Radioimmunotherapy-based conditioning for hematopoietic cell transplantation in children with malignant and nonmalignant diseases.


:Targeted irradiation of the bone marrow with radiolabeled monoclonal antibodies (radioimmunotherapy) represents a novel therapeutic approach with both myeloablative and antileukemic potential. In an open-label, single-center pilot study, 30 pediatric and adolescent patients undergoing hematopoietic cell transplantation for malignant (n = 16) and nonmalignant (n = 14) disorders received treatment with a ⁹⁰Y-labeled anti-CD66 monoclonal antibody. Patients with a high risk of relapse (n = 7) received additional treatment with standard conditioning based on either total body irradiation or busulfan to intensify the antileukemic effect. In patients with comorbidities (n = 23), radioimmunotherapy was combined with a reduced-intensity conditioning regimen to reduce systemic toxicity. Preferential irradiation of the bone marrow was achieved in all patients. Nonrelapse mortality was 4 (13%) of 30 patients. In patients with malignant diseases, the probabilities of overall and disease-free survival at 2 years were 0.69 (95% confidence interval 0.37-0.87) and 0.46 (95% confidence interval 0.19-0.70), respectively. In patients with nonmalignant diseases, the probability of both overall and disease-free survival at 2 years was 0.94 (95% confidence interval 0.63-0.99). This pilot study demonstrates that radioimmunotherapy is effective in achieving myeloablation with low additional toxicity when used in combination with standard or reduced-intensity conditioning in young patients.






Schulz AS,Glatting G,Hoenig M,Schuetz C,Gatz SA,Grewendorf S,Sparber-Sauer M,Muche R,Blumstein N,Kropshofer G,Suttorp M,Bunjes D,Debatin KM,Reske SN,Friedrich W




Has Abstract


2011-04-28 00:00:00
















  • Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor.

    abstract::Combination cytokine therapy continues to be evaluated in an effort to stimulate multilineage hematopoietic reconstitution after bone marrow myelosuppression. This study evaluated the efficacy of combination therapy with the synthetic interleukin-3 receptor agonist, Synthokine-SC55494, and recombinant methionyl human ...


    pub_type: 杂志文章


    authors: MacVittie TJ,Farese AM,Herodin F,Grab LB,Baum CM,McKearn JP

    更新日期:1996-05-15 00:00:00

  • Subset of DC-SIGN(+) dendritic cells in human blood transmits HIV-1 to T lymphocytes.

    abstract::The dendritic cell (DC)-specific molecule DC-SIGN is a receptor for the HIV-1 envelope glycoprotein gp120 and is essential for the dissemination of HIV-1. DC-SIGN is expressed by DCs, both monocyte-derived DCs and DCs in several tissues, including mucosa and lymph nodes. To identify a DC-SIGN(+) DC in blood that may b...


    pub_type: 杂志文章


    authors: Engering A,Van Vliet SJ,Geijtenbeek TB,Van Kooyk Y

    更新日期:2002-09-01 00:00:00

  • Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation.

    abstract::The effects of selectively depleting CD8+ cells from donor bone marrow were assessed in 36 patients receiving transplantation from an HLA-identical sibling as treatment for leukemia. Donor bone marrow underwent ex vivo treatment using anti-Leu-2 monoclonal antibody and complement. Patients received cyclosporine post-t...


    pub_type: 杂志文章


    authors: Champlin R,Ho W,Gajewski J,Feig S,Burnison M,Holley G,Greenberg P,Lee K,Schmid I,Giorgi J

    更新日期:1990-07-15 00:00:00

  • Differential expression of cytokines in human blood monocyte subpopulations.

    abstract::Cytokine expression was analyzed in CD14++ regular monocytes and in the novel subset of CD14+/CD16+ small monocytes. Biologic activity for tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 in the supernatant of elutriator-enriched, cell sorter-purified small monocytes was about 10-fold lower compared with re...


    pub_type: 杂志文章


    authors: Ziegler-Heitbrock HW,Ströbel M,Kieper D,Fingerle G,Schlunck T,Petersmann I,Ellwart J,Blumenstein M,Haas JG

    更新日期:1992-01-15 00:00:00

  • Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas.

    abstract::Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin's lymphoma (NHL) that is highly heterogeneous from both clinical and histopathologic viewpoints. The immunoglobulin (Ig) heavy (H) chain variable region genes were examined in 71 patients with untreated primary DLBCL. Fifty-eight potentially functio...


    pub_type: 杂志文章


    authors: Lossos IS,Okada CY,Tibshirani R,Warnke R,Vose JM,Greiner TC,Levy R

    更新日期:2000-03-01 00:00:00

  • Three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) or epirubicin, bleomycin, vinblastine, and methotrexate (EBVM) plus extended field radiation therapy in early and intermediate Hodgkin disease: 10-year results of a randomized tria

    abstract::From 1990 to 1996, a total of 386 adult patients with early/intermediate Hodgkin disease (HD) were randomly assigned to receive 3 cycles of adriamycin, bleomycin, vinblastine, dacarbazine (an alkylating agent), and methylprednisolone (ABVDm, arm A) or epirubicin, bleomycin, vinblastine, methotrexate, and methylprednis...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: le Maignan C,Desablens B,Delwail V,Dib M,Berthou C,Vigier M,Ghandour C,Atmani S,Casassus P,Maisonneuve H,Le Mevel A,Traulle C,Bernard M,Briere J,Colonna P,Andrieu JM

    更新日期:2004-01-01 00:00:00

  • Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells.

    abstract::Although the mechanisms by which all-trans-retinoic acid (RA) regulates gene transcription are well understood, very little is known on the signaling events regulating RA-dependent initiation of mRNA translation. We examined whether the mammalian target of rapamycin (mTOR)/p70 S6 kinase pathway is activated by RA. RA ...


    pub_type: 杂志文章


    authors: Lal L,Li Y,Smith J,Sassano A,Uddin S,Parmar S,Tallman MS,Minucci S,Hay N,Platanias LC

    更新日期:2005-02-15 00:00:00

  • Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

    abstract::Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated with favorable overall...


    pub_type: 杂志文章


    authors: Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Del

    更新日期:2012-03-08 00:00:00

  • Manipulating leukocyte interactions in vivo through optogenetic chemokine release.

    abstract::Light-mediated release of signaling ligands, such as chemoattractants, growth factors, and cytokines is an attractive strategy for investigation and therapeutic targeting of leukocyte communication and immune responses. We introduce a versatile optogenetic method to control ligand secretion, combining UV-conditioned e...


    pub_type: 杂志文章


    authors: Sarris M,Olekhnovitch R,Bousso P

    更新日期:2016-06-09 00:00:00

  • Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG.

    abstract::Drug-induced immune thrombocytopenia (DITP) is an adverse drug effect mediated by drug-dependent antibodies. Intravenous immunoglobulin (IVIG) is frequently used to treat DITP and primary immune thrombocytopenia (ITP). Despite IVIG's proven beneficial effects in ITP, its efficacy in DITP is unclear. We have establishe...


    pub_type: 杂志文章


    authors: Liang SX,Pinkevych M,Khachigian LM,Parish CR,Davenport MP,Chong BH

    更新日期:2010-09-16 00:00:00

  • Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation.

    abstract::Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication in hematopoietic stem cell transplant (HSCT) recipients. To determine the impact of pretransplantation hyperferritinemia on the risk of SOS after HSC transplantation, we retrospectively studied 427 HSCT recipients (179 autologous and 248 allogenei...


    pub_type: 杂志文章


    authors: Maradei SC,Maiolino A,de Azevedo AM,Colares M,Bouzas LF,Nucci M

    更新日期:2009-08-06 00:00:00

  • Chronic myelocytic leukemia (CML): failure to detect residual normal committed stem cells in vitro.

    abstract::Granulocytic colonies grown in culture from marrow and peripheral blood from five patients with Ph1-positive CML and heterozygous at the G-6-PD locus were analyzed for G-6-PD in order to identify CFU-C that do not arise from the CML clone. The patients had both B and A enzymes in normal tissues, but their CML clones t...


    pub_type: 杂志文章


    authors: Singer JW,Fialkow PJ,Steinmann L,Najfeld V,Stein SJ,Robinson WA

    更新日期:1979-02-01 00:00:00

  • Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl.

    abstract::Bcr-Abl tyrosine kinase activity initiates a number of intracellular signaling cascades that result in leukemogenesis. Imatinib mesylate, a specific Bcr-Abl tyrosine kinase inhibitor, has been highly successful in the treatment of chronic myelogenous leukemia (CML). However, the emergence of imatinib resistance and th...


    pub_type: 杂志文章


    authors: Gu JJ,Santiago L,Mitchell BS

    更新日期:2005-04-15 00:00:00

  • Human regulatory T cells in allogeneic stem cell transplantation.

    abstract::GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/...


    pub_type: 杂志文章


    authors: Ukena SN,Velaga S,Geffers R,Grosse J,Baron U,Buchholz S,Stadler M,Bruder D,Ganser A,Franzke A

    更新日期:2011-09-29 00:00:00

  • p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors.

    abstract::The proapoptotic function of p53 is thought to underlie most anticancer modalities and is also activated in response to oncogenic insults, such as overexpression of the Myc oncoprotein. Here we generated tractable B lymphomas using retroviral transduction of the MYC oncogene into hematopoietic cells with 2 knock-in al...


    pub_type: 杂志文章


    authors: Yu D,Carroll M,Thomas-Tikhonenko A

    更新日期:2007-06-01 00:00:00

  • Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10.

    abstract::Virally infected cells degrade intracellular viral proteins proteolytically and present the resulting peptides in association with major histocompatibility complex (MHC) class I molecules to CD8+ cytotoxic T lymphocytes (CTLs). These cells are normally prone to CTL-mediated elimination. However, several viruses have e...


    pub_type: 杂志文章


    authors: Zeidler R,Eissner G,Meissner P,Uebel S,Tampé R,Lazis S,Hammerschmidt W

    更新日期:1997-09-15 00:00:00

  • Involvement of bcl-2 gene in Japanese follicular lymphoma.

    abstract::A t(14;18) (q32;q21) chromosome translocation is closely associated with the follicular lymphoma, which is prevalent in the United States, and the t(14;18) causes the juxtaposition of a bcl-2 gene on chromosome 18 with an immunoglobulin heavy-chain gene locus on chromosome 14. Genomic DNAs from 30 Japanese patients wi...


    pub_type: 杂志文章


    authors: Amakawa R,Fukuhara S,Ohno H,Doi S,Oguma S,Tanabe S,Yamabe H,Edamura S,Tomono N,Nasu K

    更新日期:1989-02-15 00:00:00

  • PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway.

    abstract::Cytotoxic lymphocytes clear infected and transformed cells by releasing the content of lytic granules at cytolytic synapses, and the ability of cytolytic effectors to kill in an iterative manner has been documented previously. Although bidirectional trafficking of cytolytic machinery components along the endosomal pat...


    pub_type: 杂志文章


    authors: Capuano C,Paolini R,Molfetta R,Frati L,Santoni A,Galandrini R

    更新日期:2012-03-08 00:00:00

  • Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis.

    abstract::Several studies demonstrate that hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with severe pathological conditions such as acute respiratory distress syndrome, acute chest syndrome, and sepsis. However, the precise molecular mechanisms involved in the pathology of heme...


    pub_type: 杂志文章


    authors: James J,Srivastava A,Varghese MV,Eccles CA,Zemskova M,Rafikova O,Rafikov R

    更新日期:2020-08-06 00:00:00

  • Genetic inactivation of TRAF3 in canine and human B-cell lymphoma.

    abstract::Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas (cBCLs). We performed a survey of 84 canine NHL tumor...


    pub_type: 杂志文章


    authors: Bushell KR,Kim Y,Chan FC,Ben-Neriah S,Jenks A,Alcaide M,Fornika D,Grande BM,Arthur S,Gascoyne RD,Steidl C,Morin RD

    更新日期:2015-02-05 00:00:00

  • A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

    abstract::The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pe...


    pub_type: 杂志文章


    authors: Paugh SW,Paugh BS,Rahmani M,Kapitonov D,Almenara JA,Kordula T,Milstien S,Adams JK,Zipkin RE,Grant S,Spiegel S

    更新日期:2008-08-15 00:00:00

  • Monovalent Fc receptor blockade by an anti-Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity.

    abstract::Patients with immune thrombocytopenia (ITP) commonly have antiplatelet antibodies that cause thrombocytopenia through Fcγ receptors (FcγRs). Antibodies specific for FcγRs, designed to inhibit antibody-FcγR interaction, had been shown to improve ITP in refractory human patients. However, the development of such FcγR-sp...


    pub_type: 杂志文章


    authors: Yu X,Menard M,Prechl J,Bhakta V,Sheffield WP,Lazarus AH

    更新日期:2016-01-07 00:00:00

  • X-linked lymphoproliferative syndromes: brothers or distant cousins?

    abstract::X-linked lymphoproliferative disease (XLP1), described in the mid-1970s and molecularly defined in 1998, and XLP2, reported in 2006, are prematurely lethal genetic immunodeficiencies that share susceptibility to overwhelming inflammatory responses to certain infectious triggers. Signaling lymphocytic activation molecu...


    pub_type: 杂志文章,评审


    authors: Filipovich AH,Zhang K,Snow AL,Marsh RA

    更新日期:2010-11-04 00:00:00

  • Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts.

    abstract::Alas2 encodes the erythroid-specific delta-aminolevulinate synthase (ALAS2 or ALAS-E), the first enzyme in heme biosynthesis in erythroid cells. Mice with the Alas2-null phenotype showed massive cytoplasmic, but not mitochondrial, iron accumulation in their primitive erythroblasts. Because these animals died by day 11...


    pub_type: 杂志文章


    authors: Harigae H,Nakajima O,Suwabe N,Yokoyama H,Furuyama K,Sasaki T,Kaku M,Yamamoto M,Sassa S

    更新日期:2003-02-01 00:00:00

  • Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: a role for host NK cells in regulating HSC engraftment.

    abstract::The events that regulate engraftment and long-term repopulating ability of hematopoietic stem cells (HSCs) after transplantation are not well defined. We report for the first time that major histocompatibility complex (MHC) class I K plays a critical role in HSC engraftment via interaction with recipient natural kille...


    pub_type: 杂志文章


    authors: Huang Y,Rezzoug F,Chilton PM,Grimes HL,Cramer DE,Ildstad ST

    更新日期:2004-08-01 00:00:00

  • Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist.

    abstract::Previous results have demonstrated that anti-D therapy in children with chronic auto-immune thrombocytopenic purpura (AITP) induced a significant increase in several pro- and anti-inflammatory plasma cytokines within 2 hours of administration. To investigate the biologic basis of these early in vivo responses, we deve...


    pub_type: 杂志文章


    authors: Coopamah MD,Freedman J,Semple JW

    更新日期:2003-10-15 00:00:00

  • Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts.

    abstract::To further investigate the erythroid nature of the two human erythroleukemia cell lines, K562 and HEL-60, and to define the ontogeny of pyruvate kinase (PK) isozymes (R, M2) in developing human erythroid cells, we have studied the isozymic alterations, if any, during differentiation of these cell lines in vitro and no...


    pub_type: 杂志文章


    authors: Max-Audit I,Testa U,Kechemir D,Titeux M,Vainchenker W,Rosa R

    更新日期:1984-10-01 00:00:00

  • Photochemical inactivation of cell-associated human immunodeficiency virus in platelet concentrates.

    abstract::Photochemical decontamination (PCD) of platelet concentrates, with adequate preservation of platelet function, has been shown using 8-methoxypsoralen (8-MOP) and long wavelength UV light (UVA). To further evaluate this technique, models for the inactivation of pathogenic human cell-associated viruses and integrated pr...


    pub_type: 杂志文章


    authors: Lin L,Londe H,Hanson CV,Wiesehahn G,Isaacs S,Cimino G,Corash L

    更新日期:1993-07-01 00:00:00

  • High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome.

    abstract::We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced...


    pub_type: 临床试验,杂志文章


    authors: Jaccard A,Royer B,Bordessoule D,Brouet JC,Fermand JP

    更新日期:2002-04-15 00:00:00

  • Near-normal circulatory survival of rabbit red cells exposed to high levels of Ca and ionophore in vitro.

    abstract::The belief is widely held, on the basis of indirect evidence, that a substantial, even brief elevation of red cell Ca content must result in a marked shortening of circulatory survival. To test this notion directly, we exposed rabbit red cells in vitro to the ionophore A23187 and Ca so as to produce sustained uniform ...


    pub_type: 杂志文章


    authors: Bookchin RM,Roth EF Jr,Lew VL

    更新日期:1985-07-01 00:00:00