Abstract:
:Insights into immune-mediated thrombotic thrombocytopenic purpura (iTTP) pathophysiology have led to novel targeted therapies. Immunomodulatory strategies target anti-ADAMTS13 antibodies: rituximab is effective in inducing responses in refractory/relapsed TTP and increasing relapse-free survival; caplacizumab targets the von Willebrand factor-platelet interaction to hasten platelet count recovery and reduce mortality and TTP-related ischemic events. Bortezomib and recombinant ADAMTS13 are under investigation. This review examines how targeted therapies are disrupting current treatment paradigms to improve outcomes of iTTP.
journal_name
Bloodjournal_title
Bloodauthors
Mazepa MA,Masias C,Chaturvedi Sdoi
10.1182/blood.2019000954subject
Has Abstractpub_date
2019-08-01 00:00:00pages
415-420issue
5eissn
0006-4971issn
1528-0020pii
blood.2019000954journal_volume
134pub_type
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