当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Monitoring unfractionated heparin in children: a parallel-cohort randomized controlled trial comparing 2 dose protocols.

Monitoring unfractionated heparin in children: a parallel-cohort randomized controlled trial comparing 2 dose protocols.

Abstract：

:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, activated partial thromboplastin time (aPTT) and activated clotting time (ACT); (2) other factors influencing UFH effect; (3) the agreement between the assays; and (4) the association between UFH effect and clinical outcome. HEARTCAT was a parallel-cohort randomized controlled trial comparing high-dose (100 U/kg bolus followed by age-based continuous infusion in randomized children) vs low-dose UFH (50 U/kg bolus) during cardiac catheterization in children. Blood samples were drawn before and after UFH administration at 30, 60, and 90 minutes. Four-hundred and two samples of 149 patients were evaluable. Anti-Xa, aPTT, and ACT all showed good discrimination between UFH doses. Regression models demonstrated the following determinants of UFH effect: UFH dose, age, baseline antithrombin (for anti-Xa), and baseline levels of aPTT and ACT, respectively. UFH effects were lower in infants compared with older children, which was more pronounced at low-dose than at high-dose UFH. Agreement between the 3 assays was poor. Most aPTT values were above therapeutic range or beyond measuring limit and thus of limited value for UFH monitoring. No association of UFH dose or effect with clinical outcome could be observed. In conclusion, all assays reflected a significant UFH dose-effect relationship, however, with poor agreement between the respective tests. The age-dependency of UFH effect was confirmed. Notably, the influence of age on UFH effect was dose-dependent.

journal_name

Blood

journal_title

Blood

authors

Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

doi

10.1182/blood-2015-06-651661

subject

Has Abstract

pub_date

2015-10-29 00:00:00

pages

2091-7

issue

18

eissn

0006-4971

issn

1528-0020

pii

blood-2015-06-651661

journal_volume

126

pub_type

杂志文章,随机对照试验

相关文献

BLOOD文献大全
  • The molecular pathogenesis of primary mediastinal large B-cell lymphoma.

    abstract：:Primary mediastinal large B-cell lymphoma (PMBCL) is a recognized non-Hodgkin lymphoma entity with unique pathologic, clinical, and molecular characteristics distinct from those of other diffuse large B-cell lymphomas. Immunohistochemical characterization and molecular studies strongly suggest that PMBCL is of germina...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2011-05-326538

    authors： Steidl C,Gascoyne RD

    更新日期：2011-09-08 00:00:00

  • In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: a novel approach for cancer treatment.

    abstract：:One major obstacle to the effective treatment of cancer is to distinguish between tumor cells and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities are ideal therapeutic targets because they are unique to the disease. We describe the use of a novel approach based on the cataly...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Cobaleda C,Sánchez-García I

    更新日期：2000-02-01 00:00:00

  • Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis.

    abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-08-041004

    authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

    更新日期：2007-05-15 00:00:00

  • Accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH.

    abstract：:Telomere length has been linked to disease stage and degree of (pan-)cytopenia in patients with bone marrow failure syndromes. The aim of the current study was to analyze the impact of replicative stress on telomere length in residual glycosylphosphatidylinositol-positive (GPI+) versus GPI- hematopoiesis in patients w...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-10-3996

    authors： Beier F,Balabanov S,Buckley T,Dietz K,Hartmann U,Rojewski M,Kanz L,Schrezenmeier H,Brümmendorf TH

    更新日期：2005-07-15 00:00:00

  • A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation.

    abstract：:Cord blood (CB) is used increasingly as a source of hematopoietic stem cells because of a lower risk of acute and chronic graft-versus-host disease (GVHD). However, there is some concern regarding the ability to adequately reconstitute host immune response due to the immaturity and naivety of CB T cells. This study wa...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.v99.4.1458

    authors： Talvensaari K,Clave E,Douay C,Rabian C,Garderet L,Busson M,Garnier F,Douek D,Gluckman E,Charron D,Toubert A

    更新日期：2002-02-15 00:00:00

  • Pseudo-Bernard-Soulier syndrome: thrombocytopenia caused by autoantibody to platelet glycoprotein Ib.

    abstract：:The Bernard-Soulier syndrome is an inherited bleeding disorder that is due to a deficiency in platelet glycoprotein Ib. Bernard-Soulier platelets fail to agglutinate in response to ristocetin despite normal levels of factor VIII:von Willebrand factor. We report a patient who developed severe refractory thrombocytopeni...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Devine DV,Currie MS,Rosse WF,Greenberg CS

    更新日期：1987-08-01 00:00:00

  • Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

    abstract：:Primary myelofibrosis (PMF) is the most serious myeloproliferative disorder, characterized by clonal myeloproliferation associated with cytokine-mediated bone marrow stromal reaction including fibrosis and osteosclerosis. Current drug therapy remains mainly palliative. Because the NF-kappaB pathway is implicated in th...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2006-10-054502

    authors： Wagner-Ballon O,Pisani DF,Gastinne T,Tulliez M,Chaligné R,Lacout C,Auradé F,Villeval JL,Gonin P,Vainchenker W,Giraudier S

    更新日期：2007-07-01 00:00:00

  • Specific accumulation of circulating monocytes and polymorphonuclear leukocytes on platelet thrombi in a vascular injury model.

    abstract：:The adhesion of leukocytes to platelets deposited at the site of vascular injury may represent an important mechanism by which leukocytes contribute to hemostasis and thrombosis. In this study, we examined whether, in comparison with their distribution in circulating blood, certain leukocyte types are enriched at site...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kirchhofer D,Riederer MA,Baumgartner HR

    更新日期：1997-02-15 00:00:00

  • Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.

    abstract：:Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in the overproduction o...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2013-05-506212

    authors： Bulut GB,Sulahian R,Yao H,Huang LJ

    更新日期：2013-12-05 00:00:00

  • Determination of platelet antigens and glycoproteins in the human fetus.

    abstract：:The autosomal recessive transmission of Glanzmann's thrombasthenia (GT) and Bernard-Soulier syndrome (BSS), together with requests of families who already had children with these diseases, prompted us to investigate the feasibility of their antenatal diagnosis. The preliminary step leading to the early detection of GT...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Gruel Y,Boizard B,Daffos F,Forestier F,Caen J,Wautier JL

    更新日期：1986-08-01 00:00:00

  • Prognostic implications of evaluation for lymph node involvement by T-cell antigen receptor gene rearrangement in mycosis fungoides.

    abstract：:We investigated the correlation between the detection of clonal rearrangement of the T-cell antigen receptor gene (TCRR) in lymph node tissue with histopathologic lymph node classification in 33 patients with mycosis fungoides with and without the Sezary Syndrome. We analyzed DNA extracted from lymph nodes that were h...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lynch JW Jr,Linoilla I,Sausville EA,Steinberg SM,Ghosh BC,Nguyen DT,Schechter GP,Fischmann AB,Ihde DC,Stocker JL

    更新日期：1992-06-15 00:00:00

  • Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.

    abstract：:Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced treatment regimen. Patients were stratified into a standard-risk group (SRG), a medium-risk group (MRG), both defined by adequate early treatment response; and a high-risk group (HRG), defi...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Schrappe M,Reiter A,Ludwig WD,Harbott J,Zimmermann M,Hiddemann W,Niemeyer C,Henze G,Feldges A,Zintl F,Kornhuber B,Ritter J,Welte K,Gadner H,Riehm H

    更新日期：2000-06-01 00:00:00

  • Thrombopoietin, kit ligand, and flk2/flt3 ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34+Thy-1+Lin- cells with preserved ability to engraft SCID-hu bone.

    abstract：:CD34(+)Thy-1(+)Lin- cells are enriched for primitive hematopoietic progenitor cells (PHP), as defined by the cobblestone area-forming cell (CAFC) assay, and for bone marrow (BM) repopulating hematopoietic stem cells (HSC), as defined by the in vivo SCID-hu bone assay. We evaluated the effects of different cytokine com...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Luens KM,Travis MA,Chen BP,Hill BL,Scollay R,Murray LJ

    更新日期：1998-02-15 00:00:00

  • Identification and characterization of a differentiation antigen in human neutrophils and monocytes.

    abstract：:Human promyelocytic leukemia (HL-60) cells were induced to differentiate into macrophage-like cells by treatment with 10(-7) mol/L 1,25-dihydroxyvitamin D3 (VD3). A monoclonal antibody (MoAb, 60B8), reactive with the particulate of the differentiated cells but not of the untreated cells, was isolated. The antigen reco...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Nozawa R,Kato H,Ito T,Yokota T

    更新日期：1988-05-01 00:00:00

  • Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.

    abstract：:An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-12-127621

    authors： Cao YA,Wagers AJ,Karsunky H,Zhao H,Reeves R,Wong RJ,Stevenson DK,Weissman IL,Contag CH

    更新日期：2008-12-01 00:00:00

  • Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations.

    abstract：:There has been increasing interest in the involvement of mammalian homeobox (HOX) genes in hematopoietic regulation. The HOX genes are clustered in 4 chromosomes in mice and humans. In general, 5' end HOX gene expression is predominant in hematopoietic stem cell populations, whereas 3' end HOX gene expression are prim...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Zimmermann F,Rich IN

    更新日期：1997-04-15 00:00:00

  • Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status.

    abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-11-4394

    authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

    更新日期：2005-06-15 00:00:00

  • Identification and characterization of a high-affinity granulocyte-macrophage colony-stimulating factor receptor on primary rat oligodendrocytes.

    abstract：:We previously showed the presence of receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) on tumor tissues and tumor cell lines that are derived from the neural crest. To determine whether normal neural cells express functional GM-CSF receptors, we isolated and analyzed primary rat brain cells, incl...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Baldwin GC,Benveniste EN,Chung GY,Gasson JC,Golde DW

    更新日期：1993-12-01 00:00:00

  • Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells.

    abstract：:Because interleukin-10 (IL-10) is a potent differentiation factor of human B cells into mature plasma cells, we investigated its effect on human malignant plasma cells. IL-10 did not induce any differentiation and increase in Ig synthesis in four human IL-6-dependent malignant plasma cell lines. However, it stimulated...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Lu ZY,Zhang XG,Rodriguez C,Wijdenes J,Gu ZJ,Morel-Fournier B,Harousseau JL,Bataille R,Rossi JF,Klein B

    更新日期：1995-05-01 00:00:00

  • A unique 7p/12q chromosomal abnormality associated with recurrent abortion and hypofibrinogenemia.

    abstract：:Recurrent first trimester abortions led to evaluation of a 25-year-old woman. Studies revealed she had hypofibrinogenemia (68 mg/dL) without evidence of dysfibrinogenemia or increased fibrinogen turnover. She was also found to have a unique 46,XX, t(7;12) (p 15.2;q24.31) karyotype. Hypofibrinogenemia and identical chr...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Kitchens CS,Cruz AC,Kant JA

    更新日期：1987-10-01 00:00:00

  • Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells.

    abstract：:Transplantation of ex vivo expanded human umbilical cord blood cells (hCB) only partially enhances the hematopoietic recovery after myelosuppressive therapy. Incubation of hCB with optimal combinations of cytokines and niche cells, such as endothelial cells (ECs), could augment the efficiency of hCB expansion. We have...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-12-398115

    authors： Butler JM,Gars EJ,James DJ,Nolan DJ,Scandura JM,Rafii S

    更新日期：2012-08-09 00:00:00

  • Clonal evolution in atypical chronic granulocytic leukemia: a non-Philadelphia translocation.

    abstract：:Hemopoietic cells in chronic granulocytic leukemia (CGL) frequently contain a chromosome translocation involving chromosome 22 and another autosome, usually number 9. The translocated chromosome 22 is known as the Philadelphia (Ph) chromosome. The appearance of a second Ph chromosome is the most common cytogenetic abn...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bagby GC Jr,Kaiser-McCaw B,Hecht F,Koler RD,Linman JW

    更新日期：1978-06-01 00:00:00

  • Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.

    abstract：:Here we report that a new nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse line harboring a complete null mutation of the common cytokine receptor gamma chain (NOD/SCID/interleukin 2 receptor [IL2r] gamma(null)) efficiently supports development of functional human hemato-lymphopoiesis. Purified human...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-02-0516

    authors： Ishikawa F,Yasukawa M,Lyons B,Yoshida S,Miyamoto T,Yoshimoto G,Watanabe T,Akashi K,Shultz LD,Harada M

    更新日期：2005-09-01 00:00:00

  • Long-term suspension cultures of human cord blood myeloid cells.

    abstract：:A method is described that allows for the routine long-term (greater than 3 mo) growth of normal, immature human myeloid cells in liquid suspension culture. The techniques employ cell separation, utilization of special growth conditions (RPMI with hydrocortisone and vitamin D), and cord blood as the source of leukocyt...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Salahuddin SZ,Markham PD,Ruscetti FW,Gallo RC

    更新日期：1981-11-01 00:00:00

  • Glanzmann thrombasthenia caused by an 11.2-kb deletion in the glycoprotein IIIa (beta3) is a second mutation in Iraqi Jews that stemmed from a distinct founder.

    abstract：:Glanzmann thrombasthenia (GT) is a rare bleeding disorder resulting from mutations in either glycoprotein (GP) IIb or GPIIIa genes. The disease is relatively frequent in highly inbred populations such as Iraqi Jews. The molecular basis of GT in 6 unrelated Iraqi-Jewish patients was previously identified as an 11-bp de...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Rosenberg N,Yatuv R,Orion Y,Zivelin A,Dardik R,Peretz H,Seligsohn U

    更新日期：1997-05-15 00:00:00

  • CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection.

    abstract：:It has been suggested that human cytomegalovirus (HCMV) evades the immune system by infecting and paralyzing antigen-presenting cells. This view is based mainly on studies of dendritic cells (DCs) obtained after culture of monocytes (moDCs). It is contradicted by the asymptomatic course of HCMV infection in healthy pe...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-05-2016

    authors： Kvale EØ,Dalgaard J,Lund-Johansen F,Rollag H,Farkas L,Midtvedt K,Jahnsen FL,Brinchmann JE,Olweus J

    更新日期：2006-03-01 00:00:00

  • VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy.

    abstract：:Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing im...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-01-201731

    authors： Arons E,Suntum T,Stetler-Stevenson M,Kreitman RJ

    更新日期：2009-11-19 00:00:00

  • Deregulation of TWIST-1 in the CD34+ compartment represents a novel prognostic factor in chronic myeloid leukemia.

    abstract：:The mechanisms of resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) often remain obscure. Analysis of patient samples during disease progression revealed the up-regulation of the oncogene TWIST-1, also measured in primary samples from TKI-resistant patients. Moreover, we found that TWIS...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-11-254680

    authors： Cosset E,Hamdan G,Jeanpierre S,Voeltzel T,Sagorny K,Hayette S,Mahon FX,Dumontet C,Puisieux A,Nicolini FE,Maguer-Satta V

    更新日期：2011-02-03 00:00:00

  • Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.

    abstract：:Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving the erythroid phen...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019003062

    authors： Fagnan A,Bagger FO,Piqué-Borràs MR,Ignacimouttou C,Caulier A,Lopez CK,Robert E,Uzan B,Gelsi-Boyer V,Aid Z,Thirant C,Moll U,Tauchmann S,Kurtovic-Kozaric A,Maciejewski J,Dierks C,Spinelli O,Salmoiraghi S,Pabst T,Shimo

    更新日期：2020-08-06 00:00:00

  • Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation.

    abstract：:Treatment of AL amyloidosis patients with high-dose melphalan chemotherapy followed by autologous peripheral blood stem cell transplantation (HDM/SCT) can produce hematologic complete responses (CRs) and improvement in organ function. To determine whether these responses are accompanied by improvement in quality of li...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2004-01-0089

    authors： Seldin DC,Anderson JJ,Sanchorawala V,Malek K,Wright DG,Quillen K,Finn KT,Berk JL,Dember LM,Falk RH,Skinner M

    更新日期：2004-09-15 00:00:00