Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.

abstract：:The BCL1 lymphoma in Balb/c mice can be successfully treated with bispecific (anti-CD3 x anti-idiotype) antibodies (BSABs). In these experiments, animals were injected intraperitoneally (IP) with 5 x 10(3) tumor cells (day 0) and treated with one single intravenous (IV) injection of 5 micrograms BSAB (day 9). Because ...

journal_title：Blood

authors： Demanet C,Brissinck J,De Jonge J,Thielemans K

更新日期：1996-05-15 00:00:00

abstract：:Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes--i(21q), i(6p), i(...

journal_title：Blood

authors： Pui CH,Carroll AJ,Raimondi SC,Schell MJ,Head DR,Shuster JJ,Crist WM,Borowitz MJ,Link MP,Behm FG

更新日期：1992-05-01 00:00:00

abstract：:The t(5;12) translocation identified in patients with chronic myelomonocytic leukemia (CMML) encodes a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein. A key hypothesis for how the TEL/PDGFRbeta fusion protein would function as an oncogene is that it represents a constitutively active versi...

journal_title：Blood

authors： Bourgeade MF,Défachelles AS,Cayre YE

更新日期：1998-05-01 00:00:00

abstract：:We examined autonomous and interleukin-2 (IL-2)-responsive growth activities of leukemic cells derived from peripheral blood, as well as several clinical manifestations, including serum lactate dehydrogenase (LDH) level, of 35 patients with adult T-cell leukemia (ATL) to determine whether these properties were related...

journal_title：Blood

authors： Arima N,Hidaka S,Fujiwara H,Matsushita K,Ohtsubo H,Arimura K,Kukita T,Fukumori J,Tanaka H

更新日期：1996-04-01 00:00:00

abstract：:Mutations that produce glucose-6-phosphate dehydrogenase (G6PD) deficiency have been identified in samples from patients with hemolytic disease in the United States, and in G6PD-deficient samples from Greece, the Canary Islands, the Czech and Slovak Republics, South China, and in samples from the Coriell Cell Reposito...

journal_title：Blood

authors： Xu W,Westwood B,Bartsocas CS,Malcorra-Azpiazu JJ,Indrák K,Beutler E

更新日期：1995-01-01 00:00:00

abstract：:The cell-surface receptor c-kit and its cognate ligand stem-cell factor (SCF) or steel factor (SLF) are important for the maintenance of hematopoiesis both in vitro and in vivo. Transforming growth factor-beta (TGF-beta) has been shown to be a potent inhibitor of SLF-mediated synergistic growth of murine Lin-Sca-1+ pr...

journal_title：Blood

authors： Dubois CM,Ruscetti FW,Stankova J,Keller JR

更新日期：1994-06-01 00:00:00

abstract：:Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), in...

journal_title：Blood

authors： Richardson DR,Tran EH,Ponka P

更新日期：1995-12-01 00:00:00

abstract：:von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative variants of VWF are now well cha...

journal_title：Blood

authors： Lillicrap D

更新日期：2013-11-28 00:00:00

abstract：:Eph receptors and their ephrin ligands are involved in normal hematopoietic development and tumorigenesis. Using methylated CpG island amplification/DNA promoter microarray, we identified several EPH receptor and EPHRIN genes as potential hypermethylation targets in acute lymphoblastic leukemia (ALL). We subsequently ...

journal_title：Blood

authors： Kuang SQ,Bai H,Fang ZH,Lopez G,Yang H,Tong W,Wang ZZ,Garcia-Manero G

更新日期：2010-03-25 00:00:00

abstract：:We assessed frequency and predictive factors for major cardiovascular (CV) events in 707 patients with primary myelofibrosis (PMF) followed in 4 European institutions. A total of 236 deaths (33%) were recorded for an overall mortality of 7.7% patient-years (pt-yr). Fatal and nonfatal thromboses were registered in 51 (...

journal_title：Blood

authors： Barbui T,Carobbio A,Cervantes F,Vannucchi AM,Guglielmelli P,Antonioli E,Alvarez-Larrán A,Rambaldi A,Finazzi G,Barosi G

更新日期：2010-01-28 00:00:00

abstract：:Interleukin-1beta (IL-1beta) elevates H- and L-ferritin subunit synthesis in both human hepatoma cells (HepG2) and primary human umbilical vein endothelial cells. Ferritin induction is greater than the increase in total HepG2 protein synthesis in response to IL-1. IL-6 causes a moderate increase in L-subunit synthesis...

journal_title：Blood

authors： Rogers JT

更新日期：1996-03-15 00:00:00

abstract：:Severe factor V (FV) deficiency is a rare bleeding disorder, whose genetic bases have been characterized only in a limited number of cases. We investigated 6 unrelated patients with extremely reduced plasma FV levels, associated with a bleeding tendency ranging from moderately severe to severe. Clinical manifestations...

journal_title：Blood

authors： Montefusco MC,Duga S,Asselta R,Malcovati M,Peyvandi F,Santagostino E,Mannucci PM,Tenchini ML

更新日期：2003-11-01 00:00:00

abstract：:Various abnormalities of lymphokine production have been described in patients with aplastic anemia. To determine if abnormal production of hematopoietic growth factors could contribute to the process of aplastic anemia we studied the in vitro production of human granulocyte-macrophage colony-stimulating factor (GM-CS...

journal_title：Blood

authors： Nimer SD,Golde DW,Kwan K,Lee K,Clark S,Champlin R

更新日期：1991-07-01 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:The frequent occurrence of TF gene involvement in translocations associated with leukemia is remarkable, although not yet explained. The wide variety of TFs involved in these translocations and the different stages of cellular maturation argue against a unifying mechanism. Recombinases, active during B-cell and T-cell...

journal_title：Blood

authors： Nichols J,Nimer SD

更新日期：1992-12-15 00:00:00

abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

journal_title：Blood

authors： Krigel R,Liebes LF,Pelle E,Silber R

更新日期：1982-07-01 00:00:00

abstract：:In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squ...

journal_title：Blood

authors： Janin A,Murata H,Leboeuf C,Cayuela JM,Gluckman E,Legrès L,Desveaux A,Varna M,Ratajczak P,Soulier J,de Thé H,Bertheau P,Socié G

更新日期：2009-02-19 00:00:00

abstract：:An acquired gain-of-function mutation in the Janus kinase 2 (JAK2-V617F) is frequently found in patients with myeloproliferative disorders (MPDs). To test the hypothesis that JAK2-V617F is the disease-initiating mutation, we examined whether all cells of clonal origin carry the JAK2-V617F mutation. Using allele-specif...

journal_title：Blood

authors： Kralovics R,Teo SS,Li S,Theocharides A,Buser AS,Tichelli A,Skoda RC

更新日期：2006-08-15 00:00:00

abstract：:Activation and subsequent differentiation of naive CD8+ T cells lead to the development of memory subsets with distinct homing and effector capacities. On nonlymphoid homing subsets, expression of "inflammatory" chemokine receptors (such as CXCR3, CCR5, CX3CR1, and CXCR1) is believed to promote migration into sites of...

journal_title：Blood

authors： Gasser O,Missiou A,Eken C,Hess C

更新日期：2005-12-01 00:00:00

abstract：:Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapo-ptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprote...

journal_title：Blood

authors： Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC

更新日期：2009-02-12 00:00:00

abstract：:The balanced manifestation of effector functions and the generation of long-living memory cells is a hallmark of efficient CD8(+) T-cell response. Accumulating data pinpoint CD4(+) CD25(high) regulatory T (Treg) cells as a key factor for the inefficiency of CD8(+) T-cell responses in viral persistence. Little is known...

journal_title：Blood

authors： Nikolova M,Lelievre JD,Carriere M,Bensussan A,Lévy Y

更新日期：2009-05-07 00:00:00

abstract：:Twenty-one human immunodeficiency virus (HIV)-positive patients, including 11 acquired immunodeficiency syndrome (AIDS)-free patients with immune thrombocytopenic purpura (ITP), were studied to determine whether the megakaryocytic/platelet lineage was infected by HIV. Because purification of platelets did not reach a ...

journal_title：Blood

authors： Louache F,Bettaieb A,Henri A,Oksenhendler E,Farcet JP,Bierling P,Seligmann M,Vainchenker W

更新日期：1991-10-01 00:00:00

abstract：:In healthy carriers of human cytomegalovirus (HCMV), the virus-specific memory CD8(+) T-cell population is often dominated by CD28(-) CD45RA(hi) cells that exhibit direct ex vivo cytotoxicity but whose capacity for proliferation and generation of further memory cells has been questioned. We show that when highly purif...

journal_title：Blood

authors： Waller EC,McKinney N,Hicks R,Carmichael AJ,Sissons JG,Wills MR

更新日期：2007-12-15 00:00:00

abstract：:The activation of murine dendritic cells by Toxoplasma gondii has recently been shown to depend on a parasite protein that signals through the chemokine receptor CCR5. Here we demonstrate that this molecule, cyclophilin-18 (C-18), is an inhibitor of HIV-1 cell fusion and infection with cell-free virus. T gondii C-18 e...

journal_title：Blood

authors： Golding H,Aliberti J,King LR,Manischewitz J,Andersen J,Valenzuela J,Landau NR,Sher A

更新日期：2003-11-01 00:00:00

abstract：:A t(14;18) (q32;q21) chromosome translocation is closely associated with the follicular lymphoma, which is prevalent in the United States, and the t(14;18) causes the juxtaposition of a bcl-2 gene on chromosome 18 with an immunoglobulin heavy-chain gene locus on chromosome 14. Genomic DNAs from 30 Japanese patients wi...

journal_title：Blood

authors： Amakawa R,Fukuhara S,Ohno H,Doi S,Oguma S,Tanabe S,Yamabe H,Edamura S,Tomono N,Nasu K

更新日期：1989-02-15 00:00:00

abstract：:Donor alloreactive CD4(+) T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4(+) T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4(+) effector memory cells (CCR7(-)/CD62L(low), C...

journal_title：Blood

authors： Yamashita K,Choi U,Woltz PC,Foster SF,Sneller MC,Hakim FT,Fowler DH,Bishop MR,Pavletic SZ,Tamari M,Castro K,Barrett AJ,Childs RW,Illei GG,Leitman SF,Malech HL,Horwitz ME

更新日期：2004-05-15 00:00:00

abstract：:Platelets play a crucial role in the physiology of primary hemostasis and pathophysiologic processes such as arterial thrombosis. Accumulating evidence suggests a role of reactive oxygen species (ROSs) in platelet activation. Here we show that platelets activated with different agonists produced intracellular ROSs, wh...

journal_title：Blood

authors： Begonja AJ,Gambaryan S,Geiger J,Aktas B,Pozgajova M,Nieswandt B,Walter U

更新日期：2005-10-15 00:00:00

abstract：:During pregnancy the plasma concentration of two different inhibitors of plasminogen activators (PAIs) increases. The only one found in the plasma of nonpregnant women (PAI1) is immunologically related to a PAI of endothelial cells; its plasma activity, as deduced from the inhibition of single-chain tissue-type plasmi...

journal_title：Blood

authors： Kruithof EK,Tran-Thang C,Gudinchet A,Hauert J,Nicoloso G,Genton C,Welti H,Bachmann F

更新日期：1987-02-01 00:00:00

abstract：:We have developed an in vitro clonal assay of murine hematopoietic precursor cells that form spleen colonies (CFU-S day 12) or produce in vitro clonable progenitors in the marrow (MRA cells) of lethally irradiated mice. The assay is essentially a long-term bone marrow culture in microtiter wells containing marrow-deri...

journal_title：Blood

authors： Ploemacher RE,van der Sluijs JP,van Beurden CA,Baert MR,Chan PL

更新日期：1991-11-15 00:00:00

abstract：:This report discusses a case of T cell chronic lymphocytic leukemia (T-CLL) in an elderly white man whose lymphocytes expressed a post-thymic phenotype except for the coexpression of T4 and T8 on 80% to 95% of the cells. Because of the uncommon phenotype, in vitro functional assays were performed that showed decreased...

journal_title：Blood

authors： Simpkins H,Kiprov DD,Davis JL 3rd,Morand P,Puri S,Grahn EP

更新日期：1985-01-01 00:00:00