The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction.

abstract：:Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys. Previously, we found that macrophages engaged in recycling of red cells were depleted from the tissues of Hmox1...

journal_title：Blood

authors： Kovtunovych G,Ghosh MC,Ollivierre W,Weitzel RP,Eckhaus MA,Tisdale JF,Yachie A,Rouault TA

更新日期：2014-08-28 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune disease with a complex pathogenesis. As in many B cell-related autoimmune diseases, rituximab (RTX) has been shown to increase platelet counts in some ITP patients. From an immunologic standpoint, the mode of action of RTX and the reasons underlying its limited efficacy h...

journal_title：Blood

authors： Audia S,Samson M,Guy J,Janikashvili N,Fraszczak J,Trad M,Ciudad M,Leguy V,Berthier S,Petrella T,Aho-Glélé S,Martin L,Maynadié M,Lorcerie B,Rat P,Cheynel N,Katsanis E,Larmonier N,Bonnotte B

更新日期：2011-10-20 00:00:00

abstract：:Multiple myeloma is characterized by genomic alterations frequently involving gains and losses of chromosomes. Single nucleotide polymorphism (SNP)-based mapping arrays allow the identification of copy number changes at the sub-megabase level and the identification of loss of heterozygosity (LOH) due to monosomy and u...

journal_title：Blood

authors： Walker BA,Leone PE,Jenner MW,Li C,Gonzalez D,Johnson DC,Ross FM,Davies FE,Morgan GJ

更新日期：2006-09-01 00:00:00

abstract：:In this investigation, we studied the importance of cellular glutathione (GSH) in the hexose monophosphate shunt (HMPS) activity of unstimulated human erythrocytes and the mechanism by which pyruvate stimulates the HMPS. The rate of HMPS activity was measured by the production of radioactive CO2 from 14C-1-glucose or ...

journal_title：Blood

authors： Sagone AL Jr,Balcerzak SP,Metz EN

更新日期：1975-01-01 00:00:00

abstract：:The plasma membrane calcium pump (PMCA) is the only active Ca2+ transporter in human red blood cells (RBCs). Previous measurements of maximal Ca2+ extrusion rates (Vmax) reported only mean values in the RBC population. Despite early evidence for differences in Ca2+ extrusion capacity among RBCs, the precise Vmax distr...

journal_title：Blood

authors： Lew VL,Daw N,Perdomo D,Etzion Z,Bookchin RM,Tiffert T

更新日期：2003-12-01 00:00:00

abstract：:Biosynthesis of leukotrienes (LTs) occurs in human myeloid cells and B lymphocytes. However, the function of leukotrienes in B lymphocytes is unclear. Here, we report that B-cell chronic lymphocytic leukemia (B-CLL) cells produce leukotriene B(4), and that specific leukotriene biosynthesis inhibitors counteracted CD40...

journal_title：Blood

authors： Runarsson G,Liu A,Mahshid Y,Feltenmark S,Pettersson A,Klein E,Björkholm M,Claesson HE

更新日期：2005-02-01 00:00:00

abstract：:Fas ligand (FasL) and perforin pathways not only are the major mechanisms of T cell-mediated cytotoxicity but also are involved in homeostatic regulation of these T cells. In the present study, we tested whether CD8+ donor T cells that are deficient in both perforin and FasL (cytotoxic double deficient [cdd]) could in...

journal_title：Blood

authors： Maeda Y,Levy RB,Reddy P,Liu C,Clouthier SG,Teshima T,Ferrara JL

更新日期：2005-03-01 00:00:00

abstract：:Serial erythrocyte volume distribution curves were used to characterize changes in erythrocyte subpopulations following the induction of Heinz body hemolytic anemia in cats. Macrocytes produced in response to hemolysis were observed after loss of reticulum. After recovery from hemolysis, a gradual reduction in mean ce...

journal_title：Blood

authors： Weiser MG,Kociba GJ

更新日期：1982-08-01 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:The effect of lipopolysaccharide (LPS) on endothelial cells is a key component of the inflammatory response seen in Gram-negative sepsis. LPS does not cause death of cultured human endothelial cells. However, when the expression of new proteins is inhibited by cycloheximide, microvascular endothelial cells in culture ...

journal_title：Blood

authors： Hu X,Yee E,Harlan JM,Wong F,Karsan A

更新日期：1998-10-15 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:Adenovirus infections occur in 5% to 21% of patients following stem cell transplantation (SCT), with an associated mortality of up to 50%. However, a lack of prospective studies has hampered further developments in the understanding and management of this infection in the posttransplantation setting. We prospectively ...

journal_title：Blood

authors： Chakrabarti S,Mautner V,Osman H,Collingham KE,Fegan CD,Klapper PE,Moss PA,Milligan DW

更新日期：2002-09-01 00:00:00

abstract：:Reconstitution of cellular immunity by 3 months after hematopoietic stem cell transplantation (HSCT) is a critical determinant of the long-term success of the transplantation. We analyzed the factors affecting recovery of cytomegalovirus (CMV)-specific CD4+ and CD8+ function at 3 months after HSCT by univariate and mu...

journal_title：Blood

authors： Hakki M,Riddell SR,Storek J,Carter RA,Stevens-Ayers T,Sudour P,White K,Corey L,Boeckh M

更新日期：2003-10-15 00:00:00

abstract：:Autologous bone marrow transplantation (ABMT) makes it possible to escalate the dose of cytotoxic treatment to a lethal range. Disease-free survival (DFS) following myeloablative therapy and ABMT has been shown to be superior to conventional treatment in high risk patients with acute myelogenous leukemia (AML). It was...

journal_title：Blood

authors： Körbling M,Hunstein W,Fliedner TM,Cayeux S,Dörken B,Fehrentz D,Haas R,Ho AD,Keilholz U,Knauf W

更新日期：1989-11-01 00:00:00

abstract：:The effect of hydroxyurea in 35 patients with chronic granulocytic leukemia (CGL), who either had entered an accelerated phase of the disease or had experienced excessive myelosuppression following alkylating agents, was studied. By either intravenous or oral administration, the drug was successful in reducing periphe...

journal_title：Blood

authors： Schwartz JH,Cannellos GP

更新日期：1975-07-01 00:00:00

abstract：:Managing vitamin K antagonist (VKA) therapy is challenging in children because of a narrow therapeutic range and wide inter- and intra-individual variability in dose response. Only a few small studies have investigated the effect of nongenetic and genetic factors on the dose response to VKAs in children. In a cohort s...

journal_title：Blood

authors： Moreau C,Bajolle F,Siguret V,Lasne D,Golmard JL,Elie C,Beaune P,Cheurfi R,Bonnet D,Loriot MA

更新日期：2012-01-19 00:00:00

abstract：:Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain. The result is coma and seizures with death in more than 20% of cases. Because the brain endothelium is at the interface of these pro...

journal_title：Blood

authors： Tripathi AK,Sha W,Shulaev V,Stins MF,Sullivan DJ Jr

更新日期：2009-11-05 00:00:00

abstract：:The composition of the erythrocyte plasma membrane is extensively modified during the intracellular growth of the malaria parasite Plasmodium falciparum. It has been previously shown that an 80-kD phosphoprotein is associated with the plasma membrane of human red blood cells (RBCs) infected with trophozoite/schizont s...

journal_title：Blood

authors： Chishti AH,Maalouf GJ,Marfatia S,Palek J,Wang W,Fisher D,Liu SC

更新日期：1994-06-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an increased tendency toward leukemic transformation. We used targeted next-generation sequencing (NGS) of 104 genes to detect somatic mutations in a cohort of 197 MPN patients and followed clo...

journal_title：Blood

authors： Lundberg P,Karow A,Nienhold R,Looser R,Hao-Shen H,Nissen I,Girsberger S,Lehmann T,Passweg J,Stern M,Beisel C,Kralovics R,Skoda RC

更新日期：2014-04-03 00:00:00

abstract：:In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

journal_title：Blood

authors： Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

更新日期：2003-05-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for hemol...

journal_title：Blood

authors： Brodsky RA

更新日期：2014-10-30 00:00:00

abstract：:Hematopoietic bone marrow stem cells generate differentiated blood cells and, when transplanted, may contribute to other organs, such as the brain, heart, and liver. An understanding of in vivo clonal behavior of stem cells will have important implications for cellular and gene therapy. For the first time, we have dir...

journal_title：Blood

authors： Schmidt M,Zickler P,Hoffmann G,Haas S,Wissler M,Muessig A,Tisdale JF,Kuramoto K,Andrews RG,Wu T,Kiem HP,Dunbar CE,von Kalle C

更新日期：2002-10-15 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells frequently resist apoptosis induction by chemotherapeutic agents; however, the mechanism of unresponsiveness has not been elucidated. Here, we show that cytochrome c fails to stimulate apop...

journal_title：Blood

authors： Sun Y,Orrenius S,Pervaiz S,Fadeel B

更新日期：2005-05-15 00:00:00

abstract：:Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell type...

journal_title：Blood

authors： McCrann DJ,Eliades A,Makitalo M,Matsuno K,Ravid K

更新日期：2009-08-06 00:00:00

abstract：:Congenital erythropoietic porphyria (Günther's disease) is a rare disorder of heme biosynthesis inherited in an autosomal recessive fashion. The molecular abnormality responsible for the characteristic defect in uroporphyrinogen III synthase activity was investigated in two patients. For the first patient, complementa...

journal_title：Blood

authors： Deybach JC,de Verneuil H,Boulechfar S,Grandchamp B,Nordmann Y

更新日期：1990-05-01 00:00:00

abstract：:Mast cells accumulate at sites of neovascularization, solid tumors, and many immune reactions. Such accumulation requires directed migration of mature mast cells or their precursors. The nature of the chemoattractants that regulate mast cell motility and the identity of the receptors that mediate the chemotactic respo...

journal_title：Blood

authors： Meininger CJ,Yano H,Rottapel R,Bernstein A,Zsebo KM,Zetter BR

更新日期：1992-02-15 00:00:00

abstract：:The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and Asia submitted clinical and pathologic information on PTCLs diagnosed and ...

journal_title：Blood

authors： Savage KJ,Harris NL,Vose JM,Ullrich F,Jaffe ES,Connors JM,Rimsza L,Pileri SA,Chhanabhai M,Gascoyne RD,Armitage JO,Weisenburger DD,International Peripheral T-Cell Lymphoma Project.

更新日期：2008-06-15 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection is characterized by the massive infiltration of secondary lymphoid organs with activated CD8(+) T lymphocytes. While converging data indicated that these cells were HIV-specific cytotoxic T lymphocytes (CTLs) responsible for HIV spread limitation, direct evidence was lackin...

journal_title：Blood

authors： Hosmalin A,Samri A,Dumaurier MJ,Dudoit Y,Oksenhendler E,Karmochkine M,Autran B,Wain-Hobson S,Cheynier R

更新日期：2001-05-01 00:00:00

abstract：:Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) kinase regulates TNFα...

journal_title：Blood

authors： Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW

更新日期：2011-12-08 00:00:00

abstract：:To evaluate the importance of the thymus for the reconstitution of immunity in recipients of a T-cell-depleted bone marrow, we measured the appearance of CD4(+)CD45RA(+)RO(-) naive T cells (thymic rebound), restoration of the diversity of the T-cell-receptor (TCR) repertoire and the response to vaccinations with tetan...

journal_title：Blood

authors： Roux E,Dumont-Girard F,Starobinski M,Siegrist CA,Helg C,Chapuis B,Roosnek E

更新日期：2000-09-15 00:00:00