Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa.

abstract：:Platelet von Willebrand factor (vWF) has been suggested to play an important role in the hemostatic process. Clinical and experimental data indicate that bleeding time (BT) and platelet-vessel wall interaction cannot be normalized unless the defect of platelet vWF is also corrected. We have examined the effect of norm...

journal_title：Blood

authors： Castillo R,Monteagudo J,Escolar G,Ordinas A,Magallón M,Martín Villar J

更新日期：1991-05-01 00:00:00

abstract：:Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined mechanisms. Our studies indicate that T(H) cells frequently interact with monocytes in inflamed skin and elicit the differentiation of specialized DC subsets c...

journal_title：Blood

authors： Alonso MN,Wong MT,Zhang AL,Winer D,Suhoski MM,Tolentino LL,Gaitan J,Davidson MG,Kung TH,Galel DM,Nadeau KC,Kim J,Utz PJ,Söderström K,Engleman EG

更新日期：2011-09-22 00:00:00

abstract：:During pregnancy the plasma concentration of two different inhibitors of plasminogen activators (PAIs) increases. The only one found in the plasma of nonpregnant women (PAI1) is immunologically related to a PAI of endothelial cells; its plasma activity, as deduced from the inhibition of single-chain tissue-type plasmi...

journal_title：Blood

authors： Kruithof EK,Tran-Thang C,Gudinchet A,Hauert J,Nicoloso G,Genton C,Welti H,Bachmann F

更新日期：1987-02-01 00:00:00

abstract：:Induction of transplantation tolerance by means of bone marrow (BM) transplantation could become a reality if it was possible to achieve engraftment of hematopoietic stem cells under nonlethal preparatory cytoreduction of the recipient. To that end, BM facilitating cells, veto cells, or other tolerance-inducing cells,...

journal_title：Blood

authors： Bachar-Lustig E,Li HW,Gur H,Krauthgamer R,Marcus H,Reisner Y

更新日期：1999-11-01 00:00:00

abstract：:Human recombinant interleukin-4 (IL-4) was studied for its effects on myeloid progenitor cells from normal and leukemic bone marrow cells in the presence and absence of additional growth factors. IL-4 itself did not support myeloid cluster or colony formation (CFU-GM). However, cultures supplied with IL-4 (300 U/mL) a...

journal_title：Blood

authors： Vellenga E,de Wolf JT,Beentjes JA,Esselink MT,Smit JW,Halie MR

更新日期：1990-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to treatment. There is ...

journal_title：Blood

authors： Schuh A,Becq J,Humphray S,Alexa A,Burns A,Clifford R,Feller SM,Grocock R,Henderson S,Khrebtukova I,Kingsbury Z,Luo S,McBride D,Murray L,Menju T,Timbs A,Ross M,Taylor J,Bentley D

更新日期：2012-11-15 00:00:00

abstract：:Six hundred twelve eligible, previously untreated patients with active multiple myeloma and at least some data available for analysis were entered into a randomized trial (Southwest Oncology Group [SWOG] Phase III myeloma study 8229/30), in which the prognostic significance of pretreatment serum beta 2 microglobulin l...

journal_title：Blood

authors： Durie BG,Stock-Novack D,Salmon SE,Finley P,Beckord J,Crowley J,Coltman CA

更新日期：1990-02-15 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:In essential thrombocythemia (ET), the JAK2-V617F mutation is usually restricted to a subpopulation of neutrophils and platelets, and production of JAK2 wild-type (WT) platelets is not suppressed. Nonmutated precursor cells may, therefore, be susceptible to the acquisition of further JAK2 mutations. We used a common s...

journal_title：Blood

authors： Lambert JR,Everington T,Linch DC,Gale RE

更新日期：2009-10-01 00:00:00

abstract：:Reticulocytes release small membrane vesicles termed exosomes during their maturation into erythrocytes. It has been suggested that reticulocytes remodel the plasma membrane of the immature red cell during erythropoiesis by specifically eliminating various proteins. We report here that exosome release is associated wi...

journal_title：Blood

authors： Blanc L,Barres C,Bette-Bobillo P,Vidal M

更新日期：2007-11-01 00:00:00

abstract：:We have identified a distinct population of colony-forming cells that give rise to mononuclear cells expressing an enzyme marker and other features of the osteoclast in bone marrow cultures stimulated by conditioned medium of a murine tumor cell line. These colony-forming cells were defined as osteoclast colony-formin...

journal_title：Blood

authors： Lee MY,Lottsfeldt JL,Fevold KL

更新日期：1992-10-01 00:00:00

abstract：:The interaction of von Willebrand factor (vWF) with the alpha v beta 3 integrin of human umbilical vein endothelial cells is dependent on the RGD sequence present at residues 1744-1746 of the mature vWF subunit. We compared vWF and its two dimeric fragments, SpIII (residues 1-1365) and SpII (residues 1366-2050), as ad...

journal_title：Blood

authors： Denis C,Williams JA,Lu X,Meyer D,Baruch D

更新日期：1993-12-15 00:00:00

abstract：:Although chemotherapy can induce complete responses in patients with chronic lymphocytic leukemia (CLL), it is not considered curative. Treated patients generally develop recurrent disease requiring additional therapy, which can cause worsening immune dysfunction, myelosuppression, and selection for chemotherapy-resis...

journal_title：Blood

authors： Kater AP,van Oers MH,Kipps TJ

更新日期：2007-10-15 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized into endemic, sporadic and immunodeficiency-associated subtypes. BL has distinct pathologic and clinical features, characterized by rapidly progressive tumors with high rates of extranodal involvement. Next generation sequenci...

journal_title：Blood

authors： Crombie JL,LaCasce AS

更新日期：2020-11-10 00:00:00

abstract：:Deferoxamine (DFO) is a high-affinity Fe (III) chelator produced by Streptomyces pilosus. DFO is used clinically to remove iron from patients with iron overload disorders. Orally administered DFO cannot be absorbed, and therefore it must be injected. Here we show that DFO induces ferritin degradation in lysosomes thro...

journal_title：Blood

authors： De Domenico I,Ward DM,Kaplan J

更新日期：2009-11-12 00:00:00

abstract：:Although thrombin is a key enzyme in the coagulation cascade and is required for both normal hemostasis and pathologic thrombogenesis, it also participates in its own negative feedback via activation of protein C, which downregulates thrombin generation by enzymatically inactivating factors Va and VIIIa. Our group and...

journal_title：Blood

authors： Tucker EI,Verbout NG,Markway BD,Wallisch M,Lorentz CU,Hinds MT,Shatzel JJ,Pelc LA,Wood DC,McCarty OJT,Di Cera E,Gruber A

更新日期：2020-02-27 00:00:00

abstract：:Neuroserpin, a recently identified inhibitor of tissue-type plasminogen activator (tPA), is primarily localized to neurons within the central nervous system, where it is thought to regulate tPA activity. In the present study neuroserpin expression and its potential therapeutic benefits were examined in a rat model of ...

journal_title：Blood

authors： Yepes M,Sandkvist M,Wong MK,Coleman TA,Smith E,Cohan SL,Lawrence DA

更新日期：2000-07-15 00:00:00

abstract：:A 2-yr-old black girl presented with a thalassemic clinical picture and was found to have nearly 100% fetal hemoglobin in her red cells. Pedigree analysis indicated that she was a heterozygote for the hereditary persistence of fetal hemoglobin gene and for a beta O-thalassemia gene. A brother, who also had nearly 100%...

journal_title：Blood

authors： Beutler E,Turner E,Kuhl W

更新日期：1981-06-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is typified by the t(15;17) translocation, which leads to the formation of the PML/RARA fusion gene and predicts a beneficial response to retinoids. However, approximately 10% of all APL cases lack the classic t(15;17). This group includes (1) cases with cryptic PML/RARA gene rearran...

journal_title：Blood

authors： Sainty D,Liso V,Cantù-Rajnoldi A,Head D,Mozziconacci MJ,Arnoulet C,Benattar L,Fenu S,Mancini M,Duchayne E,Mahon FX,Gutierrez N,Birg F,Biondi A,Grimwade D,Lafage-Pochitaloff M,Hagemeijer A,Flandrin G,Groupe Français d'

更新日期：2000-08-15 00:00:00

abstract：:Brentuximab vedotin induces an overall response rate of 75% in patients with relapsed/refractory Hodgkin lymphoma, but its impact on future allogeneic transplantation (allo-HCT) is not known. We retrospectively examined the records of 18 patients with relapsed/refractory Hodgkin lymphoma who were treated on brentuxima...

journal_title：Blood

authors： Chen R,Palmer JM,Thomas SH,Tsai NC,Farol L,Nademanee A,Forman SJ,Gopal AK

更新日期：2012-06-28 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 are proteins with proteinase-inhibiting and cytokine properties. TIMP-1 is active primarily in B cells and B-cell lymphomas, whereas TIMP-2 expression is restricted to T cells. The expression of TIMP-1 and TIMP-2 in lymph nodes from patients with Hodgkin disea...

journal_title：Blood

authors： Oelmann E,Herbst H,Zühlsdorf M,Albrecht O,Nolte A,Schmitmann C,Manzke O,Diehl V,Stein H,Berdel WE

更新日期：2002-01-01 00:00:00

abstract：:The blood platelet is the only human cell known to have a circumferential band of microtubules. However, the mechanisms involved in assembly of the multi-looped coil, its interaction with the cell membrane to support discoid shape, and constriction into tight rings around centrally concentrated organelles in activated...

journal_title：Blood

authors： White JG,Krumwiede M

更新日期：1985-04-01 00:00:00

abstract：:A hairy cell leukemia population was used as a clonal model for studying the direct immunomodulatory effects of recombinant interferon-alpha A (rIFN-alpha A) and rIFN-gamma on human B-cell proliferation. The leukemic cell population KON was notably quiescent when incubated in medium alone but was induced to significan...

journal_title：Blood

authors： Mongini P,Seremetis S,Blessinger C,Rudich S,Winchester R,Brunda M

更新日期：1988-11-01 00:00:00

abstract：:To characterize juvenile chronic myelogenous leukemia (JCML), the proliferative properties of bone marrow (BM) and peripheral blood (PB) cells from nine patients were studied using assays for CFU-C and CFU-GEMM and liquid cultures. All specimens showed two reproducible abnormalities: impaired growth of normal hematopo...

journal_title：Blood

authors： Estrov Z,Grunberger T,Chan HS,Freedman MH

更新日期：1986-05-01 00:00:00

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In ...

journal_title：Blood

authors： Erkers T,Xie BJ,Kenyon LJ,Smith B,Rieck M,Jensen KP,Ji X,Basina M,Strober S,Negrin RS,Maecker HT,Meyer EH

更新日期：2020-03-12 00:00:00

abstract：:Allogeneic hematopoietic stem-cell transplantation (HSCT) remains an effective strategy for inducing durable remission in chronic myeloid leukemia (CML). Reduced-intensity conditioning (RIC) regimens extend HSCT to older patients and those with comorbidities who would otherwise not be suitable candidates for HSCT. The...

journal_title：Blood

authors： Kebriaei P,Detry MA,Giralt S,Carrasco-Yalan A,Anagnostopoulos A,Couriel D,Khouri IF,Anderlini P,Hosing C,Alousi A,Champlin RE,de Lima M

更新日期：2007-11-01 00:00:00

abstract：:Human natural killer (NK) cell development is a step-by-step process characterized by phenotypically identified stages. CD161 is a marker informative of the NK cell lineage commitment, whereas CD56, CD117, and CD94/NKG2A contribute to define discrete differentiation stages. In cells undergoing in vitro differentiation...

journal_title：Blood

authors： Montaldo E,Vitale C,Cottalasso F,Conte R,Glatzer T,Ambrosini P,Moretta L,Mingari MC

更新日期：2012-04-26 00:00:00

abstract：:ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative stat...

journal_title：Blood

authors： Neubauer A,Shannon K,Liu E

更新日期：1991-02-01 00:00:00

abstract：:Signaling mediated by various Notch receptors and their ligands regulates diverse biological processes, including lymphoid cell fate decisions. Notch1 is required during T-cell development, while Notch2 and the Notch ligand Delta-like1 control marginal zone B (MZB) cell development. We previously determined that Maste...

journal_title：Blood

authors： Wu L,Maillard I,Nakamura M,Pear WS,Griffin JD

更新日期：2007-11-15 00:00:00