Residual amounts of glycoproteins IIb and IIIa may be present in the platelets of most patients with Glanzmann's thrombasthenia.

abstract：:Targeting mechanisms of neutrophil elastase (NE) and other luminal proteins stored in myeloperoxidase (MPO)-positive secretory lysosomes/primary granules of neutrophils are unknown. These granules contain an integral membrane protein, CD63, with an adaptor protein-3-dependent granule delivery system. Therefore, we hyp...

journal_title：Blood

authors： Källquist L,Hansson M,Persson AM,Janssen H,Calafat J,Tapper H,Olsson I

更新日期：2008-10-15 00:00:00

abstract：:Even if neoplastic cells express tumor associated antigens they still may fail to function as antigen presenting cells (APC) if they lack expression of one or more molecules critical for the induction of productive immunity. These cellular defects can be repaired by physiologic activation, transfection, or fusion of t...

journal_title：Blood

authors： Cardoso AA,Schultze JL,Boussiotis VA,Freeman GJ,Seamon MJ,Laszlo S,Billet A,Sallan SE,Gribben JG,Nadler LM

更新日期：1996-07-01 00:00:00

abstract：:We established a model of canine marrow autografts after 9.2 Gy total body irradiation (TBI) to study the role of class II antigens in hematopoietic stem cell growth and differentiation. Twenty dogs were given 9.2 Gy TBI, marrow, and intravenous (IV) murine anti-class II monoclonal antibody (MoAb). Infusion of 0.6 mg/...

journal_title：Blood

authors： Greinix HT,Ladiges WC,Graham TC,Maslan S,Raff RF,Sandmaier BM,Appelbaum FR,Schuening FG,Deeg HJ,Storb R

更新日期：1991-10-15 00:00:00

abstract：:Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We h...

journal_title：Blood

authors： Chen R,Wierda WG,Chubb S,Hawtin RE,Fox JA,Keating MJ,Gandhi V,Plunkett W

更新日期：2009-05-07 00:00:00

abstract：:P-selectin expression has been shown in Helicobacter pylori-infected persons, an infection that has been clinically associated with platelet-related diseases, such as idiopathic thrombocytopenic purpura. However, the role of P-selectin expression during H pylori infection remains unclear. In this study, we hypothesize...

journal_title：Blood

authors： Yeh JJ,Tsai S,Wu DC,Wu JY,Liu TC,Chen A

更新日期：2010-05-27 00:00:00

abstract：:Since its approval in 2011, the Janus kinase 1/2 (JAK1/2) inhibitor ruxolitinib has evolved to become the centerpiece of therapy for myelofibrosis (MF), and its use in patients with hydroxyurea resistant or intolerant polycythemia vera (PV) is steadily increasing. Several other JAK2 inhibitors have entered clinical te...

journal_title：Blood

authors： Bose P,Verstovsek S

更新日期：2017-07-13 00:00:00

abstract：:Factor V (FV) deficiency is a rare bleeding disorder whose genetic basis has been described in a relatively small number of cases. Among a total of 12 genetic defects reported in severely or moderately severe deficient patients, 3 were missense mutations and in no case was the mechanism underlying the deficiency explo...

journal_title：Blood

authors： Duga S,Montefusco MC,Asselta R,Malcovati M,Peyvandi F,Santagostino E,Mannucci PM,Tenchini ML

更新日期：2003-01-01 00:00:00

abstract：:A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive im...

journal_title：Blood

authors： Shimazu T,Iida R,Zhang Q,Welner RS,Medina KL,Alberola-Lla J,Kincade PW

更新日期：2012-05-24 00:00:00

abstract：:The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endot...

journal_title：Blood

authors： Lacroix R,Sabatier F,Mialhe A,Basire A,Pannell R,Borghi H,Robert S,Lamy E,Plawinski L,Camoin-Jau L,Gurewich V,Angles-Cano E,Dignat-George F

更新日期：2007-10-01 00:00:00

abstract：:This 2-part, double-blind, placebo-controlled study was conducted to determine the safety and efficacy of etoricoxib, a COX-2 selective inhibitor, for the treatment of hemophilic arthropathy. In part 1 (6 weeks), 102 patients (> or = 12 years old) with hemophilic arthropathy were randomized to receive 90 mg etoricoxib...

journal_title：Blood

authors： Tsoukas C,Eyster ME,Shingo S,Mukhopadhyay S,Giallella KM,Curtis SP,Reicin AS,Melian A

更新日期：2006-03-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P), a bioactive lipid, is produced and stored in platelets and is released from activated platelets during blood coagulation activation. Thrombin, which is also generated during blood coagulation, has been shown to induce tissue factor (TF), the initiator of blood coagulation, in endothelial...

journal_title：Blood

authors： Takeya H,Gabazza EC,Aoki S,Ueno H,Suzuki K

更新日期：2003-09-01 00:00:00

abstract：:Oncogenic transformation of CD4(+) T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of nove...

journal_title：Blood

authors： Kress AK,Kalmer M,Rowan AG,Grassmann R,Fleckenstein B

更新日期：2011-03-31 00:00:00

abstract：:Oxidative stress has been implicated in the triggering of apoptosis in neutrophils. Because red blood cells (RBCs) are well known to scavenge oxidants including H2O2, we tested the hypothesis that RBCs inhibit apoptosis of neutrophils by reducing intracellular oxidative stress. Apoptosis of neutrophils was evaluated b...

journal_title：Blood

authors： Aoshiba K,Nakajima Y,Yasui S,Tamaoki J,Nagai A

更新日期：1999-06-01 00:00:00

abstract：:Identification of prognostic factors for patients with relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted approaches. In our phase 2 study of positron emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) and augmented ifosfamide, carboplatin, and ...

journal_title：Blood

authors： Moskowitz AJ,Schöder H,Gavane S,Thoren KL,Fleisher M,Yahalom J,McCall SJ,Cadzin BR,Fox SY,Gerecitano J,Grewal R,Hamlin PA,Horwitz SM,Kumar A,Matasar M,Ni A,Noy A,Palomba ML,Perales MA,Portlock CS,Sauter C,Straus

更新日期：2017-11-16 00:00:00

abstract：:The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the per...

journal_title：Blood

authors： Butterfield JH,Leiferman KM,Abrams J,Silver JE,Bower J,Gonchoroff N,Gleich GJ

更新日期：1992-02-01 00:00:00

abstract：:An in vitro system has been developed that mimics the passage of erythrocytes from the bone marrow to the circulation. Bone marrow egress and its proper regulation are vital physiologic processes. However, because of the inaccessibility of the marrow, it is difficult to evaluate the various factors important in contro...

journal_title：Blood

authors： Waugh RE,Sassi M

更新日期：1986-07-01 00:00:00

abstract：:Cellulose ester membranes (CEM) were coated with stromal cells from bone marrow (BM) or bone and implanted intraperitoneally (IP) in CAF1 mice for intervals of 1 to 6 months. Previous studies indicated that matrix factors [glycoproteins (GPs), proteoglycans (PGs), and glycosaminoglycans (GAGs)] were secreted by the re...

journal_title：Blood

authors： Knospe WH,Husseini SG,Fried W

更新日期：1989-07-01 00:00:00

abstract：:This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloSCT)....

journal_title：Blood

authors： Nakamura S,Yokoyama K,Shimizu E,Yusa N,Kondoh K,Ogawa M,Takei T,Kobayashi A,Ito M,Isobe M,Konuma T,Kato S,Kasajima R,Wada Y,Nagamura-Inoue T,Yamaguchi R,Takahashi S,Imoto S,Miyano S,Tojo A

更新日期：2019-06-20 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several established or novel anti-multiple myeloma (anti-MM) agents, such as dexamethasone, thalidomide, and proteasome inhibitors (PS-341), inhibit NF-kappaB activity as part of their diverse acti...

journal_title：Blood

authors： Mitsiades N,Mitsiades CS,Poulaki V,Chauhan D,Richardson PG,Hideshima T,Munshi N,Treon SP,Anderson KC

更新日期：2002-06-01 00:00:00

abstract：:Several lines of evidence indicate that macrophage inflammatory protein-1alpha (MIP-1alpha) modulates the proliferation of hematopoietic progenitor cells, depending on their maturational stages. To clarify the mechanisms for the modulation of hematopoiesis by this chemokine, we examined the expression of a receptor fo...

journal_title：Blood

authors： Su S,Mukaida N,Wang J,Zhang Y,Takami A,Nakao S,Matsushima K

更新日期：1997-07-15 00:00:00

abstract：:Tryptases are serine proteases primarily expressed in mast cells. Normal blood basophils express only trace amounts of the enzyme. However, recent immunohistochemical studies have raised the possibility that neoplastic basophils express significant amounts of tryptase. In this study, tryptase expression was analyzed i...

journal_title：Blood

authors： Samorapoompichit P,Kiener HP,Schernthaner GH,Jordan JH,Agis H,Wimazal F,Baghestanian M,Rezaie-Majd A,Sperr WR,Lechner K,Valent P

更新日期：2001-10-15 00:00:00

abstract：:Lipid rafts are detergent-resistant, cholesterol- and sphingolipid-rich membrane domains that are involved in important cellular processes such as signal transduction and intracellular trafficking. Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein. Micros...

journal_title：Blood

authors： Mairhofer M,Steiner M,Mosgoeller W,Prohaska R,Salzer U

更新日期：2002-08-01 00:00:00

abstract：:B-cell precursors are present in the thymus, and the thymic microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pr...

journal_title：Blood

authors： Hashimoto Y,Montecino-Rodriguez E,Leathers H,Stephan RP,Dorshkind K

更新日期：2002-11-15 00:00:00

abstract：:Thrombopoietin (TPO), the major growth factor for cells of the megakaryocytic lineage, is removed from circulation by binding to c-mpl receptors present on platelets and megakaryocytes. We studied patients with acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML) and used TPO-induced c-fos protein u...

journal_title：Blood

authors： Corazza F,Hermans C,D'Hondt S,Ferster A,Kentos A,Benoît Y,Sariban E

更新日期：2006-03-15 00:00:00

abstract：:Sequencing the complete factor IX gene of 2 sisters with hemophilia B with different phenotypes and no family history of hemorrhagic diathesis revealed a common 5' splice site mutation in intron 3 (T6704C) in both and an additional missense mutation (I344T) in one. The presence of dysfunctional antigen in the latter s...

journal_title：Blood

authors： Costa JM,Vidaud D,Laurendeau I,Vidaud M,Fressinaud E,Moisan JP,David A,Meyer D,Lavergne JM

更新日期：2000-08-15 00:00:00

abstract：:While the interferon (IFN)-inducible double-stranded RNA (dsRNA)-dependent protein kinase PKR is reported to initiate apoptosis in some instances, the mechanism by which diverse stress stimuli activate PKR remains unknown. Now we report that RAX, the only known cellular activator for PKR, initiates PKR activation in r...

journal_title：Blood

authors： Bennett RL,Blalock WL,Abtahi DM,Pan Y,Moyer SA,May WS

更新日期：2006-08-01 00:00:00

abstract：:Stem cell proliferation induced by potent cytokines usually leads to a loss of primitive potential through differentiation. In this study, the ability of cytokines and murine MS5 stromal cells to independently regulate the proliferation and long-term culture-initiating cell (LTC-IC) activity of primitive CD34(+)CD38(l...

journal_title：Blood

authors： Bennaceur-Griscelli A,Pondarré C,Schiavon V,Vainchenker W,Coulombel L

更新日期：2001-01-15 00:00:00

abstract：:Cord blood (CB) is used increasingly as a source of hematopoietic stem cells because of a lower risk of acute and chronic graft-versus-host disease (GVHD). However, there is some concern regarding the ability to adequately reconstitute host immune response due to the immaturity and naivety of CB T cells. This study wa...

journal_title：Blood

authors： Talvensaari K,Clave E,Douay C,Rabian C,Garderet L,Busson M,Garnier F,Douek D,Gluckman E,Charron D,Toubert A

更新日期：2002-02-15 00:00:00

abstract：:A functional thrombin receptor (TR) structurally related to other members of the seven-transmembrane receptor family has been isolated from diverse cellular types intimately involved in the regulation of the thrombotic response. This receptor recapitulates many of the previously identified sequelae of thrombin-mediate...

journal_title：Blood

authors： Bahou WF,Nierman WC,Durkin AS,Potter CL,Demetrick DJ

更新日期：1993-09-01 00:00:00

abstract：:We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2. Mutational status at diagnosis was correlated with hematologic parameters, clinical manifestations, and outcome. A total of 25 different EZH2 mutations were de...

journal_title：Blood

authors： Guglielmelli P,Biamonte F,Score J,Hidalgo-Curtis C,Cervantes F,Maffioli M,Fanelli T,Ernst T,Winkelman N,Jones AV,Zoi K,Reiter A,Duncombe A,Villani L,Bosi A,Barosi G,Cross NC,Vannucchi AM

更新日期：2011-11-10 00:00:00