Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia.

abstract：:We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reaction-mediated single-strand conformation polymorphism (PCR-SSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mu...

journal_title：Blood

authors： Kaneko H,Misawa S,Horiike S,Nakai H,Kashima K

更新日期：1995-04-15 00:00:00

abstract：:Oxygen deprivation (hypoxia) is a consistent component of ischemia that induces an inflammatory and prothrombotic response in the endothelium. In this report, it is demonstrated that exposure of endothelial cells to hypoxia (1% O(2)) increases messenger RNA and protein levels of transforming growth factor-beta2 (TGF-b...

journal_title：Blood

authors： Akman HO,Zhang H,Siddiqui MA,Solomon W,Smith EL,Batuman OA

更新日期：2001-12-01 00:00:00

abstract：:The composition of the erythrocyte plasma membrane is extensively modified during the intracellular growth of the malaria parasite Plasmodium falciparum. It has been previously shown that an 80-kD phosphoprotein is associated with the plasma membrane of human red blood cells (RBCs) infected with trophozoite/schizont s...

journal_title：Blood

authors： Chishti AH,Maalouf GJ,Marfatia S,Palek J,Wang W,Fisher D,Liu SC

更新日期：1994-06-01 00:00:00

abstract：:BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...

journal_title：Blood

authors： Richard M,Louahed J,Demoulin JB,Renauld JC

更新日期：1999-06-15 00:00:00

abstract：:Low-density lipoprotein (LDL) receptor (LDLR) and LDLR-related protein (LRP) are members of the LDLR family of endocytic receptors. LRP recognizes a wide spectrum of structurally and functionally unrelated ligands, including coagulation factor VIII (FVIII). In contrast, the ligand specificity of LDLR is restricted to ...

journal_title：Blood

authors： Bovenschen N,Mertens K,Hu L,Havekes LM,van Vlijmen BJ

更新日期：2005-08-01 00:00:00

abstract：:Expression of the von Willebrand factor (vWF) gene is restricted to the endothelial and megakaryocyte lineages. Within the endothelium, expression of vWF varies between different vascular beds. We have previously shown that the human vWF promoter spanning a region between -2182 (relative to the start site of transcrip...

journal_title：Blood

authors： Guan J,Guillot PV,Aird WC

更新日期：1999-11-15 00:00:00

abstract：:GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/...

journal_title：Blood

authors： Ukena SN,Velaga S,Geffers R,Grosse J,Baron U,Buchholz S,Stadler M,Bruder D,Ganser A,Franzke A

更新日期：2011-09-29 00:00:00

abstract：:Reduced oxygenation of a variety of cells results in transcriptional upregulation of several genes, including the hematopoietic hormone erythropoietin, the angiogenic vascular endothelial growth factor (VEGF), and glycolytic enzymes such as aldolase. Recently, the heme protein cytochrome b558 of the nicotinamide adeni...

journal_title：Blood

authors： Wenger RH,Marti HH,Schuerer-Maly CC,Kvietikova I,Bauer C,Gassmann M,Maly FE

更新日期：1996-01-15 00:00:00

abstract：:Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, muri...

journal_title：Blood

authors： Sgadari C,Farber JM,Angiolillo AL,Liao F,Teruya-Feldstein J,Burd PR,Yao L,Gupta G,Kanegane C,Tosato G

更新日期：1997-04-15 00:00:00

abstract：:Preterm birth affects 1 out of 9 infants in the United States and is the leading cause of long-term neurologic handicap and infant mortality, accounting for 35% of all infant deaths in 2008. Although cytokines including interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-6, and IL-1 are produced in response to in utero i...

journal_title：Blood

authors： Krow-Lucal ER,Kim CC,Burt TD,McCune JM

更新日期：2014-03-20 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00

abstract：:ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), thereby inhibiting platelet aggregation and arterial thrombosis. An inability to cleave ultralarge VWF resulting from hereditary or acquired deficiency of plasma ADAMTS13 activity leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura (T...

journal_title：Blood

authors： Pickens B,Mao Y,Li D,Siegel DL,Poncz M,Cines DB,Zheng XL

更新日期：2015-05-21 00:00:00

abstract：:Mutations in the kinase domain (KD) of BCR-ABL are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations before and during therapy, and whether the ...

journal_title：Blood

authors： O'Hare T,Eide CA,Deininger MW

更新日期：2007-10-01 00:00:00

abstract：:We report two patients with a distinctive biphenotypic hematologic disorder characterized by lymphoblastic lymphoma (LBL), eosinophilia, and myeloid malignancy and/or hyperplasia associated with a t(8;13)(p11;q11) chromosomal translocation in both bone marrow and lymph node specimens. Both patients presented with lymp...

journal_title：Blood

authors： Inhorn RC,Aster JC,Roach SA,Slapak CA,Soiffer R,Tantravahi R,Stone RM

更新日期：1995-04-01 00:00:00

abstract：:Congenital blood disorders are common and yet clinically challenging globin disorders. Gene therapy continues to serve as a potential therapeutic method to treat these disorders. While tremendous advances have been made in vivo, gene delivery protocols and vector prototypes still require optimization. Alternative cis-...

journal_title：Blood

authors： Staplin WR,Knezetic JA

更新日期：2003-03-01 00:00:00

abstract：:In the present study, we investigated disease characteristics and clinical outcome in young patients (< 40 years) with World Health Organization (WHO)-defined essential thrombocythemia (ET) compared with early/prefibrotic primary myelofibrosis (PMF) with presenting thrombocythemia. We recruited 213 young patients (med...

journal_title：Blood

authors： Barbui T,Thiele J,Carobbio A,Passamonti F,Rumi E,Randi ML,Bertozzi I,Vannucchi AM,Gisslinger H,Gisslinger B,Finazzi G,Ruggeri M,Rodeghiero F,Rambaldi A,Gangat N,Tefferi A

更新日期：2012-07-19 00:00:00

abstract：:D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 through disulfides to form ultralong VWF concatemers. D'D3 forms the binding site fo...

journal_title：Blood

authors： Dong X,Leksa NC,Chhabra ES,Arndt JW,Lu Q,Knockenhauer KE,Peters RT,Springer TA

更新日期：2019-04-04 00:00:00

abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

journal_title：Blood

authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

更新日期：2013-09-26 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as important regulators of the immune system. However, despite this prominence, our understanding of the function of miRNAs in the early hematopoietic stages is incomplete. In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and pro...

journal_title：Blood

authors： Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH

更新日期：2016-10-27 00:00:00

abstract：:Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations. Despite positive selection, anti-Sm production occurs only in autoimmune-prone mice. To investigate autoreactive B-cell activ...

journal_title：Blood

authors： Qian Y,Conway KL,Lu X,Seitz HM,Matsushima GK,Clarke SH

更新日期：2006-08-01 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:We previously reported that RO(+) expression correlated with increased mutation, activation, and selection among human germinal center (GC) B cells. Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, into different fractions based on RB expression. Although each subset contained RB(+) cel...

journal_title：Blood

authors： Jackson SM,Harp N,Patel D,Wulf J,Spaeth ED,Dike UK,James JA,Capra JD

更新日期：2009-04-23 00:00:00

abstract：:R115777 is a potent farnesyltransferase (FTase) inhibitor with substantial antitumor activity in preclinical models. We conducted a phase 1 study (3 + 3 design) of R115777 in patients with myelodysplastic syndrome (MDS). R115777 was administered twice daily (3-weeks-on/1-week-off schedule for 8 weeks) (starting dosage...

journal_title：Blood

authors： Kurzrock R,Kantarjian HM,Cortes JE,Singhania N,Thomas DA,Wilson EF,Wright JJ,Freireich EJ,Talpaz M,Sebti SM

更新日期：2003-12-15 00:00:00

abstract：:Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for autoimmune disorders, infectious diseases, and cancer. We analyzed one or more single nucleotide polymorphisms (SNPs) in 20 ...

journal_title：Blood

authors： Lan Q,Zheng T,Rothman N,Zhang Y,Wang SS,Shen M,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Boyle P,Zhang B,Zou K,Zhu Y,Chanock S

更新日期：2006-05-15 00:00:00

abstract：:Low-dose interferon-alpha (IFN-alpha) therapy is consistently effective in the treatment of hairy cell leukemia (HCL). In two cases of resistance to IFN-alpha administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. We tried to distingui...

journal_title：Blood

authors： Lehn P,Sigaux F,Grausz D,Loiseau P,Castaigne S,Degos L,Flandrin G,Dautry F

更新日期：1986-10-01 00:00:00

abstract：:Factor V Leiden (FVL) is associated with venous thrombosis; however, an association between FVL and arterial thrombosis remains controversial. We investigated FVL as a risk factor for myocardial infarction (MI), ischemic stroke (IS), or non-MI ischemic heart disease (non-MI-IHD). The design was 3 case-control studies ...

journal_title：Blood

authors： Juul K,Tybjaerg-Hansen A,Steffensen R,Kofoed S,Jensen G,Nordestgaard BG

更新日期：2002-07-01 00:00:00

abstract：:The peripheral blood lymphocyte surface markers and clinical features of 38 patients with common variable immunodeficiency (CVID) were assessed. These studies identified a subset of CVID consisting of 14 of the 38 patients with a distinctive T-cell immunophenotype and clinical findings. The phenotypic changes were cha...

journal_title：Blood

authors： Wright JJ,Wagner DK,Blaese RM,Hagengruber C,Waldmann TA,Fleisher TA

更新日期：1990-11-15 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia in which venous thrombosis is the most common cause of death. Here we address the risk factors for thrombosis and the role of warfarin prophylaxis in PNH. The median follow-up of 163 PNH patients was 6 years (range, 0.2-38 years). Of the patient...

journal_title：Blood

authors： Hall C,Richards S,Hillmen P

更新日期：2003-11-15 00:00:00

abstract：:Red cell enzymes, 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP), were evaluated in a 23-mo-old boy with juvenile chronic myelocytic leukemia (JCML) at the onset of his illness and 6 mo later during the accelerated phase. The activities of the age-dependent red cell enzymes, hexokinase, aldolase, py...

journal_title：Blood

authors： Travis SF

更新日期：1983-09-01 00:00:00

abstract：:Little is known about the ontogeny of naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and humans. In rodents, thymectomy on day 3 of life leads to multiple organ-specific autoimmune diseases that can be prevented by adoptive transfer of regul...

journal_title：Blood

authors： Darrasse-Jèze G,Marodon G,Salomon BL,Catala M,Klatzmann D

更新日期：2005-06-15 00:00:00