Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: a study of 111 cases.

abstract：:Through the procedure of gene amplification combined with hybridization to synthetic 19 base pair (bp) oligonucleotide probes, it has been possible to identify nine different mutations in the DNA of 47 subjects from Turkey and Northern Cyprus with a beta-thalassemia homozygosity. The IVS-I nucleotide (nt) 110 G----A a...

journal_title：Blood

authors： Diaz-Chico JC,Yang KG,Stoming TA,Efremov DG,Kutlar A,Kutlar F,Aksoy M,Altay C,Gurgey A,Kilinc Y

更新日期：1988-01-01 00:00:00

abstract：:In this investigation, we studied the importance of cellular glutathione (GSH) in the hexose monophosphate shunt (HMPS) activity of unstimulated human erythrocytes and the mechanism by which pyruvate stimulates the HMPS. The rate of HMPS activity was measured by the production of radioactive CO2 from 14C-1-glucose or ...

journal_title：Blood

authors： Sagone AL Jr,Balcerzak SP,Metz EN

更新日期：1975-01-01 00:00:00

abstract：:Endothelial cell prostacyclin (PGI2) inhibits platelet activation by raising platelet cyclic AMP. Previously, platelet activation was also shown to be blocked by plasmin formed by endothelium-derived tissue plasminogen activator (TPA). We have now studied interactions between PGI2 and plasmin in the control of platele...

journal_title：Blood

authors： Schafer AI,Zavoico GB,Loscalzo J,Maas AK

更新日期：1987-05-01 00:00:00

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:The Ca(2+)-activated K+ channels of human red blood cells (RBCs) (Gardos channels, hIK1, hSK4) can mediate rapid cell dehydration, of particular relevance to the pathophysiology of sickle cell disease. Previous investigations gave widely discrepant estimates of the number of Gardos channels per RBC, from as few as 1 t...

journal_title：Blood

authors： Lew VL,Tiffert T,Etzion Z,Perdomo D,Daw N,Macdonald L,Bookchin RM

更新日期：2005-01-01 00:00:00

abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

journal_title：Blood

authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

更新日期：2013-09-26 00:00:00

abstract：:CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with fol...

journal_title：Blood

authors： Karube K,Guo Y,Suzumiya J,Sugita Y,Nomura Y,Yamamoto K,Shimizu K,Yoshida S,Komatani H,Takeshita M,Kikuchi M,Nakamura N,Takasu O,Arakawa F,Tagawa H,Seto M,Ohshima K

更新日期：2007-04-01 00:00:00

abstract：:The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) an...

journal_title：Blood

authors： Tassara M,Döhner K,Brossart P,Held G,Götze K,Horst HA,Ringhoffer M,Köhne CH,Kremers S,Raghavachar A,Wulf G,Kirchen H,Nachbaur D,Derigs HG,Wattad M,Koller E,Brugger W,Matzdorff A,Greil R,Heil G,Paschka P,Gaidzik

更新日期：2014-06-26 00:00:00

abstract：:Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to blocked cellular differentiation. Enasidenib (AG-221/CC-90007) is a firs...

journal_title：Blood

authors： Stein EM,DiNardo CD,Pollyea DA,Fathi AT,Roboz GJ,Altman JK,Stone RM,DeAngelo DJ,Levine RL,Flinn IW,Kantarjian HM,Collins R,Patel MR,Frankel AE,Stein A,Sekeres MA,Swords RT,Medeiros BC,Willekens C,Vyas P,Tosolini A

更新日期：2017-08-10 00:00:00

abstract：:The presence of mast cell precursors in peripheral blood was examined. The beige C57BL/6 (bgj/bgj, Chediak-Higashi syndrome) mouse was parabiosed with the normal C57BL/6 mouse. Mast cells containing giant granules and originating in the beige partner appeared in the normal parabiont. A comparable proportion of normal-...

journal_title：Blood

authors： Kitamura Y,Hatanaka K,Murakami M,Shibata H

更新日期：1979-06-01 00:00:00

abstract：:In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in p...

journal_title：Blood

authors： Moreau P,Attal M,Pégourié B,Planche L,Hulin C,Facon T,Stoppa AM,Fuzibet JG,Grosbois B,Doyen C,Ketterer N,Sebban C,Kolb B,Chaleteix C,Dib M,Voillat L,Fontan J,Garderet L,Jaubert J,Mathiot C,Esseltine D,Avet-Loise

更新日期：2011-03-17 00:00:00

abstract：:Recent genomic studies have outlined a landscape of recurrent alterations within some subtypes of lymphoid cancer. Yet, the timing and cellular contexts during which these alterations occur (ie, the molecular ontogeny) remain poorly understood. Lymphoid malignancies offer an exceptional opportunity to delineate the on...

journal_title：Blood

authors： Weigert O,Weinstock DM

更新日期：2012-09-27 00:00:00

abstract：:The PI3K/Akt/mTOR pathway has emerged as a critical regulator of dendritic cell (DC) development and function. The kinase mTOR is found in 2 distinct complexes, mTORC1 and mTORC2. In this study, we show that mTORC1 but not mTORC2 is required for epidermal Langerhans cell (LC) homeostasis. Although the initial seeding ...

journal_title：Blood

authors： Kellersch B,Brocker T

更新日期：2013-01-10 00:00:00

abstract：:Mast cells play a critical role in innate immunity, allergy, and autoimmune diseases. The receptor/ligand interactions that mediate mast cell activation are poorly defined. The alpha2beta1 integrin, a receptor for collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and several v...

journal_title：Blood

authors： Edelson BT,Stricker TP,Li Z,Dickeson SK,Shepherd VL,Santoro SA,Zutter MM

更新日期：2006-01-01 00:00:00

abstract：:Drug-induced immune thrombocytopenia (DITP) is caused by drug-dependent antibodies (DDAbs) that are nonreactive in themselves but bind tightly to specific platelet membrane glycoproteins (GP) when soluble drug is present at pharmacologic concentrations. This reaction takes place without covalent linkage of drug to the...

journal_title：Blood

authors： Bougie DW,Birenbaum J,Rasmussen M,Poncz M,Aster RH

更新日期：2009-01-29 00:00:00

abstract：:Von Willebrand factor (VWF) is a key hemostatic protein synthesized in both endothelial cells and megakaryocytes. Megakaryocyte-derived VWF is stored in α-granules of platelets and is enriched in hyperactive "ultra-large" VWF multimers. To elucidate the specific contribution of platelet VWF in hemostasis and thrombosi...

journal_title：Blood

authors： Verhenne S,Denorme F,Libbrecht S,Vandenbulcke A,Pareyn I,Deckmyn H,Lambrecht A,Nieswandt B,Kleinschnitz C,Vanhoorelbeke K,De Meyer SF

更新日期：2015-10-01 00:00:00

abstract：:Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

journal_title：Blood

authors： Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

更新日期：2019-11-28 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

journal_title：Blood

authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

更新日期：2005-06-15 00:00:00

abstract：:In The Netherlands from July 1988 to October 1991, children (0 to 16 years of age) with de novo acute lymphoblastic leukemia (ALL) were treated according to protocol ALL-7 of the Dutch Childhood Leukemia Study Group (DCLSG). In this protocol, chemotherapy and treatment stratification were identical to the ALL-BFM-86 p...

journal_title：Blood

authors： Kamps WA,Bökkerink JP,Hählen K,Hermans J,Riehm H,Gadner H,Schrappe M,Slater R,van den Berg-de Ruiter E,Smets LA,de Vaan GA,Weening RS,van Weerden JF,van Wering ER,den der Does-van den Berg A

更新日期：1999-08-15 00:00:00

abstract：:Translation of small interfering RNA (siRNA)-based approaches into practical therapeutics is limited because of lack of an effective and cell-specific delivery system. Herein, we present a new method of selectively delivering siRNA to dendritic cells (DCs) in vivo using CD40 siRNA-containing immunoliposomes (siILs) th...

journal_title：Blood

authors： Zheng X,Vladau C,Zhang X,Suzuki M,Ichim TE,Zhang ZX,Li M,Carrier E,Garcia B,Jevnikar AM,Min WP

更新日期：2009-03-19 00:00:00

abstract：:Tryptases are serine proteases primarily expressed in mast cells. Normal blood basophils express only trace amounts of the enzyme. However, recent immunohistochemical studies have raised the possibility that neoplastic basophils express significant amounts of tryptase. In this study, tryptase expression was analyzed i...

journal_title：Blood

authors： Samorapoompichit P,Kiener HP,Schernthaner GH,Jordan JH,Agis H,Wimazal F,Baghestanian M,Rezaie-Majd A,Sperr WR,Lechner K,Valent P

更新日期：2001-10-15 00:00:00

abstract：:Heterogeneity in the human and rat plasma fibrinogen (FBG) gamma chains is due to differential splicing of the primary gamma chain mRNA transcript. The subunit composition of FBG containing the predominant form of the gamma chain is homodimeric (human: A alpha 2, B beta 2, gamma 50-gamma 50; rat: A alpha 2, B beta 2, ...

journal_title：Blood

authors： Lawrence SO,Wright TW,Francis CW,Fay PJ,Haidaris PJ

更新日期：1993-10-15 00:00:00

abstract：:One hundred fifty-one children with acute myelogenous leukemia (AML) entered the cooperative study BFM-78 between December 1978 and October 1982. The initial therapy consisted of an intensive induction and consolidation regimen over eight weeks with seven different drugs and cranial irradiation. It was followed by mai...

journal_title：Blood

authors： Creutzig U,Ritter J,Riehm H,Langermann HJ,Henze G,Kabisch H,Niethammer D,Jürgens H,Stollmann B,Lasson U

更新日期：1985-02-01 00:00:00

abstract：:The mechanism of lymphomagenesis of hepatitis C virus (HCV)-related B-cell lymphoma is unknown. Recently, it has been suggested that HCV may induce B-cell clonal proliferation and t(14;18) translocation in patients chronically infected with the virus. Thus, this study investigated the effect of antiviral treatment on ...

journal_title：Blood

authors： Zuckerman E,Zuckerman T,Sahar D,Streichman S,Attias D,Sabo E,Yeshurun D,Rowe JM

更新日期：2001-03-15 00:00:00

abstract：:The NADPH:O2 oxidoreductase catalyzing the respiratory burst in activated phagocytes from healthy individuals is not operative in phagocytes from patients with chronic granulomatous disease (CGD). In a microscopic slide test using the dye nitroblue tetrazolium (NBT), carriers of X-linked CGD can be recognized by a mos...

journal_title：Blood

authors： Verhoeven AJ,van Schaik ML,Roos D,Weening RS

更新日期：1988-02-01 00:00:00

abstract：:The selectins are lectin-like cell surface glycoproteins that have been implicated in playing a crucial role in the initiation of leukocyte adhesion to endothelial cells (ECs) during inflammation. Binding of selectins under conditions of flow mediates leukocyte rolling, which in vivo is almost exclusively observed in ...

journal_title：Blood

authors： Olofsson AM,Arfors KE,Ramezani L,Wolitzky BA,Butcher EC,von Andrian UH

更新日期：1994-10-15 00:00:00

abstract：:The reactivation of human cytomegalovirus (HCMV) poses a serious health threat to immune compromised individuals. As a treatment strategy, dendritic cell (DC) vaccination trials are ongoing. Recent work suggests that BDCA-3(+) (CD141(+)) subset DCs may be particularly effective in DC vaccination trials. BDCA-3(+) DCs ...

journal_title：Blood

authors： Flinsenberg TW,Compeer EB,Koning D,Klein M,Amelung FJ,van Baarle D,Boelens JJ,Boes M

更新日期：2012-12-20 00:00:00

abstract：:Plasma fibronectin (Fn) induces phagocytosis of C3b-opsonized sheep erythrocytes (EC3b) by human peripheral blood monocytes. However, Fn does not induce erythrophagocytosis of EC3b by human polymorphonuclear leukocytes (PMN), unless the PMN have been exposed to C5a or N-formyl-methionyl-leucyl-phenylalanine. Because o...

journal_title：Blood

authors： Pommier CG,O'Shea J,Chused T,Takahashi T,Ochoa M,Nutman TB,Bianco C,Brown EJ

更新日期：1984-10-01 00:00:00

abstract：:Platelet-type von Willebrand disease (vWD) is a congenital bleeding disorder characterized by heightened ristocetin-induced platelet aggregation caused by abnormally high affinity between the platelet membrane glycoprotein (GP) Ib/IX complex and von Willebrand factor (vWF). Two distinct point mutations, Gly233 to Val ...

journal_title：Blood

authors： Moriki T,Murata M,Kitaguchi T,Anbo H,Handa M,Watanabe K,Takahashi H,Ikeda Y

更新日期：1997-07-15 00:00:00

abstract：:As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL), novel therapies targeting leukemia-dysregulated pathways are necessary. Exportin-1 (XPO1), also known as chromoso...

journal_title：Blood

authors： Walker CJ,Oaks JJ,Santhanam R,Neviani P,Harb JG,Ferenchak G,Ellis JJ,Landesman Y,Eisfeld AK,Gabrail NY,Smith CL,Caligiuri MA,Hokland P,Roy DC,Reid A,Milojkovic D,Goldman JM,Apperley J,Garzon R,Marcucci G,Shacham S

更新日期：2013-10-24 00:00:00