A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28.

Abstract:

:We have characterized a splice variant (isoform) of the human CD28 T cell costimulatory receptor. The nucleotide sequence of this CD28 isoform was identical to that of CD28 in the signal peptide, the transmembrane domain, and the cytoplasmic tail, but it was missing a large segment of the extracellular ligand-binding domain, which is encoded by the second exon. This isoform (CD28i), whose message level exceeded 25% of CD28, was a transmembrane homodimer. CD28i was found noncovalently associated with CD28 and was tyrosine-phosphorylated/PI3-kinase-complexed following the crosslinking of CD28, and the CD28 costimulatory signal was enhanced in T cells expressing CD28i. These data demonstrate that CD28i, via noncovalent association with CD28, plays a role as a costimulatory signal amplifier in human T cells.

journal_name

Blood

journal_title

Blood

authors

Hanawa H,Ma Y,Mikolajczak SA,Charles ML,Yoshida T,Yoshida R,Strathdee CA,Litchfield DW,Ochi A

doi

10.1182/blood.v99.6.2138

subject

Has Abstract

pub_date

2002-03-15 00:00:00

pages

2138-45

issue

6

eissn

0006-4971

issn

1528-0020

journal_volume

99

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Myc is essential for transformation by TEL/platelet-derived growth factor receptor beta (PDGFRbeta).

    abstract::The t(5;12) translocation identified in patients with chronic myelomonocytic leukemia (CMML) encodes a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein. A key hypothesis for how the TEL/PDGFRbeta fusion protein would function as an oncogene is that it represents a constitutively active versi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Bourgeade MF,Défachelles AS,Cayre YE

    更新日期:1998-05-01 00:00:00

  • TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release.

    abstract::Exposure of endothelial cells to recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced a modest (2-fold) increase of HL-60 cell adhesion as compared to TNF-alpha (40-fold) or interleukin 1beta (IL-1beta; 20-fold). However, pretreatment of endothelial cultures with TRAIL determined a...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-10-4111

    authors: Secchiero P,Corallini F,di Iasio MG,Gonelli A,Barbarotto E,Zauli G

    更新日期:2005-05-01 00:00:00

  • The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.

    abstract::Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2019001705

    authors: Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

    更新日期:2019-11-28 00:00:00

  • The upregulation of p27Kip1 by rapamycin results in G1 arrest in exponentially growing T-cell lines.

    abstract::An immunosuppressant Rapamycin (Rap) has been reported to cause G1 arrest by inhibiting p70 S6 kinase and G1 cyclin/cdks kinase activities when added to quiescent cells with mitogens. However, antiproliferative effects of Rap on exponentially growing cells have been poorly investigated. We examined the intracellular e...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Kawamata S,Sakaida H,Hori T,Maeda M,Uchiyama T

    更新日期:1998-01-15 00:00:00

  • The sixth sense: hematopoietic stem cells detect danger through purinergic signaling.

    abstract::Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2012-04-422378

    authors: Rossi L,Salvestrini V,Ferrari D,Di Virgilio F,Lemoli RM

    更新日期:2012-09-20 00:00:00

  • Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival.

    abstract::Human neutrophils possess a very short half-life because they constitutively undergo apoptosis. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), and other agents can rescue neutrophils from apoptosis but the molecular mechanisms involved in this rescue are undefined. Here, we show by Weste...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Moulding DA,Quayle JA,Hart CA,Edwards SW

    更新日期:1998-10-01 00:00:00

  • Synthesis of abnormal heavy chains in Bence-Jones plasma cell leukemia with intracellular IgG.

    abstract::In a patient with plasma cell leukemia and a kappa type Bence Jones protein in serum and urine, the immunofluorescence study of blood plasma cells showed intracellular gamma and kappa chain determinants. Biosynthesis experiments showed the production of abnormally short heavy chains (45,000 daltons) that assembled wit...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Preud'homme JL,Labaume S,Praloran V

    更新日期:1980-12-01 00:00:00

  • Identification and characterization of epitopes of the receptor for hyaluronic acid-mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2-positive patients with acute myeloid leukemia.

    abstract::The receptor for hyaluronic acid-mediated motility (RHAMM/CD168) has been described as a leukemia-associated antigen. To define T-cell epitopes of RHAMM/CD168 toward specific immunotherapies for acute myeloid leukemia (AML), 10 potential HLA-A2-binding RHAMM/CD168 peptides (R1 to R10) were synthesized based on compute...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-12-4787

    authors: Greiner J,Li L,Ringhoffer M,Barth TF,Giannopoulos K,Guillaume P,Ritter G,Wiesneth M,Döhner H,Schmitt M

    更新日期:2005-08-01 00:00:00

  • The interphase microtubule damage checkpoint defines an S-phase commitment point and does not require p21(waf-1).

    abstract::Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described in G(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(wa...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.5.1505

    authors: Mantel CR,Braun SE,Lee Y,Kim YJ,Broxmeyer HE

    更新日期:2001-03-01 00:00:00

  • Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6.

    abstract::We established a radiation-induced murine hematopoietic cell line, Y6, that could be induced to differentiate into macrophages by interleukin-6 (IL-6). IL-6 also induced growth inhibition and apoptosis in Y6 cells. Retinoic acid (RA) inhibited such effects of IL-6 on Y6 cells. The inhibitory effect of RA on the effect...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Oritani K,Kaisho T,Nakajima K,Hirano T

    更新日期:1992-11-01 00:00:00

  • Lymphoid differentiation of the hematopoietic stem cell that reconstitutes total erythropoiesis of a genetically anemic W/Wv mouse.

    abstract::We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Nakano T,Waki N,Asai H,Kitamura Y

    更新日期:1989-04-01 00:00:00

  • Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism.

    abstract::Deficiency of folate or vitamin B(12) (cobalamin) causes megaloblastic anemia, a disease characterized by pancytopenia due to the excessive apoptosis of hematopoietic progenitor cells. Clinical and experimental studies of megaloblastic anemia have demonstrated an impairment of DNA synthesis and repair in hematopoietic...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Koury MJ,Price JO,Hicks GG

    更新日期:2000-11-01 00:00:00

  • Quantification of the preexisting CD4 T-cell repertoire specific for human erythropoietin reveals its immunogenicity potential.

    abstract::Antibody-mediated pure red cell aplasia is a rare but serious event resulting from the induction of neutralizing erythropoietin (Epo)-specific antibodies provoked by treatment with recombinant Epo. Because of the crucial role of CD4 T cells in humoral response, we have quantified the number of Epo-specific CD4 T cells...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-04-280875

    authors: Delluc S,Ravot G,Maillere B

    更新日期:2010-11-25 00:00:00

  • In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia.

    abstract::Severe congenital neutropenia (CN) is a rare bone marrow failure syndrome with a high incidence of acute leukemia. In previous studies, we could show that point mutations in the gene for the granulocyte colony-stimulating factor (G-CSF) receptor CSF3R are a highly predictive marker for leukemic development in CN patie...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-09-178087

    authors: Germeshausen M,Welte K,Ballmaier M

    更新日期:2009-01-15 00:00:00

  • The alphaC domains of fibrinogen affect the structure of the fibrin clot, its physical properties, and its susceptibility to fibrinolysis.

    abstract::The functions of the alphaC domains of fibrinogen in clotting and fibrinolysis, which have long been enigmatic, were determined using recombinant fibrinogen truncated at Aalpha chain residue 251. Scanning electron microscopy and confocal microscopy revealed that the fibers of alpha251 clots were thinner and denser, wi...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-05-2150

    authors: Collet JP,Moen JL,Veklich YI,Gorkun OV,Lord ST,Montalescot G,Weisel JW

    更新日期:2005-12-01 00:00:00

  • A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis.

    abstract::A major limitation to the widespread use of hematopoietic stem cells (HSC) is the relatively crude level of our knowledge of how to maintain these cells in vitro without loss of the long-term multilineage growth and differentiation properties required for their clinical utility. An experimental and theoretical framewo...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:

    authors: Zandstra PW,Lauffenburger DA,Eaves CJ

    更新日期:2000-08-15 00:00:00

  • Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma.

    abstract::Although molecular biologic techniques can now detect minimal numbers of residual cancer cells in patients in complete clinical remission, the clinical significance of minimal residual disease has never been conclusively established. If the detection of minimal residual disease predicts which patients will relapse, th...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Gribben JG,Neuberg D,Freedman AS,Gimmi CD,Pesek KW,Barber M,Saporito L,Woo SD,Coral F,Spector N

    更新日期:1993-06-15 00:00:00

  • Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation.

    abstract::Antigens implicated in the graft-versus-leukemia (GVL) effect in chronic myeloid leukemia (CML) include WT1, PR1, and BCR-ABL. To detect very low frequencies of these antigen-specific CD8+ T cells, we used quantitative polymerase chain reaction (qPCR) to measure interferon-gamma (IFN-gamma) mRNA production by peptide-...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-01-0150

    authors: Rezvani K,Grube M,Brenchley JM,Sconocchia G,Fujiwara H,Price DA,Gostick E,Yamada K,Melenhorst J,Childs R,Hensel N,Douek DC,Barrett AJ

    更新日期:2003-10-15 00:00:00

  • Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression.

    abstract::In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-09-2767

    authors: Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

    更新日期:2003-05-01 00:00:00

  • Perioperative management of patients on chronic antithrombotic therapy.

    abstract::Perioperative management of antithrombotic therapy is a situation that occurs frequently and requires consideration of the patient, the procedure, and an expanding array of anticoagulant and antiplatelet agents. Preoperative assessment must address each patient's risk for thromboembolic events balanced against the ris...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2012-05-423228

    authors: Ortel TL

    更新日期:2012-12-06 00:00:00

  • Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor.

    abstract::Krüppel-like factor 5 (Klf5) encodes a zinc-finger transcription factor and has been reported to be a direct target of C/EBPα, a master transcription factor critical for formation of granulocyte-macrophage progenitors (GMP) and leukemic GMP. Using an in vivo hematopoietic-specific gene ablation model, we demonstrate t...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2015-12-684514

    authors: Shahrin NH,Diakiw S,Dent LA,Brown AL,D'Andrea RJ

    更新日期:2016-07-07 00:00:00

  • Plasma microparticles of sickle patients during crisis or taking hydroxyurea modify endothelium inflammatory properties.

    abstract::Microparticles (MPs) are submicron extracellular vesicles exposing phosphatidylserine (PS), detected at high concentration in the circulation of sickle cell anemia (SS) patients. Several groups studied the biological effects of MPs generated ex vivo. Here, we analyzed for the first time the impact of circulating MPs o...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.2020004853

    authors: Garnier Y,Ferdinand S,Garnier M,Cita KC,Hierso R,Claes A,Connes P,Hardy-Dessources MD,Lapouméroulie C,Lemonne N,Etienne-Julan M,El Nemer W,Romana M

    更新日期:2020-07-09 00:00:00

  • Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability.

    abstract::Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's surface modulates the 3-dimensional structure and stability of the fibrin network. Currently, we compared the abilities of extravascular ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-06-228940

    authors: Campbell RA,Overmyer KA,Selzman CH,Sheridan BC,Wolberg AS

    更新日期:2009-11-26 00:00:00

  • The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation.

    abstract::GVHD and tumor relapse are fundamental problems in allogeneic HSCT. Recent research has linked neovascularization to GVHD, tumor growth, and graft-versus-tumor (GVT) activity. Damage of the endothelium by the conditioning regimen provides the initiation stimulus for recruitment of donor-derived endothelial cells and t...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-10-312934

    authors: Penack O,Socié G,van den Brink MR

    更新日期:2011-04-21 00:00:00

  • A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation.

    abstract::Translation of small interfering RNA (siRNA)-based approaches into practical therapeutics is limited because of lack of an effective and cell-specific delivery system. Herein, we present a new method of selectively delivering siRNA to dendritic cells (DCs) in vivo using CD40 siRNA-containing immunoliposomes (siILs) th...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-04-151191

    authors: Zheng X,Vladau C,Zhang X,Suzuki M,Ichim TE,Zhang ZX,Li M,Carrier E,Garcia B,Jevnikar AM,Min WP

    更新日期:2009-03-19 00:00:00

  • Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach.

    abstract::Hematopoietic stem cells (HSCs) show pronounced heterogeneity in self-renewal and differentiation behavior, which is reflected in their repopulation kinetics. Here, a single-cell-based mathematical model of HSC organization is used to examine the basis of HSC heterogeneity. Our modeling results, which are based on the...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-05-155374

    authors: Roeder I,Horn K,Sieburg HB,Cho R,Muller-Sieburg C,Loeffler M

    更新日期:2008-12-15 00:00:00

  • N(o)-cadherin role for HSCs.

    abstract::In this issue of Blood, Bromberg et al and Greenbaum et al delete the gene encoding the cell adhesion molecule N-cadherin in osteoblastic cells forming the hematopoietic stem cell (HSC) niche to demonstrate that N-cadherin has no role in regulating hematopoiesis. ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2012-05-431148

    authors: Levesque JP

    更新日期:2012-07-12 00:00:00

  • Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells transplanted in sheep fetuses.

    abstract::Hematopoietic stem cells (HSC) transplanted in utero are in competition with endogenous HSC; thus, ultimately the graft constitutes a relatively small fraction of total HSC pool. To enhance the engraftment of donor cells in sheep fetuses, we preincubated these cells, ex vivo, for 16 hours at 37 degrees C with the cond...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Zanjani ED,Ascensao JL,Harrison MR,Tavassoli M

    更新日期:1992-06-01 00:00:00

  • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents.

    abstract::Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), in...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Richardson DR,Tran EH,Ponka P

    更新日期:1995-12-01 00:00:00

  • Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection.

    abstract::Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a key epigenetic mechanism controlling chromatin structure, DNA accessibility, and gene expression. HDAC inhibitors induce growth arrest, differentiation, and apoptosis of tumor cells and are used as anticancer agents. Here we des...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-05-284711

    authors: Roger T,Lugrin J,Le Roy D,Goy G,Mombelli M,Koessler T,Ding XC,Chanson AL,Reymond MK,Miconnet I,Schrenzel J,François P,Calandra T

    更新日期:2011-01-27 00:00:00