Long-term health-related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia.

abstract：:Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. This study demonstrates that media conditioned by a long-term T lymphocyte line augmented the growth of erythroid colonies in vitro in the presence of erythropoietin ...

journal_title：Blood

authors： Hamburger AW

更新日期：1980-10-01 00:00:00

abstract：:A monoclonal antibody raised against cytochrome b558 reacted specifically with the 22- to 23-Kd protein, the small subunit of this cytochrome. Cytochemical studies showed that the epitope was located on the surfaces of human neutrophils and monocytes. The small subunit of cytochrome b558, therefore, was expressed at l...

journal_title：Blood

authors： Nakamura M,Sendo S,van Zwieten R,Koga T,Roos D,Kanegasaki S

更新日期：1988-11-01 00:00:00

abstract：:The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in several subtypes of B-cell non-Hodgkin lymphomas, where high-level FOXP1 protein expression has been linked to a poor prognosis. Western blotting studies of diffuse large B-cell lymphoma (DLBCL) cell lines unexpectedly identi...

journal_title：Blood

authors： Brown PJ,Ashe SL,Leich E,Burek C,Barrans S,Fenton JA,Jack AS,Pulford K,Rosenwald A,Banham AH

更新日期：2008-03-01 00:00:00

abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...

journal_title：Blood

authors： Lijfering WM,Brouwer JL,Veeger NJ,Bank I,Coppens M,Middeldorp S,Hamulyák K,Prins MH,Büller HR,van der Meer J

更新日期：2009-05-21 00:00:00

abstract：:Recruitment of polymorphonuclear neutrophils (PMNs) to sites of acute inflammation critically depends on β2 integrins (CD11/CD18). Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an important adaptor protein regulating PMN trafficking downstream of β2 integrins. Here, we show that mAbp1 const...

journal_title：Blood

authors： Jakob SM,Pick R,Brechtefeld D,Nussbaum C,Kiefer F,Sperandio M,Walzog B

更新日期：2013-05-16 00:00:00

abstract：:Both mast cells and IL-17 can contribute to host defense and pathology in part by orchestrating neutrophil recruitment, but the possible role of mast cells in IL-17-induced inflammation remains to be defined. We found that mast cells and IL-17, but neither IFN-gamma nor FcRgamma signaling, contributed significantly to...

journal_title：Blood

authors： Nakae S,Suto H,Berry GJ,Galli SJ

更新日期：2007-05-01 00:00:00

abstract：:Multiple myeloma (MM) is characterized by accumulation and dissemination of malignant plasma cells (PCs) in the bone marrow (BM). Gene expression profiling of 2 MM cell lines (OH-2 and IH-1) indicated that expression of PRL-3, a metastasis-associated tyrosine phosphatase, was induced by several mitogenic cytokines. Cy...

journal_title：Blood

authors： Fagerli UM,Holt RU,Holien T,Vaatsveen TK,Zhan F,Egeberg KW,Barlogie B,Waage A,Aarset H,Dai HY,Shaughnessy JD Jr,Sundan A,Børset M

更新日期：2008-01-15 00:00:00

abstract：:Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), in...

journal_title：Blood

authors： Richardson DR,Tran EH,Ponka P

更新日期：1995-12-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cells in a human leukocyte antigen (HLA)-dependent manner. KIR/HLA mismatched hematopoietic stem cell transplants induce alloreactive NK cells, which prevent leukemia relapse. Certain KIR/HLA combinations protect against HIV-1 infection, but the ...

journal_title：Blood

authors： Jennes W,Verheyden S,Mertens JW,Camara M,Seydi M,Dieye TN,Mboup S,Demanet C,Kestens L

更新日期：2013-02-14 00:00:00

abstract：:Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that neonatal megakaryocyte (MK) progenitors are hyperproliferative and give rise to MKs smaller and of lower ploidy than adult MKs. Based on these characteristics, neonatal MKs have been consider...

journal_title：Blood

authors： Liu ZJ,Italiano J Jr,Ferrer-Marin F,Gutti R,Bailey M,Poterjoy B,Rimsza L,Sola-Visner M

更新日期：2011-04-14 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is associated with complement system dysregulation, and more than 25% of pediatric aHUS cases are linked to mutations in complement factor H (CFH) or CFH autoantibodies. The observation of thrombocytopenia and platelet-rich thrombi in the glomerular microvasculature indicates ...

journal_title：Blood

authors： Licht C,Pluthero FG,Li L,Christensen H,Habbig S,Hoppe B,Geary DF,Zipfel PF,Kahr WH

更新日期：2009-11-12 00:00:00

abstract：:Derivative chromosome 9 deletions are seen in 10% to 15% of patients with chronic myelogenous leukemia and have been associated with a poor prognosis; however, no studies have been performed in the context of a randomized clinical trial. We developed a DNA-based deletion screen and investigated 339 chronic phase patie...

journal_title：Blood

authors： Kreil S,Pfirrmann M,Haferlach C,Waghorn K,Chase A,Hehlmann R,Reiter A,Hochhaus A,Cross NC,German Chronic Myelogenous Leukemia (CML) Study Group.

更新日期：2007-08-15 00:00:00

abstract：:Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response, many aspects of eosinophil accumulation remain unknown. This is particularly true with respect to tissue-specific mechanisms that may regulate the accumulation of ...

journal_title：Blood

authors： Larbi KY,Allen AR,Tam FW,Haskard DO,Lobb RR,Silva PM,Nourshargh S

更新日期：2000-11-15 00:00:00

abstract：:The leukemia-specific AML1/ETO fusion gene has been shown to be detected by reverse transcriptase polymerase chain reaction (RT-PCR) analysis in patients with t(8;21) acute myelogenous leukemia (AML) in long-term remission. In the present study, the AML1/ETO mRNA could be detected by RT-PCR in bone marrow (BM) and/or ...

journal_title：Blood

authors： Miyamoto T,Nagafuji K,Akashi K,Harada M,Kyo T,Akashi T,Takenaka K,Mizuno S,Gondo H,Okamura T,Dohy H,Niho Y

更新日期：1996-06-01 00:00:00

abstract：:Dendritic cells (DC) are the main stimulators of primary T-cell responses and, thus, probably play a role in the immune reactions after stem cell transplantation. Very little is known about DC in cord blood (CB) and about their potential involvement in the low incidence and severity of acute graft-versus-host disease ...

journal_title：Blood

authors： Sorg RV,Kögler G,Wernet P

更新日期：1999-04-01 00:00:00

abstract：:We evaluated phagocytic and lytic activities of peripheral blood monocytes (PBMo) from patients with thalassemia major (ThP) using C pseudotropicalis as the target. PBMo from ThP showed decreased lytic activity (P less than .001), whereas the phagocytic activity did not differ from that of the controls. Significant in...

journal_title：Blood

authors： Ballart IJ,Estevez ME,Sen L,Diez RA,Giuntoli J,de Miani SA,Peñalver J

更新日期：1986-01-01 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:To investigate whether the migratory ability of peripheral blood-derived CD34+ cells of patients undergoing autologous peripheral blood stem cell transplantation is related to the homing efficiency of these cells, the migration in vitro of these cells was determined and correlated with in vivo hematopoietic recovery. ...

journal_title：Blood

authors： Voermans C,Kooi ML,Rodenhuis S,van der Lelie H,van der Schoot CE,Gerritsen WR

更新日期：2001-02-01 00:00:00

abstract：:The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We...

journal_title：Blood

authors： Mamani-Matsuda M,Cosma A,Weller S,Faili A,Staib C,Garçon L,Hermine O,Beyne-Rauzy O,Fieschi C,Pers JO,Arakelyan N,Varet B,Sauvanet A,Berger A,Paye F,Andrieu JM,Michel M,Godeau B,Buffet P,Reynaud CA,Weill JC

更新日期：2008-05-01 00:00:00

abstract：:In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is mainly found in CD8(+) T cells and not in CD4(+) T cells. Telomerase, a ribonucleoprotein enzyme that can synthesize telomeric sequence onto chromosomal ends, can compensate for telomere loss. Here, we investigated if telomerase activity...

journal_title：Blood

authors： Wolthers KC,Otto SA,Wisman GB,Fleury S,Reiss P,ten Kate RW,van der Zee AG,Miedema F

更新日期：1999-02-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (B-CLL) is defined by the accumulation of CD5(+) B cells in the periphery and bone marrow. This disease is not characterized by highly proliferative cells but rather by the presence of leukemic cells with significant resistance to apoptosis and, therefore, prolonged survival. B-lymp...

journal_title：Blood

authors： Novak AJ,Bram RJ,Kay NE,Jelinek DF

更新日期：2002-10-15 00:00:00

abstract：:The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to skeletal muscle iron mobilization and decrease in myoglobin protein levels. To investigate the effect of enhanced erythropoiesis on systemic and muscle iron metabolism under nonhypoxic conditions, 8 healthy volunteers we...

journal_title：Blood

authors： Robach P,Recalcati S,Girelli D,Gelfi C,Aachmann-Andersen NJ,Thomsen JJ,Norgaard AM,Alberghini A,Campostrini N,Castagna A,Viganò A,Santambrogio P,Kempf T,Wollert KC,Moutereau S,Lundby C,Cairo G

更新日期：2009-06-25 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong p...

journal_title：Blood

authors： Stoppa-Lyonnet D,Soulier J,Laugé A,Dastot H,Garand R,Sigaux F,Stern MH

更新日期：1998-05-15 00:00:00

abstract：:Residual vein thrombosis (RVT) indicates a prothrombotic state and is useful for evaluating the optimal duration of oral anticoagulant treatment (OAT). Patients with a first episode of deep vein thrombosis, treated with OAT for 3 months, were managed according to RVT findings. Those with RVT were randomized to either ...

journal_title：Blood

authors： Siragusa S,Malato A,Anastasio R,Cigna V,Milio G,Amato C,Bellisi M,Attanzio MT,Cormaci O,Pellegrino M,Dolce A,Casuccio A,Bajardi G,Mariani G

更新日期：2008-08-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) undergo dramatic expansion during fetal liver development, but attempts to expand their numbers ex vivo have failed. We hypothesized that unidentified fetal liver cells produce growth factors that support HSC proliferation. Here we describe a novel population of CD3+ and Ter119- day-15 ...

journal_title：Blood

authors： Zhang CC,Lodish HF

更新日期：2004-04-01 00:00:00

abstract：:Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell neoplasm that most commonly arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. HSTCL is more common in adolescent and young adults and has a rapidly progressive clinical course and poor outcome due to its refractoriness to conventional chemo...

journal_title：Blood

authors： Pro B,Allen P,Behdad A

更新日期：2020-10-29 00:00:00

abstract：:Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) kinase regulates TNFα...

journal_title：Blood

authors： Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW

更新日期：2011-12-08 00:00:00

abstract：:Platelet activation is normally induced by primary agonists such as adenosine diphosphate (ADP), thrombin, and collagen, whereas other agonists, such as epinephrine, can play important accessory roles. It is now reported that the macrophage-derived chemokine (MDC), thymus activation-regulated chemokine (TARC), and str...

journal_title：Blood

authors： Gear AR,Suttitanamongkol S,Viisoreanu D,Polanowska-Grabowska RK,Raha S,Camerini D

更新日期：2001-02-15 00:00:00

abstract：:The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome-associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is...

journal_title：Blood

authors： Neri A,Barriga F,Inghirami G,Knowles DM,Neequaye J,Magrath IT,Dalla-Favera R

更新日期：1991-03-01 00:00:00

abstract：:Despite potential clinical importance, target cells for mother-to-child transmission of HIV-1 have not yet been identified. Cord blood-derived CD4(+) T cells are largely naive and do not express CCR5, the mandatory coreceptor for transmitted HIV-1 R5 strains in infants. In the present study, we demonstrate that in the...

journal_title：Blood

authors： Bunders MJ,van der Loos CM,Klarenbeek PL,van Hamme JL,Boer K,Wilde JC,de Vries N,van Lier RA,Kootstra N,Pals ST,Kuijpers TW

更新日期：2012-11-22 00:00:00