How targeted therapy disrupts the treatment paradigm for acquired TTP: the risks, benefits, and unknowns.

Abstract:

:Insights into immune-mediated thrombotic thrombocytopenic purpura (iTTP) pathophysiology have led to novel targeted therapies. Immunomodulatory strategies target anti-ADAMTS13 antibodies: rituximab is effective in inducing responses in refractory/relapsed TTP and increasing relapse-free survival; caplacizumab targets the von Willebrand factor-platelet interaction to hasten platelet count recovery and reduce mortality and TTP-related ischemic events. Bortezomib and recombinant ADAMTS13 are under investigation. This review examines how targeted therapies are disrupting current treatment paradigms to improve outcomes of iTTP.

journal_name

Blood

journal_title

Blood

authors

Mazepa MA,Masias C,Chaturvedi S

doi

10.1182/blood.2019000954

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

415-420

issue

5

eissn

0006-4971

issn

1528-0020

pii

blood.2019000954

journal_volume

134

pub_type

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