当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Perforin is a critical physiologic regulator of T-cell activation.

Perforin is a critical physiologic regulator of T-cell activation.

Abstract：

:Individuals with impaired perforin-dependent cytotoxic function (Ctx(-)) develop a fatal inflammatory disorder called hemophagocytic lymphohistiocytosis (HLH). It has been hypothesized that immune hyperactivation during HLH is caused by heightened infection, defective apoptosis/responsiveness of Ctx(-) lymphocytes, or enhanced antigen presentation. Whereas clinical and experimental data suggest that increased T-cell activation drives HLH, potential abnormalities of T-cell activation have not been well characterized in Ctx(-) hosts. To define such abnormalities and to test these hypotheses, we assessed in vivo T-cell activation kinetics and viral loads after lymphocytic choriomeningitis virus (LCMV) infection of Ctx(-) mice. We found that increased T-cell activation occurred early during infection of Ctx(-) mice, while they had viral burdens that were identical to those of WT animals, demonstrating that T-cell hyperactivation was independent of viral load. Furthermore, cell transfer and signaling studies indicated that increased antigenic stimulation, not a cell-intrinsic defect of responsiveness, underlay heightened T-cell activation in vivo. Finally, direct measurement of viral antigen presentation demonstrated an increase in Ctx(-) mice that was proportional to abnormal T-cell activation. We conclude that perforin-dependent cytotoxicity has an immunoregulatory role that is distinguishable from its pathogen clearance function and limits T-cell activation in the physiologic context by suppressing antigen presentation.

journal_name

Blood

journal_title

Blood

authors

Lykens JE,Terrell CE,Zoller EE,Risma K,Jordan MB

doi

10.1182/blood-2010-12-324533

subject

Has Abstract

pub_date

2011-07-21 00:00:00

pages

618-26

issue

3

eissn

0006-4971

issn

1528-0020

pii

blood-2010-12-324533

journal_volume

118

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs.

    abstract：:Whereas the final differentiation of conventional dendritic cells (CDCs) from committed precursors occurs locally in secondary lymphoid or peripheral tissues, plasmacytoid dendritic cells (PDCs) are thought to fully develop in the bone marrow from common DC progenitors before migrating to the periphery. In our study, ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-12-326678

    authors： Schlitzer A,Loschko J,Mair K,Vogelmann R,Henkel L,Einwächter H,Schiemann M,Niess JH,Reindl W,Krug A

    更新日期：2011-06-16 00:00:00

  • Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma.

    abstract：:The efficacy and safety of zanolimumab in patients with refractory cutaneous T-cell lymphoma (CTCL) have been assessed in two phase 2, multicenter, prospective, open-label, uncontrolled clinical studies. Patients with treatment refractory CD4(+) CTCL (mycosis fungoides [MF], n = 38; Sézary syndrome [SS], n = 9) receiv...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2006-12-062877

    authors： Kim YH,Duvic M,Obitz E,Gniadecki R,Iversen L,Osterborg A,Whittaker S,Illidge TM,Schwarz T,Kaufmann R,Cooper K,Knudsen KM,Lisby S,Baadsgaard O,Knox SJ

    更新日期：2007-06-01 00:00:00

  • Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.

    abstract：:Meis1 is a homeodomain transcription factor coexpressed with Hoxa9 in most human acute myeloid leukemias (AMLs). In mouse models of leukemia produced by Hoxa9, Meis1 accelerates leukemogenesis. Because Hoxa9 immortalizes myeloid progenitors in the absence of Meis1 expression, the contribution of Meis1 toward leukemia ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-12-4664

    authors： Wang GG,Pasillas MP,Kamps MP

    更新日期：2005-07-01 00:00:00

  • Identification of a leukocyte alloantigen with a high-frequency expression in leukemia patients.

    abstract：:In this report we describe the production and characterization of a monoclonal antibody to the human promyelocytic leukemia cell line HL-60. The antibody, NC-2, is of the IgG1 subclass and precipitates a 50-Kd protein from 125I-labeled HL-60 cells. The antigen is insensitive to treatment with trypsin, papain, or neura...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： O'Connor R,Bradley JG,O'Meara A,Cotter TG

    更新日期：1989-02-01 00:00:00

  • Treatment of familial hemophagocytic lymphohistiocytosis with bone marrow transplantation from HLA genetically nonidentical donors.

    abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is a rare genetic disorder associated with the onset early in life of overwhelming activation of T lymphocytes and macrophages invariably leading to death. Allogeneic bone marrow transplantation (BMT) from an HLA-identical related donor is the treatment of choice in pa...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Jabado N,de Graeff-Meeder ER,Cavazzana-Calvo M,Haddad E,Le Deist F,Benkerrou M,Dufourcq R,Caillat S,Blanche S,Fischer A

    更新日期：1997-12-15 00:00:00

  • Characterization of monoclonal antibodies that recognize canine CD34.

    abstract：:Using a polyclonal antiserum against canine CD34, we previously found that CD34 is expressed on canine bone marrow progenitor cells in a manner analogous to that found in humans. To further characterize CD34+ cells and to facilitate preclinical canine stem cell transplant studies, monoclonal antibodies (MoAbs) were ra...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： McSweeney PA,Rouleau KA,Wallace PM,Bruno B,Andrews RG,Krizanac-Bengez L,Sandmaier BM,Storb R,Wayner E,Nash RA

    更新日期：1998-03-15 00:00:00

  • Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation.

    abstract：:To explore the use of stem/progenitor cells from peripheral blood (PB) for allogeneic transplantation, we have studied the mobilization of progenitor cells in normal donors by growth factors. Normal subjects were administered either granulocyte-macrophage colony-stimulating factor (GM-CSF) at 10 micrograms/kg/d, or G-...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lane TA,Law P,Maruyama M,Young D,Burgess J,Mullen M,Mealiffe M,Terstappen LW,Hardwick A,Moubayed M

    更新日期：1995-01-01 00:00:00

  • Alteration of the erythrocyte membrane skeletal ultrastructure in hereditary spherocytosis, hereditary elliptocytosis, and pyropoikilocytosis.

    abstract：:The membrane skeleton of normal erythrocytes is largely organized into a hexagonal lattice of junctional complexes (JC) crosslinked by spectrin tetramers, and occasional double tetramers and hexamers. To explore possible skeletal alterations in hereditary spherocytosis (HS), elliptocytosis (HE), and pyropoikilocytosis...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Liu SC,Derick LH,Agre P,Palek J

    更新日期：1990-07-01 00:00:00

  • The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes.

    abstract：:We have used (cryo) electron tomography to provide a 3-dimensional (3D) map of the intracellular membrane organization of human platelets at high spatial resolution. Our study shows that the open canalicular system and dense tubular system are highly intertwined and form close associations in specialized membrane regi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-02-268680

    authors： van Nispen tot Pannerden H,de Haas F,Geerts W,Posthuma G,van Dijk S,Heijnen HF

    更新日期：2010-08-19 00:00:00

  • Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States.

    abstract：:von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2015-10-673681

    authors： Flood VH,Christopherson PA,Gill JC,Friedman KD,Haberichter SL,Bellissimo DB,Udani RA,Dasgupta M,Hoffmann RG,Ragni MV,Shapiro AD,Lusher JM,Lentz SR,Abshire TC,Leissinger C,Hoots WK,Manco-Johnson MJ,Gruppo RA,Boggio LN

    更新日期：2016-05-19 00:00:00

  • Intersubunit circular permutation of human hemoglobin.

    abstract：:For many years, human hemoglobin (Hb) isolated from erythrocytes has been investigated as a potential oxygen delivery therapeutic. Advantages with respect to the need for blood typing were balanced with various undesirable properties of cell-free Hb, including cost, overall oxygen affinity, alterations in cooperativit...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v100.1.299

    authors： Sanders KE,Lo J,Sligar SG

    更新日期：2002-07-01 00:00:00

  • Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea.

    abstract：:Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further define the role of rIFN-α, we investigated the outcomes of pegylated-rIFN-α2a (PEG) therapy in ET and PV patients previously treated with...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood.2019000428

    authors： Yacoub A,Mascarenhas J,Kosiorek H,Prchal JT,Berenzon D,Baer MR,Ritchie E,Silver RT,Kessler C,Winton E,Finazzi MC,Rambaldi A,Vannucchi AM,Leibowitz D,Rondelli D,Arcasoy MO,Catchatourian R,Vadakara J,Rosti V,Hexner E

    更新日期：2019-10-31 00:00:00

  • Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells.

    abstract：:The mechanisms underlying granulocyte-colony stimulating factor (G-CSF)-induced mobilization of granulocytic lineage cells from the bone marrow to the peripheral blood remain elusive. We provide evidence that the transcriptional repressor growth factor independence-1 (Gfi-1) is involved in G-CSF-induced mobilization o...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-03-081448

    authors： De La Luz Sierra M,Gasperini P,McCormick PJ,Zhu J,Tosato G

    更新日期：2007-10-01 00:00:00

  • Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival.

    abstract：:The physical interactions between B cells and stromal cells from the lymphoid tissue microenvironment are critical to the survival of normal and malignant B cells. They are principally mediated by integrins expressed on B cells and counterreceptors on stromal cells. Specifically, alpha4beta1 integrin engagement rescue...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-05-1519

    authors： Astier AL,Xu R,Svoboda M,Hinds E,Munoz O,de Beaumont R,Crean CD,Gabig T,Freedman AS

    更新日期：2003-02-01 00:00:00

  • Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies.

    abstract：:We aimed to determine the prognostic impact of monosomal karyotype (MK) in acute myeloid leukemia (AML) in the context of the current World Health Organization (WHO) classification and to evaluate the outcome of MK(+) patients after allogeneic HSCT. Of 1058 patients with abnormal cytogenetics, 319 (30%) were MK MK(+)....

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2011-07-367508

    authors： Kayser S,Zucknick M,Döhner K,Krauter J,Köhne CH,Horst HA,Held G,von Lilienfeld-Toal M,Wilhelm S,Rummel M,Germing U,Götze K,Nachbaur D,Schlegelberger B,Göhring G,Späth D,Morlok C,Teleanu V,Ganser A,Döhner H,Schlenk

    更新日期：2012-01-12 00:00:00

  • Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts.

    abstract：:To further investigate the erythroid nature of the two human erythroleukemia cell lines, K562 and HEL-60, and to define the ontogeny of pyruvate kinase (PK) isozymes (R, M2) in developing human erythroid cells, we have studied the isozymic alterations, if any, during differentiation of these cell lines in vitro and no...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Max-Audit I,Testa U,Kechemir D,Titeux M,Vainchenker W,Rosa R

    更新日期：1984-10-01 00:00:00

  • Global gene expression analysis of human erythroid progenitors.

    abstract：:Understanding the pattern of gene expression during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here, we isolated 4 distinct populations at successive erythropoietin-dependent stages of erythropoiesis, including the terminal, pyknotic stage. The transcriptome was determined using Affy...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-07-290825

    authors： Merryweather-Clarke AT,Atzberger A,Soneji S,Gray N,Clark K,Waugh C,McGowan SJ,Taylor S,Nandi AK,Wood WG,Roberts DJ,Higgs DR,Buckle VJ,Robson KJ

    更新日期：2011-03-31 00:00:00

  • Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.

    abstract：:Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. Previous studies showed that the interaction between CBFβ-smooth muscle myosin heavy chain (SMMHC; encoded by CBFB-MYH11) and RUNX1 plays a critical role in...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2017-04-780106

    authors： Zhen T,Kwon EM,Zhao L,Hsu J,Hyde RK,Lu Y,Alemu L,Speck NA,Liu PP

    更新日期：2017-11-30 00:00:00

  • Mechanical properties of sickle cell membranes.

    abstract：:The mechanical properties of sickle erythrocyte membranes were evaluated in the ektacytometer. When ghosts from the total red blood cell population were examined, the rigidity of the resealed ghosts and their rate of fragmentation by shear stress (t1/2) were normal. However, fractionation on Stractan density gradients...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Messmann R,Gannon S,Sarnaik S,Johnson RM

    更新日期：1990-04-15 00:00:00

  • High-dose etoposide and cyclophosphamide without bone marrow transplantation for resistant hematologic malignancy.

    abstract：:Seventy-five patients with resistant acute leukemia or lymphoma received high-dose cyclophosphamide and etoposide to explore the activity of this combination in resistant hematologic malignancies, and to determine the maximum doses of these drugs that can be combined without bone marrow transplantation. Etoposide was ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Brown RA,Herzig RH,Wolff SN,Frei-Lahr D,Pineiro L,Bolwell BJ,Lowder JN,Harden EA,Hande KR,Herzig GP

    更新日期：1990-08-01 00:00:00

  • Cyclin A1 expression in leukemia and normal hematopoietic cells.

    abstract：:Human cyclin A1 is a newly cloned, tissue-specific cyclin that is prominently expressed in normal testis. In this study, we showed that cyclin A1 was highly expressed in a subset of leukemia samples from patients. The highest frequency of cyclin A1 overexpression was observed in acute myelocytic leukemias, especially ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Yang R,Nakamaki T,Lübbert M,Said J,Sakashita A,Freyaldenhoven BS,Spira S,Huynh V,Müller C,Koeffler HP

    更新日期：1999-03-15 00:00:00

  • Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa.

    abstract：:The glycoprotein (GP) IIb-IIIa complex was isolated from human platelet membranes by immunoaffinity chromatography using a monoclonal antibody specific for GP IIb-IIIa. GP IIb and IIIa were further separated in the presence of sodium dodecyl sulfate (SDS) by gel filtration high-performance liquid chromatography (HPLC)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Hiraiwa A,Matsukage A,Shiku H,Takahashi T,Naito K,Yamada K

    更新日期：1987-02-01 00:00:00

  • Cyclophosphamide induces type I interferon and augments the number of CD44(hi) T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer.

    abstract：:In a previous study, we reported that a single injection of cyclophosphamide (CTX) in tumor-bearing mice resulted in tumor eradication when the animals were subsequently injected with tumor-sensitized lymphocytes. Notably, CTX acted by inducing bystander effects on T cells, and the response to the combined CTX/adoptiv...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Schiavoni G,Mattei F,Di Pucchio T,Santini SM,Bracci L,Belardelli F,Proietti E

    更新日期：2000-03-15 00:00:00

  • Reversal of neutropenia with intravenous gammaglobulin in autoimmune neutropenia of infancy.

    abstract：:Intravenous gammaglobulin (IVIgG) was used to treat autoimmune neutropenia of infancy in two males with repeated infections. The neutrophil count increased significantly in both patients with the initial IVIgG therapy; 1 patient went into remission. The neutrophil count in the other remained above baseline for 3 wk, a...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bussel J,Lalezari P,Hilgartner M,Partin J,Fikrig S,O'Malley J,Barandun S

    更新日期：1983-08-01 00:00:00

  • The alphaC domains of fibrinogen affect the structure of the fibrin clot, its physical properties, and its susceptibility to fibrinolysis.

    abstract：:The functions of the alphaC domains of fibrinogen in clotting and fibrinolysis, which have long been enigmatic, were determined using recombinant fibrinogen truncated at Aalpha chain residue 251. Scanning electron microscopy and confocal microscopy revealed that the fibers of alpha251 clots were thinner and denser, wi...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-05-2150

    authors： Collet JP,Moen JL,Veklich YI,Gorkun OV,Lord ST,Montalescot G,Weisel JW

    更新日期：2005-12-01 00:00:00

  • An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand.

    abstract：:Identification of receptor activator of nuclear factor-kappaB (RANK) and RANK-ligand (RANKL) has provided new insights into the osteoclast differentiation pathway. Osteoclast precursor cells were isolated using monoclonal antibodies against c-Fms and RANK, and the effect of adherence on the in vitro differentiation an...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Miyamoto T,Arai F,Ohneda O,Takagi K,Anderson DM,Suda T

    更新日期：2000-12-15 00:00:00

  • How I treat acute lymphoblastic leukemia in older adolescents and young adults.

    abstract：:At the intersection between children and older adults, the care of adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) poses unique challenges and issues beyond those faced by other age groups. Although the survival of AYA patients is inferior to younger children, growing evidence suggest...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2014-11-551481

    authors： Curran E,Stock W

    更新日期：2015-06-11 00:00:00

  • Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction.

    abstract：:Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarc...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-05-1831

    authors： Massa M,Rosti V,Ferrario M,Campanelli R,Ramajoli I,Rosso R,De Ferrari GM,Ferlini M,Goffredo L,Bertoletti A,Klersy C,Pecci A,Moratti R,Tavazzi L

    更新日期：2005-01-01 00:00:00

  • Sex hormones and the regulation of erythroid spleen colonies development of fetal liver origin.

    abstract：:The development of erythroid colonies of fetal liver hemopoietic cell origin in adult irradiated polycythemic mice was studied. It was found that orchidectomy sharply reduced the number of erythroid colonies developed in the spleen of these polycythemic male recipients. Estrogen injection to the orchidectomized polycy...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bleiberg I,Perah G

    更新日期：1975-04-01 00:00:00

  • Visualization of nitric oxide production by individual platelets during adhesion in flowing blood.

    abstract：:Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using a sens...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-06-579474

    authors： Cozzi MR,Guglielmini G,Battiston M,Momi S,Lombardi E,Miller EC,De Zanet D,Mazzucato M,Gresele P,De Marco L

    更新日期：2015-01-22 00:00:00