Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.

abstract：:Neuropilin-1 (Npn-1) is a receptor shared by class 3 semaphorins and heparin-binding forms of vascular endothelial growth factor (VEGF), protein families that regulate endothelial and neuronal-cell function. Ligand interaction with Npn-1 dictates the choice of signal transducer; plexins transduce semaphorin signals, a...

journal_title：Blood

authors： Narazaki M,Tosato G

更新日期：2006-05-15 00:00:00

abstract：:Platelets are pivotal to the process of arterial thrombosis resulting in ischemic stroke. Occlusive thrombosis is initiated by the interaction of von Willebrand factor (vWf) and platelet glycoprotein (GP) Ibalpha. Three polymorphisms have been described in GP Ibalpha (Kozak T/C polymorphism, variable number of tandem ...

journal_title：Blood

authors： Baker RI,Eikelboom J,Lofthouse E,Staples N,Afshar-Kharghan V,López JA,Shen Y,Berndt MC,Hankey G

更新日期：2001-07-01 00:00:00

abstract：:The prevalence, the prognostic effect, and interaction with other molecular markers of DNMT3A mutations was studied in 415 patients with acute myeloid leukemia (AML) younger than 60 years. We show mutations in DNMT3A in 96 of 415 patients with newly diagnosed AML (23.1%). Univariate Cox regression analysis showed that...

journal_title：Blood

authors： Ribeiro AF,Pratcorona M,Erpelinck-Verschueren C,Rockova V,Sanders M,Abbas S,Figueroa ME,Zeilemaker A,Melnick A,Löwenberg B,Valk PJ,Delwel R

更新日期：2012-06-14 00:00:00

abstract：:Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...

journal_title：Blood

authors： Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

更新日期：1986-03-01 00:00:00

abstract：:Crystallographic and electron microscopy studies revealed genuflexed (bent) integrins in both unliganded (inactive) and physiologic ligandbound (active) states, suggesting that local conformational changes are sufficient for activation. Herein we have explored the role of local changes in the contact region between th...

journal_title：Blood

authors： Gupta V,Gylling A,Alonso JL,Sugimori T,Ianakiev P,Xiong JP,Arnaout MA

更新日期：2007-04-15 00:00:00

abstract：:Highly purified natural killer (NK) cell suspensions were tested for their capacity to release colony-stimulating activity (CSA) in vitro. NK cell suspensions comprised primarily CD16+ cells and were devoid of CD3+ T cells, CD15+ monocytes, and of B cells. CSA was detected in the NK cell supernatants and sustained the...

journal_title：Blood

authors： Pistoia V,Zupo S,Corcione A,Roncella S,Matera L,Ghio R,Ferrarini M

更新日期：1989-07-01 00:00:00

abstract：:The treatment of mice with high doses of 5-fluorouracil (5-FU) results in an enrichment of primitive hematopoietic progenitors. Using this procedure, we obtained a new class of murine hematopoietic colonies that had very high secondary plating efficiencies in vitro and could differentiate into not only myeloid cells b...

journal_title：Blood

authors： Tsunoda J,Okada S,Suda J,Nagayoshi K,Nakauchi H,Hatake K,Miura Y,Suda T

更新日期：1991-07-15 00:00:00

abstract：:Fas (CD95/Apo-1) mutations were previously reported as the genetic defect responsible for human lymphoproliferative syndrome associated with autoimmune manifestations (also known as autoimmune lymphoproliferative syndrome or Canale-Smith syndrome). We have identified 14 new heterozygous Fas mutations. Analysis of pati...

journal_title：Blood

authors： Rieux-Laucat F,Blachère S,Danielan S,De Villartay JP,Oleastro M,Solary E,Bader-Meunier B,Arkwright P,Pondaré C,Bernaudin F,Chapel H,Nielsen S,Berrah M,Fischer A,Le Deist F

更新日期：1999-10-15 00:00:00

abstract：:In this issue of Blood, Donadieu et al present what may be the most encouraging data to date on a group of patients with Langerhans cell histiocytosis (LCH), which historically has poor disease-free survival and poor overall survival. ...

journal_title：Blood

authors： Stine KC

更新日期：2015-09-17 00:00:00

abstract：:By stimulating the expression of murine IP-10 and Mig, CXC chemokines that inhibit neovascularization and cause damage to established tumor vasculature, human B cells immortalized with Epstein-Barr virus (EBV) can promote an effective antitumor response in athymic mice. In the present study, we examined the potential ...

journal_title：Blood

authors： Cherney BW,Sgadari C,Kanegane C,Wang F,Tosato G

更新日期：1998-04-01 00:00:00

abstract：:Lymphocyte kinetic studies employing 51-chromium-labeled autologous lymphocytes were performed in nine normal volunteers in order to determine the effects of hydrocortisone administration on the recirculating versus the nonrecirculating intravascular lymphocyte pools. Following infusion of labeled cells, the recircula...

journal_title：Blood

authors： Fauci AS,Dale DC

更新日期：1975-08-01 00:00:00

abstract：:The receptors for interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are heterodimers comprised of ligand specific alpha chains and a common beta chain. The genes encoding the IL-5 receptor alpha chain and the common beta chain reside on chromosome 3 and 22 respectively, while th...

journal_title：Blood

authors： Kremer E,Baker E,D'Andrea RJ,Slim R,Phillips H,Moretti PA,Lopez AF,Petit C,Vadas MA,Sutherland GR

更新日期：1993-07-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) has previously been shown to stimulate granulocyte, macrophage, and megakaryocyte lineages to act as an erythroid burst-promoting activity and to stimulate limited replication of spleen colony-forming cells. Here we demonstrate that murine GM-CSF alone or in co...

journal_title：Blood

authors： McNiece IK,Robinson BE,Quesenberry PJ

更新日期：1988-07-01 00:00:00

abstract：:Perioperative management of antithrombotic therapy is a situation that occurs frequently and requires consideration of the patient, the procedure, and an expanding array of anticoagulant and antiplatelet agents. Preoperative assessment must address each patient's risk for thromboembolic events balanced against the ris...

journal_title：Blood

authors： Ortel TL

更新日期：2012-12-06 00:00:00

abstract：:Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated...

journal_title：Blood

authors： Coughlin CM,Vance BA,Grupp SA,Vonderheide RH

更新日期：2004-03-15 00:00:00

abstract：:We report the transient response of a patient with the ETV6-ABL fusion gene to imatinib mesylate (STI571). A 38-year-old man was referred with an erroneous diagnosis of Philadelphia-positive chronic myeloid leukemia in blastic transformation for treatment with the ABL tyrosine kinase inhibitor, STI571. Further investi...

journal_title：Blood

authors： O'Brien SG,Vieira SA,Connors S,Bown N,Chang J,Capdeville R,Melo JV

更新日期：2002-05-01 00:00:00

abstract：:Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications ...

journal_title：Blood

authors： Iannone R,Luznik L,Engstrom LW,Tennessee SL,Askin FB,Casella JF,Kickler TS,Goodman SN,Hawkins AL,Griffin CA,Noffsinger L,Fuchs EJ

更新日期：2001-06-15 00:00:00

abstract：:To assess the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation, we studied 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) given unmodified marrow grafts from HLA-id...

journal_title：Blood

authors： Sullivan KM,Weiden PL,Storb R,Witherspoon RP,Fefer A,Fisher L,Buckner CD,Anasetti C,Appelbaum FR,Badger C

更新日期：1989-05-01 00:00:00

abstract：:Platelets contain and release several matrix metalloproteinases (MMPs). Among these, active MMP-2 enhances platelet aggregation by favoring the activation of phosphatidylinositol 3- kinase (PI3K) and contributes to arterial thrombosis. The platelet surface target of MMP-2 and the mechanism through which it primes plat...

journal_title：Blood

authors： Sebastiano M,Momi S,Falcinelli E,Bury L,Hoylaerts MF,Gresele P

更新日期：2017-02-16 00:00:00

abstract：:Phospholipase C (PLC)-mediated hydrolysis of membrane phospholipids results in the production of diacylglycerol, inositol phosphates, and choline metabolites. Inositol triphosphate increases calcium levels, while diacylglycerol activates protein kinase C. The present studies demonstrate that exogenous PLC generates in...

journal_title：Blood

authors： Stone RM,Weber BL,Spriggs DR,Kufe DW

更新日期：1988-08-01 00:00:00

abstract：:Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin. Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains largely unknown. EC-specific inactivation of either VE or N-cadherin leads to early fetal lethality suggesting that these cadherins play a nonredun...

journal_title：Blood

authors： Giampietro C,Taddei A,Corada M,Sarra-Ferraris GM,Alcalay M,Cavallaro U,Orsenigo F,Lampugnani MG,Dejana E

更新日期：2012-03-01 00:00:00

abstract：:On encountering a danger signal, dendritic cells (DCs) undergo a complex maturation process and become specialized in antigen presentation. We previously reported that engagement of major histocompatibility complex (MHC) class II molecules located on immature DCs in membrane rafts by lymphocyte activation gene-3 (LAG-...

journal_title：Blood

authors： Andreae S,Buisson S,Triebel F

更新日期：2003-09-15 00:00:00

abstract：:As a mediator of neurogenic inflammation and pain, we hypothesized that levels of the neuropeptide Substance P (SP) would be elevated in patients with sickle cell disease (SCD) with vaso-occlusive pain crisis. SP is a known stimulator of tumor necrosis factor-alpha (TNF-alpha) release and a promoter of interleukin-8 (...

journal_title：Blood

authors： Michaels LA,Ohene-Frempong K,Zhao H,Douglas SD

更新日期：1998-11-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has previously been shown to inhibit the growth of OPM-2 human myeloma cells. The growth inhibition was postulated to result from a transcriptional downregulation of interleukin-6 receptor alpha (IL-6Ralpha) with IL-6Rbeta (gp130) unaffected. To formally test this hypothesis, an expressi...

journal_title：Blood

authors： Chen YH,Lavelle D,DeSimone J,Uddin S,Platanias LC,Hankewych M

更新日期：1999-07-01 00:00:00

abstract：:The transmembrane 4 superfamily (TM4SF) has come into prominence for its association with a wide range of cell surface molecules, especially integrins. We report that TM4SF molecules CD9, CD63, and CD81 are physically associated with c-kit receptor tyrosine kinase in the human factor-dependent myeloid cell line, MO7e....

journal_title：Blood

authors： Anzai N,Lee Y,Youn BS,Fukuda S,Kim YJ,Mantel C,Akashi M,Broxmeyer HE

更新日期：2002-06-15 00:00:00

abstract：:The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revo...

journal_title：Blood

authors： Silvennoinen O,Hubbard SR

更新日期：2015-05-28 00:00:00

abstract：:Oncogenic transformation of CD4(+) T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of nove...

journal_title：Blood

authors： Kress AK,Kalmer M,Rowan AG,Grassmann R,Fleckenstein B

更新日期：2011-03-31 00:00:00

abstract：:Ischemia of the heart, brain, and limbs is a leading cause of morbidity and mortality worldwide. Treatment with tissue type plasminogen activator (tPA) can dissolve blood clots and can ameliorate the clinical outcome in ischemic diseases. But the underlying mechanism by which tPA improves ischemic tissue regeneration ...

journal_title：Blood

authors： Ohki M,Ohki Y,Ishihara M,Nishida C,Tashiro Y,Akiyama H,Komiyama H,Lund LR,Nitta A,Yamada K,Zhu Z,Ogawa H,Yagita H,Okumura K,Nakauchi H,Werb Z,Heissig B,Hattori K

更新日期：2010-05-27 00:00:00

abstract：:Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transc...

journal_title：Blood

authors： Lee J,Kim K,Kim JH,Jin HM,Choi HK,Lee SH,Kook H,Kim KK,Yokota Y,Lee SY,Choi Y,Kim N

更新日期：2006-04-01 00:00:00

abstract：:BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate-resistant BCR-ABL kinase domain (KD) mutants, except T315I. We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL) cells to compare incidence and types of KD mutants emerging in the p...

journal_title：Blood

authors： Bradeen HA,Eide CA,O'Hare T,Johnson KJ,Willis SG,Lee FY,Druker BJ,Deininger MW

更新日期：2006-10-01 00:00:00