Abstract:
:Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected from the discovery of additional recurrent molecular lesions, coupled with the development of novel targeted treatment through high-throughput genomics and innovative drug-screening systems. We discuss specific areas of research that promise to further refine current treatment and to improve the cure rate and quality of life of the patients.
journal_name
Bloodjournal_title
Bloodauthors
Pui CH,Mullighan CG,Evans WE,Relling MVdoi
10.1182/blood-2012-05-378943subject
Has Abstractpub_date
2012-08-09 00:00:00pages
1165-74issue
6eissn
0006-4971issn
1528-0020pii
blood-2012-05-378943journal_volume
120pub_type
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