Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives.

abstract：:Insights into immune-mediated thrombotic thrombocytopenic purpura (iTTP) pathophysiology have led to novel targeted therapies. Immunomodulatory strategies target anti-ADAMTS13 antibodies: rituximab is effective in inducing responses in refractory/relapsed TTP and increasing relapse-free survival; caplacizumab targets ...

journal_title：Blood

authors： Mazepa MA,Masias C,Chaturvedi S

更新日期：2019-08-01 00:00:00

abstract：:Donor hematopoietic stem cells (HSCs) can correct T-cell deficiencies in patients with severe combined immunodeficiency by replacing resident thymus cells. However, as those progenitors that naturally migrate to the thymus are not capable of supporting long-term thymopoiesis, a successful transplant is thought to requ...

journal_title：Blood

authors： de Barros SC,Vicente R,Chebli K,Jacquet C,Zimmermann VS,Taylor N

更新日期：2013-03-14 00:00:00

abstract：:CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus ve...

journal_title：Blood

authors： Tatsis N,Fitzgerald JC,Reyes-Sandoval A,Harris-McCoy KC,Hensley SE,Zhou D,Lin SW,Bian A,Xiang ZQ,Iparraguirre A,Lopez-Camacho C,Wherry EJ,Ertl HC

更新日期：2007-09-15 00:00:00

abstract：:The International Prognostic Scoring System (IPSS) has been widely used to predict the prognosis of patients with myelodysplastic syndrome (MDS). However, IPSS does not always provide a sufficiently precise evaluation of patients to allow the appropriate choice of clinical interventions. Here, we analyzed the expressi...

journal_title：Blood

authors： Mihara K,Chowdhury M,Nakaju N,Hidani S,Ihara A,Hyodo H,Yasunaga S,Takihara Y,Kimura A

更新日期：2006-01-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...

journal_title：Blood

authors：

更新日期：1998-04-15 00:00:00

abstract：:Immunosuppressive therapy can produce hematologic improvement in a large proportion of patients with severe aplastic anemia. Antithymocyte globulin (ATG) is the current treatment of choice for patients who do not have histocompatible sibling donors or who are otherwise inegligible for allogeneic bone marrow transplant...

journal_title：Blood

authors： Rosenfeld SJ,Kimball J,Vining D,Young NS

更新日期：1995-06-01 00:00:00

abstract：:Acquired hemophilia is a rare bleeding disorder characterized by the spontaneous occurrence of inhibitory antibodies against endogenous factor VIII (FVIII). IgG from some patients with acquired hemophilia hydrolyze FVIII. Because of the complex etiology of the disease, no clinical parameter, including the presence of ...

journal_title：Blood

authors： Wootla B,Christophe OD,Mahendra A,Dimitrov JD,Repessé Y,Ollivier V,Friboulet A,Borel-Derlon A,Levesque H,Borg JY,Andre S,Bayry J,Calvez T,Kaveri SV,Lacroix-Desmazes S

更新日期：2011-02-17 00:00:00

abstract：:The cytokine interleukin (IL)-7 exerts essential roles in lymph node (LN) organogenesis and lymphocyte development and homeostasis. Recent studies have identified lymphatic endothelial cells (LECs) as a major source of IL-7 in LNs. Here, we report that LECs not only produce IL-7, but also express the IL-7 receptor cha...

journal_title：Blood

authors： Iolyeva M,Aebischer D,Proulx ST,Willrodt AH,Ecoiffier T,Häner S,Bouchaud G,Krieg C,Onder L,Ludewig B,Santambrogio L,Boyman O,Chen L,Finke D,Halin C

更新日期：2013-09-26 00:00:00

abstract：:Three recipients of HLA-identical bone marrow transplants developed chronic graft-versus-host disease (cGVHD) and hypergammaglobulinemia. All three had evidence of abnormal B-lymphocyte function, including a polyclonal increase in immunoglobulins (Ig), antinuclear antibodies, rheumatoid factor, lymphocytotoxins, and i...

journal_title：Blood

authors： Saxon A,McIntyre RE,Stevens RH,Gale RP

更新日期：1981-10-01 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:Previous studies of follicular lymphoma (FL) patients treated heterogeneously have suggested that decreased numbers of regulatory T cells correlates with improved survival. We studied advanced-stage FL patients from a single institution phase 2 trial. All patients were treated uniformly with multiagent chemotherapy an...

journal_title：Blood

authors： Farinha P,Al-Tourah A,Gill K,Klasa R,Connors JM,Gascoyne RD

更新日期：2010-01-14 00:00:00

abstract：:To define the efficacy of venetoclax with extended follow-up and identify clinical or biological treatment effect modifiers, updated data for previously treated patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) enrolled in 4 early-phase trials were pooled. Rates of response, complete...

journal_title：Blood

authors： Roberts AW,Ma S,Kipps TJ,Coutre SE,Davids MS,Eichhorst B,Hallek M,Byrd JC,Humphrey K,Zhou L,Chyla B,Nielsen J,Potluri J,Kim SY,Verdugo M,Stilgenbauer S,Wierda WG,Seymour JF

更新日期：2019-07-11 00:00:00

abstract：:In utero transplantation (IUT) is becoming a viable option for the treatment of various immune and metabolic disorders diagnosed early in gestation. In this study, donor fetal liver cells had a 10-fold competitive engraftment advantage relative to adult bone marrow in allogeneic fetal severe combined immunodeficient (...

journal_title：Blood

authors： Taylor PA,McElmurry RT,Lees CJ,Harrison DE,Blazar BR

更新日期：2002-03-01 00:00:00

abstract：:Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide-specific IgG responses totally independent of T-cell help. Ind...

journal_title：Blood

authors： Pihlgren M,Silva AB,Madani R,Giriens V,Waeckerle-Men Y,Fettelschoss A,Hickman DT,López-Deber MP,Ndao DM,Vukicevic M,Buccarello AL,Gafner V,Chuard N,Reis P,Piorkowska K,Pfeifer A,Kündig TM,Muhs A,Johansen P

更新日期：2013-01-03 00:00:00

abstract：:Perfluorocarbons have shown promise as clinical blood substitutes. Although early experience in Japan with one such product--Fluosol-DA--has been uncomplicated, we observed an adverse pulmonary reaction in the first American patient to receive it and know of similar reactions in two other Americans so treated. Postula...

journal_title：Blood

authors： Vercellotti GM,Hammerschmidt DE,Craddock PR,Jacob HS

更新日期：1982-06-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), members of the transforming growth factor (TGF)-beta superfamily, are a group of related proteins that are capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. We show in this report a novel function of BMPs in hematopoietic cell...

journal_title：Blood

authors： Kawamura C,Kizaki M,Yamato K,Uchida H,Fukuchi Y,Hattori Y,Koseki T,Nishihara T,Ikeda Y

更新日期：2000-09-15 00:00:00

abstract：:Individuals with impaired perforin-dependent cytotoxic function (Ctx(-)) develop a fatal inflammatory disorder called hemophagocytic lymphohistiocytosis (HLH). It has been hypothesized that immune hyperactivation during HLH is caused by heightened infection, defective apoptosis/responsiveness of Ctx(-) lymphocytes, or...

journal_title：Blood

authors： Lykens JE,Terrell CE,Zoller EE,Risma K,Jordan MB

更新日期：2011-07-21 00:00:00

abstract：:Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined mechanisms. Our studies indicate that T(H) cells frequently interact with monocytes in inflamed skin and elicit the differentiation of specialized DC subsets c...

journal_title：Blood

authors： Alonso MN,Wong MT,Zhang AL,Winer D,Suhoski MM,Tolentino LL,Gaitan J,Davidson MG,Kung TH,Galel DM,Nadeau KC,Kim J,Utz PJ,Söderström K,Engleman EG

更新日期：2011-09-22 00:00:00

abstract：:C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors such as imatinib mesylate (imatinib) are effective in managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase-independent pathways support LSC survival. Given that the bone marrow (BM)...

journal_title：Blood

authors： Ng KP,Manjeri A,Lee KL,Huang W,Tan SY,Chuah CT,Poellinger L,Ong ST

更新日期：2014-05-22 00:00:00

abstract：:This phase 2 study evaluated whether substituting bortezomib for vincristine in frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy could improve efficacy in non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB DLBCL), centrally confirmed by immunohist...

journal_title：Blood

authors： Offner F,Samoilova O,Osmanov E,Eom HS,Topp MS,Raposo J,Pavlov V,Ricci D,Chaturvedi S,Zhu E,van de Velde H,Enny C,Rizo A,Ferhanoglu B

更新日期：2015-10-15 00:00:00

abstract：:Interleukin-6 (IL-6) administered as a single intravenous (IV) injection caused the following changes in the peripheral circulation of rats: (a) a biphasic neutrophilia with an initial peak at 1.5 hours and a second sustained wave of neutrophilia between four and 12 hours, (b) a mild lymphocytosis at 0.5 hours and a m...

journal_title：Blood

authors： Ulich TR,del Castillo J,Guo KZ

更新日期：1989-01-01 00:00:00

abstract：:The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP IIb/IIIa from the nonactivated to the activated state. Because several blocking agents/inhibitors are ligand-mimetics, ...

journal_title：Blood

authors： Peter K,Schwarz M,Ylänne J,Kohler B,Moser M,Nordt T,Salbach P,Kübler W,Bode C

更新日期：1998-11-01 00:00:00

abstract：:Osteolytic bone destruction and its complications, bone pain, pathologic fractures, and hypercalcemia, are a major source of morbidity and mortality in patients with multiple myeloma. The bone destruction in multiple myeloma is due to increased osteoclast (OCL) activity and decreased bone formation in areas of bone ad...

journal_title：Blood

authors： Alsina M,Boyce B,Devlin RD,Anderson JL,Craig F,Mundy GR,Roodman GD

更新日期：1996-02-15 00:00:00

abstract：:A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To furth...

journal_title：Blood

authors： Corazza F,Beguin Y,Bergmann P,André M,Ferster A,Devalck C,Fondu P,Buyse M,Sariban E

更新日期：1998-09-01 00:00:00

abstract：:Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not fully understood. In the present study, we show that whereas steady-state hematopoiesis is normal in basic fibroblast growth factor (FGF-2)-knockout mice, parathyroid hormone stimulation and myeloablative treatments failed to induce n...

journal_title：Blood

authors： Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T

更新日期：2012-08-30 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that monitor the antigenic environment and activate naive T cells. The role of DCs is not only to sense danger but also to tolerize the immune system to antigens encountered in the absence of maturation/inflammatory stimuli. Indeed, if a naive T cell encou...

journal_title：Blood

authors： Levings MK,Gregori S,Tresoldi E,Cazzaniga S,Bonini C,Roncarolo MG

更新日期：2005-02-01 00:00:00

abstract：:Nitric oxide (NO), an important effector molecule involved in immune regulation and host defense, was shown to induce apoptosis in lymphoma cells. In the present report the NO donor glycerol trinitrate was found to induce apoptosis in Jurkat cells that are sensitive to CD95-mediated kill. In contrast, a CD95-resistant...

journal_title：Blood

authors： Chlichlia K,Peter ME,Rocha M,Scaffidi C,Bucur M,Krammer PH,Schirrmacher V,Umansky V

更新日期：1998-06-01 00:00:00

abstract：:A decrease in inhibitor titer has been reported in some patients with acquired factor VIII inhibitors treated with intravenous gammaglobulin (IGIV). We have conducted a prospective, multicenter study of high-dose IGIV in treatment of this disorder to determine efficacy. Nineteen patients received induction therapy wit...

journal_title：Blood

authors： Schwartz RS,Gabriel DA,Aledort LM,Green D,Kessler CM

更新日期：1995-07-15 00:00:00

abstract：:This study was performed to assess the utility of tumor-derived fragmentary DNA, or circulating tumor DNA (ctDNA), for identifying high-risk patients for relapse of acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloSCT)....

journal_title：Blood

authors： Nakamura S,Yokoyama K,Shimizu E,Yusa N,Kondoh K,Ogawa M,Takei T,Kobayashi A,Ito M,Isobe M,Konuma T,Kato S,Kasajima R,Wada Y,Nagamura-Inoue T,Yamaguchi R,Takahashi S,Imoto S,Miyano S,Tojo A

更新日期：2019-06-20 00:00:00

abstract：:Combretastatin A-4-phosphate (CA-4-P) is a tubulin-binding compound currently in clinical trial as a tumor vascular-targeting agent. In endothelial cells, CA-4-P is known to cause microtubule depolymerization, but little is known about its subsequent effects on cell morphology and function. Here, we demonstrate that w...

journal_title：Blood

authors： Kanthou C,Tozer GM

更新日期：2002-03-15 00:00:00