Abstract:
:Low-dose interferon-alpha (IFN-alpha) therapy is consistently effective in the treatment of hairy cell leukemia (HCL). In two cases of resistance to IFN-alpha administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. We tried to distinguish variant and typical hairy cells (HCs) by Northern blot analysis of the oncogenes expressed in vivo. We report that variant HCs contain c-myc transcripts in contrast to typical HCs, whereas c-fos transcripts are detected in both cell types. We also report that the mRNA levels of c-myc are not modified in variant HCs by IFN-alpha treatment, whereas the level of c-fos mRNA is modulated in both types of HCs. Our findings suggest that the failure to modulate c-myc expression in vivo might indicate the limits of low-dose IFN-alpha therapy.
journal_name
Bloodjournal_title
Bloodauthors
Lehn P,Sigaux F,Grausz D,Loiseau P,Castaigne S,Degos L,Flandrin G,Dautry Fsubject
Has Abstractpub_date
1986-10-01 00:00:00pages
967-70issue
4eissn
0006-4971issn
1528-0020journal_volume
68pub_type
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