Abstract：
:Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon-gamma (IFN-gamma) and for their cytotoxic response. In patients with IL12RB1 mutations that lead to a complete IL-12Rbeta1 deficiency, the size of this naturally reactive NK cell subset is diminished, in particular for the IFN-gamma production. Similar data were obtained from a patient with a complete deficit in IL-12p40. In addition, the size of the subset of effector memory T cells expressing CD56 was severely decreased in IL-12Rbeta1- and IL-12p40-deficient patients. Human NK cells thus require in vivo priming with IL-12/23 to acquire their full spectrum of functional reactivity, while T cells are dependent upon IL-12/23 signals for the differentiation and/or the maintenance of CD56(+) effector memory T cells. The susceptibility of IL-12/23 axis-deficient patients to Mycobacterium and Salmonella infections in combination with the absence of mycobacteriosis or salmonellosis in the rare cases of human NK cell deficiencies point to a role for CD56(+) T cells in the control of these infections in humans.
journal_name
Bloodjournal_title
Bloodauthors
Guia S,Cognet C,de Beaucoudrey L,Tessmer MS,Jouanguy E,Berger C,Filipe-Santos O,Feinberg J,Camcioglu Y,Levy J,Al Jumaah S,Al-Hajjar S,Stephan JL,Fieschi C,Abel L,Brossay L,Casanova JL,Vivier Edoi
10.1182/blood-2007-11-122259subject
Has Abstractpub_date
2008-05-15 00:00:00pages
5008-16issue
10eissn
0006-4971issn
1528-0020pii
blood-2007-11-122259journal_volume
111pub_type
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