Isolation of microtubule coils from normal human platelets.

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells targeting CD19 have emerged as a leading engineered T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma. The phase 1/2 clinical trials that led to US Food and Drug Administration approval excluded patients with central nervous system (CNS) involvement, due to stri...

journal_title：Blood

authors： Frigault MJ,Dietrich J,Martinez-Lage M,Leick M,Choi BD,DeFilipp Z,Chen YB,Abramson J,Crombie J,Armand P,Nayak L,Panzini C,Riley LS,Gallagher K,Maus MV

更新日期：2019-09-12 00:00:00

abstract：:Among the most striking morphological features of acute nonlymphoblastic leukemias (ANLL) is the occurrence of eosinophilic cytoplasmic inclusions known as Auer rods on Auer bodies. We examined immature myeloid cells from the peripheral blood of 9 human fetuses of 16-19 wk gestation for the presence of such structures...

journal_title：Blood

authors： Newburger PE,Novak TJ,McCaffrey RP

更新日期：1983-03-01 00:00:00

abstract：:Serine proteinase inhibitors (serpins) play a vital regulatory role in a wide range of biological processes, and serpins from viruses have been implicated in pathogen evasion of the host defence system. For the first time, we report a functional serpin gene from nematodes that may function in this manner. This gene, n...

journal_title：Blood

authors： Zang X,Yazdanbakhsh M,Jiang H,Kanost MR,Maizels RM

更新日期：1999-08-15 00:00:00

abstract：:The prognosis of acute myeloid leukemia (AML) is very poor in elderly patients, especially in those classically defined as having unfavorable cytogenetics. The recent monosomal karyotype (MK) entity, defined as 2 or more autosomal monosomies or combination of 1 monosomy with structural abnormalities, has been reported...

journal_title：Blood

authors： Perrot A,Luquet I,Pigneux A,Mugneret F,Delaunay J,Harousseau JL,Barin C,Cahn JY,Guardiola P,Himberlin C,Recher C,Vey N,Lioure B,Ojeda-Uribe M,Fegueux N,Berthou C,Randriamalala E,Béné MC,Ifrah N,Witz F,Groupe Ouest

更新日期：2011-07-21 00:00:00

abstract：:In the phase 3 Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease Who Have Reached Therapeutic Goals With Enzyme Replacement Therapy (ENCORE), at 1 year, eliglustat was noninferior to imiglucerase enzyme therapy in maintaining stable platelet counts, hemoglobin concentrations, and spleen and l...

journal_title：Blood

authors： Cox TM,Drelichman G,Cravo R,Balwani M,Burrow TA,Martins AM,Lukina E,Rosenbloom B,Goker-Alpan O,Watman N,El-Beshlawy A,Kishnani PS,Pedroso ML,Gaemers SJM,Tayag R,Peterschmitt MJ

更新日期：2017-04-27 00:00:00

abstract：:To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138(+) plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters desc...

journal_title：Blood

authors： Broyl A,Hose D,Lokhorst H,de Knegt Y,Peeters J,Jauch A,Bertsch U,Buijs A,Stevens-Kroef M,Beverloo HB,Vellenga E,Zweegman S,Kersten MJ,van der Holt B,el Jarari L,Mulligan G,Goldschmidt H,van Duin M,Sonneveld P

更新日期：2010-10-07 00:00:00

abstract：:Natural killer (NK) cells can alter the outcome of hematopoietic cell transplantation (HCT) if donor alloreactivity targets the recipient. Since most NK cells express inhibitory killer-immunoglobulin receptors (KIRs), we hypothesized that the susceptibility of recipient cells to donor NK cell-mediated lysis is genetic...

journal_title：Blood

authors： Miller JS,Cooley S,Parham P,Farag SS,Verneris MR,McQueen KL,Guethlein LA,Trachtenberg EA,Haagenson M,Horowitz MM,Klein JP,Weisdorf DJ

更新日期：2007-06-01 00:00:00

abstract：:To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVB...

journal_title：Blood

authors： Walmsley M,Cleaver D,Patient R

更新日期：2008-02-01 00:00:00

abstract：:Reversible interactions of glycoconjugates on leukocytes with P- and E-selectin on endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the first step in their recruitment to sites of injury. Although selectin ligands on hematopoietic precursors have been identified, here we review ...

journal_title：Blood

authors： Zarbock A,Ley K,McEver RP,Hidalgo A

更新日期：2011-12-22 00:00:00

abstract：:During thrombopoiesis, maturing megakaryocytes (MKs) migrate within the complex bone marrow stromal microenvironment from the proliferative osteoblastic niche to the capillary-rich vascular niche where proplatelet formation and platelet release occurs. This physiologic process involves proliferation, differentiation, ...

journal_title：Blood

authors： Dhanjal TS,Pendaries C,Ross EA,Larson MK,Protty MB,Buckley CD,Watson SP

更新日期：2007-05-15 00:00:00

abstract：:Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invasive telemetric moni...

journal_title：Blood

authors： Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

更新日期：2011-04-07 00:00:00

abstract：:Interleukin-10 (IL-10) selectively inhibited lipopolysaccharide (LPS)-induced chemoattractant cytokine gene expression: levels of IP-10 mRNA were markedly suppressed in IL-10-treated mouse peritoneal macrophages, whereas the expression of the RANTES mRNA was only modestly reduced. IL-10 inhibited IP-10 mRNA accumulati...

journal_title：Blood

authors： Tebo JM,Kim HS,Gao J,Armstrong DA,Hamilton TA

更新日期：1998-12-15 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-li...

journal_title：Blood

authors： Gupta M,Hendrickson AE,Yun SS,Han JJ,Schneider PA,Koh BD,Stenson MJ,Wellik LE,Shing JC,Peterson KL,Flatten KS,Hess AD,Smith BD,Karp JE,Barr S,Witzig TE,Kaufmann SH

更新日期：2012-01-12 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional profiling has been used to highlight similarities between DLBCL tumor cells and normal B-cell subtypes and associate genes and pathways with ...

journal_title：Blood

authors： Monti S,Savage KJ,Kutok JL,Feuerhake F,Kurtin P,Mihm M,Wu B,Pasqualucci L,Neuberg D,Aguiar RC,Dal Cin P,Ladd C,Pinkus GS,Salles G,Harris NL,Dalla-Favera R,Habermann TM,Aster JC,Golub TR,Shipp MA

更新日期：2005-03-01 00:00:00

abstract：:Survival in infants younger than 1 year who have acute lymphoblastic leukemia (ALL) is inferior whether MLL is rearranged (R) or germline (G). MLL translocations confer chemotherapy resistance, and infants experience excess complications. We characterized in vitro sensitivity to the pan-antiapoptotic BCL-2 family inhi...

journal_title：Blood

authors： Urtishak KA,Edwards AY,Wang LS,Hudome A,Robinson BW,Barrett JS,Cao K,Cory L,Moore JS,Bantly AD,Yu QC,Chen IM,Atlas SR,Willman CL,Kundu M,Carroll AJ,Heerema NA,Devidas M,Hilden JM,Dreyer ZE,Hunger SP,Reaman GH,

更新日期：2013-04-04 00:00:00

abstract：:In this issue of Blood, Baychelier et al identify a ligand for a major natural killer (NK) cell receptor that mediates natural cytotoxicity toward tumor cells, thus ending a search that lasted well over a decade. ...

journal_title：Blood

authors： Rajagopalan S,Long EO

更新日期：2013-10-24 00:00:00

abstract：:Multiple myeloma (MM) is associated with severe normochromic/normocytic anemia. This study demonstrates that the abnormal up-regulation of apoptogenic receptors, including both Fas ligand (L) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), by highly malignant myeloma cells is involved in the patho...

journal_title：Blood

authors： Silvestris F,Cafforio P,Tucci M,Dammacco F

更新日期：2002-02-15 00:00:00

abstract：:The pathologic hallmarks of thrombotic thrombocytopenic purpura (TTP) include endothelial cell proliferation and subendothelial hyalin deposits in the microvasculature leading to symptomatic thrombotic occlusions. Plasma or sera from three consecutive patients with TTP were subjected to multiple analyses to determine ...

journal_title：Blood

authors： Burns ER,Zucker-Franklin D

更新日期：1982-10-01 00:00:00

abstract：:In children with acute lymphoblastic leukemia (ALL), the level of minimal residual disease (MRD) at the end of induction strongly predicts outcome, presumably because it measures both drug sensitivity and the number of leukemic cells requiring elimination. Children with high levels (> 10(-3) leukemic cells per marrow ...

journal_title：Blood

authors： Brisco J,Hughes E,Neoh SH,Sykes PJ,Bradstock K,Enno A,Szer J,McCaul K,Morley AA

更新日期：1996-06-15 00:00:00

abstract：:Anemia is a common clinical problem, and there is much interest in its role in promoting left ventricular hypertrophy through increasing cardiac workload. Normally, red blood cell production is adjusted through the regulation of erythropoietin (Epo) production by the kidney. One important cause of anemia is relative d...

journal_title：Blood

authors： Binley K,Askham Z,Iqball S,Spearman H,Martin L,de Alwis M,Thrasher AJ,Ali RR,Maxwell PH,Kingsman S,Naylor S

更新日期：2002-10-01 00:00:00

abstract：:HGAL is a newly identified germinal center (GC)-specific gene whose expression by the tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas. The function of HGAL is unknown. Previous studies demonstrated that HGAL is dispensable for GC formation, immuno...

journal_title：Blood

authors： Lu X,Chen J,Malumbres R,Cubedo Gil E,Helfman DM,Lossos IS

更新日期：2007-12-15 00:00:00

abstract：:The presence of multiple VHDJH joinings in upwards of 30% of acute lymphoblastic leukemias (ALL) suggests a relative instability of the rearranged immunoglobulin heavy chain (IgH) gene, but the mechanisms involved are not completely understood. An investigation of the structure of the VHDJH joinings using complementar...

journal_title：Blood

authors： Wasserman R,Yamada M,Ito Y,Finger LR,Reichard BA,Shane S,Lange B,Rovera G

更新日期：1992-01-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma (MM) patients, but not in cells from control subjects (Rettig et al, Science 276:1851, 1997). We sought to confirm these observation...

journal_title：Blood

authors： Tisdale JF,Stewart AK,Dickstein B,Little RF,Dubé I,Cappe D,Dunbar CE,Brown KE

更新日期：1998-10-15 00:00:00

abstract：:For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is poor, and there is a need for novel therapies to improve outcome. We screened samples from children with B-lineage ALL entered into the ALL-REZ BFM 2002 clinical trial (www.clinicaltrials.gov, #NCT00114348) for somatic mutations ac...

journal_title：Blood

authors： Irving J,Matheson E,Minto L,Blair H,Case M,Halsey C,Swidenbank I,Ponthan F,Kirschner-Schwabe R,Groeneveld-Krentz S,Hof J,Allan J,Harrison C,Vormoor J,von Stackelberg A,Eckert C

更新日期：2014-11-27 00:00:00

abstract：:This study was undertaken to gain further insight into the severely impaired natural killer (NK) activity we and others have previously observed in patients with chronic lymphocytic leukemia (CLL). Normal individuals' NK cells are large granular lymphocytes (LGL) that (A) bind to and lyse NK-sensitive cells, including...

journal_title：Blood

authors： Kay NE,Zarling JM

更新日期：1984-02-01 00:00:00

abstract：:A novel Hodgkin's disease (HD) derived cell line, L1236, was established from the peripheral blood of a patient with advanced Hodgkin's disease. Analysis of immunoglobulin (Ig) gene rearrangements revealed a biallelic Ig heavy chain and a monoallelic Ig kappa light chain gene rearrangement, pointing to a B-lymphoid or...

journal_title：Blood

authors： Wolf J,Kapp U,Bohlen H,Kornacker M,Schoch C,Stahl B,Mücke S,von Kalle C,Fonatsch C,Schaefer HE,Hansmann ML,Diehl V

更新日期：1996-04-15 00:00:00

abstract：:Targeted irradiation of the bone marrow with radiolabeled monoclonal antibodies (radioimmunotherapy) represents a novel therapeutic approach with both myeloablative and antileukemic potential. In an open-label, single-center pilot study, 30 pediatric and adolescent patients undergoing hematopoietic cell transplantatio...

journal_title：Blood

authors： Schulz AS,Glatting G,Hoenig M,Schuetz C,Gatz SA,Grewendorf S,Sparber-Sauer M,Muche R,Blumstein N,Kropshofer G,Suttorp M,Bunjes D,Debatin KM,Reske SN,Friedrich W

更新日期：2011-04-28 00:00:00

abstract：:The effects of protein deprivation on erythropoietin (Ep) production were studied. The posthypoxia plasma Ep levels of rats fed a protein-free diet for only 1 day prior to being exposed to 0.5 atmosphere for 7 hr were significantly lower than those of comparably hypoxic rats maintained on a normal diet. The postthypox...

journal_title：Blood

authors： Anagnostou A,Schade S,Ashkinaz M,Barone J,Fried W

更新日期：1977-12-01 00:00:00

abstract：:Natural killer cells (NK) were studied to determine factors important in their expansion. Flourescence-activated cell sorter (FACS) purified CD56+/CD3- NK cells cultured alone for 18 days in rIL-2 containing medium (1,000 U/mL) showed enhanced cytotoxicity but only minimal expansion. NK expansion was increased (12.5 +...

journal_title：Blood

authors： Pierson BA,Gupta K,Hu WS,Miller JS

更新日期：1996-01-01 00:00:00