Gimap4 accelerates T-cell death.

abstract：:Six patients with relapsed hairy cell leukemia after splenectomy were treated with high-dose methotrexate and leucovorin rescue. Five patients had objective responses as determined by improved blood counts. In two of them, the response has continued for more than 14 and 44 months, respectively. Intensive treatment wit...

journal_title：Blood

authors： Joosten P,Hagenbeek A,Löwenberg B,Sizoo W

更新日期：1985-07-01 00:00:00

abstract：:The effect of HbA and HbF on both the aggregation and deaggregation of deoxy HbS and deoxy HbCHarlem in concentrated phosphate buffers was studied by a turbidimetric method. Although pure deoxy HbA is fully soluble in 2.4 M potassium phosphate buffer, the same concentration of deoxy HbAS was insoluble in the same buff...

journal_title：Blood

authors： Adachi K,Asakura T,Schwartz E

更新日期：1980-03-01 00:00:00

abstract：:The microsomal fraction of M1 cells (an established cell line of myeloid leukemia) was capable of catalyzing acylation of sn-glycerol 3-phosphate by long-chain fatty acyl-CoA thioesters. The principal lipid product formed was identified as phosphatidic acid. Palmityl-CoA, stearyl-CoA, and oleyl-CoA were more effective...

journal_title：Blood

authors： Okuma M,Ichikawa Y,Yamashita S,Kitajima K,Numa S

更新日期：1976-03-01 00:00:00

abstract：:Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that heme-laden MPs have a physiopathological impact. Up to one-third of c...

journal_title：Blood

authors： Camus SM,De Moraes JA,Bonnin P,Abbyad P,Le Jeune S,Lionnet F,Loufrani L,Grimaud L,Lambry JC,Charue D,Kiger L,Renard JM,Larroque C,Le Clésiau H,Tedgui A,Bruneval P,Barja-Fidalgo C,Alexandrou A,Tharaux PL,Boulanger CM

更新日期：2015-06-11 00:00:00

abstract：:In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were...

journal_title：Blood

authors： Cavé H,Suciu S,Preudhomme C,Poppe B,Robert A,Uyttebroeck A,Malet M,Boutard P,Benoit Y,Mauvieux L,Lutz P,Méchinaud F,Grardel N,Mazingue F,Dupont M,Margueritte G,Pages MP,Bertrand Y,Plouvier E,Brunie G,Bastard C,P

更新日期：2004-01-15 00:00:00

abstract：:Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-defici...

journal_title：Blood

authors： van Den Engel NK,Heidenthal E,Vinke A,Kolb H,Martin S

更新日期：2000-02-15 00:00:00

abstract：:Recent studies have identified several populations of progenitor cells in the human thymus. The hematopoietic precursor activity of these populations has been determined. The most primitive human thymocytes express high levels of CD34 and lack CD1a. These cells acquire CD1a and differentiate into CD4(+)CD8(+) through ...

journal_title：Blood

authors： Blom B,Verschuren MC,Heemskerk MH,Bakker AQ,van Gastel-Mol EJ,Wolvers-Tettero IL,van Dongen JJ,Spits H

更新日期：1999-05-01 00:00:00

abstract：:The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (I...

journal_title：Blood

authors： Rao KN,Smuda C,Gregory GD,Min B,Brown MA

更新日期：2013-10-10 00:00:00

abstract：:This study reports a lentiviral gene transfer protocol for efficient transduction of adult human peripheral blood (PB)-derived CD34+ NOD/SCID-repopulating cells (SRCs) using vesicular stomatitis virus-G protein (VSV-G)-pseudotyped lentiviruses encoding for enhanced green fluorescence protein (eGFP). Lentiviral stocks ...

journal_title：Blood

authors： Scherr M,Battmer K,Blömer U,Schiedlmeier B,Ganser A,Grez M,Eder M

更新日期：2002-01-15 00:00:00

abstract：:Activated protein C (APC) reduces mortality in severe sepsis patients. APC exerts anticoagulant activities via inactivation of factors Va and VIIIa and cytoprotective activities via endothelial protein C receptor and protease-activated receptor-1. APC mutants with selectively altered and opposite activity profiles, th...

journal_title：Blood

authors： Mosnier LO,Zampolli A,Kerschen EJ,Schuepbach RA,Banerjee Y,Fernández JA,Yang XV,Riewald M,Weiler H,Ruggeri ZM,Griffin JH

更新日期：2009-06-04 00:00:00

abstract：:Genetic alteration is considered a probable cause of malignant lymphoma. Folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, and their metabolic pathways might thus affect disease susceptibility. In the present study, 2 polymorphisms were evaluated for a folate metabolic enzyme,...

journal_title：Blood

authors： Matsuo K,Suzuki R,Hamajima N,Ogura M,Kagami Y,Taji H,Kondoh E,Maeda S,Asakura S,Kaba S,Nakamura S,Seto M,Morishima Y,Tajima K

更新日期：2001-05-15 00:00:00

abstract：:The RUNX1/AML1 gene is the most frequently mutated gene in human leukemia. Conditional deletion of Runx1 in adult mice results in an increase of hematopoietic stem cells (HSCs), which serve as target cells for leukemia; however, Runx1(-/-) mice do not develop spontaneous leukemia. Here we show that maintenance of Runx...

journal_title：Blood

authors： Jacob B,Osato M,Yamashita N,Wang CQ,Taniuchi I,Littman DR,Asou N,Ito Y

更新日期：2010-02-25 00:00:00

abstract：:The Bcl-2 proto-oncogene was discovered at the t(14;18) breakpoint found in most follicular B-cell lymphomas and some diffuse large-cell lymphomas. Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and extending cell survival by blocking programmed cell death. We examined Bcl-2 protein expression ...

journal_title：Blood

authors： Zutter M,Hockenbery D,Silverman GA,Korsmeyer SJ

更新日期：1991-08-15 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:Neutrophil (PMN) activation is associated with increased surface expression of several membrane proteins that are translocated from intracellular pools. Indirect evidence suggests that the intracellular storage pools of complement receptor type 1 (CR1) in resting PMN are distinct from traditional granules and may be t...

journal_title：Blood

authors： Kumar A,Wetzler E,Berger M

更新日期：1997-06-15 00:00:00

abstract：:Mutations in the SH2D1A gene have been described in most patients with the clinical syndrome of X-linked lymphoproliferative disease (XLP). The diagnosis of XLP is still difficult given its clinical heterogeneity and the lack of a readily available rapid diagnostic laboratory test, particularly in patients without a f...

journal_title：Blood

authors： Tabata Y,Villanueva J,Lee SM,Zhang K,Kanegane H,Miyawaki T,Sumegi J,Filipovich AH

更新日期：2005-04-15 00:00:00

abstract：:Secondary chromosomal aberrations were surveyed in non-Hodgkin's lymphomas (NHL) reported in the literature with one of the following, presently recognized, primary abnormalities: t(2;5), +3, t(3;14), del(6q), +X, and -Y. Of 2,175 NHLs with clonal karyotypic changes, 908 (42%) had one of the 13 selected primary chromo...

journal_title：Blood

authors： Johansson B,Mertens F,Mitelman F

更新日期：1995-11-15 00:00:00

abstract：:Recent analyses of circulating blood B cells in myeloma have generated controversy concerning the exact levels of these cells and whether they may represent circulating clonal tumor B cells. Previous reports suggested that CD19+ B cells are markedly increased in myeloma patients and that this population shares clonoty...

journal_title：Blood

authors： Kay NE,Leong T,Kyle RA,Greipp P,Billadeau D,Van Ness B,Bone N,Oken MM

更新日期：1997-07-01 00:00:00

abstract：:Hemophiliac patients with chronic hepatitis C might be exposed to and become infected with multiple hepatitis C virus (HCV) strains by means of frequent use of blood products, even if they are infected with a single subtype of HCV. To test this hypothesis, we analyzed the genetic diversity of hypervariable region 1 (H...

journal_title：Blood

authors： Toyoda H,Fukuda Y,Koyama Y,Nakano I,Kinoshita M,Hadama T,Takamatsu J,Hayakawa T

更新日期：1996-08-15 00:00:00

abstract：:As a dendritic cell (DC) matures, it becomes more potent as an antigen-presenting cell. This functional change is accompanied by a change in DC immunophenotype. The signal transduction events underlying this process are poorly characterized. In this study, we have investigated the signal transduction pathways involved...

journal_title：Blood

authors： Ardeshna KM,Pizzey AR,Devereux S,Khwaja A

更新日期：2000-08-01 00:00:00

abstract：:Deletion of Runx1 in adult mice produces a myeloproliferative phenotype. We now find that Runx1 gene deletion increases marrow monocyte while reducing granulocyte progenitors and that exogenous RUNX1 rescues granulopoiesis. Deletion of Runx1 reduces Cebpa mRNA in lineage-negative marrow cells and in granulocyte-monocy...

journal_title：Blood

authors： Guo H,Ma O,Speck NA,Friedman AD

更新日期：2012-05-10 00:00:00

abstract：:Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in patients with refractory CGVHD a total of 80 patients who failed to respond to prednisone (PSE) or PSE and cyclosporine (CSA) were treated with thalidomide. Sixt...

journal_title：Blood

authors： Parker PM,Chao N,Nademanee A,O'Donnell MR,Schmidt GM,Snyder DS,Stein AS,Smith EP,Molina A,Stepan DE,Kashyap A,Planas I,Spielberger R,Somlo G,Margolin K,Zwingenberger K,Wilsman K,Negrin RS,Long GD,Niland JC,Blume K

更新日期：1995-11-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodeficiency is mainly due to ...

journal_title：Blood

authors： Gallego MD,Santamaría M,Peña J,Molina IJ

更新日期：1997-10-15 00:00:00

abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

journal_title：Blood

authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

更新日期：2013-03-21 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

journal_title：Blood

authors： Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

更新日期：2008-11-01 00:00:00

abstract：:The reduction of nitroblue tetrazolium dye by human neutrophils was measured in the presence of serum in which the complement system had been activated through the alternate pathway by interaction with inulin. Neutrophils incubated with serum inulin supernatants reduced the dye and showed a general increase in oxidati...

journal_title：Blood

authors： Strauss RG,Mauer AM,Asbrock T,Spitzer RE,Stitzel AE

更新日期：1975-06-01 00:00:00

abstract：:The CCAAT/enhancer binding protein-alpha (C/EBPalpha) is a transcription factor required for differentiation of myeloid progenitors. In addition to specific DNA binding, C/EBPalpha is also involved in protein-protein interactions, some of which (p21, Cdk2/Cdk4, E2F) appear to be required for inhibition of proliferatio...

journal_title：Blood

authors： Keeshan K,Santilli G,Corradini F,Perrotti D,Calabretta B

更新日期：2003-08-15 00:00:00

abstract：:Ectopic expression of mutated K-ras or N-ras in the interleukin 6 (IL-6)-dependent ANBL6 multiple myeloma cell line induces cytokine-independent growth. To investigate the signaling pathways activated by oncogenic ras that may stimulate IL-6-independent growth, we compared ANBL6 cells stably transfected with mutated K...

journal_title：Blood

authors： Hu L,Shi Y,Hsu JH,Gera J,Van Ness B,Lichtenstein A

更新日期：2003-04-15 00:00:00

abstract：:The blockade of platelet integrin glycoprotein (GP) IIb/IIIa is a promising new antiplatelet strategy. The binding of ligands or of the ligand-mimetic peptide RGD causes a conformational change of GP IIb/IIIa from the nonactivated to the activated state. Because several blocking agents/inhibitors are ligand-mimetics, ...

journal_title：Blood

authors： Peter K,Schwarz M,Ylänne J,Kohler B,Moser M,Nordt T,Salbach P,Kübler W,Bode C

更新日期：1998-11-01 00:00:00

abstract：:The expression of early and mature B cell markers, surface beta 2-microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the...

journal_title：Blood

authors： Epstein J,Barlogie B,Katzmann J,Alexanian R

更新日期：1988-04-01 00:00:00