Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine.

abstract：:Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of alloreactive donor T cells causing significant morbidity and mortality following allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both human...

journal_title：Blood

authors： Schneidawind D,Baker J,Pierini A,Buechele C,Luong RH,Meyer EH,Negrin RS

更新日期：2015-05-28 00:00:00

abstract：:The interleukin (IL)-22R1 chain of the heterodimeric IL-22 receptor is not expressed on normal leukocytes, but this receptor is expressed on T cells from anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large cell lymphoma (ALCL) patients. To investigate the consequences of aberrant expression of this receptor ...

journal_title：Blood

authors： Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA

更新日期：2011-01-13 00:00:00

abstract：:Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

journal_title：Blood

authors： Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

更新日期：2019-11-28 00:00:00

abstract：:The human beta-globin locus control region (LCR) confers high-level, tissue-specific expression to the beta-globin genes. Tandem Maf recognition elements (MAREs) within the hypersensitive site 2 (HS2) subregion of the LCR are important for the strong enhancer activity of the LCR. Multiple proteins are capable of inter...

journal_title：Blood

authors： Forsberg EC,Downs KM,Bresnick EH

更新日期：2000-07-01 00:00:00

abstract：:The nature of cells present in the blood, marrow, and spleen of patients with hairy cell leukemia is largely debated. These cells have been tentatively categorized on the basis of either monocytic or lymphocytic markers, and the accumulating data points to the fact that they share some characteristics of both cell typ...

journal_title：Blood

authors： Reyes F,Gourdin MF,Farcet JP,Dreyfus B,Breton-Gorius J

更新日期：1978-09-01 00:00:00

abstract：:Cutaneous involvement is seen in ~ 50% of adult T-cell leukemia/lymphoma (ATLL) patients. We investigated the association between skin eruption type and prognosis in 119 ATLL patients. ATLL eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), ...

journal_title：Blood

authors： Sawada Y,Hino R,Hama K,Ohmori S,Fueki H,Yamada S,Fukamachi S,Tajiri M,Kubo R,Yoshioka M,Nakashima D,Sugita K,Yoshiki R,Shimauchi T,Mori T,Izu K,Kobayashi M,Nakamura M,Tokura Y

更新日期：2011-04-14 00:00:00

abstract：:Investigators in the United Kingdom have shown that hereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history is an ineffective screen, and tissue staining used to type amyloid is unreliable. Misdiagnosis of AL can lead to inappropriate use of chemotherapy and failure to diag...

journal_title：Blood

authors： Comenzo RL,Zhou P,Fleisher M,Clark B,Teruya-Feldstein J

更新日期：2006-05-01 00:00:00

abstract：:We have identified an intergenic transcriptional activity that is located between the human HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during granulocytic differentiation. The novel gene, termed HOTAIRM1 (HOX antisense intergenic RNA myeloid 1), is transcribed antisense to the HOXA g...

journal_title：Blood

authors： Zhang X,Lian Z,Padden C,Gerstein MB,Rozowsky J,Snyder M,Gingeras TR,Kapranov P,Weissman SM,Newburger PE

更新日期：2009-03-12 00:00:00

abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

journal_title：Blood

authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

更新日期：2009-12-10 00:00:00

abstract：:After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) is responsible for cytoadherence of infected cells to host endothelial receptors. Thi...

journal_title：Blood

authors： Knuepfer E,Rug M,Klonis N,Tilley L,Cowman AF

更新日期：2005-05-15 00:00:00

abstract：:The influence of intestinal bacterial decontamination on the occurrence of grades II to IV acute graft-versus-host disease (GVHD) was retrospectively analyzed in 194 predominantly adult patients treated by genotypically identical sibling marrow transplantation under conditions of strict protective isolation and intest...

journal_title：Blood

authors： Beelen DW,Haralambie E,Brandt H,Linzenmeier G,Müller KD,Quabeck K,Sayer HG,Graeven U,Mahmoud HK,Schaefer UW

更新日期：1992-11-15 00:00:00

abstract：:Interleukin 21 (IL-21) is a member of the common gamma-chain family of cytokines, which influence a broad spectrum of immunologic responses. A number of studies have examined the function of IL-21, but its specific role in Th1/Th2-cell differentiation and related effector responses remains to be clarified. Thus, we ge...

journal_title：Blood

authors： Fröhlich A,Marsland BJ,Sonderegger I,Kurrer M,Hodge MR,Harris NL,Kopf M

更新日期：2007-03-01 00:00:00

abstract：:Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of...

journal_title：Blood

authors： Corral J,Iniesta JA,González-Conejero R,Villalón M,Vicente V

更新日期：2001-05-15 00:00:00

abstract：:An animal model for malignant mastocytosis is described in mice reconstituted with bone marrow cells expressing the v-erbB oncogene. The lethal mast cell disease is characterized by massive infiltration of bone marrow, spleen, and several other visceral organs by connective tissue mast cells, which normally reside in ...

journal_title：Blood

authors： von Rüden T,Kandels S,Radaszkiewicz T,Ullrich A,Wagner EF

更新日期：1992-06-15 00:00:00

abstract：:Small nuclear U1-RNAs (snRNAs), the spliceosome components selectively recognizing donor splice sites (5'ss), were engineered to restore correct mRNA processing in a cellular model of severe coagulation factor VII (FVII) deficiency, caused by the IVS7 9726 + 5g/a change. Three U1-snRNAs, complementary to the mutated 5...

journal_title：Blood

authors： Pinotti M,Rizzotto L,Balestra D,Lewandowska MA,Cavallari N,Marchetti G,Bernardi F,Pagani F

更新日期：2008-03-01 00:00:00

abstract：:Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry 2 mutations (CEBPA(double-mut)), usually biallelic, whereas single heterozygous mutations (CEBP...

journal_title：Blood

authors： Wouters BJ,Löwenberg B,Erpelinck-Verschueren CA,van Putten WL,Valk PJ,Delwel R

更新日期：2009-03-26 00:00:00

abstract：:Depletion of guanine nucleotide pools after inhibition of inosine monophosphate dehydrogenase (IMPDH) potently inhibits DNA synthesis by arresting cells in G1 and has been shown to induce the differentiation of cultured myeloid and erythroid cell lines, as well as chronic granulocytic leukemic cells after blast transf...

journal_title：Blood

authors： Laliberté J,Yee A,Xiong Y,Mitchell BS

更新日期：1998-04-15 00:00:00

abstract：:We evaluated the potential role of photoradiation therapy with a benzoporphyrin derivative, monoacid ring A (BPD-MA), and dihematoporphyrin ether (DHE), for the ex vivo purging of residual tumor cells from autologous bone marrow (BM) grafts. BPD-MA and DHE photosensitizing activity was tested against two human large-c...

journal_title：Blood

authors： Lemoli RM,Igarashi T,Knizewski M,Acaba L,Richter A,Jain A,Mitchell D,Levy J,Gulati SC

更新日期：1993-02-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. However, only a limited number of target genes have been identified. We have studied 10 MCL cell lines and 28 primary tumors with a combination of a high-density single...

journal_title：Blood

authors： Beà S,Salaverria I,Armengol L,Pinyol M,Fernández V,Hartmann EM,Jares P,Amador V,Hernández L,Navarro A,Ott G,Rosenwald A,Estivill X,Campo E

更新日期：2009-03-26 00:00:00

abstract：:The stress-activated protein/c-Jun N-terminal kinases (SAPK/JNK) have been shown to be activated by pro-inflammatory cytokines, as well as physical and chemical stresses. We now show that a variety of hematopoietic growth factors, including Steel locus factor (SLF), granulocyte-macrophage colony-stimulating factor (GM...

journal_title：Blood

authors： Foltz IN,Schrader JW

更新日期：1997-05-01 00:00:00

abstract：:Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B cells and an infiltration of the skin and the intestine by activated oligoclonal T lymphocytes, indicating that a profound defect in the lymphoid developmental program could be accountable for this condition. Inherited mutations ...

journal_title：Blood

authors： Corneo B,Moshous D,Güngör T,Wulffraat N,Philippet P,Le Deist FL,Fischer A,de Villartay JP

更新日期：2001-05-01 00:00:00

abstract：:Sequencing the complete factor IX gene of 2 sisters with hemophilia B with different phenotypes and no family history of hemorrhagic diathesis revealed a common 5' splice site mutation in intron 3 (T6704C) in both and an additional missense mutation (I344T) in one. The presence of dysfunctional antigen in the latter s...

journal_title：Blood

authors： Costa JM,Vidaud D,Laurendeau I,Vidaud M,Fressinaud E,Moisan JP,David A,Meyer D,Lavergne JM

更新日期：2000-08-15 00:00:00

abstract：:Prevention of erythrocyte dehydration is a potential therapeutic strategy for sickle cell disease. Increasing erythrocyte magnesium (Mg) could inhibit sickle cell dehydration by increasing chloride (CI) and water content and by inhibiting potassium chloride (K-CI) cotransport. In transgenic SAD 1 and (control) C57BL/6...

journal_title：Blood

authors： De Franceschi L,Beuzard Y,Jouault H,Brugnara C

更新日期：1996-10-01 00:00:00

abstract：:Macrophages and dendritic cells play an important role in regulating B-cell responses, including proliferation to antigens such as trinitrophenyl (TNP)-Ficoll and TNP-Brucella abortus. However, the mechanisms and molecule(s) that regulate these processes are relatively undefined. In this report, we show that human mac...

journal_title：Blood

authors： Craxton A,Magaletti D,Ryan EJ,Clark EA

更新日期：2003-06-01 00:00:00

abstract：:Little is known about the behavior of hematopoietic stem cells (HSCs) in primates because direct observations and competitive-repopulation assays are not feasible. Therefore, we used 2 different and independent experimental strategies, the tracking of transgene expression after retroviral-mediated gene transfer (N = 1...

journal_title：Blood

authors： Shepherd BE,Kiem HP,Lansdorp PM,Dunbar CE,Aubert G,LaRochelle A,Seggewiss R,Guttorp P,Abkowitz JL

更新日期：2007-09-15 00:00:00

abstract：:Immune thrombocytopenias are usually associated with normal or increased numbers of megakaryocytes in the marrow. Therefore, the mechanism(s) responsible for the destruction of circulating platelets may not affect megakaryocytes in the same way. One of the possibilities which could account for the differential effect ...

journal_title：Blood

authors： Stahl CP,Zucker-Franklin D,McDonald TP

更新日期：1986-02-01 00:00:00

abstract：:The frequent occurrence of TF gene involvement in translocations associated with leukemia is remarkable, although not yet explained. The wide variety of TFs involved in these translocations and the different stages of cellular maturation argue against a unifying mechanism. Recombinases, active during B-cell and T-cell...

journal_title：Blood

authors： Nichols J,Nimer SD

更新日期：1992-12-15 00:00:00

abstract：:The abl oncogene is translocated from chromosome 9 to 22 in the creation of the Philadelphia (Ph1) chromosome. This article describes new translocation breakpoints identified in two patients with chronic myelogenous leukemia using Southern blotting and cloned human DNA probes from chromosome 9. The translocation break...

journal_title：Blood

authors： Leibowitz D,Schaefer-Rego K,Popenoe DW,Mears JG,Bank A

更新日期：1985-07-01 00:00:00

abstract：:Biosynthesis of leukotrienes (LTs) occurs in human myeloid cells and B lymphocytes. However, the function of leukotrienes in B lymphocytes is unclear. Here, we report that B-cell chronic lymphocytic leukemia (B-CLL) cells produce leukotriene B(4), and that specific leukotriene biosynthesis inhibitors counteracted CD40...

journal_title：Blood

authors： Runarsson G,Liu A,Mahshid Y,Feltenmark S,Pettersson A,Klein E,Björkholm M,Claesson HE

更新日期：2005-02-01 00:00:00

abstract：:In this issue of Blood, Sun and colleagues from the Bone Marrow Transplant Survivors Study report the chronic health outcomes of more than 1000 survivors of stem cell transplantation. Their results demonstrate a significant burden of chronic conditions among survivors. ...

journal_title：Blood

authors： Cutler C

更新日期：2010-10-28 00:00:00