Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis.

abstract：:Factor VIII (FVIII) functions as a cofactor within the intrinsic pathway of blood coagulation. Quantitative or qualitative deficiencies of FVIII result in the inherited bleeding disorder hemophilia A. Expression of FVIII (domain structure A1-A2-B-A3-C1-C2) in heterologous mammalian systems is 2 to 3 orders of magnitud...

journal_title：Blood

authors： Miao HZ,Sirachainan N,Palmer L,Kucab P,Cunningham MA,Kaufman RJ,Pipe SW

更新日期：2004-05-01 00:00:00

abstract：:The cytokine interleukin (IL)-7 exerts essential roles in lymph node (LN) organogenesis and lymphocyte development and homeostasis. Recent studies have identified lymphatic endothelial cells (LECs) as a major source of IL-7 in LNs. Here, we report that LECs not only produce IL-7, but also express the IL-7 receptor cha...

journal_title：Blood

authors： Iolyeva M,Aebischer D,Proulx ST,Willrodt AH,Ecoiffier T,Häner S,Bouchaud G,Krieg C,Onder L,Ludewig B,Santambrogio L,Boyman O,Chen L,Finke D,Halin C

更新日期：2013-09-26 00:00:00

abstract：:Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor...

journal_title：Blood

authors： Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR

更新日期：2008-10-15 00:00:00

abstract：:We studied the expression of CD5 and immunoglobulin variable gene families in a panel of monoclonal Epstein-Barr virus (EBV) transformed lines, chronic lymphocytic leukemias (CLLs) and CD5+ and CD5- B-cell lymphomas. The CD5 gene expression was in all cases identical to that of T-cell malignancies. The utilization of ...

journal_title：Blood

authors： Mayer R,Logtenberg T,Strauchen J,Dimitriu-Bona A,Mayer L,Mechanic S,Chiorazzi N,Borche L,Dighiero G,Mannheimer-Lory A

更新日期：1990-04-01 00:00:00

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...

journal_title：Blood

authors： Nichols WL,Gastineau DA,Solberg LA Jr,Mann KG

更新日期：1985-06-01 00:00:00

abstract：:The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role in the regulation ...

journal_title：Blood

authors： Kapitsinou PP,Liu Q,Unger TL,Rha J,Davidoff O,Keith B,Epstein JA,Moores SL,Erickson-Miller CL,Haase VH

更新日期：2010-10-21 00:00:00

abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

journal_title：Blood

authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

更新日期：2009-12-10 00:00:00

abstract：:Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain. The result is coma and seizures with death in more than 20% of cases. Because the brain endothelium is at the interface of these pro...

journal_title：Blood

authors： Tripathi AK,Sha W,Shulaev V,Stins MF,Sullivan DJ Jr

更新日期：2009-11-05 00:00:00

abstract：:Hematofluorometric determination of zinc protoporphyrin (ZPP) is a screening method for the assessment of iron deficiency (ID). Chronic disorders are frequently accompanied by anemias of unclear origin, most probably caused by an impairment of iron metabolism. We investigated the relevance of ZPP for the detection of ...

journal_title：Blood

authors： Hastka J,Lasserre JJ,Schwarzbeck A,Strauch M,Hehlmann R

更新日期：1993-03-01 00:00:00

abstract：:Stroke is a leading cause of death and disability. The only therapy available is recombinant tissue plasminogen activator, but side effects limit its use. Platelets play a crucial role during stroke, and the inflammatory reaction promotes neurodegeneration. von Willebrand factor (VWF), an adhesion molecule for platele...

journal_title：Blood

authors： Zhao BQ,Chauhan AK,Canault M,Patten IS,Yang JJ,Dockal M,Scheiflinger F,Wagner DD

更新日期：2009-10-08 00:00:00

abstract：:Adenovirus infections occur in 5% to 21% of patients following stem cell transplantation (SCT), with an associated mortality of up to 50%. However, a lack of prospective studies has hampered further developments in the understanding and management of this infection in the posttransplantation setting. We prospectively ...

journal_title：Blood

authors： Chakrabarti S,Mautner V,Osman H,Collingham KE,Fegan CD,Klapper PE,Moss PA,Milligan DW

更新日期：2002-09-01 00:00:00

abstract：:Significant comorbidites and lethality complicate GVHD and its treatment. Targeting the cytokine milieu may improve GVHD control; and IL6 is an attractive candidate, given its role in dendritic cell activation and T-cell differentiation. Tocilizumab is a humanized mAb to IL6-receptor-α (IL6R-α), which is Food and Drug...

journal_title：Blood

authors： Betts BC,St Angelo ET,Kennedy M,Young JW

更新日期：2011-11-10 00:00:00

abstract：:Until recently, the identification of cellular factors that govern the developmental program of human stem cells has been difficult due to the absence of repopulation assays that detect human stem cells. The transplantation of human bone marrow (BM) or cord blood (CB) into non-obese diabetic (NOD)/severe-combined immu...

journal_title：Blood

authors： Kapp U,Bhatia M,Bonnet D,Murdoch B,Dick JE

更新日期：1998-09-15 00:00:00

abstract：:Twenty-four patients whose cells contained a variety of 11q23 rearrangements, including translocations, insertions, and an inversion, were studied using fluorescence in situ hybridization with cosmid, phage, and plasmid probes mapped to 11q22-24. In 17 patients, the breakpoints of the common 11q23 translocations invol...

journal_title：Blood

authors： Kobayashi H,Espinosa R 3rd,Thirman MJ,Gill HJ,Fernald AA,Diaz MO,Le Beau MM,Rowley JD

更新日期：1993-07-15 00:00:00

abstract：:The incidence of venous thromboembolism (VTE) in adult patients with sickle cell disease (SCD) is high. However, overlapping features between the clinical presentation of VTE and SCD complications and a low index of suspicion for thrombosis can influence patient management decisions. VTE in SCD can therefore present m...

journal_title：Blood

authors： Shet AS,Wun T

更新日期：2018-10-25 00:00:00

abstract：:The purpose of this study was to determine the relative merits of idarubicin and daunorubicin in acute myeloid leukemia (AML) therapy. Thirty-two sites provided 214 previously untreated adults with AML aged 15 years or more who were randomized to receive for induction therapy cytarabine 100 mg/m2/d as a continuous 7-d...

journal_title：Blood

authors： Wiernik PH,Banks PL,Case DC Jr,Arlin ZA,Periman PO,Todd MB,Ritch PS,Enck RE,Weitberg AB

更新日期：1992-01-15 00:00:00

abstract：:In The Netherlands from July 1988 to October 1991, children (0 to 16 years of age) with de novo acute lymphoblastic leukemia (ALL) were treated according to protocol ALL-7 of the Dutch Childhood Leukemia Study Group (DCLSG). In this protocol, chemotherapy and treatment stratification were identical to the ALL-BFM-86 p...

journal_title：Blood

authors： Kamps WA,Bökkerink JP,Hählen K,Hermans J,Riehm H,Gadner H,Schrappe M,Slater R,van den Berg-de Ruiter E,Smets LA,de Vaan GA,Weening RS,van Weerden JF,van Wering ER,den der Does-van den Berg A

更新日期：1999-08-15 00:00:00

abstract：:Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases. We observed tha...

journal_title：Blood

authors： Costa LF,Balcells M,Edelman ER,Nadler LM,Cardoso AA

更新日期：2006-01-01 00:00:00

abstract：:Despite matching for serologically defined HLA-A, B, DR antigens, acute graft-versus-host disease (GVHD) is a major complication contributing to increased morbidity and mortality in patients who undergo marrow transplantation from unrelated donors. The extent to which unrecognized mismatching for alleles that encode D...

journal_title：Blood

authors： Petersdorf EW,Longton GM,Anasetti C,Martin PJ,Mickelson EM,Smith AG,Hansen JA

更新日期：1995-08-15 00:00:00

abstract：:The SJL/J mouse strain has a high spontaneous incidence of a B-cell neoplasm, reticulum cell neoplasm type B (RCN B). In addition, following irradiation, 10% to 30% of these mice develop acute myelomonocytic leukemia (radiation-induced acute myeloid leukemia [RI-AML]), an incidence that can be increased to 50% by trea...

journal_title：Blood

authors： Haran-Ghera N,Krautghamer R,Lapidot T,Peled A,Dominguez MG,Stanley ER

更新日期：1997-04-01 00:00:00

abstract：:Impaired immune reconstitution has moved to the forefront of clinical problems limiting progress in allogeneic bone marrow transplantation (BMT). The identification of therapies that can enhance immune reconstitution by increasing thymopoiesis is critical to solving this problem. Interleukin 7 (IL-7) is the most poten...

journal_title：Blood

authors： Sinha ML,Fry TJ,Fowler DH,Miller G,Mackall CL

更新日期：2002-10-01 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:Ionophore A23187-induced 14C-serotonin secretion and thromboxane B2(TxB2) formation were found to be absent in citrated platelet-rich plasma (PRP) from thrombasthenic subjects and in normal PRP treated with glycoprotein (GP) IIb-IIIa complex-specific monoclonal antibodies. Both responses were restored to normal levels...

journal_title：Blood

authors： Lages B,Weiss HJ

更新日期：1994-05-01 00:00:00

abstract：:von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a...

journal_title：Blood

authors： Flood VH,Christopherson PA,Gill JC,Friedman KD,Haberichter SL,Bellissimo DB,Udani RA,Dasgupta M,Hoffmann RG,Ragni MV,Shapiro AD,Lusher JM,Lentz SR,Abshire TC,Leissinger C,Hoots WK,Manco-Johnson MJ,Gruppo RA,Boggio LN

更新日期：2016-05-19 00:00:00

abstract：:In a previous study, we reported that a single injection of cyclophosphamide (CTX) in tumor-bearing mice resulted in tumor eradication when the animals were subsequently injected with tumor-sensitized lymphocytes. Notably, CTX acted by inducing bystander effects on T cells, and the response to the combined CTX/adoptiv...

journal_title：Blood

authors： Schiavoni G,Mattei F,Di Pucchio T,Santini SM,Bracci L,Belardelli F,Proietti E

更新日期：2000-03-15 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is an increasingly common cause of morbidity and mortality in allogeneic stem cell transplantation (alloSCT). Relative to acute GVHD (aGVHD), much less is understood about cGVHD. Using the B10.D2 --> BALB/c murine cGVHD model, which shares critical pathologic features with hum...

journal_title：Blood

authors： Anderson BE,McNiff JM,Matte C,Athanasiadis I,Shlomchik WD,Shlomchik MJ

更新日期：2004-09-01 00:00:00

abstract：:Outcome in multiple myeloma is highly variable and a better understanding of the factors that influence disease biology is essential to understand and predict behavior in individual patients. In the present study, we analyzed combined genomewide DNA methylation and gene expression data of patients treated in the Medic...

journal_title：Blood

authors： Kaiser MF,Johnson DC,Wu P,Walker BA,Brioli A,Mirabella F,Wardell CP,Melchor L,Davies FE,Morgan GJ

更新日期：2013-07-11 00:00:00

abstract：:Von Willebrand factor (VWF) is a key hemostatic protein synthesized in both endothelial cells and megakaryocytes. Megakaryocyte-derived VWF is stored in α-granules of platelets and is enriched in hyperactive "ultra-large" VWF multimers. To elucidate the specific contribution of platelet VWF in hemostasis and thrombosi...

journal_title：Blood

authors： Verhenne S,Denorme F,Libbrecht S,Vandenbulcke A,Pareyn I,Deckmyn H,Lambrecht A,Nieswandt B,Kleinschnitz C,Vanhoorelbeke K,De Meyer SF

更新日期：2015-10-01 00:00:00

abstract：:Multinucleated giant cells (MGC) are a common feature of granulomas that develop during various inflammatory reactions. MGC originate from fusion of monocytes or macrophages, but the exact mechanism of their generation is still unclear. In the present study, we investigated the influence of monocyte to macrophage matu...

journal_title：Blood

authors： Möst J,Spötl L,Mayr G,Gasser A,Sarti A,Dierich MP

更新日期：1997-01-15 00:00:00