Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.

abstract：:Expression of B7 family costimulatory molecules on B cells defines their capacity to function as antigen presenting cells (APCs). B cells that do not express B7 costimulatory molecules induce T-cell tolerance. Therefore, the expression of B7 costimulatory molecules on malignant B cells might be critical for their reco...

journal_title：Blood

authors： Dorfman DM,Schultze JL,Shahsafaei A,Michalak S,Gribben JG,Freeman GJ,Pinkus GS,Nadler LM

更新日期：1997-12-01 00:00:00

abstract：:The microbiota is known to influence the generation of hematopoietic progenitors, although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and Gram-negative bacteria, but their role in steady-state hematopoiesis has never been characteriz...

journal_title：Blood

authors： Iwamura C,Bouladoux N,Belkaid Y,Sher A,Jankovic D

更新日期：2017-01-12 00:00:00

abstract：:The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-dione small molecule ...

journal_title：Blood

authors： Lin YW,Beharry ZM,Hill EG,Song JH,Wang W,Xia Z,Zhang Z,Aplan PD,Aster JC,Smith CD,Kraft AS

更新日期：2010-01-28 00:00:00

abstract：:To characterize and clarify the function of CD34 antigen experimentally, we isolated two types of CD34 mRNA from a cDNA library of murine stromal cell line, PA-6 stimulated with lipopolysaccharide (LPS) and 12-o-tetra-decanoylphorbol 13-acetate (TPA) using a human CD34 probe. In addition to the clone (open reading fra...

journal_title：Blood

authors： Suda J,Sudo T,Ito M,Ohno N,Yamaguchi Y,Suda T

更新日期：1992-05-01 00:00:00

abstract：:Identification of the 25 known human blood group molecules is of fundamental importance for the fields of erythroid cell biology and transfusion medicine. Here we provide the first molecular description of the "Dombrock" blood group system. A candidate gene was identified by in silico analyses of approximately 5000 ex...

journal_title：Blood

authors： Gubin AN,Njoroge JM,Wojda U,Pack SD,Rios M,Reid ME,Miller JL

更新日期：2000-10-01 00:00:00

abstract：:The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia (APL) is essential for a number of proapoptotic and growth-suppressive pathways as well as for the activity of differentiating agents such as retinoic acid (RA). In human APL, the dose of PML is reduced to heterozygosity given that one a...

journal_title：Blood

authors： Gurrieri C,Nafa K,Merghoub T,Bernardi R,Capodieci P,Biondi A,Nimer S,Douer D,Cordon-Cardo C,Gallagher R,Pandolfi PP

更新日期：2004-03-15 00:00:00

abstract：:In this study human mononuclear phagocytes from the bone marrow (promonocytes and monocytes), peripheral blood monocytes, and tissue macrophages from the skin and the peritoneal cavity were studied with respect to their morphological, cytochemical, and functional characteristics, cell surface receptors, and 3H-thymidi...

journal_title：Blood

authors： van Furth R,Raeburn JA,van Zwet TL

更新日期：1979-08-01 00:00:00

abstract：:We have investigated whether recombinant erythropoietin (r-Epo) elicits a change in intracellular free calcium (IFC) in purified Epo-responsive cells in spleens of mice treated with phenylhydrazine. Colony-forming units (CFU-E) were prepared by negative selection through immunologic panning. Anti-Forssman, Mac-1, Ia, ...

journal_title：Blood

authors： Imagawa S,Smith BR,Palmer-Crocker R,Bunn HF

更新日期：1989-05-01 00:00:00

abstract：:Persistent NF-κB activation is a hallmark of the malignant Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL). Genomic lesions, Epstein-Barr virus infection, soluble factors, and tumor-microenvironment interactions contribute to this activation. Here, in an unbiased approach to identify the cHL cel...

journal_title：Blood

authors： von Hoff L,Kärgel E,Franke V,McShane E,Schulz-Beiss KW,Patone G,Schleussner N,Kolesnichenko M,Hübner N,Daumke O,Selbach M,Akalin A,Mathas S,Scheidereit C

更新日期：2019-03-28 00:00:00

abstract：:This study examined the prognostic value of circulating peripheral blood plasma cells (PBPCs) in patients with primary systemic amyloidosis (AL). A sensitive slide-based immunofluorescence technique was used to assess 147 patients for circulating PBPCs. Circulating monoclonal plasma cells were quantified as a percenta...

journal_title：Blood

authors： Pardanani A,Witzig TE,Schroeder G,McElroy EA,Fonseca R,Dispenzieri A,Lacy MQ,Lust JA,Kyle RA,Greipp PR,Gertz MA,Rajkumar SV

更新日期：2003-02-01 00:00:00

abstract：:Endotoxin is a component of gram-negative bacteria that causes hematologic and immunologic changes through its induction of cytokines. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of IL-1 that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity....

journal_title：Blood

authors： Granowitz EV,Porat R,Mier JW,Orencole SF,Callahan MV,Cannon JG,Lynch EA,Ye K,Poutsiaka DD,Vannier E

更新日期：1993-11-15 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy. Rituximab is able to cause selective in vivo destruction of B lymphocytes, with abrogation of antibody production. In a prospective study, we have evaluated the...

journal_title：Blood

authors： Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

更新日期：2003-05-15 00:00:00

abstract：:Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication in hematopoietic stem cell transplant (HSCT) recipients. To determine the impact of pretransplantation hyperferritinemia on the risk of SOS after HSC transplantation, we retrospectively studied 427 HSCT recipients (179 autologous and 248 allogenei...

journal_title：Blood

authors： Maradei SC,Maiolino A,de Azevedo AM,Colares M,Bouzas LF,Nucci M

更新日期：2009-08-06 00:00:00

abstract：:Factor V Leiden (factor V Arg506Gln), the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. The relationship between this genetic abnormality and arterial disease is still unresolved. To assess whether factor V Leiden increases the risk of myocardial inf...

journal_title：Blood

authors： Rosendaal FR,Siscovick DS,Schwartz SM,Beverly RK,Psaty BM,Longstreth WT Jr,Raghunathan TE,Koepsell TD,Reitsma PH

更新日期：1997-04-15 00:00:00

abstract：:At inflammatory sites, proteoglycans are both secreted by activated mononuclear leukocytes and released as a consequence of extracellular matrix degradation. Chondroitin 4-sulfate proteoglycans constitute the predominant ones produced by activated human monocytes/macrophages. In this study, we show that two chondroiti...

journal_title：Blood

authors： Rachmilewitz J,Tykocinski ML

更新日期：1998-07-01 00:00:00

abstract：:All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). Genetic analyses of MGUS cells have provided evidence that it is a genetically advanced lesion, wherein tumor cells carry many of the genetic changes found i...

journal_title：Blood

authors： Dhodapkar MV

更新日期：2016-12-08 00:00:00

abstract：:An abnormal von Willebrand factor (vWF) gene restriction pattern has been found in a patient with von Willebrand disease. Because this gene alteration is not present in his parents or in 50 normal and 25 affected subjects, and the restriction fragment length polymorphism haplotypes are inherited normally in the patien...

journal_title：Blood

authors： Bernardi F,Marchetti G,Guerra S,Casonato A,Gemmati D,Patracchini P,Ballerini G,Conconi F

更新日期：1990-02-01 00:00:00

abstract：:Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of developing lymphoid and myeloid cells. Deregulation of Notch signaling determines several human diso...

journal_title：Blood

authors： Nwabo Kamdje AH,Krampera M

更新日期：2011-12-15 00:00:00

abstract：:Three cases of T-lymphoblastic lymphomas (T-LL) expressing the T cell antigen receptor gamma delta (TCR gamma delta) are reported. All of them were CD3+/beta F1-/TCR delta 1+. Moreover, neoplastic cells reacted with the delta TCS1 monoclonal antibody (MoAb) which binds to the non-disulfide-linked form of the TCR gamma...

journal_title：Blood

authors： Falini B,Flenghi L,Fagioli M,Martelli MF,Pileri S,Grignani F,Beltrami A,Novero D,Pelicci PG

更新日期：1989-11-15 00:00:00

abstract：:One major obstacle to the effective treatment of cancer is to distinguish between tumor cells and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities are ideal therapeutic targets because they are unique to the disease. We describe the use of a novel approach based on the cataly...

journal_title：Blood

authors： Cobaleda C,Sánchez-García I

更新日期：2000-02-01 00:00:00

abstract：:In the maternal decidua, natural killer (NK) cells, characterized by lack of CD16, are found in direct contact with the fetal extravillous trophoblasts (EVTs). It is yet unknown which factors contribute to the specific homing of this unique NK subset to the decidua. In this study we analyze the chemokine receptor repe...

journal_title：Blood

authors： Hanna J,Wald O,Goldman-Wohl D,Prus D,Markel G,Gazit R,Katz G,Haimov-Kochman R,Fujii N,Yagel S,Peled A,Mandelboim O

更新日期：2003-09-01 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00

abstract：:Increasingly, allogeneic and even more often autologous bone marrow transplants are being done to correct a wide variety of diseases. In addition, autologous marrow transplants potentially provide an opportune means of delivering genes in transfected, engrafting stem cells. However, despite its widespread clinical use...

journal_title：Blood

authors： Nilsson SK,Dooner MS,Tiarks CY,Weier HU,Quesenberry PJ

更新日期：1997-06-01 00:00:00

abstract：:Induction of transplantation tolerance by means of bone marrow (BM) transplantation could become a reality if it was possible to achieve engraftment of hematopoietic stem cells under nonlethal preparatory cytoreduction of the recipient. To that end, BM facilitating cells, veto cells, or other tolerance-inducing cells,...

journal_title：Blood

authors： Bachar-Lustig E,Li HW,Gur H,Krauthgamer R,Marcus H,Reisner Y

更新日期：1999-11-01 00:00:00

abstract：:In this phase 2 multicenter trial, we evaluated the efficacy of the combination of bortezomib, dexamethasone, and rituximab (BDR) in 59 previously untreated symptomatic patients with Waldenström macroglobulinemia (WM), most of which were of advanced age and with adverse prognostic factors. BDR consisted of a single 21...

journal_title：Blood

authors： Gavriatopoulou M,García-Sanz R,Kastritis E,Morel P,Kyrtsonis MC,Michalis E,Kartasis Z,Leleu X,Palladini G,Tedeschi A,Gika D,Merlini G,Sonneveld P,Dimopoulos MA

更新日期：2017-01-26 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is considered the standard therapy for chronic myeloid leukemia (CML) patients not suitable for allogeneic stem cell transplantation. From 1987 through 1992, 195 patients in the Benelux with recent untreated CML were randomized between low-dose IFN-alpha2b (3 MIU, 5 days/wk) or hydroxyurea...

journal_title：Blood

authors：

更新日期：1998-04-15 00:00:00

abstract：:Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...

journal_title：Blood

authors： Zhu J,Muia J,Gupta G,Westfield LA,Vanhoorelbeke K,Tolia NH,Sadler JE

更新日期：2019-04-25 00:00:00

abstract：:The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic mice, we show that...

journal_title：Blood

authors： Goardon N,Schuh A,Hajar I,Ma X,Jouault H,Dzierzak E,Roméo PH,Maouche-Chrétien L

更新日期：2002-07-15 00:00:00

abstract：:A new type of A alpha Glu-11 to Gly substitution has been identified in a congenitally abnormal fibrinogen, fibrinogen Mitaka II, derived from a 14-year-old female suffering from easy bruising since childhood. Plasma of the patient and fibrinogen purified therefrom were found to clot slowly by thrombin but in a normal...

journal_title：Blood

authors： Niwa K,Yaginuma A,Nakanishi M,Wada Y,Sugo T,Asakura S,Watanabe N,Matsuda M

更新日期：1993-12-15 00:00:00

abstract：:Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is poorly understood. We demonstrated herein that hematopoietic CD34+ cells constitutively produced endogenous secreted IL-15 (ES-IL-15) that activated different transcriptio...

journal_title：Blood

authors： Giron-Michel J,Caignard A,Fogli M,Brouty-Boyé D,Briard D,van Dijk M,Meazza R,Ferrini S,Lebousse-Kerdilès C,Clay D,Bompais H,Chouaib S,Péault B,Azzarone B

更新日期：2003-07-01 00:00:00