Donor versus no-donor comparison of newly diagnosed myeloma patients included in the HOVON-50 multiple myeloma study.

abstract：:Hemophilia B Leyden is an X chromosome-linked bleeding disorder characterized by an altered developmental expression of blood coagulation factor IX. This form of hemophilia B has been found to be associated with a variety of single point mutations in the factor IX promoter region. We now describe a novel point mutatio...

journal_title：Blood

authors： Reijnen MJ,Peerlinck K,Maasdam D,Bertina RM,Reitsma PH

更新日期：1993-07-01 00:00:00

abstract：:The expression of tumor-associated antigens (TAAs) might play a critical role in the control of minimal residual disease (MRD) in acute myeloid leukemia (AML), and therefore might be associated with clinical outcome in AML. In a DNA microarray analysis of 116 AML samples, we found a significant correlation between hig...

journal_title：Blood

authors： Greiner J,Schmitt M,Li L,Giannopoulos K,Bosch K,Schmitt A,Dohner K,Schlenk RF,Pollack JR,Dohner H,Bullinger L

更新日期：2006-12-15 00:00:00

abstract：:Serum cytokines and chemokines may reflect tumor biology and host response in follicular lymphoma (FL). To determine whether the addition of these biological factors may further refine prognostication, 30 cytokines and chemokines were measured in pretreatment serum specimens from newly diagnosed FL patients (n = 209) ...

journal_title：Blood

authors： Mir MA,Maurer MJ,Ziesmer SC,Slager SL,Habermann T,Macon WR,Link BK,Syrbu S,Witzig T,Friedberg JW,Press O,LeBlanc M,Cerhan JR,Novak A,Ansell SM

更新日期：2015-02-05 00:00:00

abstract：:Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate the contribution o...

journal_title：Blood

authors： Mitchell JL,Lionikiene AS,Georgiev G,Klemmer A,Brain C,Kim PY,Mutch NJ

更新日期：2016-12-15 00:00:00

abstract：:In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-t...

journal_title：Blood

authors： Advani R,Rubin E,Mohandas N,Schrier SL

更新日期：1992-02-15 00:00:00

abstract：:The treatment of multiple myeloma is considered a continuously evolving paradigm as a result of the growing availability of new and highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Clinical trials advocate long-term rather than sh...

journal_title：Blood

authors： Delforge M,Ludwig H

更新日期：2017-04-27 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive disease characterized by congenital anomalies, aplastic anemia, and a susceptibility to leukemia. There are at least 8 complementation groups (A through H). Extensive analyses of the FA group C gene FANCC in Western countries revealed that 10% to 15% of FA patients have mu...

journal_title：Blood

authors： Futaki M,Yamashita T,Yagasaki H,Toda T,Yabe M,Kato S,Asano S,Nakahata T

更新日期：2000-02-15 00:00:00

abstract：:Epithelial mesenchymal transitions are a remarkable example of cellular plasticity. These transitions are the hallmark of embryo development, are pivotal in cancer progression, and seem to occur infrequently in adult organisms. The reduced incidence of transitions in the adult could result from restrictive functions o...

journal_title：Blood

authors： Prindull G,Zipori D

更新日期：2004-04-15 00:00:00

abstract：:We studied eight patients with intermittent bleeding episodes usually following trauma and associated with the ingestion of medicine known to interfere with platelet function. All patients had a normal or minimally prolonged baseline bleeding time. All had a normal platelet count, glass bead retention test, and platel...

journal_title：Blood

authors： Czapek EE,Deykin D,Salzman E,Lian EC,Hellerstein LJ,Rosoff CB

更新日期：1978-07-01 00:00:00

abstract：:Ubiquitin is suggested to play a key role in essential intracellular functions, such as heat shock response, protein breakdown, and regulation of immune responses. Ubiquitin has also been detected in the extracellular space, but the function and biologic significance is unclear. We describe a new function of extracell...

journal_title：Blood

authors： Majetschak M,Krehmeier U,Bardenheuer M,Denz C,Quintel M,Voggenreiter G,Obertacke U

更新日期：2003-03-01 00:00:00

abstract：:Stromal cells are believed to regulate lympho-hematopoiesis through direct cell-cell interactions and the release of growth factors. Many questions remain, however, about their lineage derivation and functional heterogeneity. We previously prepared a panel of stromal cell lines from murine spleen and bone marrow and c...

journal_title：Blood

authors： Gimble JM,Pietrangeli C,Henley A,Dorheim MA,Silver J,Namen A,Takeichi M,Goridis C,Kincade PW

更新日期：1989-07-01 00:00:00

abstract：:High-molecular weight DNAs of fresh bone marrow cells from 32 patients with fresh leukemia were assayed for the presence of transmissible activated transforming genes by a DNA-mediated gene transfer technique using NIH/3T3 cells. DNAs of bone marrow cells from four of the 32 patients induced transformation of NIH/3T3 ...

journal_title：Blood

authors： Hirai H,Tanaka S,Azuma M,Anraku Y,Kobayashi Y,Fujisawa M,Okabe T,Urabe A,Takaku F

更新日期：1985-12-01 00:00:00

abstract：:Leukocyte alpha4beta1 integrins regulate hematopoietic and lymphoid development, as well as the emigration of circulating cells to sites of inflammation. Because vascular cell adhesion molecule-1 (VCAM-1) binding to high-affinity alpha4beta1 is stable, these integrins can be detected and selectively precipitated from ...

journal_title：Blood

authors： Hyduk SJ,Oh J,Xiao H,Chen M,Cybulsky MI

更新日期：2004-11-01 00:00:00

abstract：:The cell-surface expression of the MIC2 antigen defined by the monoclonal antibody 12E7 was investigated on human leukocytes in bone marrow (BM), thymus, and peripheral blood (PB) using multiparameter flow cytometry and cell sorting. In contrast to preceding reports, we found that the MIC2 antigen is not restricted to...

journal_title：Blood

authors： Dworzak MN,Fritsch G,Buchinger P,Fleischer C,Printz D,Zellner A,Schöllhammer A,Steiner G,Ambros PF,Gadner H

更新日期：1994-01-15 00:00:00

abstract：:We have explored the role of plasminogen activator inhibitor type 2 (PAI-2) in THP-1 monocyte-like cells. These cells possess a mutation in the PAI-2 gene and do not produce an active PAI-2 protein. Transfection of THP-1 cells with plasmids expressing active PAI-2 reduced the cells' inherent adhesive properties and de...

journal_title：Blood

authors： Yu H,Maurer F,Medcalf RL

更新日期：2002-04-15 00:00:00

abstract：:The introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has dramatically changed the management of chronic lymphocytic leukemia (CLL). Although responses have been durable in the majority of patients, relapses do occur, especially in the high-risk patient population. Most relapses occur as the result ...

journal_title：Blood

authors： Woyach JA

更新日期：2017-03-09 00:00:00

abstract：:Since the introduction of replacement therapy in the early 1960s by the infusion of plasma-derived factor VIII and IX preparations, important changes have occurred for hemophilia patients. We studied the medical and social developments over 30 years of hemophilia treatment. Since 1972, 5 cross-sectional national posta...

journal_title：Blood

authors： Plug I,van der Bom JG,Peters M,Mauser-Bunschoten EP,de Goede-Bolder A,Heijnen L,Smit C,Zwart-van Rijkom JE,Willemse J,Rosendaal FR

更新日期：2004-12-01 00:00:00

abstract：:Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and maturation, primarily of the megakaryocyte lineage. The signaling pathways responsible for these events are thought to involve the Janus family of nonreceptor tyrosine kinases (JAKs) and the sig...

journal_title：Blood

authors： Drachman JG,Sabath DF,Fox NE,Kaushansky K

更新日期：1997-01-15 00:00:00

abstract：:BMS-354825 (dasatinib) and AMN107 (nilotinib) are potent alternate Abl inhibitors with activity against many imatinib mesylate-resistant BCR-ABL kinase domain (KD) mutants, except T315I. We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL) cells to compare incidence and types of KD mutants emerging in the p...

journal_title：Blood

authors： Bradeen HA,Eide CA,O'Hare T,Johnson KJ,Willis SG,Lee FY,Druker BJ,Deininger MW

更新日期：2006-10-01 00:00:00

abstract：:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected f...

journal_title：Blood

authors： Pui CH,Mullighan CG,Evans WE,Relling MV

更新日期：2012-08-09 00:00:00

abstract：:CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with fol...

journal_title：Blood

authors： Karube K,Guo Y,Suzumiya J,Sugita Y,Nomura Y,Yamamoto K,Shimizu K,Yoshida S,Komatani H,Takeshita M,Kikuchi M,Nakamura N,Takasu O,Arakawa F,Tagawa H,Seto M,Ohshima K

更新日期：2007-04-01 00:00:00

abstract：:B-cell precursors are present in the thymus, and the thymic microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pr...

journal_title：Blood

authors： Hashimoto Y,Montecino-Rodriguez E,Leathers H,Stephan RP,Dorshkind K

更新日期：2002-11-15 00:00:00

abstract：:Essential thrombocythemia (ET) and polycythemia vera (PV) are characterized by persistent platelet activation. The mechanisms involved in their clearance are poorly characterized. In the present study, we report that leukocytes were actively involved in platelet disposal in 51 patients with ET and 30 with PV, but not ...

journal_title：Blood

authors： Maugeri N,Malato S,Femia EA,Pugliano M,Campana L,Lunghi F,Rovere-Querini P,Lussana F,Podda G,Cattaneo M,Ciceri F,Manfredi AA

更新日期：2011-09-22 00:00:00

abstract：:The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-in...

journal_title：Blood

authors： Weller S,Braun MC,Tan BK,Rosenwald A,Cordier C,Conley ME,Plebani A,Kumararatne DS,Bonnet D,Tournilhac O,Tchernia G,Steiniger B,Staudt LM,Casanova JL,Reynaud CA,Weill JC

更新日期：2004-12-01 00:00:00

abstract：:Erythropoiesis is regulated at multiple levels to ensure the proper generation of mature red cells under multiple physiological conditions. To probe the contribution of long noncoding RNAs (lncRNAs) to this process, we examined >1 billion RNA-seq reads of polyadenylated and nonpolyadenylated RNA from differentiating m...

journal_title：Blood

authors： Alvarez-Dominguez JR,Hu W,Yuan B,Shi J,Park SS,Gromatzky AA,van Oudenaarden A,Lodish HF

更新日期：2014-01-23 00:00:00

abstract：:Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identification of new molecular targets. Because of low sample sizes and hetero...

journal_title：Blood

authors： Baaten CCFMJ,Meacham S,de Witt SM,Feijge MAH,Adams DJ,Akkerman JN,Cosemans JMEM,Grassi L,Jupe S,Kostadima M,Mattheij NJA,Prins MH,Ramirez-Solis R,Soehnlein O,Swieringa F,Weber C,White JK,Ouwehand WH,Heemskerk JWM

更新日期：2018-12-13 00:00:00

abstract：:Recent reports have shown that leukocyte-leukocyte adhesion is dependent on L-selectin and that leukocyte recognition of L-selectin may be mediated by P-selectin glycoprotein ligand-1 (PSGL-1). We show that the specific attachment and rolling of human neutrophils and the leukemia cell lines HL-60 and U937 on immobiliz...

journal_title：Blood

authors： Ramos CL,Smith MJ,Snapp KR,Kansas GS,Stickney GW,Ley K,Lawrence MB

更新日期：1998-02-01 00:00:00

abstract：:The calcium, sodium, and magnesium permeability of erythrocytes from blood stored at 4 degrees C in various anticoagulant media has been studied and compared to that of fresh erythrocytes. Passive influx of CA2+ was measured at 37 degrees C in cells pretreated to abolish Ca2+ pumping and was up to fivefold greater for...

journal_title：Blood

authors： Wiley JS,McCulloch KE,Bowden DS

更新日期：1982-07-01 00:00:00

abstract：:Multiple mechanisms operate to ensure T-cell tolerance toward self-antigens. Three main processes have been described: clonal deletion, anergy, and deviation to CD4(+) regulatory T cells (Tregs) that suppress autoreactive T cells that have escaped the first 2 mechanisms. Although it is accepted that dendritic cells (D...

journal_title：Blood

authors： Morlacchi S,Soldani C,Viola A,Sarukhan A

更新日期：2011-07-28 00:00:00

abstract：:The dendritic cell (DC)-specific molecule DC-SIGN is a receptor for the HIV-1 envelope glycoprotein gp120 and is essential for the dissemination of HIV-1. DC-SIGN is expressed by DCs, both monocyte-derived DCs and DCs in several tissues, including mucosa and lymph nodes. To identify a DC-SIGN(+) DC in blood that may b...

journal_title：Blood

authors： Engering A,Van Vliet SJ,Geijtenbeek TB,Van Kooyk Y

更新日期：2002-09-01 00:00:00