Synergism between recombinant growth factors, GM-CSF and G-CSF, acting on the blast cells of acute myeloblastic leukemia.

abstract：:The terminal differentiation of B cells into antibody-secreting cells (ASCs) is a critical component of adaptive immune responses. However, it is a very sensitive process, which dysfunctions lead to a great variety of lymphoproliferative neoplasia including germinal center-derived lymphomas. To better characterize the...

journal_title：Blood

authors： Pignarre A,Chatonnet F,Caron G,Haas M,Desmots-Loyer F,Fest T

更新日期：2020-11-04 00:00:00

abstract：:We have analyzed the binding of Sp1, a ubiquitously expressed transactivator, to the promoter region of the gamma genes. Low-affinity Sp1 sites were found at -50 and -200. A high-affinity site was detected at -140, over the CACCC sequence. To analyze the function of these sites, Drosophila SL-2 cells, which lack Sp1, ...

journal_title：Blood

authors： Gumucio DL,Rood KL,Blanchard-McQuate KL,Gray TA,Saulino A,Collins FS

更新日期：1991-10-01 00:00:00

abstract：:von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative variants of VWF are now well cha...

journal_title：Blood

authors： Lillicrap D

更新日期：2013-11-28 00:00:00

abstract：:The TEL/PDGFbetaR fusion protein is expressed as the consequence of a recurring t(5;12) translocation associated with chronic myelomonocytic leukemia (CMML). Unlike other activated protein tyrosine kinases associated with hematopoietic malignancies, TEL/PDGFbetaR is invariably associated with a myeloid leukemia phenot...

journal_title：Blood

authors： Tomasson MH,Williams IR,Hasserjian R,Udomsakdi C,McGrath SM,Schwaller J,Druker B,Gilliland DG

更新日期：1999-03-01 00:00:00

abstract：:Cyclin dependent kinase (CDK) inhibitors, such as flavopiridol, demonstrate significant single-agent activity in chronic lymphocytic leukemia (CLL), but the mechanism of action in these nonproliferating cells is unclear. Here we demonstrate that CLL cells undergo autophagy after treatment with therapeutic agents, incl...

journal_title：Blood

authors： Mahoney E,Lucas DM,Gupta SV,Wagner AJ,Herman SE,Smith LL,Yeh YY,Andritsos L,Jones JA,Flynn JM,Blum KA,Zhang X,Lehman A,Kong H,Gurcan M,Grever MR,Johnson AJ,Byrd JC

更新日期：2012-08-09 00:00:00

abstract：:NKG2D is an activation receptor that allows natural killer (NK) cells to detect diseased host cells. The engagement of NKG2D with corresponding ligand results in surface modulation of the receptor and reduced function upon subsequent receptor engagement. However, it is not clear whether in addition to modulation the N...

journal_title：Blood

authors： Coudert JD,Zimmer J,Tomasello E,Cebecauer M,Colonna M,Vivier E,Held W

更新日期：2005-09-01 00:00:00

abstract：:Variations of the partial thromboplastin time (PTT) were tested to determine the best screening method for detection of inhibitors of factor VIII. Variables tested included the duration of preincubation of a mixture of patient plasma and factor VIII source (normal plasma), the ratio of the patient plasma to the normal...

journal_title：Blood

authors： Lossing TS,Kasper CK,Feinstein DI

更新日期：1977-05-01 00:00:00

abstract：:Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) is located in the activation peptide (AP) just 3 amino acids away from the thrombin cleavage site. This mutation has been associated with a protective effect against occlusive arterial diseases and venous thrombosis; however, its biochemical c...

journal_title：Blood

authors： Balogh I,Szôke G,Kárpáti L,Wartiovaara U,Katona E,Komáromi I,Haramura G,Pfliegler G,Mikkola H,Muszbek L

更新日期：2000-10-01 00:00:00

abstract：:HIV/AIDS has long been at the forefront of the development of gene- and cell-based therapies. Although conventional gene therapy approaches typically involve the addition of anti-HIV genes to cells using semirandomly integrating viral vectors, newer genome editing technologies based on engineered nucleases are now all...

journal_title：Blood

authors： Wang CX,Cannon PM

更新日期：2016-05-26 00:00:00

abstract：:Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells. The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases. We observed tha...

journal_title：Blood

authors： Costa LF,Balcells M,Edelman ER,Nadler LM,Cardoso AA

更新日期：2006-01-01 00:00:00

abstract：:To investigate the tropism of the T-lymphotropic human herpesvirus 7 (HHV-7) for hematopoietic progenitors, cord blood CD34(+) cells were inoculated in vitro with HHV-7 and then induced to differentiate along the granulocytic and erythroid lineages by the addition of appropriate cytokine cocktails. In semisolid assays...

journal_title：Blood

authors： Mirandola P,Secchiero P,Pierpaoli S,Visani G,Zamai L,Vitale M,Capitani S,Zauli G

更新日期：2000-07-01 00:00:00

abstract：:The molecular basis for the hereditary persistence of fetal hemoglobin (HPFH) phenotype was studied in a Chinese individual who was heterozygous for a nondeletion form of A gamma-HPFH. Both allelic A gamma-globin genes were isolated by molecular cloning and subjected to nucleotide sequence analysis. One A gamma gene p...

journal_title：Blood

authors： Gelinas R,Bender M,Lotshaw C,Waber P,Kazazian H Jr,Stamatoyannopoulos G

更新日期：1986-06-01 00:00:00

abstract：:Aurora-A kinase (Aur-A) is a member of the serine/threonine kinase family that regulates the cell division process, and has recently been implicated in tumorigenesis. In this study, we identified an antigenic 9-amino-acid epitope (Aur-A(207-215): YLILEYAPL) derived from Aur-A capable of generating leukemia-reactive cy...

journal_title：Blood

authors： Ochi T,Fujiwara H,Suemori K,Azuma T,Yakushijin Y,Hato T,Kuzushima K,Yasukawa M

更新日期：2009-01-01 00:00:00

abstract：:Evidence is presented showing that a protein tyrosine phosphatase different from CD45 is present on the membrane of human hematopoietic cells. The molecule recognized by the monoclonal antibody 143-41, which has been classified as CD148 in the VI International Workshop on Leukocyte Differentiation Antigens, was immuno...

journal_title：Blood

authors： de la Fuente-García MA,Nicolás JM,Freed JH,Palou E,Thomas AP,Vilella R,Vives J,Gayá A

更新日期：1998-04-15 00:00:00

abstract：:As the principal component of the membrane skeleton, spectrin confers integrity and flexibility to red cell membranes. Although this network involves many interactions, the most common hemolytic anemia mutations that disrupt erythrocyte morphology affect the spectrin tetramerization domains. Although much is known cli...

journal_title：Blood

authors： Ipsaro JJ,Harper SL,Messick TE,Marmorstein R,Mondragón A,Speicher DW

更新日期：2010-06-10 00:00:00

abstract：:Beginning in 1985, patients in British Columbia with Hodgkin lymphoma (HL) that was not controlled by conventional chemotherapy routinely underwent high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT). Long-term complications of HD-ASCT have become apparent as more patients survive without recurre...

journal_title：Blood

authors： Lavoie JC,Connors JM,Phillips GL,Reece DE,Barnett MJ,Forrest DL,Gascoyne RD,Hogge DE,Nantel SH,Shepherd JD,Smith CA,Song KW,Sutherland HJ,Toze CL,Voss NJ,Nevill TJ

更新日期：2005-08-15 00:00:00

abstract：:Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic T lymphocytes or CD3- natural killer (NK) cells. Chronic antigen stimulation is postulated to promote long-term survival of LGL leukemia cells through constitutive activation of multiple survival pathways, resulting in global dysr...

journal_title：Blood

authors： Yang J,LeBlanc FR,Dighe SA,Hamele CE,Olson TL,Feith DJ,Loughran TP Jr

更新日期：2018-06-21 00:00:00

abstract：:Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not supp...

journal_title：Blood

authors： Barchet W,Price JD,Cella M,Colonna M,MacMillan SK,Cobb JP,Thompson PA,Murphy KM,Atkinson JP,Kemper C

更新日期：2006-02-15 00:00:00

abstract：:The pathophysiology of iron-induced compromised fertility in women with thalassemia major (TM) was evaluated in 26 adult TM females. Low gonadotropin secretion resulted in reduced ovarian antral follicle count and ovarian volume, but levels of anti-müllerian hormone (AMH), a sensitive marker for ovarian reserve indepe...

journal_title：Blood

authors： Singer ST,Vichinsky EP,Gildengorin G,van Disseldorp J,Rosen M,Cedars MI

更新日期：2011-09-08 00:00:00

abstract：:The subcellular localization of the platelet membrane receptors glycoproteins (GP) Ib and IIb/IIIa [corrected] has been studied within resting platelets by a combination of biochemical and cytochemical techniques. While both GPIb and GPIIb/IIIa are localized within the plasma membrane and surface-connected canalicular...

journal_title：Blood

authors： Cramer EM,Lu H,Caen JP,Soria C,Berndt MC,Tenza D

更新日期：1991-02-15 00:00:00

abstract：:Despite the importance of phosphoinositide 3-kinase (PI3K) in B-cell development, its activation mechanism still remains elusive. In this study, we show that deletion of both BCAP and CD19 leads to an almost complete block of BCR-mediated Akt activation and to severe defects in generation of immature and mature B cell...

journal_title：Blood

authors： Aiba Y,Kameyama M,Yamazaki T,Tedder TF,Kurosaki T

更新日期：2008-02-01 00:00:00

abstract：:In this article, we present evidence that sialic acid-containing surface components play a role in the regulation of erythropoiesis. A 1-hr exposure of mouse bone marrow cells to high concentrations of neuraminidase reduced erythroid colony formation. Coculture of 10(6) untreated thymocytes with neuraminidase-treated ...

journal_title：Blood

authors： LaRussa VF,Sieber F,Sensenbrenner LL,Sharkis SJ

更新日期：1984-04-01 00:00:00

abstract：:With the aim of establishing whether the HR2 haplotype in factor V affects the risk of venous thromboembolism, a retrospective multicenter cohort study was performed in 810 family members identified through 174 probands who suffered from at least 1 episode of deep vein thrombosis and/or pulmonary embolism and had an i...

journal_title：Blood

authors： Faioni EM,Franchi F,Bucciarelli P,Margaglione M,De Stefano V,Castaman G,Finazzi G,Mannucci PM

更新日期：1999-11-01 00:00:00

abstract：:CD8+ Foxp3+ T cells (Tregs) are a potent regulatory population whose functional and ontological similarities to CD4+ Fox3+ T cells have not been well delineated. Using an experimental model of graft-versus-host disease (GVHD), we observed that CD8+ Tregs were significantly less potent than CD4+ Tregs for the suppressi...

journal_title：Blood

authors： Agle K,Vincent BG,Piper C,Belle L,Zhou V,Shlomchik W,Serody JS,Drobyski WR

更新日期：2018-07-26 00:00:00

abstract：:The conjunctival microcirculation of 18 homozygous sickle cell disease (SCD) patients during steady-state, painful crisis, and postcrisis conditions was recorded on high-resolution videotapes using intravital microscopy. Selected videotape sequences were subsequently coded, frame-captured, studied, and blindly analyze...

journal_title：Blood

authors： Cheung AT,Chen PC,Larkin EC,Duong PL,Ramanujam S,Tablin F,Wun T

更新日期：2002-06-01 00:00:00

abstract：:Intravital microscopy was used to monitor leukocyte traffic across rat mesenteric postcapillary venules induced by the inactive terminal complement (C) complex (iTCC) topically applied to ileal mesentery. Leukocytes started rolling within 15 minutes from the administration of iTCC, and by 1 hour they adhered almost co...

journal_title：Blood

authors： Dobrina A,Pausa M,Fischetti F,Bulla R,Vecile E,Ferrero E,Mantovani A,Tedesco F

更新日期：2002-01-01 00:00:00

abstract：:The ability to determine the functional capacity of putative human hematopoietic stem cell (HSC) populations requires in vivo assays in which long-term multilineage differentiation can be assessed. We hypothesized that if human fetal bone was transplanted adjacent to a fetal thymus fragment in severe combined immunode...

journal_title：Blood

authors： Fraser CC,Kaneshima H,Hansteen G,Kilpatrick M,Hoffman R,Chen BP

更新日期：1995-09-01 00:00:00

abstract：:In previous studies we have found that monocytes produce soluble factors that stimulate human umbilical vein endothelial cells to produce granulocyte-macrophage colony-stimulating activity (CSA), burst-promoting activity (BPA), and megakaryocyte colony-stimulating activity (Meg-CSA) as well as factors that stimulate T...

journal_title：Blood

authors： Broudy VC,Zuckerman KS,Jetmalani S,Fitchen JH,Bagby GC Jr

更新日期：1986-08-01 00:00:00

abstract：:The administration of interleukin-2 (IL-2) may induce complete remissions in acute myelogenous leukemia (AML) patients with a low proportion of residual bone marrow (BM) blasts. To confirm this preliminary observation, we treated 14 AML patients with advanced disease and with a residual BM blastosis that ranged betwee...

journal_title：Blood

authors： Meloni G,Foa R,Vignetti M,Guarini A,Fenu S,Tosti S,Tos AG,Mandelli F

更新日期：1994-10-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non-nodal MCL (nnMCL), that differ in their clinicobiological behavior. To identify the genetic and epigenetic alterations determining this diversity, we used w...

journal_title：Blood

authors： Nadeu F,Martin-Garcia D,Clot G,Díaz-Navarro A,Duran-Ferrer M,Navarro A,Vilarrasa-Blasi R,Kulis M,Royo R,Gutiérrez-Abril J,Valdés-Mas R,López C,Chapaprieta V,Puiggros M,Castellano G,Costa D,Aymerich M,Jares P,Espinet B

更新日期：2020-09-17 00:00:00