Abstract:
:Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both encoded by the unique V kappa IV gene. Mice secreting the LCDD chain but not those producing the control chain showed deposits with a distribution similar to that observed in patients. These data show that discrete changes in V region sequences can play a major role in tissue deposition of human L chains.
journal_name
Bloodjournal_title
Bloodauthors
Khamlichi AA,Rocca A,Touchard G,Aucouturier P,Preud'homme JL,Cogné Msubject
Has Abstractpub_date
1995-11-15 00:00:00pages
3655-9issue
10eissn
0006-4971issn
1528-0020journal_volume
86pub_type
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