Abstract:
:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a double band pattern for GPlb and about half the normal level of GPlb beta and GPIX. Therefore, we conclude that the Bernard-Soulier syndrome is heterogeneous and is probably not due to gene deletions.
journal_name
Bloodjournal_title
Bloodauthors
Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJsubject
Has Abstractpub_date
1988-09-01 00:00:00pages
1086-8issue
3eissn
0006-4971issn
1528-0020journal_volume
72pub_type
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