Induction of donor-type chimerism and transplantation tolerance across major histocompatibility barriers in sublethally irradiated mice by Sca-1(+)Lin(-) bone marrow progenitor cells: synergism with non-alloreactive (host x donor)F(1) T cells.

abstract：:Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence...

journal_title：Blood

authors： Kundu M,Lindsten T,Yang CY,Wu J,Zhao F,Zhang J,Selak MA,Ney PA,Thompson CB

更新日期：2008-08-15 00:00:00

abstract：:Commercial porcine factor VIII concentrate (Hyate:C) is effective in treatment of patients with hemophilia A who have circulating antibodies to factor VIII. The molecular forms of factor VIII in the concentrate were identified and evaluated in light of the known properties of porcine and human factor VIII. The factor ...

journal_title：Blood

authors： Lollar P,Parker CG,Tracy RP

更新日期：1988-01-01 00:00:00

abstract：:Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia. We have found that in human erythrocytes, Prx2 was extremely sensitive to oxidation by H(2)O(2), as dimerization was observed after exposure of ...

journal_title：Blood

authors： Low FM,Hampton MB,Peskin AV,Winterbourn CC

更新日期：2007-03-15 00:00:00

abstract：:For activation T cells engage antigen-presenting cells (APCs) in lymphatic tissues. The contact duration and kinetics (static versus dynamic) vary considerably in different model systems; however, it is unclear whether T cells, APCs, or the environment are responsible for the observed discrepancies. Using 3-D collagen...

journal_title：Blood

authors： Gunzer M,Weishaupt C,Hillmer A,Basoglu Y,Friedl P,Dittmar KE,Kolanus W,Varga G,Grabbe S

更新日期：2004-11-01 00:00:00

abstract：:Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and its mutations are the major cause of juvenile hemochromatosis (JH), a recessive disease leading to iron overload. Defective HJV reduces hepcidin up-regulation both in humans and in Hjv-deficient mice. To investigate the JH pathogenesis and the fun...

journal_title：Blood

authors： Silvestri L,Pagani A,Fazi C,Gerardi G,Levi S,Arosio P,Camaschella C

更新日期：2007-05-15 00:00:00

abstract：:A large English pedigree in which heterocellular hereditary persistence of fetal hemoglobin (HPFH) segregates is described. beta-globin cluster deletions and gamma gene promoter mutations associated with HPFH have been excluded. Of particular importance in this pedigree is the absence of any cosegregating hemoglobinop...

journal_title：Blood

authors： Craig JE,Rochette J,Sampietro M,Wilkie AO,Barnetson R,Hatton CS,Demenais F,Thein SL

更新日期：1997-07-01 00:00:00

abstract：:To prospectively evaluate allogeneic stem cell transplantation (allo-SCT) for myeloma as part of first-line therapy, a donor versus no-donor analysis was performed of patients treated in the HOVON-50 study, a study that was originally designed to examine thalidomide combined with intensive therapy. Two hundred sixty p...

journal_title：Blood

authors： Lokhorst HM,van der Holt B,Cornelissen JJ,Kersten MJ,van Oers M,Raymakers R,Minnema MC,Zweegman S,Janssen JJ,Zijlmans M,Bos G,Schaap N,Wittebol S,de Weerdt O,Ammerlaan R,Sonneveld P

更新日期：2012-06-28 00:00:00

abstract：:Lipid rafts are detergent-resistant, cholesterol- and sphingolipid-rich membrane domains that are involved in important cellular processes such as signal transduction and intracellular trafficking. Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein. Micros...

journal_title：Blood

authors： Mairhofer M,Steiner M,Mosgoeller W,Prohaska R,Salzer U

更新日期：2002-08-01 00:00:00

abstract：:The translocation between chromosomes 8 and 21, t(8;21) (q22;q22), is the most frequent abnormality in acute myeloid leukemia (AML) with French-American-British type M2 (FAB-M2) morphology. The breakpoints in this translocation have been characterized at the molecular level, and the genes involved are AML1 on chromoso...

journal_title：Blood

authors： Nucifora G,Larson RA,Rowley JD

更新日期：1993-08-01 00:00:00

abstract：:The ability of platelets to adsorb vinblastine has been used to treat patients with immune thrombocytopenia. It is hypothesized that the drug-platelet complex is coated with antibody, taken up by macrophages which are then destroyed by the drug. We gave 16 courses of vinblastine-platelets to six patients with immune t...

journal_title：Blood

authors： Kelton JG,McDonald JW,Barr RM,Walker I,Nicholson W,Neame PB,Hamid C,Wong TY,Hirsh J

更新日期：1981-03-01 00:00:00

abstract：:Conventional assays evaluating antitumor activity of immune effector cells have limitations that preclude their high-throughput application. We adapted the recently developed Compartment-Specific Bioluminescence Imaging (CS-BLI) technique to perform high-throughput quantification of innate antitumor activity and to sh...

journal_title：Blood

authors： McMillin DW,Delmore J,Negri JM,Vanneman M,Koyama S,Schlossman RL,Munshi NC,Laubach J,Richardson PG,Dranoff G,Anderson KC,Mitsiades CS

更新日期：2012-04-12 00:00:00

abstract：:Recent phenotypic analysis of plasma cells showed that normal plasma cells do express the B-cell lineage-specific molecule CD19, but their malignant counterpart (myeloma cells) are CD19-. To clarify the meaning of loss of CD19 antigen on myeloma cells, we first compared the expression of CD19 and Pax-5 genes among B c...

journal_title：Blood

authors： Mahmoud MS,Huang N,Nobuyoshi M,Lisukov IA,Tanaka H,Kawano MM

更新日期：1996-05-15 00:00:00

abstract：:Despite increasing use of targeted therapies to treat cancer, anemia remains a common complication of cancer therapy. Physician concerns about the safety of intravenous (IV) iron products and erythropoiesis-stimulating agents (ESAs) have resulted in many patients with cancer receiving no or suboptimal anemia therapy. ...

journal_title：Blood

authors： Gilreath JA,Rodgers GM

更新日期：2020-08-13 00:00:00

abstract：:We analyzed factors having an impact on response to treatment and survival in 78 consecutive patients with chronic myeloid leukemia (CML) in blastic transformation (BT) referred to the Hammersmith Hospital from January 1995 to December 2000. BT was defined as the presence of at least 30% blasts in blood or marrow or e...

journal_title：Blood

authors： Wadhwa J,Szydlo RM,Apperley JF,Chase A,Bua M,Marin D,Olavarria E,Kanfer E,Goldman JM

更新日期：2002-04-01 00:00:00

abstract：:The expression and function of a glycoprotein Ib (GPIb) complex on human umbilical vein endothelial cells (HUVECs) is still a matter of controversy. We characterized HUVEC GPIb using viper venom proteins: alboaggregins A and B, echicetin, botrocetin, and echistatin. Echicetin is an antagonist, and alboaggregins act as...

journal_title：Blood

authors： Tan L,Kowalska MA,Romo GM,Lopez JA,Darzynkiewicz Z,Niewiarowski S

更新日期：1999-04-15 00:00:00

abstract：:We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515)...

journal_title：Blood

authors： Rumi E,Pietra D,Pascutto C,Guglielmelli P,Martínez-Trillos A,Casetti I,Colomer D,Pieri L,Pratcorona M,Rotunno G,Sant'Antonio E,Bellini M,Cavalloni C,Mannarelli C,Milanesi C,Boveri E,Ferretti V,Astori C,Rosti V,Cerva

更新日期：2014-08-14 00:00:00

abstract：:Chemoresistance is a major problem in the treatment of patients with multiple myeloma (MM). Because of the central role of the nuclear transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) in chemoresistance, cell survival, and proliferation, we investig...

journal_title：Blood

authors： Bharti AC,Shishodia S,Reuben JM,Weber D,Alexanian R,Raj-Vadhan S,Estrov Z,Talpaz M,Aggarwal BB

更新日期：2004-04-15 00:00:00

abstract：:In a prospective multicenter study, 368 acute lymphoblastic leukemia (ALL) patients aged 15 to 65 years were treated with an intensified induction and reinduction regimen; 272 (73.9%) achieved complete remission (CR). The median remission duration (MRD) is 24.3 months, and the probability of being in continuous CR (CC...

journal_title：Blood

authors： Hoelzer D,Thiel E,Löffler H,Büchner T,Ganser A,Heil G,Koch P,Freund M,Diedrich H,Rühl H

更新日期：1988-01-01 00:00:00

abstract：:For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is poor, and there is a need for novel therapies to improve outcome. We screened samples from children with B-lineage ALL entered into the ALL-REZ BFM 2002 clinical trial (www.clinicaltrials.gov, #NCT00114348) for somatic mutations ac...

journal_title：Blood

authors： Irving J,Matheson E,Minto L,Blair H,Case M,Halsey C,Swidenbank I,Ponthan F,Kirschner-Schwabe R,Groeneveld-Krentz S,Hof J,Allan J,Harrison C,Vormoor J,von Stackelberg A,Eckert C

更新日期：2014-11-27 00:00:00

abstract：:Peripheral blood cells are increasingly used in place of bone marrow as a source of hematopoietic stem cells for allogeneic transplantation. The relative efficacy of these 2 approaches is unknown. This retrospective multivariate analysis compared results of 288 HLA-identical sibling blood stem cell transplantations wi...

journal_title：Blood

authors： Champlin RE,Schmitz N,Horowitz MM,Chapuis B,Chopra R,Cornelissen JJ,Gale RP,Goldman JM,Loberiza FR Jr,Hertenstein B,Klein JP,Montserrat E,Zhang MJ,Ringdén O,Tomany SC,Rowlings PA,Van Hoef ME,Gratwohl A

更新日期：2000-06-15 00:00:00

abstract：:Recently (J Pharmacol Exp Ther 261:580, 1992), we have shown that K562 leukemia cells express a calcium-signaling purinoceptor with characteristics of the P2T receptor subtype for adenosine diphosphate (ADP) previously found only in platelets. Because these results suggested that the P2T receptor may be an early marke...

journal_title：Blood

authors： Murgo AJ,Contrera JG,Sistare FD

更新日期：1994-03-01 00:00:00

abstract：:Although recent advances have enabled hematopoietic stem cells (HSCs) to be enriched to near purity, more information about their characteristics will improve our understanding of their development and stage-related functions. Here, using microarray technology, we identified endothelial cell-selective adhesion molecul...

journal_title：Blood

authors： Yokota T,Oritani K,Butz S,Kokame K,Kincade PW,Miyata T,Vestweber D,Kanakura Y

更新日期：2009-03-26 00:00:00

abstract：:A monoclonal antibody raised against cytochrome b558 reacted specifically with the 22- to 23-Kd protein, the small subunit of this cytochrome. Cytochemical studies showed that the epitope was located on the surfaces of human neutrophils and monocytes. The small subunit of cytochrome b558, therefore, was expressed at l...

journal_title：Blood

authors： Nakamura M,Sendo S,van Zwieten R,Koga T,Roos D,Kanegasaki S

更新日期：1988-11-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) has previously been shown to inhibit the growth of OPM-2 human myeloma cells. The growth inhibition was postulated to result from a transcriptional downregulation of interleukin-6 receptor alpha (IL-6Ralpha) with IL-6Rbeta (gp130) unaffected. To formally test this hypothesis, an expressi...

journal_title：Blood

authors： Chen YH,Lavelle D,DeSimone J,Uddin S,Platanias LC,Hankewych M

更新日期：1999-07-01 00:00:00

abstract：:Mammalian TOR (mTOR) regulates cell growth, proliferation, and migration. Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mouse by neo-insertion that partially disrupts mTOR transcription and creates a potential physiologic model of mTORC1/TORC2 inhibition. Homozygous knock-in mice exhi...

journal_title：Blood

authors： Zhang S,Readinger JA,DuBois W,Janka-Junttila M,Robinson R,Pruitt M,Bliskovsky V,Wu JZ,Sakakibara K,Patel J,Parent CA,Tessarollo L,Schwartzberg PL,Mock BA

更新日期：2011-01-27 00:00:00

abstract：:Leukemia-cell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV) each is associated with aggressive disease in patients with chronic lymphocytic leukemia (CLL). To assess the relative strength of each marker, we defined thresholds for designating a case as positive for C...

journal_title：Blood

authors： Rassenti LZ,Jain S,Keating MJ,Wierda WG,Grever MR,Byrd JC,Kay NE,Brown JR,Gribben JG,Neuberg DS,He F,Greaves AW,Rai KR,Kipps TJ

更新日期：2008-09-01 00:00:00

abstract：:Alloreactive T cells present in a bone marrow transplant are responsible for graft-versus-host disease (GVHD), but their depletion is associated with impaired engraftment, immunosuppression, and loss of the graft-versus-leukemia effect. We developed a therapeutic strategy against GVHD based on the selective destructio...

journal_title：Blood

authors： Cohen JL,Boyer O,Salomon B,Onclercq R,Charlotte F,Bruel S,Boisserie G,Klatzmann D

更新日期：1997-06-15 00:00:00

abstract：:An immunosuppressant Rapamycin (Rap) has been reported to cause G1 arrest by inhibiting p70 S6 kinase and G1 cyclin/cdks kinase activities when added to quiescent cells with mitogens. However, antiproliferative effects of Rap on exponentially growing cells have been poorly investigated. We examined the intracellular e...

journal_title：Blood

authors： Kawamata S,Sakaida H,Hori T,Maeda M,Uchiyama T

更新日期：1998-01-15 00:00:00

abstract：:Laminin is a heterotrimeric glycoprotein that plays a central role in promoting neutrophil chemotaxis, motility, and attachment to basement membrane. Rabbit peritoneal exudate neutrophils stain positively for laminin, which is presumed to be of exogenous origin and bound to laminin receptors on the cell surface. We ex...

journal_title：Blood

authors： Tweardy DJ,Sasaki M,Cardamone JJ Jr,McCoy JP Jr,Bonidie MJ,Signorella AP

更新日期：1990-10-01 00:00:00

abstract：:Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 ...

journal_title：Blood

authors： Bergerson RJ,Collier LS,Sarver AL,Been RA,Lugthart S,Diers MD,Zuber J,Rappaport AR,Nixon MJ,Silverstein KA,Fan D,Lamblin AF,Wolff L,Kersey JH,Delwel R,Lowe SW,O'Sullivan MG,Kogan SC,Adams DJ,Largaespada DA

更新日期：2012-05-10 00:00:00