Gadd45a regulates hematopoietic stem cell stress responses in mice.

abstract：:Anticoagulation with vitamin K antagonists (VKAs) is problematic because of difficulties in safely managing dosing. Polymorphisms in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase genes (VKORC1) have been shown to affect VKA dosing in adults. The association of these polymorphisms on VKA dosing in childr...

journal_title：Blood

authors： Nowak-Göttl U,Dietrich K,Schaffranek D,Eldin NS,Yasui Y,Geisen C,Mitchell LG

更新日期：2010-12-23 00:00:00

abstract：:The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG) joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis of clinical, biologic, and early response data predictive of event-free survival (EFS) in acute lymphoblastic leukemia (ALL) to develop a new classification ...

journal_title：Blood

authors： Schultz KR,Pullen DJ,Sather HN,Shuster JJ,Devidas M,Borowitz MJ,Carroll AJ,Heerema NA,Rubnitz JE,Loh ML,Raetz EA,Winick NJ,Hunger SP,Carroll WL,Gaynon PS,Camitta BM

更新日期：2007-02-01 00:00:00

abstract：:Peripheral blood mononuclear cells from five patients with essential thrombocythemia (ET) were cultured in vitro to evaluate restricted megakaryocytic (CFU-Meg), myeloid (CFU-GM), and erythroid (BFU-E) progenitor cell development. Varying concentrations of aplastic canine serum served as the source of megakaryocyte co...

journal_title：Blood

authors： Mazur EM,Cohen JL,Bogart L

更新日期：1988-06-01 00:00:00

abstract：:The switch from fetal to adult hemoglobin is incomplete; the residual fetal hemoglobin in adults is restricted to a subset of erythrocytes called F cells. F-cell levels are influenced by a sequence variant (C-->T) at position -158 upstream of the gamma-globin gene, termed the XmnI-Ggamma polymorphism. How the Ggamma-1...

journal_title：Blood

authors： Garner C,Silver N,Best S,Menzel S,Martin C,Spector TD,Thein SL

更新日期：2004-10-01 00:00:00

abstract：:Important predictors of adverse outcomes of thrombosis in children, including postthrombotic syndrome (PTS), have recently been identified. Given this knowledge and the encouraging preliminary pediatric experience with systemic thrombolysis, we sought to retrospectively analyze our institutional experience with a thro...

journal_title：Blood

authors： Goldenberg NA,Durham JD,Knapp-Clevenger R,Manco-Johnson MJ

更新日期：2007-07-01 00:00:00

abstract：:Recent studies suggest that the evolutionary history of a cancer is important in forecasting clinical outlook. To gain insight into the clonal dynamics of multiple myeloma (MM) and its possible influence on patient outcomes, we analyzed whole exome sequencing tumor data for 333 patients from Myeloma XI, a UK phase 3 t...

journal_title：Blood

authors： Johnson DC,Lenive O,Mitchell J,Jackson G,Owen R,Drayson M,Cook G,Jones JR,Pawlyn C,Davies FE,Walker BA,Wardell C,Gregory WM,Cairns D,Morgan GJ,Houlston RS,Kaiser MF

更新日期：2017-10-05 00:00:00

abstract：:The evolutionarily conserved immune system of the zebrafish (Danio rerio), in combination with its genetic tractability, position it as an excellent model system in which to elucidate the origin and function of vertebrate immune cells. We recently reported the existence of antigen-presenting mononuclear phagocytes in ...

journal_title：Blood

authors： Wittamer V,Bertrand JY,Gutschow PW,Traver D

更新日期：2011-06-30 00:00:00

abstract：:Vascular bypass procedures in the central nervous system (CNS) remain technically challenging, hindered by complications and often failing to prevent adverse outcome such as stroke. Thus, there is an unmet clinical need for a safe and effective CNS revascularization. Vascular endothelial growth factors (VEGFs) are pro...

journal_title：Blood

authors： Gaál EI,Tammela T,Anisimov A,Marbacher S,Honkanen P,Zarkada G,Leppänen VM,Tatlisumak T,Hernesniemi J,Niemelä M,Alitalo K

更新日期：2013-08-01 00:00:00

abstract：:In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the...

journal_title：Blood

authors： Flowers ME,Parker PM,Johnston LJ,Matos AV,Storer B,Bensinger WI,Storb R,Appelbaum FR,Forman SJ,Blume KG,Martin PJ

更新日期：2002-07-15 00:00:00

abstract：:Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/or long-term outcome...

journal_title：Blood

authors： Lichter DI,Danaee H,Pickard MD,Tayber O,Sintchak M,Shi H,Richardson PG,Cavenagh J,Bladé J,Façon T,Niesvizky R,Alsina M,Dalton W,Sonneveld P,Lonial S,van de Velde H,Ricci D,Esseltine DL,Trepicchio WL,Mulligan G,And

更新日期：2012-11-29 00:00:00

abstract：:The urokinase receptor (uPAR) plays an important role in regulation of fibronolysis, cell migration, and adhesion. In this study, we examined whether uPAR plays a role in modulating efferocytosis of neutrophils. Macrophages from uPAR(-/-) mice demonstrated enhanced ability to engulf viable wild-type (WT) neutrophils i...

journal_title：Blood

authors： Park YJ,Liu G,Tsuruta Y,Lorne E,Abraham E

更新日期：2009-07-23 00:00:00

abstract：:T-cell receptor (TCR) beta-chain proteins appear early (approximately 15th week of gestation) during human thymic ontogenesis. These beta-chain proteins, which appear before terminal deoxynucleotidyl transferase (TdT), could be an expression of a fully rearranged (V-D-J), incompletely rearranged (D-J), or germline TCR...

journal_title：Blood

authors： Bonati A,Zanelli P,Ferrari S,Plebani A,Starcich B,Savi M,Neri TM

更新日期：1992-03-15 00:00:00

abstract：:c-Myc (Myc hereafter) is found to be deregulated and/or amplified in most acute myeloid leukemias (AMLs). Almost all AML cells are dependent upon Myc for their proliferation and survival. Thus, Myc has been proposed as a critical anti-AML target. Myc has Max-mediated transactivational and Myc-interacting zinc finger p...

journal_title：Blood

authors： Zhang L,Li J,Xu H,Shao X,Fu L,Hou Y,Hao C,Li W,Joshi K,Wei W,Xu Y,Zhang F,Dai S,Breslin P,Zhang J,Zhang J

更新日期：2020-04-02 00:00:00

abstract：:Extracorporeal immunoadsorption of plasma to remove IgG and circulating immune complexes (CIC) was evaluated as a therapy for adults with treatment-resistant immune thrombocytopenic purpura (ITP). Seventy-two patients with initial platelet counts less than 50,000/microL who had failed at least two other therapies were...

journal_title：Blood

authors： Snyder HW Jr,Cochran SK,Balint JP Jr,Bertram JH,Mittelman A,Guthrie TH Jr,Jones FR

更新日期：1992-05-01 00:00:00

abstract：:The Bcl-2 proto-oncogene was discovered at the t(14;18) breakpoint found in most follicular B-cell lymphomas and some diffuse large-cell lymphomas. Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and extending cell survival by blocking programmed cell death. We examined Bcl-2 protein expression ...

journal_title：Blood

authors： Zutter M,Hockenbery D,Silverman GA,Korsmeyer SJ

更新日期：1991-08-15 00:00:00

abstract：:The effect of recombinant human erythropoietin (rHuEpo) on megakaryopoiesis remains controversial. Treatment with rHuEpo in renal failure patients has been associated with a slight elevation of platelet counts. In animal studies, high doses of rHuEpo produced an increase of platelet counts followed by a gradual return...

journal_title：Blood

authors： Loo M,Beguin Y

更新日期：1999-05-15 00:00:00

abstract：:The multimeric size and the function of circulating von Willebrand factor are modulated via its proteolytic cleavage by the plasma metalloproteinase, ADAMTS13. It is unclear how ADAMTS13 activity is regulated within the vascular system. In the absence of a regulatory mechanism, ADAMTS13 activity might compromise plate...

journal_title：Blood

authors： Crawley JT,Lam JK,Rance JB,Mollica LR,O'Donnell JS,Lane DA

更新日期：2005-02-01 00:00:00

abstract：:We have analyzed the reactivation of fetal hemoglobin (HbF) synthesis under rigorous in vitro conditions, ie, in mature erythroblasts generated by erythroid burst-forming units (BFU-E) stringently purified from normal adult peripheral blood and grown in fetal calf serum(FCS)-free semisolid or liquid phase culture. In ...

journal_title：Blood

authors： Peschle C,Gabbianelli M,Testa U,Pelosi E,Barberi T,Fossati C,Valtieri M,Leone L

更新日期：1993-01-15 00:00:00

abstract：:Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may...

journal_title：Blood

authors： Tyner JW,Erickson H,Deininger MW,Willis SG,Eide CA,Levine RL,Heinrich MC,Gattermann N,Gilliland DG,Druker BJ,Loriaux MM

更新日期：2009-02-19 00:00:00

abstract：:The POEMS syndrome (coined to refer to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) remains poorly understood. Ambiguity exists over the features necessary to establish the diagnosis, treatment efficacy, and prognosis. We identified 99 patients with POEMS syndrome. Minimal criteria were a...

journal_title：Blood

authors： Dispenzieri A,Kyle RA,Lacy MQ,Rajkumar SV,Therneau TM,Larson DR,Greipp PR,Witzig TE,Basu R,Suarez GA,Fonseca R,Lust JA,Gertz MA

更新日期：2003-04-01 00:00:00

abstract：:Circulating monoclonal B cells may be detected in healthy adults, a condition called monoclonal B-cell lymphocytosis (MBL). MBL has also been identified in donated blood, but no systematic study of blood donors has been reported. Using sensitive and specific laboratory methods, we detected MBL in 149 (7.1%; 95% confid...

journal_title：Blood

authors： Shim YK,Rachel JM,Ghia P,Boren J,Abbasi F,Dagklis A,Venable G,Kang J,Degheidy H,Plapp FV,Vogt RF,Menitove JE,Marti GE

更新日期：2014-02-27 00:00:00

abstract：:In previous studies, the prevalence of HLA-linked hemochromatosis, thought to be the most common genetic illness in whites, has been estimated by identifying homozygotes in the population. Because not all homozygotes express the disease phenotypically, the accuracy of these estimates is uncertain. We analyzed the dist...

journal_title：Blood

authors： McLaren CE,Gordeuk VR,Looker AC,Hasselblad V,Edwards CQ,Griffen LM,Kushner JP,Brittenham GM

更新日期：1995-09-01 00:00:00

abstract：:Recent studies have shown a discrepancy between the level of tissue factor (TF) expression and the level of TF procoagulant activity on the apical and basolateral surface domains of polarized epithelial cells. The present investigation was performed to elucidate possible reasons for the discordant expression of TF and...

journal_title：Blood

authors： Hansen CB,van Deurs B,Petersen LC,Rao LV

更新日期：1999-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and lymphotoxin (LT; TNF-beta) are major cytokines produced by B lymphocytes. Stimulation by okadaic acid, a phosphatase 1 and 2A inhibitor, markedly increased TNF mRNA accumulation and cytokine production. On the other hand, the accumulation of LT mRNA was not affected by okadaic acid desp...

journal_title：Blood

authors： Xia HZ,Kannapell CC,Fu SM,Sung SS

更新日期：1993-11-01 00:00:00

abstract：:Circulating monocytes can differentiate into dendritic cells (moDCs), which are potent inducers of adaptive immune responses. Previous reports show that granulocyte macrophage-colony-stimulating factor (GM-CSF) and interleukin-4 induce monocyte differentiation into moDCs in vitro, but little is known about the physiol...

journal_title：Blood

authors： Zhang AL,Colmenero P,Purath U,Teixeira de Matos C,Hueber W,Klareskog L,Tarner IH,Engleman EG,Söderström K

更新日期：2007-10-01 00:00:00

abstract：:We previously reported the inhibitory action of interleukin-6 (IL-6) on B lymphopoiesis with SHIP(-/-) mice and showed that IL-6 biases lineage commitment toward myeloid cell fates in vitro and in vivo. Because elevated IL-6 is a feature of chronic inflammatory diseases, we applied an animal model of systemic lupus er...

journal_title：Blood

authors： Maeda K,Malykhin A,Teague-Weber BN,Sun XH,Farris AD,Coggeshall KM

更新日期：2009-05-07 00:00:00

abstract：:Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), ...

journal_title：Blood

authors： Dertschnig S,Nusspaumer G,Ivanek R,Hauri-Hohl MM,Holländer GA,Krenger W

更新日期：2013-08-01 00:00:00

abstract：:Erythroid Kruppel-like factor (EKLF) is a transcription factor of the C2H2 zinc-finger class that is essential for definitive erythropoiesis. We generated immortal erythroid cell lines from EKLF(-/-) fetal liver progenitor cells that harbor a single copy of the entire human beta-globin locus and then reintroduced EKLF...

journal_title：Blood

authors： Coghill E,Eccleston S,Fox V,Cerruti L,Brown C,Cunningham J,Jane S,Perkins A

更新日期：2001-03-15 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in patients with refractory CGVHD a total of 80 patients who failed to respond to prednisone (PSE) or PSE and cyclosporine (CSA) were treated with thalidomide. Sixt...

journal_title：Blood

authors： Parker PM,Chao N,Nademanee A,O'Donnell MR,Schmidt GM,Snyder DS,Stein AS,Smith EP,Molina A,Stepan DE,Kashyap A,Planas I,Spielberger R,Somlo G,Margolin K,Zwingenberger K,Wilsman K,Negrin RS,Long GD,Niland JC,Blume K

更新日期：1995-11-01 00:00:00