Abstract:
:The relationship between neutrophil function and the neutrophil antigen, Kx, as well as the linkage of the gene, Xk, with Xg was examined in a kindred with X-linked chronic granulomatous disease. Four of the eight male siblings had chronic granulomatous disease by clinical history and tests of neutrophil function, and all four had Kx-negative neutrophils. The remaining four were in good health and had normal nitroblue tetrazolium reduction tests. However, one of these latter four had Kx-negative neutrophils that functioned normally. These data suggest that closely linked but distinct genes on the X chromosome code for chronic granulomatous disease and Kx. In addition, close linkage was demonstrated between Xk and Xg, a gene coding for an erythrocyte surface antigen.
journal_name
Bloodjournal_title
Bloodauthors
Densen P,Wilkinson-Kroovand S,Mandell GL,Sullivan G,Oyen R,Marsh WLsubject
Has Abstractpub_date
1981-07-01 00:00:00pages
34-7issue
1eissn
0006-4971issn
1528-0020journal_volume
58pub_type
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