel J,Davies SM,Jodele S

更新日期：2011-08-11 00:00:00

abstract：:We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele-matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received...

journal_title：Blood

authors： Atsuta Y,Suzuki R,Nagamura-Inoue T,Taniguchi S,Takahashi S,Kai S,Sakamaki H,Kouzai Y,Kasai M,Fukuda T,Azuma H,Takanashi M,Okamoto S,Tsuchida M,Kawa K,Morishima Y,Kodera Y,Kato S,Japan Cord Blood Bank Network.

更新日期：2009-02-19 00:00:00

abstract：:Mutations in the Bcr-Abl kinase domain may cause, or contribute to, resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia patients. Recommendations aimed to rationalize the use of BCR-ABL mutation testing in chronic myeloid leukemia have been compiled by a panel of experts appointed by the Europe...

journal_title：Blood

authors： Soverini S,Hochhaus A,Nicolini FE,Gruber F,Lange T,Saglio G,Pane F,Müller MC,Ernst T,Rosti G,Porkka K,Baccarani M,Cross NC,Martinelli G

更新日期：2011-08-04 00:00:00

abstract：:IgE and IgE receptors (FcεRI) are well-known inducers of allergy. We recently found in mice that active systemic anaphylaxis depends on IgG and IgG receptors (FcγRIIIA and FcγRIV) expressed by neutrophils, rather than on IgE and FcεRI expressed by mast cells and basophils. In humans, neutrophils, mast cells, basophils...

journal_title：Blood

authors： Jönsson F,Mancardi DA,Zhao W,Kita Y,Iannascoli B,Khun H,van Rooijen N,Shimizu T,Schwartz LB,Daëron M,Bruhns P

更新日期：2012-03-15 00:00:00

abstract：:Deep venous thrombosis (DVT) remains a common and serious cardiovascular problem with both fatal and long-term consequences. The consequences of DVT include the development of postthrombotic syndrome in 25% to 60% of DVT patients. Despite the clinical importance of venous thrombus resolution, the cellular and molecula...

journal_title：Blood

authors： Mukhopadhyay S,Antalis TM,Nguyen KP,Hoofnagle MH,Sarkar R

更新日期：2017-06-15 00:00:00

abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...

journal_title：Blood

authors： Lijfering WM,Brouwer JL,Veeger NJ,Bank I,Coppens M,Middeldorp S,Hamulyák K,Prins MH,Büller HR,van der Meer J

更新日期：2009-05-21 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1)-Tat, the transactivating gene product of HIV-1, has been shown to interact with different cell types, inducing gene expression, altering their growth and migratory behavior. In this study we examined whether Tat might affect functions of acquired immunodeficiency syndrome (AIDS)-...

journal_title：Blood

authors： Chirivi RG,Taraboletti G,Bani MR,Barra L,Piccinini G,Giacca M,Bussolino F,Giavazzi R

更新日期：1999-09-01 00:00:00

abstract：:We have explored the role of plasminogen activator inhibitor type 2 (PAI-2) in THP-1 monocyte-like cells. These cells possess a mutation in the PAI-2 gene and do not produce an active PAI-2 protein. Transfection of THP-1 cells with plasmids expressing active PAI-2 reduced the cells' inherent adhesive properties and de...

journal_title：Blood

authors： Yu H,Maurer F,Medcalf RL

更新日期：2002-04-15 00:00:00

abstract：:CD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft-versus-host disease (GVHD) in murine models of allogeneic hematopoietic stem cell transplantation. W...

journal_title：Blood

authors： Nishikii H,Kim BS,Yokoyama Y,Chen Y,Baker J,Pierini A,Alvarez M,Mavers M,Maas-Bauer K,Pan Y,Chiba S,Negrin RS

更新日期：2016-12-15 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is considered a negative regulator of inflammation, as inhibition of STAT3 signaling enhances antitumor immunity. However, STAT3 activation is a key oncogenic pathway in natural killer (NK)-lineage large granular lymphomas, and we recently reported enhanced pr...

journal_title：Blood

authors： Zhu S,Phatarpekar PV,Denman CJ,Senyukov VV,Somanchi SS,Nguyen-Jackson HT,Mace EM,Freeman AF,Watowich SS,Orange JS,Holland SM,Lee DA

更新日期：2014-07-17 00:00:00

abstract：:Mechanisms involving the in vitro effect of rituximab in cells from 55 patients with B-cell lymphoproliferative disorders were investigated. No cytotoxic effect was observed when cells were incubated with rituximab alone, but in the presence of human AB serum rituximab induced complement-dependent cell death (R-CDC). ...

journal_title：Blood

authors： Bellosillo B,Villamor N,López-Guillermo A,Marcé S,Esteve J,Campo E,Colomer D,Montserrat E

更新日期：2001-11-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) show pronounced heterogeneity in self-renewal and differentiation behavior, which is reflected in their repopulation kinetics. Here, a single-cell-based mathematical model of HSC organization is used to examine the basis of HSC heterogeneity. Our modeling results, which are based on the...

journal_title：Blood

authors： Roeder I,Horn K,Sieburg HB,Cho R,Muller-Sieburg C,Loeffler M

更新日期：2008-12-15 00:00:00

abstract：:Low-grade follicular non-Hodgkin's lymphomas are characterized by the presence of a t(14;18) chromosomal translocation that results in deregulation of the B-cell lymphoma (Bcl-2) gene. Studies in cell lines and transgenic animal models have suggested that this results in the suppression of apoptotic cell death in germ...

journal_title：Blood

authors： Johnson PW,Watt SM,Betts DR,Davies D,Jordan S,Norton AJ,Lister TA

更新日期：1993-09-15 00:00:00

abstract：:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions an...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-01 00:00:00

abstract：:Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome (ALPS; Canale-Smith syndrome), a disorder of lymphocyte homeostasis usually associated with germline Fas mutations. Fas (CD95/APO-1) is a cell surface receptor that initiates programmed cell death, or apoptosis, of activated lymphocytes. L...

journal_title：Blood

authors： Straus SE,Jaffe ES,Puck JM,Dale JK,Elkon KB,Rösen-Wolff A,Peters AM,Sneller MC,Hallahan CW,Wang J,Fischer RE,Jackson CE,Lin AY,Bäumler C,Siegert E,Marx A,Vaishnaw AK,Grodzicky T,Fleisher TA,Lenardo MJ

更新日期：2001-07-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors regulating lipid and cholesterol metabolism. Recent data revealed a cross talk between LXR and Toll-like receptor signaling in macrophages, indicating a role in immunity. Here, we show that LXRalpha is expressed in human myeloid dendritic cells (DCs) and induced during di...

journal_title：Blood

authors： Geyeregger R,Zeyda M,Bauer W,Kriehuber E,Säemann MD,Zlabinger GJ,Maurer D,Stulnig TM

更新日期：2007-05-15 00:00:00

abstract：:The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT)...

journal_title：Blood

authors： Niclot S,Pruvot Q,Besson C,Savoy D,Macintyre E,Salles G,Brousse N,Varet B,Landais P,Taupin P,Junien C,Baudry-Bluteau D

更新日期：2006-07-01 00:00:00

abstract：:A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer) has been recently discovered. In this study, we tested its efficacy in inhibiting clot-bound thrombin activity and platelet thrombus formation in an ex vivo whole artery angioplasty model. The...

journal_title：Blood

authors： Li WX,Kaplan AV,Grant GW,Toole JJ,Leung LL

更新日期：1994-02-01 00:00:00

abstract：:Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-i...

journal_title：Blood

authors： Bäumler CB,Böhler T,Herr I,Benner A,Krammer PH,Debatin KM

更新日期：1996-09-01 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00