Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells.

abstract：:Mutations of the NPM1 gene (NPM1mut) are among the most common genetic alterations in acute myeloid leukemia and are suitable for minimal residual disease detection. We retrospectively investigated the prognostic impact of NPM1mut-based minimal residual disease detection from bone marrow for development of relapse by ...

journal_title：Blood

authors： Shayegi N,Kramer M,Bornhäuser M,Schaich M,Schetelig J,Platzbecker U,Röllig C,Heiderich C,Landt O,Ehninger G,Thiede C,Study Alliance Leukemia (SAL).

更新日期：2013-07-04 00:00:00

abstract：:c-MYC inhibits differentiation and regulates the process by which cells acquire biomass, cell growth. Down-regulation of c-MYC, reduced cell growth, and decreased activity of the PI3K/AKT/mTORC1 signal transduction pathway are features of the terminal differentiation of committed myeloid precursors to polymorphonuclea...

journal_title：Blood

authors： Wall M,Poortinga G,Hannan KM,Pearson RB,Hannan RD,McArthur GA

更新日期：2008-09-15 00:00:00

abstract：:The mechanism of lymphomagenesis of hepatitis C virus (HCV)-related B-cell lymphoma is unknown. Recently, it has been suggested that HCV may induce B-cell clonal proliferation and t(14;18) translocation in patients chronically infected with the virus. Thus, this study investigated the effect of antiviral treatment on ...

journal_title：Blood

authors： Zuckerman E,Zuckerman T,Sahar D,Streichman S,Attias D,Sabo E,Yeshurun D,Rowe JM

更新日期：2001-03-15 00:00:00

abstract：:Constitutively active JAK2V617F and thrombopoietin receptor (TpoR) W515L/K mutants are major determinants of human myeloproliferative neoplasms (MPNs). We show that a TpoRW515 mutation (W515A), which we detected in 2 myelofibrosis patients, and the Delta5TpoR active mutant, where the juxtamembrane R/KW(515)QFP motif i...

journal_title：Blood

authors： Pecquet C,Staerk J,Chaligné R,Goss V,Lee KA,Zhang X,Rush J,Van Hees J,Poirel HA,Scheiff JM,Vainchenker W,Giraudier S,Polakiewicz RD,Constantinescu SN

更新日期：2010-02-04 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) family of cytokines regulates vascular development and inflammatory responses. We have recently shown that exposure of human umbilical vein endothelial cells (HUVECs) to hypoxia (1% O(2)) increases gene expression and bioactivation of TGF-beta2 and induces its downstream ...

journal_title：Blood

authors： Zhang H,Akman HO,Smith EL,Zhao J,Murphy-Ullrich JE,Batuman OA

更新日期：2003-03-15 00:00:00

abstract：:Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-defici...

journal_title：Blood

authors： van Den Engel NK,Heidenthal E,Vinke A,Kolb H,Martin S

更新日期：2000-02-15 00:00:00

abstract：:The mechanism(s) underlying the release of stem/progenitor cells from bone marrow into the circulation is poorly understood. We hypothesized that matrix metalloproteinases (MMPs), especially gelatinases, which are believed to participate in the proteolysis of basement membranes and in the migration of leukocytes, may ...

journal_title：Blood

authors： Janowska-Wieczorek A,Marquez LA,Nabholtz JM,Cabuhat ML,Montaño J,Chang H,Rozmus J,Russell JA,Edwards DR,Turner AR

更新日期：1999-05-15 00:00:00

abstract：:MRP14 (S100A9) is the major calcium-binding protein of neutrophils and monocytes. Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major alterations of cytoskeletal metabolism. MRP14, in complex with its b...

journal_title：Blood

authors： Vogl T,Ludwig S,Goebeler M,Strey A,Thorey IS,Reichelt R,Foell D,Gerke V,Manitz MP,Nacken W,Werner S,Sorg C,Roth J

更新日期：2004-12-15 00:00:00

abstract：:We prospectively studied 98 chronic myeloid leukemia (CML) patients after bone marrow transplantation by competitive polymerase chain reaction to detect and quantify leukemia-specific BCR-ABL mRNA. Of 69 patients who had persistently undetectable, decreasing, or low BCR-ABL levels ( < 50 transcripts/microgram RNA) on ...

journal_title：Blood

authors： Lin F,van Rhee F,Goldman JM,Cross NC

更新日期：1996-05-15 00:00:00

abstract：:The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these incl...

journal_title：Blood

authors： Payne CM,Jones JF,Sieber OF Jr,Fulginiti VA

更新日期：1977-07-01 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:Concentrations of plasma fibrinopeptide A (FPA) were measured by radioimmunoassay in 50 patients with venous thromboembolism or disseminated intravascular coagulation or both. A consistent discrepancy was observed in values obtained with two anti-FPA antisera. Analysis of extracts from plasma of these patients by high...

journal_title：Blood

authors： Leeksma OC,Meijer-Huizinga F,Stoepman-van Dalen EA,van Ginkel CJ,van Aken WG,van Mourik JA

更新日期：1986-05-01 00:00:00

abstract：:The PIT1/SLC20A1 protein, a well-described sodium/phosphate cotransporter and retrovirus receptor, has been identified recently as a modular of proliferation and apoptosis in vitro. The targeted deletion of the PIT1 gene in mice revealed a lethal phenotype due to severe anemia attributed to defects in liver developmen...

journal_title：Blood

authors： Forand A,Beck L,Leroy C,Rousseau A,Boitez V,Cohen I,Courtois G,Hermine O,Friedlander G

更新日期：2013-01-24 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is a herpesvirus linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma, and a proportion of Castleman's disease. KSHV encodes viral interleukin-6 (vIL-6), which is structurally homologous to human and muri...

journal_title：Blood

authors： Aoki Y,Jaffe ES,Chang Y,Jones K,Teruya-Feldstein J,Moore PS,Tosato G

更新日期：1999-06-15 00:00:00

abstract：:To explore the use of stem/progenitor cells from peripheral blood (PB) for allogeneic transplantation, we have studied the mobilization of progenitor cells in normal donors by growth factors. Normal subjects were administered either granulocyte-macrophage colony-stimulating factor (GM-CSF) at 10 micrograms/kg/d, or G-...

journal_title：Blood

authors： Lane TA,Law P,Maruyama M,Young D,Burgess J,Mullen M,Mealiffe M,Terstappen LW,Hardwick A,Moubayed M

更新日期：1995-01-01 00:00:00

abstract：:Oncogenic rearrangements of the tyrosine kinase receptor anaplastic lymphoma kinase (ALK), most commonly represented by the nucleophosmin/ALK fusion protein (NPM/ALK), are involved in the pathogenesis of anaplastic large-cell lymphomas (ALCLs). In an effort to identify new intracellular transducers operative in ALK-po...

journal_title：Blood

authors： Bacchiocchi R,Baldanzi G,Carbonari D,Capomagi C,Colombo E,van Blitterswijk WJ,Graziani A,Fazioli F

更新日期：2005-09-15 00:00:00

abstract：:Magnetic resonance imaging (MRI) is able to detect the increase of adipocytes in the hematopoietic bone marrow that occurs as a consequence of radiotherapy and is indicative of the loss of myeloid tissue. By monitoring this process, it is also possible to determine the recovery of the bone marrow. The amount of viable...

journal_title：Blood

authors： Casamassima F,Ruggiero C,Caramella D,Tinacci E,Villari N,Ruggiero M

更新日期：1989-05-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclear factor (NF)-kappaB activity by blocking proteasomal degradation of inhibitor of kappaBalpha (IkappaBalpha). Bortezomib in...

journal_title：Blood

authors： Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC

更新日期：2009-07-30 00:00:00

abstract：:Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. Relatives...

journal_title：Blood

authors： Lijfering WM,Mulder R,ten Kate MK,Veeger NJ,Mulder AB,van der Meer J

更新日期：2009-02-05 00:00:00

abstract：:Survivin has been described as an important regulator of late mitosis and as antiapoptotic in various cells. In this issue of Blood, Wen and colleagues describe a megakaryocyte-specific knockout of survivin, with no influence on megakaryocyte survival, and a stimulating effect on polyploidy. ...

journal_title：Blood

authors： Ravid K

更新日期：2009-07-02 00:00:00

abstract：:Rapid exclusion of heparin-induced thrombocytopenia (HIT) is needed to determine which patients can continue to receive heparin. In this prospective management study, 526 participants had a 4Ts score, rapid particle gel immunoassay (platelet factor 4/heparin [PF4/H]-PaGIA), and serotonin-release assay (SRA) performed....

journal_title：Blood

authors： Linkins LA,Bates SM,Lee AY,Heddle NM,Wang G,Warkentin TE

更新日期：2015-07-30 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as important regulators of the immune system. However, despite this prominence, our understanding of the function of miRNAs in the early hematopoietic stages is incomplete. In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and pro...

journal_title：Blood

authors： Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH

更新日期：2016-10-27 00:00:00

abstract：:Identification of genes involved in in vitro differentiation induction of embryonic stem cells (ESCs) into hematopoietic stem cells (HSCs) has been challenged during last decade. To date, a homeobox transcription factor Hoxb4 has been only demonstrated to possess such an effect in mice. Here, we show that HSC-like cel...

journal_title：Blood

authors： Kitajima K,Minehata K,Sakimura K,Nakano T,Hara T

更新日期：2011-04-07 00:00:00

abstract：:Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invasive telemetric moni...

journal_title：Blood

authors： Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

更新日期：2011-04-07 00:00:00

abstract：:We recently defined a critical role for p53 in regulating the quiescence of adult hematopoietic stem cells (HSCs) and identified necdin as a candidate p53 target gene. Necdin is a growth-suppressing protein and the gene encoding it is one of several that are deleted in patients with Prader-Willi syndrome. To define th...

journal_title：Blood

authors： Asai T,Liu Y,Di Giandomenico S,Bae N,Ndiaye-Lobry D,Deblasio A,Menendez S,Antipin Y,Reva B,Wevrick R,Nimer SD

更新日期：2012-08-23 00:00:00

abstract：:The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic toxicity and preferentially drives the expansion of CD4(+)CD25(+)Foxp3(+) regulatory T cel...

journal_title：Blood

authors： Berger C,Berger M,Hackman RC,Gough M,Elliott C,Jensen MC,Riddell SR

更新日期：2009-09-17 00:00:00

abstract：:The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gen...

journal_title：Blood

authors： Anderson KP,Crable SC,Lingrel JB

更新日期：2000-03-01 00:00:00

abstract：:Myelodysplastic syndromes (MDSs) are chronic and often progressive myeloid neoplasms associated with remarkable heterogeneity in the histomorphology and clinical course. Various somatic mutations are involved in the pathogenesis of MDS. Recently, mutations in a gene encoding a spliceosomal protein, SF3B1, were discove...

journal_title：Blood

authors： Makishima H,Visconte V,Sakaguchi H,Jankowska AM,Abu Kar S,Jerez A,Przychodzen B,Bupathi M,Guinta K,Afable MG,Sekeres MA,Padgett RA,Tiu RV,Maciejewski JP

更新日期：2012-04-05 00:00:00

abstract：:High-molecular weight DNAs of fresh bone marrow cells from 32 patients with fresh leukemia were assayed for the presence of transmissible activated transforming genes by a DNA-mediated gene transfer technique using NIH/3T3 cells. DNAs of bone marrow cells from four of the 32 patients induced transformation of NIH/3T3 ...

journal_title：Blood

authors： Hirai H,Tanaka S,Azuma M,Anraku Y,Kobayashi Y,Fujisawa M,Okabe T,Urabe A,Takaku F

更新日期：1985-12-01 00:00:00

abstract：:The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (I...

journal_title：Blood

authors： Rao KN,Smuda C,Gregory GD,Min B,Brown MA

更新日期：2013-10-10 00:00:00