Role of CD28 in fatal autoimmune disorder in scurfy mice.

abstract：:The t(5;12) translocation identified in patients with chronic myelomonocytic leukemia (CMML) encodes a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein. A key hypothesis for how the TEL/PDGFRbeta fusion protein would function as an oncogene is that it represents a constitutively active versi...

journal_title：Blood

authors： Bourgeade MF,Défachelles AS,Cayre YE

更新日期：1998-05-01 00:00:00

abstract：:T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative responses to polyclonal stimulation of post-HSCT peripheral blood mononuclear cells (PB-MCs) were markedly (4-fold) improved by ...

journal_title：Blood

authors： Hainz U,Obexer P,Winkler C,Sedlmayr P,Takikawa O,Greinix H,Lawitschka A,Pötschger U,Fuchs D,Ladisch S,Heitger A

更新日期：2005-05-15 00:00:00

abstract：:Patients with relapsed chronic lymphocytic leukemia (CLL) and high-risk features, such as fludarabine refractoriness, complex karyotype, or abnormalities of chromosome 17p, experience poor outcomes after standard fludaradine-based regimens. Alemtuzumab is a chimeric CD52 monoclonal antibody with activity in CLL patien...

journal_title：Blood

authors： Badoux XC,Keating MJ,Wang X,O'Brien SM,Ferrajoli A,Faderl S,Burger J,Koller C,Lerner S,Kantarjian H,Wierda WG

更新日期：2011-08-25 00:00:00

abstract：:Endothelial cells synthesize a heterodimeric adhesion molecule, the vitronectin receptor (VnR), which is similar to the platelet glycoprotein (GP)IIb/IIIa complex. The subunits of the endothelial VnR (VnR alpha and GPIIIa) have been studied for their ability to express alloantigens associated with platelet GPIIb and I...

journal_title：Blood

authors： Giltay JC,Leeksma OC,von dem Borne AE,van Mourik JA

更新日期：1988-07-01 00:00:00

abstract：:Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell neoplasm that most commonly arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. HSTCL is more common in adolescent and young adults and has a rapidly progressive clinical course and poor outcome due to its refractoriness to conventional chemo...

journal_title：Blood

authors： Pro B,Allen P,Behdad A

更新日期：2020-10-29 00:00:00

abstract：:Two fractions of human prothrombin can be isolated from single donor plasma by the technique of heparin-agarose chromatography in (sodium) citrate buffer, pH 7.5, as previously reported for pooled plasma. The two fractions, designated H-II1 and H-II2, are found in a ratio of approximately 4:1. Both forms comigrate in ...

journal_title：Blood

authors： Bajaj SP,Rapaport SI,Prodonos C,Russell WA

更新日期：1981-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional...

journal_title：Blood

authors： Schinke C,Giricz O,Li W,Shastri A,Gordon S,Barreyro L,Bhagat T,Bhattacharyya S,Ramachandra N,Bartenstein M,Pellagatti A,Boultwood J,Wickrema A,Yu Y,Will B,Wei S,Steidl U,Verma A

更新日期：2015-05-14 00:00:00

abstract：:The importance of the second messengers calcium (Ca(2+)) and diacylglycerol (DAG) in platelet signal transduction was established more than 30 years ago. Whereas protein kinase C (PKC) family members were discovered as the targets of DAG, little is known about the molecular identity of the main Ca(2+) sensor(s). We he...

journal_title：Blood

authors： Stefanini L,Roden RC,Bergmeier W

更新日期：2009-09-17 00:00:00

abstract：:We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, alpha87 (F8) His --> Tyr] resides in the alpha1-globin gene. The proportion of Hb M observed is higher than that predicted for an alpha1-globin variant. Our evidence suggests that the greater-than-expected proportion of ...

journal_title：Blood

authors： Ameri A,Fairbanks VF,Yanik GA,Mahdi F,Thibodeau SN,McCormick DJ,Boxer LA,McDonagh KT

更新日期：1999-09-01 00:00:00

abstract：:Vascular tube morphogenesis requires the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracellular matrices. To date, there is little understanding of how EC polarity is controlled during these highly dynamic and rapid morphogenic events. We show that the microtubule tip comp...

journal_title：Blood

authors： Kim DJ,Martinez-Lemus LA,Davis GE

更新日期：2013-04-25 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) enhances thymopoiesis but given the broad distribution of IGF-1 receptors (IGF-1Rs), its mechanism of action has remained unclear. To identify points of thymic regulation by IGF-1, we examined its effects on T-cell precursors, thymocytes, and thymic epithelial cells (TECs) in norma...

journal_title：Blood

authors： Chu YW,Schmitz S,Choudhury B,Telford W,Kapoor V,Garfield S,Howe D,Gress RE

更新日期：2008-10-01 00:00:00

abstract：:High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIII-induced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectin...

journal_title：Blood

authors： Kirby EP,Mills DC,Holmsen H,Russo M

更新日期：1982-12-01 00:00:00

abstract：:Our previous studies have identified mechanisms by which cytokine production, blocked by Ly49G2 receptor cross-linking, can be overridden. In this study we analyzed the regulation of other ITAM-positive receptor signaling on NK, NKT, and T cells and characterized the biochemical pathways involved in this signaling. Ou...

journal_title：Blood

authors： Ortaldo JR,Winkler-Pickett R,Wigginton J,Horner M,Bere EW,Mason AT,Bhat N,Cherry J,Sanford M,Hodge DL,Young HA

更新日期：2006-02-15 00:00:00

abstract：:Drug-dependent antibodies (DDAbs) can cause the precipitous destruction of platelets if a patient is exposed to the drug for which the antibodies are specific. The molecular character of the epitopes recognized is poorly understood, and the mechanism by which drugs promote tight binding of these antibodies to platelet...

journal_title：Blood

authors： Peterson JA,Nyree CE,Newman PJ,Aster RH

更新日期：2003-02-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play an important role in the regulation of the immune response. MDSC expansion occurs in many circumstances, including cancer, inflammation, stresses, and transplant tolerance. Liver transplants in mice are spontaneously accepted, but hepatocyte transplants are acutely rejecte...

journal_title：Blood

authors： Hsieh CC,Chou HS,Yang HR,Lin F,Bhatt S,Qin J,Wang L,Fung JJ,Qian S,Lu L

更新日期：2013-03-07 00:00:00

abstract：:The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects wit...

journal_title：Blood

authors： Layrisse M,Martínez-Torres C,Renzy M,Leets I

更新日期：1975-05-01 00:00:00

abstract：:B-cell precursors are present in the thymus, and the thymic microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pr...

journal_title：Blood

authors： Hashimoto Y,Montecino-Rodriguez E,Leathers H,Stephan RP,Dorshkind K

更新日期：2002-11-15 00:00:00

abstract：:We investigated the effect of platelets on ovarian cancer and the role of adenosine diphosphate (ADP) receptors (P2Y12 and P2Y1) on platelets in the growth of primary ovarian cancer tumors. We showed that in murine models of ovarian cancer, a P2Y12 inhibitor (ticagrelor) reduced tumor growth by 60% compared with aspir...

journal_title：Blood

authors： Cho MS,Noh K,Haemmerle M,Li D,Park H,Hu Q,Hisamatsu T,Mitamura T,Mak SLC,Kunapuli S,Ma Q,Sood AK,Afshar-Kharghan V

更新日期：2017-09-07 00:00:00

abstract：:In the past 5 years we have witnessed significant advances in both the diagnostic process and optimal therapy for patients with essential thrombocythemia (ET). Insights into the underlying molecular mechanisms have been accompanied by the development of new diagnostic tests and by an improved understanding of the rela...

journal_title：Blood

authors： Beer PA,Erber WN,Campbell PJ,Green AR

更新日期：2011-02-03 00:00:00

abstract：:The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT)...

journal_title：Blood

authors： Niclot S,Pruvot Q,Besson C,Savoy D,Macintyre E,Salles G,Brousse N,Varet B,Landais P,Taupin P,Junien C,Baudry-Bluteau D

更新日期：2006-07-01 00:00:00

abstract：:Gadd45a has been involved in DNA damage response and in many malignancies, including leukemia. However, the function of Gadd45a in hematopoietic stem cells (HSCs) remains unknown. Here, we reported that Gadd45a-deficient (Gadd45a(-/-)) mice showed a normal hematologic phenotype under homeostatic conditions. However, f...

journal_title：Blood

authors： Chen Y,Ma X,Zhang M,Wang X,Wang C,Wang H,Guo P,Yuan W,Rudolph KL,Zhan Q,Ju Z

更新日期：2014-02-06 00:00:00

abstract：:The turnover rates of beta and gamma globin messenger RNAs and of beta and gamma globin protein synthesis in human reticulocytes have been measured. Our goal was to determine whether beta globin mRNA is significantly more stable than gamma globin mRNA during the final stages of erythroid cell maturation. Such a result...

journal_title：Blood

authors： Ross J,Sullivan TD

更新日期：1985-11-01 00:00:00

abstract：:Recent advances in molecular biology have led to the identification of hematopoietic growth factors that support and influence the proliferation of hematopoietic progenitor cells in vitro and in vivo. Although these factors have been extensively studied, little is known of their role in the regulation of cell-cycling ...

journal_title：Blood

authors： Tanaka R,Katayama N,Ohishi K,Mahmud N,Itoh R,Tanaka Y,Komada Y,Minami N,Sakurai M,Shirakawa S

更新日期：1995-07-01 00:00:00

abstract：:Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the 3' untranslated regio...

journal_title：Blood

authors： Jarolim P,Rubin HL,Brabec V,Palek J

更新日期：1995-06-01 00:00:00

abstract：:Mutations leading to the alteration of cell-cycle checkpoint functions are a common feature of most cancers. Because of the highly regulated nature of the cell cycle, it seems likely that variation in gene dosage of key components due to functional regulatory polymorphisms could play an important role in cancer develo...

journal_title：Blood

authors： Healy J,Bélanger H,Beaulieu P,Larivière M,Labuda D,Sinnett D

更新日期：2007-01-15 00:00:00

abstract：:All-trans retinoic acid induces leukemic cells from patients with acute promyelocytic leukemia (M3) to differentiate in vitro to mature granulocytes which express the CD15 antigen and are capable of respiratory burst function. Of 35 M3 samples, only one failed to respond. In eight cases, we compared the efficacy of tw...

journal_title：Blood

authors： Chomienne C,Ballerini P,Balitrand N,Daniel MT,Fenaux P,Castaigne S,Degos L

更新日期：1990-11-01 00:00:00

abstract：:Three patients developed blastic transformation of essential thrombocythemia (tET). Morphological studies in all patients showed that the majority of blasts had either myeloblastic or myelomonoblastic differentiation. Immunologic assays of hematopoietic cells were performed in two patients. In patient 1, 86% of periph...

journal_title：Blood

authors： Frei-Lahr D,Barton JC,Hoffman R,Burkett LL,Prchal JT

更新日期：1984-04-01 00:00:00

abstract：:Different biologic features have been associated with a more or less aggressive clinical course in chronic lymphocytic leukemia (CLL). In the present study, 20 patients with highly stable CLL observed at a single institution over a period of 10 to 23 years and who never required treatment were extensively characterize...

journal_title：Blood

authors： Guarini A,Gaidano G,Mauro FR,Capello D,Mancini F,De Propris MS,Mancini M,Orsini E,Gentile M,Breccia M,Cuneo A,Castoldi G,Foa R

更新日期：2003-08-01 00:00:00

abstract：:A monoclonal antibody (MoAb) (LYP18), generated against human platelet glycoprotein IIb/IIIa (GPIIb/IIIa), immuno-precipitated a IIb/IIIa-like GP complex from a highly tumorigenic human melanoma cell line (M3Dau). The M3Dau melanoma cells specifically bound 125I-labeled LYP18. To study the biologic role of these IIb/I...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Bailly M,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-15 00:00:00

abstract：:Surface marker and gene rearrangement data have supported various hypotheses about the origin of the malignant cell in Hodgkin's disease. Cytogenetic data about this disorder, however, are very scanty. To determine if any chromosomal abnormalities that could add further information to this controversial point are pres...

journal_title：Blood

authors： Cabanillas F,Pathak S,Trujillo J,Grant G,Cork A,Hagemeister FB,Velasquez WS,McLaughlin P,Redman J,Katz R

更新日期：1988-06-01 00:00:00