Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation.

abstract：:Recent studies have identified several populations of progenitor cells in the human thymus. The hematopoietic precursor activity of these populations has been determined. The most primitive human thymocytes express high levels of CD34 and lack CD1a. These cells acquire CD1a and differentiate into CD4(+)CD8(+) through ...

journal_title：Blood

authors： Blom B,Verschuren MC,Heemskerk MH,Bakker AQ,van Gastel-Mol EJ,Wolvers-Tettero IL,van Dongen JJ,Spits H

更新日期：1999-05-01 00:00:00

abstract：:The erythroid Krüppel-like factor (EKLF) is a key regulatory protein in globin gene expression. This zinc finger transcription factor is required for expression of the adult beta globin gene, and it has been suggested that it plays an important role in the developmental switch from fetal gamma to adult beta globin gen...

journal_title：Blood

authors： Anderson KP,Crable SC,Lingrel JB

更新日期：2000-03-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene on the X-chromosome that result in skeletal and cardiac muscle damage and premature death. Studies in mice, including the mdx mouse model of DMD, have demonstrated that circulating bone marrow-derived cells can participate in skeletal musc...

journal_title：Blood

authors： Dell'Agnola C,Wang Z,Storb R,Tapscott SJ,Kuhr CS,Hauschka SD,Lee RS,Sale GE,Zellmer E,Gisburne S,Bogan J,Kornegay JN,Cooper BJ,Gooley TA,Little MT

更新日期：2004-12-15 00:00:00

abstract：:Growing evidence supports a pathophysiological role for platelets during the manifestation of postischemic reperfusion injury; in the current study, we investigated the nature and the molecular determinants of platelet-endothelial cell interactions induced by ischemia/reperfusion (I/R). Platelet-endothelium and leukoc...

journal_title：Blood

authors： Massberg S,Enders G,Leiderer R,Eisenmenger S,Vestweber D,Krombach F,Messmer K

更新日期：1998-07-15 00:00:00

abstract：:In an effort to develop a clinically useful approach to overcoming P-glycoprotein-mediated multidrug resistance (MDR1), we evaluated combined chemosensitization with verapamil and quinine in a multidrug-resistant (MDR) human myeloma cell line model. In clonogenic assay, verapamil was used at concentrations from 0.1 to...

journal_title：Blood

authors： Lehnert M,Dalton WS,Roe D,Emerson S,Salmon SE

更新日期：1991-01-15 00:00:00

abstract：:Varying, limiting numbers of unseparated or purified cells (Ly-5.1), either from 14.5-day-old fetal liver (FL) or from adult bone marrow (BM) were coinjected with 10(5) unseparated BM cells (Ly-5.2) into lethally irradiated adult C57B1/6 recipients (Ly-5.2). The kinetics of donor cell repopulation of the lymphoid and ...

journal_title：Blood

authors： Rebel VI,Miller CL,Eaves CJ,Lansdorp PM

更新日期：1996-04-15 00:00:00

abstract：:Endotoxin-free purified recombinant human erythroid-potentiating activity (EPA) was administered to normal and bled mice. In anemic ICR mice EPA treatment led to a significant increase in the number of reticulocytes in the peripheral blood and erythroid precursors in the spleen. Stimulation of CFU-E and BFU-E in the s...

journal_title：Blood

authors： Niskanen E,Gasson JC,Teates CD,Golde DW

更新日期：1988-08-01 00:00:00

abstract：:Stem cell factor (SCF) and interleukin-3 (IL-3) both act on several target hematopoietic populations, including mast cells. We have isolated a unique murine mast cell line, B6M, that is phenotypically similar to immature mast cells. For B6M cells, IL-3 is a survival factor and alone does not stimulate proliferation. S...

journal_title：Blood

authors： O'Farrell AM,Ichihara M,Mui AL,Miyajima A

更新日期：1996-05-01 00:00:00

abstract：:Fibrinogen was isolated from the plasma of a 25-year-old female with a history of mild bleeding and several recent moderate to severe hemorrhagic episodes. Coagulability with thrombin approached 100% and varied directly with the time of incubation with the enzyme. High-performance liquid chromatography analysis of thr...

journal_title：Blood

authors： Siebenlist KR,Prchal JT,Mosesson MW

更新日期：1988-03-01 00:00:00

abstract：:We investigated the effects of granulocyte colony-stimulating factor (G-CSF) on cytokine and cytokine receptor plasma levels and on the in vivo host response to Salmonella abortus equi endotoxin in healthy males. Twenty volunteers received 0.8 ng/kg endotoxin and saline intravenously 1 week apart in randomized order. ...

journal_title：Blood

authors： Pollmächer T,Korth C,Mullington J,Schreiber W,Sauer J,Vedder H,Galanos C,Holsboer F

更新日期：1996-02-01 00:00:00

abstract：:Current treatment strategies for Hodgkin lymphoma result in excellent survival but often confer significant long-term toxicity. We designed ABVE-PC (doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide) to (1) enhance treatment efficacy by dose-dense drug delivery and (2) reduce risk of long-te...

journal_title：Blood

authors： Schwartz CL,Constine LS,Villaluna D,London WB,Hutchison RE,Sposto R,Lipshultz SE,Turner CS,deAlarcon PA,Chauvenet A

更新日期：2009-09-03 00:00:00

abstract：:miRNAs have emerged as master regulators of cancer-related events. miRNA dysregulation also occurs in Kaposi sarcoma (KS). Exploring the roles of KS-associated miRNAs should help to identify novel angiogenesis and lymphangiogenesis pathways. In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSH...

journal_title：Blood

authors： Wu YH,Hu TF,Chen YC,Tsai YN,Tsai YH,Cheng CC,Wang HW

更新日期：2011-09-08 00:00:00

abstract：:Our previous studies have identified mechanisms by which cytokine production, blocked by Ly49G2 receptor cross-linking, can be overridden. In this study we analyzed the regulation of other ITAM-positive receptor signaling on NK, NKT, and T cells and characterized the biochemical pathways involved in this signaling. Ou...

journal_title：Blood

authors： Ortaldo JR,Winkler-Pickett R,Wigginton J,Horner M,Bere EW,Mason AT,Bhat N,Cherry J,Sanford M,Hodge DL,Young HA

更新日期：2006-02-15 00:00:00

abstract：:A high proportion of carriers of classic hemophilia can be identified in the laboratory because, in comparison to normal women, the concentration of antigens related to antihemophilic factor (AHF, factor VIII) that are detected in their plasma by heterologous antiserum (factor VIIIR:Ag) is relatively higher than the t...

journal_title：Blood

authors： Fishman DJ,Jones PK,Menitove JE,Ratnoff OD,Everson B

更新日期：1982-06-01 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells that are highly effective adjuvants for immunizing against pathogens and tumor antigens. The potential merit of genetic approaches to loading DCs with antigens is to express high and sustained levels of proteins that can be subsequently processed and pres...

journal_title：Blood

authors： Dyall J,Latouche JB,Schnell S,Sadelain M

更新日期：2001-01-01 00:00:00

abstract：:Allogeneic bone marrow transplantation is still limited by the morbidity and mortality caused by graft-versus-host disease (GVHD), resulting from host recognition by donor T lymphocytes. It is possible to drastically reduce the T-cell content of the graft. However, transplanted T cells can also have a beneficial effec...

journal_title：Blood

authors： Gallot G,Hallet MM,Gaschet J,Moreau JF,Vivien R,Bonneville M,Milpied N,Vié H

更新日期：1996-08-01 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00

abstract：:We have characterized a splice variant (isoform) of the human CD28 T cell costimulatory receptor. The nucleotide sequence of this CD28 isoform was identical to that of CD28 in the signal peptide, the transmembrane domain, and the cytoplasmic tail, but it was missing a large segment of the extracellular ligand-binding ...

journal_title：Blood

authors： Hanawa H,Ma Y,Mikolajczak SA,Charles ML,Yoshida T,Yoshida R,Strathdee CA,Litchfield DW,Ochi A

更新日期：2002-03-15 00:00:00

abstract：:Lipid rafts are detergent-resistant, cholesterol- and sphingolipid-rich membrane domains that are involved in important cellular processes such as signal transduction and intracellular trafficking. Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein. Micros...

journal_title：Blood

authors： Mairhofer M,Steiner M,Mosgoeller W,Prohaska R,Salzer U

更新日期：2002-08-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemother...

journal_title：Blood

authors： Munneke JM,Björklund AT,Mjösberg JM,Garming-Legert K,Bernink JH,Blom B,Huisman C,van Oers MH,Spits H,Malmberg KJ,Hazenberg MD

更新日期：2014-07-31 00:00:00

abstract：:Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and its human homologue GOS19.1/LD78 are members of the C-C chemokine/intercrine family of secreted proteins. They have proinflammatory properties and also inhibit cell cycle progression of hematopoietic stem cells. Characterization of MIP-1 alpha receptor(s) has b...

journal_title：Blood

authors： Avalos BR,Bartynski KJ,Elder PJ,Kotur MS,Burton WG,Wilkie NM

更新日期：1994-09-15 00:00:00

abstract：:Programmed cell death or apoptosis is a prominent feature of low-risk myelodysplastic syndromes (MDS), although the underlying mechanism remains controversial. High-risk MDS have less apoptosis associated with increased expression of the prosurvival BCL2-related proteins. To address the mechanism and pathogenic role o...

journal_title：Blood

authors： Slape CI,Saw J,Jowett JB,Aplan PD,Strasser A,Jane SM,Curtis DJ

更新日期：2012-09-20 00:00:00

abstract：:Three families with polycythemia inherited through apparently different modes are described. Secondary causes of polycythemia were ruled out. Erythropoietin (EPO) levels were normal or low, even after phlebotomy. In vitro erythroid colony growth in standard assay cultures containing EPO was normal; however, in the abs...

journal_title：Blood

authors： Emanuel PD,Eaves CJ,Broudy VC,Papayannopoulou T,Moore MR,D'Andrea AD,Prchal JF,Eaves AC,Prchal JT

更新日期：1992-06-01 00:00:00

abstract：:Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers. All 50 household contac...

journal_title：Blood

authors： Lawrence DN,Jason JM,Bouhasin JD,McDougal JS,Knutsen AP,Evatt BL,Joist JH

更新日期：1985-09-01 00:00:00

abstract：:To study the role of the stress-induced "readthrough" acetylcholinesterase splice variant, AChE-R, in thrombopoiesis, we used transgenic mice overexpressing human AChE-R (TgR). Increased AChE hydrolytic activity in the peripheral blood of TgR mice was associated with increased thrombopoietin levels and platelet counts...

journal_title：Blood

authors： Pick M,Perry C,Lapidot T,Guimaraes-Sternberg C,Naparstek E,Deutsch V,Soreq H

更新日期：2006-04-15 00:00:00

abstract：:The interleukin-4 receptor (IL-4R) is expressed as a 140-Kd membrane glycoprotein that binds IL-4 with high affinity. Recently, cDNA clones for the murine IL-4R have been isolated. One clone encodes an integral membrane protein, while another encodes a protein in which translation is terminated before the transmembran...

journal_title：Blood

authors： Jacobs CA,Lynch DH,Roux ER,Miller R,Davis B,Widmer MB,Wignall J,VandenBos T,Park LS,Beckmann MP

更新日期：1991-06-01 00:00:00

abstract：:The anti-CD20 antibody rituximab depletes human B cells from peripheral blood, but it remains controversial to what extent tissue-resident B cells are affected. In representative patients with rheumatoid arthritis, we here demonstrate that recently activated presumably short-lived plasmablasts expressing HLA-DR(high) ...

journal_title：Blood

authors： Mei HE,Frölich D,Giesecke C,Loddenkemper C,Reiter K,Schmidt S,Feist E,Daridon C,Tony HP,Radbruch A,Dörner T

更新日期：2010-12-09 00:00:00

abstract：:Venous limb gangrene (VLG) can occur in cancer patients, but the clinical picture and pathogenesis remain uncertain. We identified 10 patients with metastatic cancer (7 pathologically proven) who developed severe venous limb ischemia (phlegmasia/VLG) after initiating treatment of deep-vein thrombosis (DVT); in 8 patie...

journal_title：Blood

authors： Warkentin TE,Cook RJ,Sarode R,Sloane DA,Crowther MA

更新日期：2015-07-23 00:00:00

abstract：:A small quantity of extracellular calcium is required for the stimulation of lymphocytes by mitogens such as plant lectins. Lectin binding to the lymphocyte surface and early postbinding events that eventually lead to DNA synthesis are calcium dependent. Mitogenic lectins such as PHA and Con-A rapidly increase the siz...

journal_title：Blood

authors： Lichtman AH,Segel GB,Lichtman MA

更新日期：1983-03-01 00:00:00