Abstract：
:Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 mice with a murine leukemia virus (MuLV). MuLV-infected Mll-AF9 mice succumbed to disease significantly faster than controls presenting predominantly with myeloid leukemia while infected WT animals developed predominantly lymphoid leukemia. We identified 88 candidate cancer genes near common sites of proviral insertion. Analysis of transcript levels revealed significantly elevated expression of Mn1, and a trend toward increased expression of Bcl11a and Fosb in Mll-AF9 murine leukemia samples with proviral insertions proximal to these genes. Accordingly, FOSB and BCL11A were also overexpressed in human AML harboring MLL gene translocations. FOSB was revealed to be essential for growth in mouse and human myeloid leukemia cells using shRNA lentiviral vectors in vitro. Importantly, MN1 cooperated with Mll-AF9 in leukemogenesis in an in vivo BM viral transduction and transplantation assay. Together, our data identified genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL fusion oncogenes.
journal_name
Bloodjournal_title
Bloodauthors
Bergerson RJ,Collier LS,Sarver AL,Been RA,Lugthart S,Diers MD,Zuber J,Rappaport AR,Nixon MJ,Silverstein KA,Fan D,Lamblin AF,Wolff L,Kersey JH,Delwel R,Lowe SW,O'Sullivan MG,Kogan SC,Adams DJ,Largaespada DAdoi
10.1182/blood-2010-04-281428subject
Has Abstractpub_date
2012-05-10 00:00:00pages
4512-23issue
19eissn
0006-4971issn
1528-0020pii
blood-2010-04-281428journal_volume
119pub_type
杂志文章相关文献
BLOOD文献大全abstract：:To facilitate the investigation of the direct interaction between hematopoietic progenitors and colony-stimulating factors, we have developed a method to purify human marrow progenitor cells. Using density centrifugation, negative panning with concanavalin A coated plates, positive selection of CD34-positive cells wit...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-08-15 00:00:00
abstract：:Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore conducted a comprehensive assessment of 114,548 lymphoid neoplasms diagnosed during 1992-2001 in 12 Surveillance, Epidemiology, ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2005-06-2508
更新日期：2006-01-01 00:00:00
abstract：:Blockade of the CD40/CD154 signal is a potential immunomodulatory strategy for T-cell-mediated diseases. As a part of a phase 1, multicenter, dose-escalating trial of humanized monoclonal antibody to CD154 (IDEC-131/E6040) in patients with refractory immune thrombocytopenic purpura (ITP), the autoimmune response to gl...
journal_title：Blood
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1182/blood-2003-06-2167
更新日期：2004-02-15 00:00:00
abstract：:To further evaluate the role of sialic acid in the dysfibrinogenemia associated with liver disease, we studied the effect of removal of excess sialic acid residues from the fibrinogen of five patients with liver disease on the thrombin time and fibrin monomer aggregation. Patient fibrinogens containing 1.4-3.4 residue...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：:The ontogeny of a 57-Kd cationic antimicrobial protein (CAP57) that has substantial similarities to bactericidal permeability increasing protein (BPI) has been determined immunocytochemically. CAP57 was detected in the granules of mature peripheral blood neutrophils. However, it was absent from other cells of the peri...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-08-15 00:00:00
abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...
journal_title：Blood
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1182/blood-2003-08-2644
更新日期：2004-02-15 00:00:00
abstract：:Hematopoiesis is tightly controlled by transcription regulatory networks, but how and when specific transcription factors control lineage commitment are still largely unknown. Within the hematopoietic stem cell (Lin(-)Sca-1(+)c-Kit(+)) compartment these lineage-specific transcription factors are expressed at low level...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-03-275404
更新日期：2010-11-18 00:00:00
abstract：:Recent studies have reported that the pharmacokinetics of high-dose busulfan in bone marrow transplantation (BMT) are age-dependent: with the usual dosage of 16 mg/kg over 4 days, systemic exposure is two to four times lower in children than in adults. Data suggested that the dose of busulfan should rather be calculat...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Perforin (pfp) and interferon-gamma (IFN-gamma) together in C57BL/6 (B6) and BALB/c mouse strains provided optimal protection in 3 separate tumor models controlled by innate immunity. Using experimental (B6, RM-1 prostate carcinoma) and spontaneous (BALB/c, DA3 mammary carcinoma) models of metastatic cancer, mice defi...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v97.1.192
更新日期：2001-01-01 00:00:00
abstract：:Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymp...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2012-08-447375
更新日期：2013-09-19 00:00:00
abstract：:The majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy. However, high-dose therapy with autologous hematopoietic cell transplant (AHCT) allows for the cure of an additional portion of patients with relapsed or primary refractory disease. Positron emission tomography-negative complete remiss...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2017-09-772673
更新日期：2018-04-12 00:00:00
abstract：:Murine IgM monoclonal antibody STRO-1 identifies a cell surface antigen expressed by stromal elements in human bone marrow (BM). STRO-1 binds to approximately 10% of BM mononuclear cells, greater than 95% of which are nucleated erythroid precursors, but does not react with committed progenitor cells (colony-forming un...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer) has been recently discovered. In this study, we tested its efficacy in inhibiting clot-bound thrombin activity and platelet thrombus formation in an ex vivo whole artery angioplasty model. The...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, highly abundant in plasma, that potently regulates endothelial responses through interaction with its receptors (S1PRs). Here, we studied the role of S1PR2 ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2012-11-467191
更新日期：2013-07-18 00:00:00
abstract：:Chromosome 11q deletions are frequently observed in chronic lymphocytic leukemia (CLL) in association with progressive disease and a poor prognosis. A minimal region of deletion has been assigned to 11q22-q23. Trinucleotide repeats have been associated with anticipation in disease, and evidence of anticipation has bee...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v97.2.509
更新日期：2001-01-15 00:00:00
abstract：:We developed a risk score to predict event-free survival (EFS) after allogeneic hematopoietic cell transplantation for sickle cell disease. The study population (n = 1425) was randomly split into training (n = 1070) and validation (n = 355) cohorts. Risk factors were identified and validated via Cox regression models....
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.2020005687
更新日期：2020-07-30 00:00:00
abstract：:Hematide is an investigational pegylated synthetic peptide that stimulates erythropoiesis in animal models and is being developed for the treatment of anemia associated with chronic renal failure and cancer. This study evaluated the safety and pharmacodynamics of single, intravenous doses (0.025, 0.05, and 0.1 mg/kg) ...
journal_title：Blood
pub_type： 杂志文章,随机对照试验
doi：10.1182/blood-2006-04-015818
更新日期：2006-09-15 00:00:00
abstract：:To determine the hematopoietic cell lineage of mitotic cells in human bone marrow on direct examination and after 24-hour culture, marrow mitoses from four healthy individuals were studied, using a new technique that allows analysis of karyotypes in cells whose cell membrane and cytoplasm have been preserved. Mitoses ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：:The extended (E) isoform unique to Fibrinogen420 (Fib420) is distinguished from the conventional chain of Fibrinogen340 by the presence of an additional 236-residue carboxyl terminus globular domain (EC). A recombinant form of EC (rEC), having a predicted mass of 27,653 Daltons, was expressed in yeast (Pichia pastoris...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-11-15 00:00:00
abstract：:CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in lymphocyte differentiation and selection. It is expressed on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. We investigated the expressio...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Normal human bone marrow contains cells capable of forming colonies of hemopoietic cells in fibrin clots in diffusion chambers implanted intraperitoneally (i.p.) into irradiated mice. The present paper describes the proliferation of such colony-forming units (CFUD) in cultures in vivo. Cells harvested from diffusion c...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Containers constructed of polyvinylchloride (PVC) are used for the storage of platelet concentrates (PC) for transfusion, At 22 degrees C, pH often falls to such low levels (pH is less that 6.0) that viability is lost. Far lesser degrees of pH fall are observed in bags constructed of polyethylene (PE). In this study, ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response. Because activated macrophages produce large amounts of reactive oxygen species (ROS) that can cause DNA lesions, we examined the role of NBS1 in ma...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2015-04-637371
更新日期：2015-11-26 00:00:00
abstract：:Individuals with impaired perforin-dependent cytotoxic function (Ctx(-)) develop a fatal inflammatory disorder called hemophagocytic lymphohistiocytosis (HLH). It has been hypothesized that immune hyperactivation during HLH is caused by heightened infection, defective apoptosis/responsiveness of Ctx(-) lymphocytes, or...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-12-324533
更新日期：2011-07-21 00:00:00
abstract：:Acquisition of mature T cell function and the T cell antigen receptor repertoire occur in the thymus. In an effort to delineate the cascade of events leading to T cell maturation, we analyzed a series of clonal human precursor T cell neoplasms representing early, middle, and late stages of intrathymic differentiation....
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less than 10 mumol/L. The inhibitory effect depended on the incubation time, with the effect increasing with longer incubation periods. Because tellurite causes swelling of red cells, and because...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:Rabbit polyclonal antibodies were raised against synthetic peptides corresponding to hydrophilic regions of the human Rhesus (Rh) IX cDNA-encoded polypeptide predicted to be extracellularly or intracellularly exposed in the topologic model of the Rh blood group protein. Four antibodies encompassing residues 33-45 (MPC...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-07-15 00:00:00
abstract：:Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). We investigated the feasibility of intensified preemptive immunotherapy in children receiving allo-SCT for AML. Eighty-four...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：10.1182/blood-2011-04-348805
更新日期：2011-11-17 00:00:00
abstract：:1-deamino-8-d-arginine vasopressin (desmopressin [DDAVP]) is clinically efficacious in patients with mild platelet function disorders but it is not known which mechanisms mediate this effect. Our aim was to evaluate the impact of in vivo DDAVP administration in these patients. We assessed von Willebrand factor (VWF), ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-04-497123
更新日期：2014-03-20 00:00:00
abstract：:Scott syndrome is an hereditary bleeding disorder characterized by a deficiency in platelet procoagulant activity. Unlike normal blood cells, Scott platelets, as well as erythrocytes and lymphocytes, are strongly impaired in their ability to scramble their membrane phospholipids when challenged with Ca2+. In normal ce...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-03-15 00:00:00
