Abstract:
:In this article, we present evidence that sialic acid-containing surface components play a role in the regulation of erythropoiesis. A 1-hr exposure of mouse bone marrow cells to high concentrations of neuraminidase reduced erythroid colony formation. Coculture of 10(6) untreated thymocytes with neuraminidase-treated bone marrow cells restored erythroid colony growth. Neuraminidase-treated thymocytes retained their ability to suppress erythroid colony formation by untreated marrow cells, but lost their ability to enhance erythroid colony formation. Continuous exposure to low concentrations of neuraminidase enhanced erythroid bone marrow cell colony growth in response to a suboptimal dose of erythropoietin.
journal_name
Bloodjournal_title
Bloodauthors
LaRussa VF,Sieber F,Sensenbrenner LL,Sharkis SJsubject
Has Abstractpub_date
1984-04-01 00:00:00pages
784-8issue
4eissn
0006-4971issn
1528-0020journal_volume
63pub_type
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